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Antagonism of Transcription Factor MYC2 by eDS1/PAD4 Complexes Bolsters Salicylic Acid Defense in Arabidopsis effector-Triggered Immunity

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Molecular Plant 2018年第8期11卷 1053-1066页

作者： Haitao Cui Jingde Qiu Yue Zhou Deepak D. Bhandari Chunhui Zhao Jaqueline Bautor jane e. Parker Department of Plant-Microbe Interactions Max-Planck Institute for Plant Breeding Research Carl-von-Linne Weg 10 50829 Cologne Germany Department of Plant Developmental Biology Max-Planck Institute for Plant Breeding Research 50829 Cologne Germany Key Laboratory of Ministry of education for Genetics Breeding and Multiple Utilization of Crops Plant Immunity Center Fujian Agriculture University Fuzhou 350002 China These authors contributed equaily to this article.

In plant immunity, pathogen-activated intracellular nucleotide binding/leucine rich repeat （NLR） receptors mobilize disease resistance pathways, but the downstream signaling mechanisms remain obscure. enhanced disease susceptibility 1 （eDS1） controls transcriptional reprogramming in resistance triggered by Toll-lnterleukinl-Receptor domain （TIR）-family NLRs （TNLs）. Transcriptional induction of the salicylic acid （SA） hormone defense sector provides one crucial barrier against biotrophic pathogens. Here, we present genetic and molecular evidence that in Arabidopsis an eDS1 complex with its partner PAD4 inhibits MYC2, a master regulator of SA-antagonizing jasmonic acid （JA） hormone pathways. In the TNL immune response, eDSl/PAD4 interference with MYC2 boosts the SA defense sector independently of eDS1-induced SA synthesis, thereby effectively blocking actions of a potent bacterial JA mimic, coronatine （COR）. We show that antagonism of MYC2 occurs after COR has been sensed inside the nucleus but before or coincident with MYC2 binding to a target promoter, pANAC019. The stable interaction of PAD4 with MYC2 in planta is competed by eDS1-PAD4 complexes. However, suppression of MYC2-promoted genes requires eDS1 together with PAD4, pointing to an essential eDS1-PAD4 heterodimer activity in MYC2 inhibition. Taken together, these results uncover an immune receptor signaling circuit that intersects with hormone pathway crosstalk to reduce bacterial pathogen growth.

关键词： NLR receptor stress hormone network Pseudomonas syringae AvrRps4 RRS1/RPS4 coi1

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Paying a Price for Loving Red Meat

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科技英语学习 2009年第7期 M0002-M0002,3-5页

作者： jane e.Brody 张英

你是否经常拿汉堡包和热狗当午餐呢？喜欢周末去郊外野餐吃烤肉或去西餐厅吃牛排吗？实际上，我们在大饱口福的同时，也极大地损害着自身的健康。美国一项为期10年的随访调查研究表明，大量食用红色肉类及热狗、培根等经过加工的肉类食... 详细信息

你是否经常拿汉堡包和热狗当午餐呢？喜欢周末去郊外野餐吃烤肉或去西餐厅吃牛排吗？实际上，我们在大饱口福的同时，也极大地损害着自身的健康。美国一项为期10年的随访调查研究表明，大量食用红色肉类及热狗、培根等经过加工的肉类食品会导致老年人死亡率的上升。

关键词：英语学习学习方法翻译阅读

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Diabetes pathogenesis and management:the endothelium comes of age

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Journal of Molecular Cell Biology 2021年第7期13卷 500-512页

作者： Kaitlin M.Love eugene J.Barrett Steven K.Malin jane e.B.Reusch Judith G.Regensteiner Zhenqi Liu Division of endocrinology and Metabolism Department of MedicineUniversity of Virginia Health SystemCharlottesvilleVA 22908USA Department of Kinesiology and Health Rutgers UniversityNew BrunswickNJUSA Division of endocrinology Metabolism and NutritionRutgers UniversityNew BrunswickNJUSA New Jersey Institute for Food Nutrition and HealthRutgers UniversityNew BrunswickNJUSA Institute of Translational Medicine and Research Rutgers UniversityNew BrunswickNJUSA Center for Women’s Health Research University of Colorado School of MedicineAuroraCOUSA Department of Medicine University of ColoradoAnschutz Medical CampusAuroraCOUSA Rocky Mountain Regional Veterans Affairs Medical Center AuroraCOUSA

endothelium,acting as a barrier,protects tissues against factors that provoke insulin resistance and type 2 diabetes and itself responds to the insult of insulin resistance inducers with altered *** insulin resistance and vascular dysfunction occur early in the evolution of insulin resistance-related disease,can co-exist with and even contribute to the development of metabolic insulin resistance,and promote vascular complications in those *** impact of endothelial insulin resistance and vascular dysfunction varies depending on the blood vessel size and location,resulting in decreased arterial plasticity,increased atherosclerosis and vascular resistance,and decreased tissue *** with insulin resistance and diabetes are disproportionately impacted by cardiovascular disease,likely related to differential sex-hormone endothelium ***,reducing endothelial insulin resistance and improving endothelial function in the conduit arteries may reduce atherosclerotic complications,in the resistance arteries lead to better blood pressure control,and in the microvasculature lead to less microvascular complications and more effective tissue *** diabetes therapeutic modalities,including medications and exercise training,improve endothelial insulin action and vascular *** action may delay the onset of type 2 diabetes and/or its complications,making the vascular endothelium an attractive therapeutic target for type 2 diabetes and potentially type 1 diabetes.

