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生物医学研究热点之信息计量分析

生物医学研究热点之信息计量分析

作者：覃佳慧（jane h.qin）南京大学

学位级别：硕士

《SCIENCE》是美国科学促进会出版的一份学术期刊,为全世界最权威的学术期刊之一。该期刊主要关注于出版重要的原创性、前沿性科学研究和科研综述。每年年末,《SCIENCE》期刊会在当年发表的论文主题中评选十个最能代表当年科学界突破的... 详细信息

《SCIENCE》是美国科学促进会出版的一份学术期刊,为全世界最权威的学术期刊之一。该期刊主要关注于出版重要的原创性、前沿性科学研究和科研综述。每年年末,《SCIENCE》期刊会在当年发表的论文主题中评选十个最能代表当年科学界突破的科研主题,称为“年度突破”(Breakthrough of the Year)。“年度突破”表现了期刊编委成员对于当年涌现的新技术的价值和发展潜力的判断,而被选中的主题往往也是主题所在学科或领域当前的研究热点。在2010年至2016年间评选的“年度突破”中,出现了三个研究起始时间相近、论文数量相当、研究内容相近但核心内容相互独立的生物医学主题,分别是合成生物学、诱导多能干细胞、CRISPR/Cas9。本文以这三个热点主题的论文为对象,选择Web of Science中SCI核心合集数据库收录的在2018年及之前发表的这三个热点主题相关论文为数据集,并以论文为客体,每个热点主题数据集为总体抽取h核论文代表高影响力论文作为全部论文的比较对象。通过科学计量学方法、社会网络分析法、内容分析法,从国家、机构、论文、期刊、关键词五个角度出发,分析三个热点主题的研究现状、主题间差异、主题间交叉关系和相互作用,为相关主题研究人员开展研究、寻求合作伙伴、相关领域人才评价提供建议和参考。其中科学计量分析中选择了h指数、g指数、学术迹为测度,社会网络分析法中选择了度数中心性、特征向量中心性、中介中心性为测度。为了分析主题研究现状,使用科学计量测度,结合内容分析法,测度了三个热点主题论文在国家、机构、作者的分布,并给出了科学计量分析结果。在国家层面,美国、日本、英国、德国、中国在三个主题的论文数量、科学计量指标均位列前10乃至前5名。在机构层面,三个热点主题各有不完全一致的核心机构。在作者层面,结合科学计量指标和内容分析法,给出了核心作者的科学计量排序,并按照排序分析了核心作者的代表研究和最新研究进展。为了分析主题合作关系,使用社会网络分析法,结合内容分析法,分析三个热点主题论文合著网络的结构和重要节点,通过可视化直观地展示合著网络的结构。在作者合著网络中,结合内容分析法分析重要节点的代表研究和最新研究进展。并对科学计量分析结果和社会网络分析结果进行相关性分析,结果表示两者为中度到弱相关关系,是两种不同的分析方式,分布表示评价对象的直接学术贡献、通过合作推动知识流动贡献程度,二者可以互相补充使用。在期刊分析中,使用学术迹测度了热点对应的核心期刊,发现三个主题的核心期刊在综合性期刊和学科性期刊的分布各有特点,分布规律和主题论文数量发展趋势可能有对应关系。关键词分析中,使用社会网络分析法分析了共词网络,结果表明三个主题的主要核心内容存在差异,同时共词网络的可视化结果显示三个主题的研究内容存在交叉。分析三个热点对应的国内外公共政策,结合计量分析结果探讨公共政策环境对科研活动的影响。

关键词：合成生物学诱导多能干细胞 CRISPR/Cas9 科学计量学社会网络分析

Nanoindentation responses of NiCoFe medium-entropy alloys from cryogenic to elevated temperatures

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Journal of Iron and Steel Research International 2024年第8期31卷 2068-2077页

作者： qin-qin Xu Kamran Karimi Amirhossein h.Naghdi Wen-yi huo Chong Wei Stefanos Papanikolaou NOMATEN Centre of Excellence National Centre for Nuclear ResearchOtwock 05-400MazowszePoland College of Mechanical and Electrical Engineering Nanjing Forestry UniversityNanjing 210037JiangsuChina Science and Technology on Thermo Structural Composite Materials Laboratory Northwestern Polytechnical UniversityXi'an 710072ShaanxiChina School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072ShaanxiChina

