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SARS-coV-2 variants are associated with different clinical courses in children with MIS-c

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World Journal of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emelia Bainto Helen Harvey Adriana H.Tremoulet jane c.Burns Kirsten B.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Background Recent infection with SARS‑coV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-c).SARS‑coV-2 has undergone different *** publications exist about specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-c at Rady children’s Hospital-San Diego between May 2020 and March *** epidemiologic data,including viral genomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-c waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to c,20G,21c(Epsilon),20I(Alpha),and 20J(Gamma).The third wave had Delta strains(clades 21A,21I,and 21J),and the fourth had Omicron variants(clades 21K,21L,and 22c).MIS-c presented with similar symptoms and laboratory findings across all *** patients were admitted to the pediatric intensive care unit(PIcU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-coV-2 triggered MIS-c with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： complications cOVID-19 MIS-c SARS-coV-2 variants

Anonymous TollPass: A Blockchain-Based Privacy-Preserving Electronic Toll Payment Model

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computers, Materials & continua 2024年第6期79卷 3495-3518页

作者： jane Kim Soojin Lee chan Yeob Yeun Seung-Hyun Seo Department of Electronic&Electrical Engineering Graduate SchoolHanyang UniversitySeoul04763Korea Department of Electrical Engineering and computer Science Khalifa University of Science and TechnologyAbu Dhabi127788United Arab Emirates School of Electrical Engineering Hanyang UniversityERICAAnsan15588Korea

As big data,Artificial Intelligence,and Vehicle-to-Everything(V2X)communication have advanced,Intelligent Transportation Systems(ITS)are being developed to enable efficient and safe transportation *** Toll collection(ETc),which is one of the services included in ITS systems,is an automated system that allows vehicles to pass through toll plazas without stopping for manual *** ETc system is widely deployed on highways due to its contribution to stabilizing the overall traffic system *** ensure secure and efficient toll payments,designing a distributed model for sharing toll payment information among untrusted toll service providers is ***,the current ETc system operates under a centralized ***,both toll service providers and toll plazas know the toll usage history of *** raises concerns about revealing the entire driving routes and patterns of *** address these issues,blockchain technology,suitable for secure data management and data sharing in distributed systems,is being applied to the ETc *** enables efficient and transparent management of ETc ***,the public nature of blockchain poses a challenge where users’usage records are exposed to all *** tackle this,we propose a blockchain-based toll ticket model named AnonymousTollPass that considers the privacy of *** proposed model utilizes traceable ring signatures to provide unlinkability between tickets used by a vehicle and prevent the identity of the vehicle using the ticket from being identified among the ring members for the ***,malicious vehicles’identities can be traced when they attempt to reuse *** conducting simulations,we show the effectiveness of the proposed model and demonstrate that gas fees required for executing the proposed smart contracts are only 10%(when the ring size is 50)of the fees required in previous studies.

关键词： Blockchain electronic toll collection smart contract traceable ring signature

Evaluation of a Wireless Solar Powered Personal Weather Station

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Agricultural Sciences 2024年第1期15卷 36-53页

作者： Robert J. Lascano Timothy S. Goebel Dennis c. Gitz III John E. stout cropping Systems Research Laboratory Wind Erosion and Water Conservation Research Unit USDA-ARS Lubbock TX USA

We are evaluating dryland cotton production in Martin county, Texas, measuring cotton lint yield per unit of rainfall. Our goal is to collect rainfall data per 250 - 400 ha. Upon selection of a rainfall gauge, we realized that the cost of using, for example, a tipping bucket-type rain gauge would be too expensive and thus searched for an alternative method. We selected an all-in-one commercially available weather station;hereafter, referred to as a Personal Weather Station (PWS) that is both wireless and solar powered. Our objective was to evaluate average measurements of rainfall obtained with the PWS and to compare these to measurements obtained with an automatic weather station (AWS). For this purpose, we installed four PWS deployed within 20 m of the Plant Stress and Water conservation Meteorological Tower that was used as our AWS, located at USDA-ARS cropping Systems Research Laboratory, Lubbock, TX. In addition, we measured and compared hourly average values of short-wave irradiance (Rg), air temperature (Tair) and relative humidity (RH), and wind speed (WS), and calculated values of dewpoint temperature (Tdew). This comparison was done over a 242-day period (1 October 2022-31 May 2023) and results indicated that there was no statistical difference in measurements of rainfall between the PWS and AWS. Hourly average values of Rg measured with the PWS and AWS agreed on clear days, but PWS measurements were higher on cloudy days. There was no statistical difference between PWS and AWS hourly average measurements of Tair, RH, and calculated Tdew. Hourly average measurements of Rg and WS were more variable. We concluded that the PWS we selected will provide adequate values of rainfall and other weather variables to meet our goal of evaluating dryland cotton lint yield per unit rainfall.

