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Does exercise have a protective effect on cognitive function under hypoxia? A systematic review with meta-analysis

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Journal of Sport and Health Science 2020年第6期9卷 562-577页

作者： Myungjin Jung Liye Zou jane Jie Yu Seungho Ryu Zhaowei Kong Lin Yang Minsoo Kang Jingyuan Lin Hong Li Lee Smith Paul D.Loprinzi Health and Sport Analytics Laboratory Department of HealthExercise Science and Recreation ManagementUniversity of MississippiUniversity ParkMS 38677USA Exercise and Mental Health Laboratory School of PsychologyShenzhen UniversityShenzhen 518060China Department of Sports Science and Physical Education The Chinese University of Hong KongShatinNew TerritoriesHong Kong 999077China Faculty of Education University of MacaoTaipaMacao 999078China Department of cancer Epidemiology and Prevention Research CancerControl AlbertaAlberta Health ServicesCalgaryAB T2S 3C3Canada Departments of Oncology and community Health Sciences Cumming School of MedicineUniversity of CalgaryCalgaryAB T2N 4Z6Canada The cambridge centre for Sport and Exercise Sciences Anglia Ruskin UniversityCambridgeCB11PTUK Exercise and Memory Laboratory Department of HealthExercise Science and Recreation ManagementUniversity of MississippiOxfordMS 38677USA

Objective:This study aimed to examine(1)the independent effects of hypoxia on cognitive function and(2)the effects of exercise on cognition while under ***:Design:Systematic review with *** sources:PubMed,Scopus,Web of Science,PsychInfo,and SPORTDiscus were *** criteria for selecting studies:randomized controlled trials and nonrandomized controlled studies that investigated the effects of chronic or acute exercise on cognition under hypoxia were considered(Aim 2),as were studies investigating the effects of hypoxia on cognition(Aim 1).Results:In total,18 studies met our inclusionary criteria for the systematic review,and 12 studies were *** to hypoxia impaired attentional ability(standardized mean difference(SMD)=-0.4),executive function(SMD=-0.18),and memory function(SMD=-0.26),but not information processing(SMD=0.27).Aggregated results indicated that performing exercise under a hypoxia setting had a significant effect on cognitive improvement(SMD=0.3,95%confidence interval:0.14-0.45,I^2=54%,pcharacteristics(e.g.,age,cognitive task type,exercise type,exercise intensity,training type,and hypoxia level)moderated the effects of hypoxia and exercise on cognitive ***:Exercise during exposure to hypoxia improves cognitive *** association appears to be moderated by individual and exercise/hypoxia-related characteristics.

关键词： cognition Executive function Exercise Hypoxia Memory

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作者： jane Sadhna Jagernath 中国农业科学院

学位级别：硕士

由稻瘟病菌引起的稻瘟病对全球水稻生产构成严重威胁。近年来,稻瘟病菌的致病相关基因已经被广泛鉴定,但是其致病机制仍有必要进一步分析。线粒体作为真核细胞中一种重要的细胞器,除了提供能量以外,还参与包括细胞信号转导、细胞分化、... 详细信息