NiCoFe alloy,a medium-entropy alloy,shows potential for applications in extreme ***,there is a theoretical barrier concerning the unclear understanding of its high-temperature dislocation motion *** load response exhibits distinct signatures relevant to thermal activation,most notably a decrease in critical force(i.e,softening)from cryogenic to elevated temperatures,e.g.,from 200 to 1000 *** onset of plasticity is characterized by the nucleation of stacking faults and prismatic loops at low temperatures,whereas the surface nucleation of Shockley partial dislocations dominates plasticity at elevated *** show that thermal effects lead to non-uniform atom pile-ups and control the rate of phase transformation with increasing indentation *** findings in this work extend the understanding of the mechanical response of NiCoFe alloys under indentation at different temperatures,shedding light on the underlying dislocation motion mechanisms and surface deformation *** observed transformation-induced plasticity mechanism has implications for the properties of medium-entropy alloys and their potential applications in extreme environments.

关键词： Orientation Dislocations Mechanical behaviors Phase transition

The Coarse l^(p)-Novikov Conjecture and Banach Spaces with Property(h)

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Chinese Annals of Mathematics,Series B 2024年第2期45卷 193-220页

作者： huan WANG qin WANG Research Center for Operator Algebras School of Mathematical SciencesEast China Normal UniversityShanghai 200241China Key Laboratory of MEA Ministry of Educationand Shanghai Key Laboratory of PMMPEast China Normal UniversityShanghai 200241China

In this paper,for 1he authors show that the coarse l^(p)-Novikov conjecture holds for metric spaces with bounded geometry which are coarsely embeddable into a Banach space with Kasparov-Yu’s Property(h).

关键词： The coarse l^(p)-Novikov conjecture Banach spaces with Property(h) Coarse geometry K-Theory

Effectiveness of mindfulness-based interventions on the well-being of healthcare workers:a systematic review and meta-analysis

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General Psychiatry 2024年第3期37卷 335-344页

作者： Natasha Yixuan Ong Finn Jing Jie Teo jane Zi Ying Ee Chun En Yau Julian Thumboo hiang Khoon Tan qin Xiang Ng NUS Yong Loo Lin School of Medicine National University of SingaporeSingapore health Services Research Unit Singapore General HospitalSingapore Singhealth Duke-NUS Medicine Academic Clinical Programme Duke-NUS Medical SchoolSingapore Singhealth Duke-NUS Global health Institute Singapore Duke Global health Institute Duke UniversityDurhamNorth CarolinaUSA Division of Surgery and Surgical Oncology Singapore General HospitalSingapore Saw Swee hock School of Public health National University of Singapore and National University Health SystemSingapore

Background Growing evidence attests to the efficacy of mindfulness-based interventions(MBIs),but their effectiveness for healthcare workers remains *** To evaluate the evidence for MBIs in improving healthcare workers’psychological *** A systematic literature search was conducted on Medline,Embase,Cumulative Index for Nursing and Allied health Literature,PsycINFO and Cochrane Central Register of Controlled Trials up to 31 August 2022 using the keywords‘healthcare worker’,‘doctor’,‘nurse’,‘allied health’,‘mindfulness’,‘wellness’,‘workshop’and‘program’.Randomised controlled trials with a defined MBI focusing on healthcare workers and quantitative outcome measures related to subjective or psychological well-being were eligible for inclusion.R V.4.0.3 was used for data analysis,with the standardised mean difference as the primary outcome,employing DerSimonian and Laird’s random effects *** of Recommendations,Assessment,Development and Evaluation framework was used to evaluate the quality of ***’s Risk of Bias 2 tool was used to assess the risk of bias in the included *** A total of 27 studies with 2506 participants were included,mostly from the USA,involving various healthcare *** such as stress reduction programmes,apps,meditation and training showed small to large effects on anxiety,burnout,stress,depression,psychological distress and job strain outcomes of the *** effects were also seen in self-compassion,empathy,mindfulness and ***,long-term outcomes(1 month or longer postintervention)varied,and the effects were not consistently *** MBIs offer short-term benefits in reducing stress-related symptoms in healthcare *** review also highlights limitations such as intervention heterogeneity,reduced power in specific subgroup analyses and variable study quality.

