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年龄与发育进程问卷上海市儿童常模及心理测量学特性研究

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中华儿科杂志 2010年第7期48卷 492-496页

作者：卞晓燕姚国英 SQUIRES jane 魏梅 cHEN ching-I 方秉华上海交通大学附属儿童医院上海市儿童医院上海市儿童保健所 200040 美国俄勒冈大学人类发育中心早期干预研究所

目的引进年龄与发育进程问卷（ASQ）,研究ASQ中文版（ASQ-c）、ASQ-c上海市3～66个月儿童常模及其心理测量学特性.方法翻译、回译、改编ASQ成***-c 19个月龄组、每个月龄组393～517名,共8472名3～66个月常模样本儿童的父母/照看人完... 详细信息

目的引进年龄与发育进程问卷（ASQ）,研究ASQ中文版（ASQ-c）、ASQ-c上海市3～66个月儿童常模及其心理测量学特性.方法翻译、回译、改编ASQ成***-c 19个月龄组、每个月龄组393～517名,共8472名3～66个月常模样本儿童的父母/照看人完成与儿童年龄相应的ASQ-c.其中519名父母/照看人完成ASQ-c后6 d内专业人员再次完成相同ASQ-c,为测试者间信度检验样本;651名父母/照看人间隔10～23 d再次完成相同ASQ-c,为重测信度检验样本;～6、～12、～18、～24、～30个月5个月龄组、每个月龄组42～60名,共255名儿童用贝利婴儿发育量表第2版（BSID Ⅱ）测试作为效度检验样本.采用SPSS 13.0进行统计分析.结果 85.25%儿童的父母/照看人能够独立完成ASQ-c;完成了ASQ-c及其离均差常模;ASQ-c的cronbach＇s α系数为0.77;父母/照看人与专业人员分别测试的量表总分间r为0.84（P＜0.0001）,父母/照看人两次测试的量表总分间r为0.82（P＜0.0001）;ASQ-c与BSID Ⅱ发育诊断的一致率为84.31%,敏感度为85.00%,特异度为84.26%..结论上海市儿童的父母/照看人完成ASQ-c可行;ASQ-c具有良好的心理测量学特性,值得进一步研究并引进.

关键词：儿童发育问卷调查模型,心理学贝利婴儿发育量表-Ⅱ

Polymorphisms in NF-κB,PXR,LXR,PPARγ and risk of inflammatory bowel disease

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World Journal of Gastroenterology 2011年第2期17卷 197-206页

作者： Vibeke Andersen jane christensen Anja Ernst Bent A Jacobsen Anne Tjφnneland Henrik B Krarup Ulla Vogel Department of Medical Viborg Regional Hospital Institute of cancer Epidemiology Danish Cancer Society Department of clinical Biochemistry Aarhus University Hospital Department of Medical Gastroenterology Aarhus University Hospital National Food Institute Technical University of Denmark Institute for Science Systems and ModelsUniversity of Roskilde National Research centre for the Working Environment

AIM:To investigate the contribution of polymorphisms in nuclear receptors to risk of inflammatory bowel disease(IBD) . METHODS:Genotypes of nuclear factor(NF) -κB(NFKB1) NFκB-94ins/del(rs28362491) ;peroxisome proliferatoractivated receptor(PPAR) -γ(PPARγ) PPARγPro12Ala(rs1801282) and c1431T(rs 3856806) ;pregnane X receptor(PXR) (NR1I2) PXR A-24381c(rs1523127) ,c8055T(2276707) ,and A7635G(rs 6785049) ;and liver X receptor(LXR) (NR1H2) LXR T-rs1405655-c and T-rs2695121-c were assessed in a Danish case-control study of 327 crohn's disease patients,495 ulcerative colitis(Uc) patients,and 779 healthy *** ratio(OR) and 95%cI were estimated by logistic regression models. RESULTS:The PXR A7635G variant,the PPARγPro12Ala and LXR T-rs2695121-c homozygous variant genotypes were associated with risk of Uc(OR:1.31,95% cI:1.03-1.66,P=0.03,OR:2.30,95%cI:1.04-5.08,P=0.04,and OR:1.41,95%cI:1.00-1.98,P=0.05,respectively) compared to the corresponding homozygous wild-type *** never smokers,PXR A7635G and the LXR T-rs1405655-c and T-rs2695121-c variant genotypes were associated with risk of IBD(OR:1.41,95%cI:1.05-1.91,P=0.02,OR:1.63,95%cI:1.21-2.20,P=0.001,and OR:2.02,95%cI:1.36-2.99,P=0.0005,respectively) compared to the respective homozygous variant *** A7635G(rs6785049) variant genotype was associated with a higher risk of Uc diagnosis before the age of 40 years and with a higher risk of extensive disease(OR:1.34,95%cI:1.03-1.75 and OR:2.49,95%cI:1.24-5.03,respectively) . cONcLUSION:common PXR and LXR polymorphisms may contribute to risk of IBD,especially among never smokers.