由稻瘟病菌引起的稻瘟病对全球水稻生产构成严重威胁。近年来,稻瘟病菌的致病相关基因已经被广泛鉴定,但是其致病机制仍有必要进一步分析。线粒体作为真核细胞中一种重要的细胞器,除了提供能量以外,还参与包括细胞信号转导、细胞分化、衰老、细胞死亡、维持对细胞周期和细胞生长的控制等重要生命活动过程,这些功能使得线粒体成为有效控制疾病的靶标位点。本试验主要分析了Mo Uth1、Mo BI-1和Mo BI-1b等三个定位于线粒体的蛋白在稻瘟病菌致病过程中的功能。在前期研究中,我们发现Mo Whi2是稻瘟病菌致病所必需的。为了进一步分析Mo Whi2的功能,我们通过酵母双杂交筛选稻瘟病菌c DNA文库鉴定到了与Mo Whi2互作的一个SUN家族蛋白Mo Uth1。在酿酒酵母中Uth1调控线粒体活性,并参与多种细胞过程。敲除Mo UTH1后稻瘟病菌营养菌丝生长减缓,并且气生菌丝发白、产孢量显著降低及分生孢子形态存在缺陷。苗期喷雾接种实验表明Mo UTH1缺失后稻瘟病菌致病力显著下降,进一步通过叶鞘接种分析,显微镜下观察发现缺失突变株的侵染菌丝被限制在第一个被侵染的寄主细胞内,而不能够向临近细胞扩展。此外,本研究表明Mo UTH1缺失后,对氧化应激胁迫以及渗透胁迫表现更为敏感,暗示Mo UTH1参与氧化胁迫和细胞壁完整性过程。本实验结果表明:Mo UTH1在稻瘟病菌的生长、产孢、致病、应激反应及细胞壁完整性等过程中发挥重要作用。未来我们的研究重点将着重阐明稻瘟病菌侵染过程中Mo UTH1所发挥地确切作用和分子机制。此外,我们还分析了Bax-Inhibitor-1家族蛋白Mo BI-1和Mo BI-1b在稻瘟病菌致病过程中的功能。BI-1为促凋亡蛋白Bax的抑制剂,在动植物中能够抑制细胞的凋亡。在丝状真菌中,BI-1的同源基因分布广泛,但是其具体的生物学功能仍然未知。本研究中,我们在稻瘟病菌中鉴定到了两个Bax-Inhibitor-1的同源蛋白Mo BI-1和Mo BI-1b。敲除Mo BI-1和Mo BI-1b基因后,稻瘟病菌的产孢量下降和致病力减弱,且大部分附着胞仅可以分化形成初级侵染菌丝。亚细胞定位观察表明Mo BI-1和Mo BI-1b定位在线粒体上,进一步分析表明Mo BI-1和Mo BI-1b参与细胞内ATP的合成。Mo BI-1和Mo BI-1b的功能分析为植物真菌的致病分子机制提供了新的认识。

关键词：稻瘟病菌致病力线粒体 SUN家族程序性细胞死亡

年龄与发育进程问卷中文版的婴幼儿发育筛查界值标准研究

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中华儿科杂志 2010年第11期48卷 824-828页

作者：姚国英卞晓燕 SQUIRES jane 魏梅宋魏上海交通大学附属儿童医院上海市儿童医院上海市儿童保健所 200040 美国俄勒冈大学人类发育中心早期干预研究所上海市嘉定区妇幼保健院

目的研究年龄与发育进程问卷中文版（ASQ-c）不同界值对婴幼儿发育筛查的效度及准确性.方法收集了3～31个月婴幼儿269例.由父母/照看人完成婴幼儿月龄相应的ASQ-c,由专业人员用贝利婴儿发育量表第二版（BSID Ⅱ）测试婴幼儿.采用BSID... 详细信息

目的研究年龄与发育进程问卷中文版（ASQ-c）不同界值对婴幼儿发育筛查的效度及准确性.方法收集了3～31个月婴幼儿269例.由父母/照看人完成婴幼儿月龄相应的ASQ-c,由专业人员用贝利婴儿发育量表第二版（BSID Ⅱ）测试婴幼儿.采用BSID Ⅱ平均值（（-x））-2标准差（s）为发育迟滞的界值、（-x）-s为可疑发育迟滞和发育迟滞的界值,检验不同ASQ-c界值的效度及准确性.结果 BSID Ⅱ为（-x）-2 s时,ASQ-c为（-x）-2 s的一致百分率为83.64%,敏感度及特异度都在80%以上、ROc下面积为0.86;ASQ-c为（-x）-1.5 s的一致百分率为71.75%,敏感度为100.00%、特异度为68.72%、ROc下面积为0.84;ASQ-c为（-x）-s的一致百分率为55.02%,敏感度为100.00%、特异度为50.21%、ROc下面积为*** Ⅱ为（-x）-s时,ASQ-c为（-x）-2 s的一致百分率为85.87%,敏感度为68.57%,特异度为91.96%、ROc下面积为0.77;ASQ-c为（-x）-1.5 s的一致百分率为80.67%,敏感度及特异度都在70%以上、ROc下面积为0.82;ASQ-c为（-x）-s的一致百分率为68.40%,敏感度为94.29%、特异度为59.30%、ROc下面积为0.80;BSID Ⅱ为（-x）-（1～2）s时,ASQ-c为（-x）-2 s、（-x）-1.5 s及（-x）-s的识别率分别为56.82%、77.27%及90.91%.结论识别婴幼儿发育迟滞,ASQ-c的（-x）-2 s效度最好,准确性最高;识别婴幼儿可疑发育迟滞和发育迟滞,ASQ-c的（-x）-1.5 s敏感度及特异度都比较适宜,准确性最高;识别婴幼儿可疑发育迟滞,ASQ-c的（-x）-s识别率最高.