关键词： nurse sustained workers

Immunological Exploration of helicobacter pylori Serotype O_(2) O-Antigen by Using a Synthetic Glycan Library

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Chinese Journal of Chemistry 2024年第3期42卷 243-251页

作者： Ming Zhao Guangzong Tian Chunjun qin Xiaopeng Zou Peter h. Seeberger Jing hu Jian Yin Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of Biotechnology & School of Life Sciences and Health EngineeringJiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China Biomolecular Systems Department Max Planck Institute of Colloids and InterfacesAm Mühlenberg 1Potsdam14476 Germany Wuxi School of Medicine Jiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China

helicobacter pylori(***)infection is a threat to human *** lipopolysaccharide(LPS)O-antigen holds promise for developing *** is meaningful to explore the immunological activity of oligosaccharides with different lengths and frameshifts for antigen ***,a glycan library of *** O2 O-antigen containing eight fragments is *** screening with *** O2 LPS sera and patients’sera by glycan microarray,the disaccharide hPO2G-2b and trisaccharide hPO2G-3a show strong antigenicity and then are separately conjugated with carrier protein *** glycoconjugates elicit a robust immunoglobulin G(IgG)immune response in *** anti-hPO2G-3a IgG antibodies possess a much stronger binding affinity with the LPS and bacteria of *** O2 than the anti-hPO2G-2b IgG *** is no cross-reaction between both sera IgG antibodies with LPS and bacteria of *** O1,O6,and *** results demonstrate the trisaccharide hPO2G-3a is a promising candidate for *** vaccine development.

关键词： Glycoconjugates helicobacter pylori Immunology Microarrays O-antigen Oligosaccharides

SARS-CoV-2 variants are associated with different clinical courses in children with MIS-C

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World Journal of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emelia Bainto helen harvey Adriana h.Tremoulet jane C.Burns Kirsten B.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research Center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Background Recent infection with SARS‑CoV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-C).SARS‑CoV-2 has undergone different *** publications exist about specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-C at Rady Children’s hospital-San Diego between May 2020 and March *** epidemiologic data,including viral genomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-C waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to C,20G,21C(Epsilon),20I(Alpha),and 20J(Gamma).The third wave had Delta strains(clades 21A,21I,and 21J),and the fourth had Omicron variants(clades 21K,21L,and 22C).MIS-C presented with similar symptoms and laboratory findings across all *** patients were admitted to the pediatric intensive care unit(PICU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-CoV-2 triggered MIS-C with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： Complications COVID-19 MIS-C SARS-CoV-2 variants

In situ meso-tetra(4-carboxyphenyl)porphyrin ligand substitution in hf-MOF for enhanced catalytic activity and stability in photoredox reactions

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Rare Metals 2024年第6期43卷 2682-2694页

作者： Jie hu hong-Xin Lao Xiu-Wu Xu Wei-Kang Wang Le-Le Wang qin-qin Liu School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China College of Chemistry and Materials Engineering Research Center of Carbon NeutralityAnhui Normal UniversityWuhu 241002China Fujian Provincial Key Laboratory of Ecology-Toxicological Effects and Control for Emerging Contaminants Putian UniversityPutian 351100China

Though there are numerous intrinsic merits of metal-organic frameworks(MOFs),low charge separation efficiency has imposed heavy restrictions on their photocatalytic ***,in situ porphyrin ligand substitution,as a strategy for improving the charge separation efficiency and increasing the amounts of active sites,has been designed and realized in a hf-biphenyl dicarboxylic acid(BPDC)***,a size and geometry matched meso-tetra(4-carboxyphenyl)porphyrin(TCPP)ligand was selected and doped into hf-BPDC MOF by forming coordinating bonds with hf centers,forming dualligand hf-BPDC-TCPP *** resultant hf-BPDC-TCPP MOF showed significantly improved activity and chemical stability in the photocatalytic h_(2)generation(261μmol·g^(-1)·h^(-1))and tetracycline(TC)degradation reactions(95.8%),which was 48 and 1.47 folds higher than that of the hf-BPDC *** and electrochemical studies revealed that the introduction of porphyrin ligand could generate a stronger internal electric field for boosting the charge separation and transfer,increase the specific surface area for providing more active sites,and narrow the band gap to enhance the visible light *** in situ ligand substitution method provides a promising approach to build a tunable platform for constructing high-performance MOF photocatalysts.