关键词： diabetes insulin resistance endothelium vascular function

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Bone blood stem cells

Bone blood stem cells

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International Conference on Osteoporosis and Bone Research 2008

作者： jane e.Aubin Department of Molecular Genetics University of TorontoTorontoOntarioCanada

＜正＞The fact that bone formation takes place not only during dev- elopment but throughout life suggests that there is a large reservoir of cells in the body capable of *** nature of these cells over the lifetime of the animal,contributions from stem cell versus com- mitted progenitor pools,and identification of developmental tran-

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Integrated Research on Disaster Risk—Addressing the Challenge of Natural and Human-Induced environmental Hazards

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International Journal of Disaster Risk Science 2010年第1期1卷 48-49页

作者： jane e.Rovins International Program Office for the Integrated Research on Disaster Risk(IRDR)program Beijing 100190China

The Hyogo Framework for Action(HFA)states:ctT he starting point for reducing disaster risk and for promoting a culture o f disaster resilience lies in the knowledge o f the hazards and the physical,social,economic and environmental vulnerabili-ties to disasters that most societies face,and o f the ways in which hazards and vulnerabilities are changing in the short and long te rm,...,5(UNISDR 2005,7).

关键词： disaster starting Human

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基于文献计量的中外人工智能政策研究现状及启示

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情报杂志 2021年第1期40卷 48-55页

作者：郑烨任牡丹 jane e.Fountain 西北工业大学人文与经法学院西安710072 麻省大学安默斯特分校国家数字政府研究中心安默斯特01003

[目的/意义]人工智能已成为推动新一轮科技革命和产业变革的重要技术力量,世界各国加紧出台了相关政策。通过对当前研究进行及时梳理,可为今后国内人工智能政策的理论推进及政策出台和完善等提供指导。[方法/过程]以国外SSCI和国内CSSC... 详细信息

[目的/意义]人工智能已成为推动新一轮科技革命和产业变革的重要技术力量,世界各国加紧出台了相关政策。通过对当前研究进行及时梳理,可为今后国内人工智能政策的理论推进及政策出台和完善等提供指导。[方法/过程]以国外SSCI和国内CSSCI期刊数据库收录的395篇研究论文为样本,采用文献计量分析和比较研究法对中外人工智能政策研究的高共被引文献、热点主题及演进趋势等进行深入探索。[结果/结论]与国外相比,国内研究起步较晚但势头迅猛;高共被引文献反映了人工智能领域存在的问题和风险、应用前景、技术革新及对社会的影响;国外研究热点涵盖了知识管理等十二类主题,而国内研究热点则包括国家治理背景下人工智能政策发展路径等三类主题;国外研究的演进特征体现在三个方面,而国内研究则体现在两个方面。最后,从加快形成和构建人工智能政策研究的理论框架体系等三个方面提出对国内研究的启示。

关键词：人工智能人工智能政策高共被引文献研究主题演进趋势

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To Lower Risk on Jogging Trail,Get Off the Couch

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当代外语研究 2006年第11期 30-33页

作者： jane e.Brody 张英英

研究数据表明,每年有相当多的人死于跑步途中引发的突发性心脏病。对此人们不禁怀疑:“难道跑步对维护心脏健康是有损无益的吗?”研究人员明确回答了这个问题:虽然人在剧烈运动中有可能死于突发性心脏病,但是有规律、经常且适量的运动... 详细信息

研究数据表明,每年有相当多的人死于跑步途中引发的突发性心脏病。对此人们不禁怀疑:“难道跑步对维护心脏健康是有损无益的吗?”研究人员明确回答了这个问题:虽然人在剧烈运动中有可能死于突发性心脏病,但是有规律、经常且适量的运动如慢跑等,对降低人体运动过程中受到突发心脏病侵袭的风险是有帮助的。研究还显示,经常跑步者比一般人要更加长寿,因此我们如果想活得更健康、更长久,就马上从沙发里跳出来,开始做运动吧!