关键词： crohn's disease Genetic susceptibility Single nucleotide polymorphisms Smoking status Transcription factors Ulcerative colitis

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Essential biology /

The bisulfite genomic sequencing protocol

2001年

作者： Neil A. campbell jane B. Reece.

Includes index.

ISBN: (纸本)0805373934

Includes index.

关键词： Biology.

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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Advances in Lung cancer 2013年第1期2卷 21-25页

作者： jane J. Pappas André Toulouse Walter Edward clarke Bradley Department of Anatomy and Neuroscience University College Cork Cork Ireland Department of Pharmacology and Therapeutics McGill University Montreal Canada

The bisulfite genomic sequencing (BGS) protocol has gained worldwide popularity as the method of choice for analyzing DNA methylation. It is this popular because it is a powerful protocol and it may be coupled with many other applications. However, users often run into a slew ofproblems, including incomplete conversion,overly degraded DNA, sub-optimal PcR amplifications, false positives, uninformative results, or altogether failed experiments. We pinpoint the reasons why these problems arise and carefully explain the critical steps toward accomplishing a successful experiment step-by-step. This protocol has worked successfully (>99.9% conversion) on as little as 100 ng of DNA derived from nearly 10-year-old DNA samples extracted from whole blood stored at -80°c and resulted in enough converted DNA for more than 50 PcRreactions. The aim of this article is to makelearning and usage of BGS easier, more efficient and standardized for all users.

关键词： Bisulfite Genomic Sequencing DNA Methylation Epigenetics cancer

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动物行为揭秘：真的只是爱玩耍？

英语学习 2015年第4期 27-29页

作者： jane c. Hu 柒月马玉芳

雪后的山坡上，乌鸦像孩子一样滑雪嬉戏，玩得不亦乐乎，这样的一幕总会让人感到惊奇。其实，多动物都颇有“娱乐精神”，比袋鼠会拳击，狐狸会蹦床，章会玩玩具，鱼儿会相互追逐和跃……那么问题来了：对于动们来说，这些行为真的只是... 详细信息

雪后的山坡上，乌鸦像孩子一样滑雪嬉戏，玩得不亦乐乎，这样的一幕总会让人感到惊奇。其实，多动物都颇有“娱乐精神”，比袋鼠会拳击，狐狸会蹦床，章会玩玩具，鱼儿会相互追逐和跃……那么问题来了：对于动们来说，这些行为真的只是玩那么简单吗？科学家们好像发了其他的答案……

关键词：动物行为玩耍娱乐精神科学家乌鸦袋鼠

Six Sigma企业与品质管理系统在制膜工业上的应用

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膜科学与技术 2006年第1期26卷 1-2页

作者：黎念之乔家瑜 NL chemical Technology Inc. Mount ProspectIllinoisU.S.A.

六西格玛作为一种有效的企业和品质管理系统,已被许多美国大公司采用.将六西格玛用于制膜工业,可以使膜产品具有更强的市场竞争力.文章通过一些实例,介绍了六西格玛在科研和制膜方面的应用.

关键词：六西格玛膜反渗透膜管理品质控制

Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British columbia,canada

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World Journal of Gastroenterology 2018年第11期24卷 1216-1227页

作者： Mawuena Binka Zahid A Butt Stanley Wong Mei chong jane A Buxton Nuria chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua British columbia centre for Disease control Vancouver BC V5Z4R4Canada School of Population and Public Health University of British ColumbiaVancouver BC V6T1Z3Canada Division of Population and Public Health Ministry of HealthVictoria BC V8W9P1Canada Department of Pathology and Laboratory Medicine University of British ColumbiaVancouver BC V6T1Z2Canada

AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British columbia(Bc).METHODS We used data from the Bc Hepatitis Testers cohort(BcHTc),which includes all individuals tested for hepatitis c virus(HcV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in Bc since *** data were integrated with prescription drug,medical visit,hospitalization and mortality *** cases were classified as acute or chronic according to provincial *** compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative ***46498 of the 1058056 eligible Bc-HTc participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic *** alcohol use,injection drug use,and HIV or HcV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative *** multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HcV or HIV infection,and injection drug *** odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic *** with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV *** odds increased with increasing socioeconomic *** Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,preven