关键词：儿童发育筛查问卷调查参考标准

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Trends and Determinants of contraceptive Method choice in china

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china Population and Development Studies 2017年第1期1卷 67-82页

作者： Min QIN Sabu S.PADMADAS jane FALKINGHAM ESRc center for Population change University of SouthamptonChina Population and Development Research CenterBeijingChina centre for Global Health PopulationPoverty&PolicyChina Research Centre and Department of Social Statistics and DemographyUniversity of SouthamptonUnited Kindom ESRc centre for Population change and china Research centre University of SouthamptonUnited Kindom

contraception promotion is a crucial component of the family planning programme in *** the mid-1990s,state strategy has gradually shifted from demographie targets towards a c1ient-centred,informed choiee *** for this study are drawn from six national Population and Family Planning surveys conducted during *** from all six surveys are used for describing the trends in contraception use and changes in method mix over the last three *** for individuals taken from the 2001 and 2006 surveys are applied to investigate the effect of changing strategies on parity-specific methods *** individual and community level data from the 2006 survey are then used to exarnine the determinants of informed *** logistic regression models are fitted for each of the two *** results show that contraceptive prevalence rate among married women of reproductive age in china was over 70%in the 1980s and reached 80%in the 1990s,with the method mix dominated by sterilization and lUD.A shift towards increase in condom use and a decrease in sterilization was observed among new users between 1996-2001 and *** multilevel analysis shows that between 1996-2001 and 2001-2006,the proportion of users choosing methods"highly recommended"by providers of farnily planning services dec1ined *** provision of a mix of contraceptives by the community plays a positive role for informed *** the historical top-down approach towards promoting long-acting methods has weakened over time,institutional forces continue to influence the method choices made by *** community contraception provision and providing adequate counselling could benefit informed choiee of contraception method and this,in turn,could contribute to improving women's reproductive health.

关键词： Farnily Planning Informed choiees china

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为预防性临床试验做准备:HD预测性研究

世界核心医学期刊文摘(神经病学分册) 2006年第10期 11-12页

作者： Paulsen J.S. Hayden M. stout J.c. 郭俊 University of Iowa carver college of Medicine 1-305 MEB Iowa City IA 52242- 1000 United States Dr.

Background: The optimal design and outcome measures for preventive clinical trials in neurodegenerative diseases are unknown. Objective: To examine measures that may be associated with disease in the largest cohort ever recruited of prediagnosed individuals carrying the gene expansion for Huntington disease (HD). Design: The Predict- HD study is a multicenter observational research study in progress at 17 sites in the United States, 4 in canada, and 3 in Australia. Setting: Genetics and HD outpatient clinics. Participants: Five hundred five at- risk individuals who had previously undergone elective DNA analyses for the cAG expansion in the HD gene (predictive testing) and did not currently have a clinical diagnosis of HD. Main Outcome Measures: Basal ganglia volumes on magnetic resonance images, estimated probability of diagnosis (based on cAG repeat length), performances on 21 standardized cognitive tasks, total scores on 3 scales of psychiatric distress, and motor diagnosis based on the Unified Huntington' s Disease Rating Scale. Results: Several variables showed progressive decline as the diagnostic ratings advanced toward manifest disease. Estimated probability of diagnosis was associated with Unified Huntington' s Disease Rating Scale prediagnostic stages and varied from 15% in persons with no motor abnormalities to nearly 40% in those with abnormalities suggestive of probable disease. Striatal volumes, cognitive performances, and even psychiatric ratings declined significantly with motor manifestations of disease. conclusions: The documentation of biological and refined clinical markers suggests several clinical end points for preventive clinical trials. Longitudinal study is critical to further validate possible markers for prediagnosed HD.