关键词：心脏病突发性跑步健康剧烈运动冠心病运动过程研究数据研究人员尸体解剖

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让教学成为神圣的艺术

让教学成为神圣的艺术

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2017年

作者： Rev.jane e.Vennard

《让教学成为神圣的艺术》以多种方式进行研究，揭开了教学的神秘面纱，展现了教育教学中方方面面的欢乐。作者简·e.温纳德将传统方式与**规方式结合，引用自己和其他教师的亲身经历，向读者们展现了一副开阔的教学画面，并阐述了教师... 详细信息

《让教学成为神圣的艺术》以多种方式进行研究，揭开了教学的神秘面纱，展现了教育教学中方方面面的欢乐。作者简·e.温纳德将传统方式与**规方式结合，引用自己和其他教师的亲身经历，向读者们展现了一副开阔的教学画面，并阐述了教师在日常生活中所应当关心留意的责任。作者生动地描写了教学生活中的混乱、疑惑、欢乐与挫败，使读者能够从中获取经验并铭记自己的教学历程。此外，本书设计了许多练习与活动，以此引导读者进行反思，帮助读者从挫折中重新振作，积极面对教学生活。本书适合广大教育工作者阅读。

关键词：教育工作

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eastern Oyster (<i>Crassostrea virginica</i>) Filtration efficiency of Chlorophyll-<i>a</i>under Dynamic Conditions in the Hudson-Raritan estuary at Pier 40, New York City

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Open Journal of ecology 2019年第7期9卷 238-271页

作者： jane e. Perrino Dennis R. Ruez Jr. Department environmental Studies University of Illinois Springfield Springfield IL USA

eastern oyster (Crassostrea virginica) abundance has declined severely over the past century along the Atlantic and Gulf coasts of the United States. For varied reasons, overfishing among the foremost, bivalves no longer make up considerable reefs as was common. While discourse continues on oyster restoration and augmentation, gaps in knowledge of C. virginica and regional environmental interactions remain. Our primary aim was to examine the C. virginica filter feeding of phytoplankton in the Hudson River estuary, New York City. Secondarily, this study examined the filtration of these oysters in relation to environmental attributes. Chlorophyll-a, the predominant photosynthesizing pigment in red and green algae, is an indicator of phytoplankton productivity in aquatic settings. Crassostrea virginica consumes first-tier plankton from the water column’s seston;thus analysis of chlorophyll-a content allows estimating phytoplankton concentrations, from which oyster filtration efficiency (Fe) was quantified. Water conditions (temperature, dissolved oxygen, pH, salinity, turbidity, tide and flow rate) also were recorded. Spectrophotometric determination of chlorophyll-a concentration methodology was derived from the Standard Methods text favored by the US ePA. This project compared real-time Hudson River estuary (HRe) water samples prior to passing through a contained oyster reef and samples of water post-filtration. This sampling scenario was unique as the contained reef used was fed by HRe water. Most studies on oyster filtration have been laboratory-based, and few assessed oysters in the field. This study took place at Pier 40, the River Project Wetlab, lower Hudson River along Manhattan. The Fe of this reef was calculated for two months during various environmental states which can be the basis of future investigations. Statistically significant differences were found between pre- and post-filtration water samples (Z = 4.620, p es a glimpse

关键词： Chlorophyll-a Crassostrea virginica Filtration efficiency Hudson River

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Trimodality treatment in gastric and gastroesophageal junction cancers:Current approach and future perspectives

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 181-202页

作者： Nikolaos Charalampakis Sergios Tsakatikas Dimitrios Schizas Stylianos Kykalos Maria Tolia Rodanthi Fioretzaki Georgios Papageorgiou Ioannis Katsaros Ahmed Adel Fouad Abdelhakeem Matheus Sewastjanow-Silva jane e Rogers Jaffer A Ajani Department of Medical Oncology Metaxa Cancer Hospital of PiraeusPiraeus 18537Greece TheFirst Department of Surgery National and Kapodistrian University of AthensLaikon General HospitalAthens 11527Greece TheSecond Propedeutic Department of Surgery National and Kapodistrian University of AthensLaikon General HospitalAthens 11527Greece Department of Radiation Oncology University Hospital of CreteHeraklion 71110Greece Department of General Surgery Metaxa Cancer Hospital of PiraeusPiraeus 18537Greece Department of Gastrointestinal Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States

Gastric and gastroesophageal junction(GeJ)cancers represent an aggressive group of malignancies with poor prognosis even when diagnosed in relatively early stage,with an increasing incidence both in Asia and in Western *** cancers are characterized by heterogeneity as a result of different pathogenetic mechanisms as shown in recent molecular ***,the understanding of phenotypic and genotypic correlations/classifications has been *** therapeutic strategies have also advanced and moved beyond surgical extirpation alone,with the incorporation of other treatment modalities,such as radiation and chemotherapy(including biologics).Chemoradiotherapy has been used as postoperative treatment after suboptimal gastrectomy to ensure local disease control but also improvement in *** chemoradiotherapy/chemotherapy has been employed to increase the chance of a successful R0 resection and pathologic complete response rate,which is associated with improved long-term *** studies have defined various chemotherapy regimens to accompany radiation(before and after surgery).Recently,addition of immunotherapy after trimodality of gastroesophageal cancer has produced an advantage in disease-free *** agents used in the metastatic setting are being investigated in the early setting with mixed *** aim of this review is to summarize the existing data on trimodality approaches for gastric and GeJ cancers,highlight the remaining questions and present the current research effort addressing them.

关键词： Gastric cancer Gastroesophageal junction cancer Trimodality treatment Chemoradiotherapy Surgery Immunotherapy

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