关键词： Hepatitis B virus Ethnicity Drug use Acute hepatitis B Bc Hepatitis Testers cohort North America

Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome

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chinese Medical Journal 2005年第17期118卷 1413-1421页

作者： Loretta Yc Yam Alfred YF chan Thomas MT cheung Eva LH Tsui jane cK chan Vivian cW Wong Division of Respiratory and critical care Medicine Department of MedicinePamela Youde Nethersole Eastern HospitalHong KongChina Hong Kong Hospital Authority Head Office Hong KongChina

Background Severe acute respiratory syndrome is frequently complicated by respiratory failure requiring ventilatory *** aimed to compare the efficacy of non-invasive ventilation against invasive mechanical ventilation treating respiratory failure in this *** Retrospective analysis was conducted on all respiratory failure patients identified from the Hong Kong Hospital Authority Severe Acute Respiratory Syndrome *** rate,mortality and secondary outcome of a hospital utilizing non-invasive ventilation under standard infection control conditions(NIV Hospita1)were compared against 13 hospitals using solely invasive ventilation(IMV Hospitals).Multiple logistic regression analyses with adjustments for confounding variables were performed to test for association between outcomes and hospital *** Both hospital groups had comparable demographics and clinical profiles,but NIV Hospital(42 patients)had higher lactate dehydrogenase ratio and worse radiographic score on admission and ribavirin-corticosteroid *** to IMV Hospitals(451 patients).NIV Hospital had lower adjusted odds ratios for intubation(0.36,95%c10.164-0.791,P=0.011)and death(0.235.95%c10.077-0.716,P=0.O 11),and improved earlier after pulsed steroid *** were no instances of transmission of severe acute respiratory syndrome among health care workers due to the use of non-invasive *** compared to invasive mechanical ventilation,non-invasive ventilation as initial ventilatory support for acute respiratory failure in the presence of severe acute respiratory syndrome appeared to be associated with reduced intubation need and mortality.

关键词： acute respiratory failure infection control invasive mechanical ventilation non-invasive ventilation severe acute respiratory syndrome

内分泌干扰物与石油、天然气开采--潜在的环境污染与评估复杂环境混合物的建议(待续)

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环境与职业医学 2016年第6期33卷 627-631页

作者： christopher D.Kassotis Donald E.Tillitt chung-Ho Lin jane A.McElroy Susan c.Nagel 袁亚群(翻译) 金泰廙(审校) Nicholas School of the Environment Duke UniversityDurhamNorth CarolinaUSA U.S.Geological Survey Columbia Environmental Research CenterColumbiaMissouriUSA Department of Forestry School of Natural ResourcesUniversity of MissouriColumbiaMissouriUSA Department of Family and community Medicine School of MedicineUniversity of MissouriColumbiaMissouriUSA Department of Obstetrics Gynecology and Women's HealthSchool of MedicineUniversity of MissouriColumbiaMissouriUSA 不详

[背景]65年前发展起来的水力压裂技术,近期与水平钻井技术结合,开采了以前认为不可获得的石油及天然气储备。虽然这些技术大大提高了国内石油和天然气产量,但该过程使用了近1 000种化学物质,包括许多已知的或可疑的内分泌干扰物,这也引... 详细信息

[背景]65年前发展起来的水力压裂技术,近期与水平钻井技术结合,开采了以前认为不可获得的石油及天然气储备。虽然这些技术大大提高了国内石油和天然气产量,但该过程使用了近1 000种化学物质,包括许多已知的或可疑的内分泌干扰物,这也引发了对当地供水潜在污染的担忧。[目的]针对所使用化学品的激素和抗激素活性,讨论对钻井密集区域进行健康评估时增加内分泌评估的必要性。[方法]我们讨论了以下相关文献:a.石油及天然气开采所致地表及地下水污染;b.潜在人类暴露,尤其对地表和地下水中存在自然和人为来源的总激素和抗激素活性的情况;我们也讨论了初步分析结果和关键知识空白。[讨论]由于石油和天然气化学物的潜在环境释放会干扰内分泌受体系统,我们推荐了针对具有激素活性的复杂环境混合物的评估方法。[结论]我们描述了一个以内分泌为主的全面健康评估理念,并为这一理念提供了支持信息:应用这一组分将有助于解释报道的不良健康趋势,也有助于为环境影响评估及监测项目提供建议。

关键词：天然气开采内分泌干扰物抗激素水平钻井地下水污染水力压裂技术环境释放化学物质天然气化学环境影响评估