关键词：临床试验预测性预防性

Risk Assessment capacity Building Program in Zaporizhzhia Ukraine: Emissions Inventory construction, Ambient Modeling, and Hazard Results

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Journal of Environmental Protection 2013年第12期4卷 1476-1487页

作者： jane c. caldwell Andrei Serdyuk Olena Turos Arina Petrosian Oleg Kartavtsev Simon Avaliani Alexander Golub Elena Strukova Michael Brody 1Office of the chief Financial Officer US Environmental Protection Agency Washington DC USA 2American University Washington DC USA. American University Washington DC USA National center for Environmental Assessment Office of Research and Development US Environmental Protection Agency Washington DC USA O. M. Marzeiev Institute for Hygiene and Medical Ecology National Academy of Medical Sciences Kyiv Ukraine Russian Academy of Advanced Medical Studies Center for Risk Assessment Moscow Russia World Bank Washington DC USA

Historically, Ukraine has been a major source of industrial production for the former Soviet Union and the source of pollution associated with an aging industrial infrastructure. The US Environmental Protection Agency (US EPA) and the Ukrainian Ministry of Environment and Natural Resources (MENR) entered into partnership to develop Ukrainian expertise and capacity in risk assessment so that Ukraine could more effectively use its National and Regional Environmental Protection Funds and set priorities for cleanup and regulation. Ukrainian scientists, local officials, and EPA consultants conducted a pilot study in the heavily industrialized Zaporizhzhia Oblast so that the process, analytical tools, and approach for a risk assessment could be developed for and tailored to Ukrainian needs. As a first step, site-specific information was obtained from multiple sources of air pollution and an emissions inventory of air pollution developed. Efforts by local officials were critical for emissions inventory construction. After refinements were made to the inventory, Ukrainian scientists then performed exposure modeling using this information so that ambient concentrations of pollutants could be estimated. 11 industry types (i.e., enterprises) were identified as a major emission source. Results of the modeling effort demonstrated that emissions estimates of particulate matter (as measured by particles of less than 10 micron diameter or “PM10”) and a number of carcinogens were consistent with those from other cities with high concentrations of metallurgical industries in former Soviet Union countries, and were above safety standards. Hazard information was gathered from international databases for each of the estimated pollutants. Using such data, prioritization and identification of potential health concerns can be made, but most importantly, the expertise and experience gained from the pilot allowed for continued support of risk assessment capacity building in the Ukraine and s

关键词： Air Pollution Exposure Modeling Ukraine Risk Assessment

Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats

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World Journal of Gastroenterology 2017年第21期23卷 3805-3814页

作者： Yi Tan jane Kim Jing cheng Madeleine Ong Wei-Guo Lao Xing-Liang Jin Yi-Guang Lin Linda Xiao Xue-Qiong Zhu Xian-Qin Qu School of Medical and Molecular Biosciences University of Technology Sydney The Second Affiliated Hospital of Wenzhou Medical University