关键词： Ligand substitution Metal organic frameworks Meso-tetra(4-carboxyphenyl)porphyrin hydrogen evolution reaction Tetracycline degradation

Ganoderma Lucidum Spore Oil enhances the effect of cyclophosphamide via inhibiting programmed death-1 and prolongs the survival of h22 tumor-bearing mice

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Journal of Traditional Chinese Medicine 2024年第4期44卷 652-659页

作者： JIANG Zhaojian CAI hongfei YUAN Cheng CAO Lin XU Wendong hAN Yaming ZhANG qin LI Jing WANG qin LIU Juyan Guangzhou hanFang Pharmaceutical Company Limited National Engineering Research Center of Pharmaceutical Processing Technology of Traditional Chinese Medicine and Drug InnovationGuangdong Provincial Key Laboratory of Medicinal LipidsGuangzhou 510240China Zhongshan Medical College Sun Yat-sen UniversityGuangzhou 510080China Guangzhou Pharmaceutical holdings Limited Guangzhou 510130China National Engineering Research Center of Pharmaceutical Processing Technology of Traditional Chinese Medicine and Drug Innovation Guangzhou 510240China

OBJECTIVE:To investigate the effect of Ganoderma Lucidum Spore Oil(GLSO)on the tumor growth and survival of h22 tumor-bearing mice treated with cyclophosphamide(CTX),and explore the underlying ***:Allograft h22 hepatocellular carcinoma mouse model was applied to investigate the effect of GLSO on the tumor growth and survival of animals,and Kaplan-Meier survival analysis was used to analyze the life *** biochemical examination was used to determine the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),urea(UREA)and creatinine(CRE).Western blot analysis was performed to detect Programmed Death-1(PD-1),Programmed Death Ligand 1(PD-L1),Janus Kinase 2(JAK2),phosphorylated Signal Transducer and Activator of Transcription 3(p-STAT3),and Signal Transducer and Activator of Transcription 3(STAT3)***:GLSO increased the anti-tumor effect of CTX and prolonged the survival of h22 tumor-bearing mice treated with ***,GLSO increased the thymus index and showed no obvious toxicity to liver functions of *** also decreased the level of UREA in h22 tumor-bearing mice treated with ***,GLSO could inhibit the expression of PD-1 in spleen,which was independent of JAK2 expression and STAT3 ***,GLSO did not affect the expression of PD-L1,JAK2,and p-STAT3 in tumor ***:GLSO could strengthen the anti-tumor effect of CTX and prolong the life span of h22 tumorbearing mice,while the underlying mechanism might be relevant to the amelioration effect of thymus function and inhibition of PD-1 expression in ***,these findings implied the promising role of GLSO in combination with CTX to extend the survival of patients in clinical chemotherapy of hepatocellular carcinoma.

关键词： carcinoma,hepatocellular cyclophosphamide survival programmed cell death 1 receptor Ganoderma Lucidum SporeOil

Effect of streamlined nose length on aerodynamic performance of high-speed train with a speed of 400 km/h

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第7期25卷 525-540页

作者： Nianxun LI Tian LI Zhiyuan DAI Deng qin Jiye ZhANG State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong UniversityChengdu 610031China

The streamlined nose length(SNL)plays a crucial role in determining the aerodynamic performance of high-speed *** appropriate SNL can not only effectively reduce the magnitude of aerodynamic drag and lift forces,but also improve the performance of the high-speed train in tunnel passing and crosswind *** this study,a numerical simulation of the aerodynamic performance of high-speed trains at a speed of 400 km/h,with varying SNLs,is conducted using the k-ωshear stress transport(SST)turbulence *** different SNLs include 6.0,7.0,8.0,9.0,9.8,12.0,15.0,and 18.0 *** order to validate the accuracy of the numerical simulation,its results are compared with wind tunnel test data obtained from the *** simulation is carried out using compressible and incompressible gases to determine the effect of gas compressibility on *** impact of SNL on the aerodynamic performance of the trains is analyzed in terms of aerodynamic forces,velocity,and pressure *** comparison to the original train,the train with a 6.0 m SNL experienced a 10.8%increase in overall aerodynamic ***,the lift forces on the head and tail cars increased by 35.7%and 75.5%,*** the other hand,the train with an 18.0 m SNL exhibited a 16.5%decrease in aerodynamic ***,the lift forces on the head and tail cars decreased by 21.9%and 49.7%,*** aerodynamic drag force of the entire train varies linearly with the SNL,while the aerodynamic lift of the tail car follows a quadratic function in relation to the SNL.

关键词： Streamlined nose length(SNL) high-speed train Aerodynamic performance Numerical simulation Flow structures