AIM To investigate protective effects and molecular mechanisms of green tea polyphenols(GTP) on nonalcoholic fatty liver disease(NAFLD) in Zucker fatty(ZF) *** Male ZF rats were fed a high-fat diet(HFD) for 2 wk then treated with GTP(200 mg/kg) or saline(5 m L/kg) for 8 wk, with Zucker lean rat as their control. At the end of experiment, serum and liver tissue were collected for measurement of metabolic parameters, alanine aminotransferase(ALT) and aspartate aminotransferase(AST), inflammatory cytokines and hepatic triglyceride and liver histology. Immunoblotting was used to detect phosphorylation of AMP-activated protein kinase(AMPK) acetyl-co A carboxylase(Acc), and sterol regulatory element-binding protein 1c(SREBP1c). RESULTS Genetically obese ZF rats on a HFD presented with metabolic features of hepatic pathological changes comparable to human with NAFLD. GTP intervention decreased weight gain(10.1%, P = 0.052) and significantly lowered visceral fat(31.0%, P compared with ZF-controls, GTP treatment significantly reduced fasting serum insulin, glucose and lipids levels. Reduction in serum ALT and AST levels(both P circulation. The increased hepatic TG accumulation and cytoplasmic lipid droplet were attenuated by GTP treatment, associated with significantly increased expression of AMPK-Thr172(P cc and SREBP1c(both P cating diminished hepatic lipogenesis and triglycerides out flux from liver in GTP treated rats. cONcLUSION The protective effects of GTP against HFD-induced NAFLD in genetically obese ZF rats are positively correlated to reduction in hepatic lipogenesis through upregulating the AMPK pathway.

关键词： Non-alcoholic fatty liver disease Green tea polyphenols Hepatic lipogenesis Inflammatory cytokines AMP-activated protein kinase

Validation of the Physical Activity Questionnaire for Older children(PAQ-c) among chinese children

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Biomedical and Environmental Sciences 2016年第3期29卷 177-186页

作者： WANG Jing Jing BARANOWSKI Tom LAU Wc Patrick cHEN Tzu An PITKETHLY Amanda jane Department of Physical Education Faculty of Social Sciences Hong Kong Baptist University children's Nutrition Research center Department of Pediatrics Baylor College of Medicine

Objective This study initially validates the chinese version of the Physical Activity Questionnaire for Older children （PAQ-c）, which has been identified as a potentially valid instrument to assess moderate-to-vigorous physical activity （MVPA） in children among diverse racial groups. Methods The psychometric properties of the PAQ-c with 742 Hong Kong chinese children were assessed with the scale＇s internal consistency, reliability, test-retest reliability, confirmatory factory analysis （cFA） in the overall sample, and multistep invariance tests across gender groups as well as convergent validity with body mass index （BMI）, and an accelerometry-based MVPA. Results The cronbach alpha coefficient （α=0.79）, composite reliability value （p=0.81）, and the intraclass correlation coefficient （α=0.82） indicate the satisfactory reliability of the PAQ-c score. The cFA indicated data fit a single factor model, suggesting that the PAQ-c measures only one construct, on MVPA over the previous 7 days. The multiple-group cFAs suggested that the factor Ioadings and variances and covariances of the PAQ-c measurement model were invariant across gender groups. The PAQ-c score was related to accelerometry-based MVPA （r=0.33） and inversely related to BMI （r=0.18）. conclusion This study demonstrates the reliability and validity of the PAQ-c in chinese children.

关键词： Physical activity Measurement children Reliability Validity

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Analysis of the Driving Force of Hydrodynamics in Lake Naivasha, Kenya

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Open Journal of Modern Hydrology 2015年第4期5卷 95-104页

作者： jane N. Ndungu Wenlong chen Denie c. M. Augustijn Suzanne J. M. H. Hulscher MEEP Kenya Marine and Fisheries Research Institute Mombasa Kenya Twente Water centre University of Twente Enschede The Netherlands

The hydrodynamics in Lake Naivasha, a shallow endorheic lake, are simulated using the Delft3D Flow Module to investigate the major driving forces of hydrodynamics in the lake. The results showed wind as the major forcing. The shallow zones of the lake showed currents movement in the same direction as the wind while the deep zones showed currents movements against the wind direction. These findings were confirmed and further explained using an idealized model. Limited exchange between the crescent Lake (crater lake which is temporally separated from the lake during low water levels) and the main lake was observed. These findings can explain the spatial variability of the water quality in the lake. Similar studies could be used in exploratory studies of the spatial-temporal variability in water quality in other shallow water systems.

关键词： Hydrodynamics Water Quality Shallow Lakes Wind-Driven currents Lake Naivasha