关键词： Automation Sensors citizen Weather Station Mesonet Rainfall Weather Variables

Risk factors for hepatocellular carcinoma associated with hepatitis c genotype 3 infection:A systematic review

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1596-1612页

作者： Hamzah Z Farooq Michael James jane Abbott Patrick Oyibo Pip Divall Naheed choudhry Graham R Foster Blizard Institute Queen Mary University of LondonLondon E12ATUnited Kingdom School of Health and Psychological Sciences University of LondonLondon EC1V 0HBUnited Kingdom University Hospitals of Leicester Library University Hospitals of Leicester NHS TrustLeicester LE39QPUnited Kingdom

BAcKGROUND Hepatitis c virus(HcV)is a blood-borne virus which globally affects around 79 million people and is associated with high morbidity and *** infection leads to cirrhosis in a large proportion of patients and often causes hepatocellular carcinoma(Hcc)in people with *** the 6 HcV genotypes(G1-G6),genotype-3 accounts for 17.9%of *** genotype-3 responds least well to directly-acting antivirals and patients with genotype-3 infection are at increased risk of Hcc even if they do not have *** To systematically review and critically appraise all risk factors for Hcc secondary to HcV-G3 in all ***,we studied possible risk factors for Hcc due to HcV-G3 in the literature from 1946 to *** This systematic review aimed to synthesise existing and published studies of risk factors for Hcc secondary to HcV genotype-3 and evaluate their strengths and *** searched Web of Science,Medline,EMBASE,and cENTRAL for publications reporting risk factors for Hcc due to HcV genotype-3 in all settings,*** Four thousand one hundred and forty-four records were identified from the four databases with 260 records removed as *** thousand eight hundred and eighty-four records were screened with 3514 *** hundred and seventy-one full-texts were assessed for eligibility with seven studies included for *** the seven studies,three studies were retrospective case-control trials,two retrospective cohort studies,one a prospective cohort study and one a cross-sectional study *** were based in hospital settings with four in Pakistan,two in South Korea and one in the United *** total number of participants were 9621 of which 167 developed Hcc(1.7%).All seven studies found cirrhosis to be a risk factor for Hcc secondary to HcV genotype-3 followed by higher age(five-studies),with two studies each showing male sex,high alpha feto-protein,directly-acting antivirals trea

关键词： Hepatocellular carcinoma Hepatitis c Genotype 3 Systematic review Blood-borne viruses Liver cancer

calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice

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World Journal of Gastroenterology 2024年第3期30卷 268-279页

作者： Lie-Qi Tang Johnathan Fraebel Shi Jin Steven P Winesett jane Harrell Wen-Han chang Sam Xianjun cheng Department of Pediatrics University of FloridaGainesvilleFL 32610United States college of Medicine University of FloridaGainesvilleFL 32610United States Applied Physiology and Kinesiology University of FloridaGainesvilleFL 32610United States Brain Rehabilitation Research center Malcom Randall VA Medical CenterGainesvilleFL 32610United States Department of Medicine Endocrine Research UnitVeterans Affairs Medical CenterUniversity of CaliforniaSan FranciscoSan FranciscoCA 94121United States Department of Pediatric Gastroenterology Hepatologyand NutritionUniversity of Florida Shands Children’s HospitalGainesvilleFL 32608United States

BAcKGROUND Enterotoxins produce diarrhea through direct epithelial action and indirectly by activating the enteric nervous ***-sensing receptor(caSR)inhibits both *** latter has been well documented in vitro but not in *** hypothesis to be tested was that activating caSR inhibits diarrhea in *** To determine whether caSR agonists ameliorate secretory diarrhea evoked by cholera toxin(cTX)in *** cTX was given orally to c57BL/6 mice to induce *** and calci-mimetic R568 were used to activate *** maximize their local intestinal actions,calcium was administered luminally via oral rehydration solution(ORS),whereas R568 was applied serosally using an intraperitoneal *** verify that their actions resulted from the intestine,effects were also examined on cre-lox intestine-specific caSR *** outcome was measured biochemically by monitoring changes in fecal cl-or clinically by assessing stool consistency and weight *** cTX induced secretory diarrhea,as evidenced by increases in fecal cl-,stool consistency,and weight loss following cTX exposure,but did not alter caSR,neither in content nor in ***,calcium and R568 were each able to ameliorate diarrhea when applied to diseased *** caSR involvement is suggested by gene knockout experiments where the anti-diarrheal actions of R568 were lost in intestinal epithelial caSR knockouts(villincre/casrflox/flox)and neuronal caSR knockouts(nestincre/casrflox/flox).cONcLUSION Treatment of acute secretory diarrheas remains a global *** advances in diarrhea research,few have been made in the realm of diarrhea *** therapy has remained the standard of care,although it does not halt the losses of intestinal fluid and ions caused by *** is no cost-effective therapeutic for *** and other studies suggest that adding calcium to ORS or using calcimimetics to activate intestinal caSR might

关键词： cholera Enteric nervous system Secretory diarrhea Oral rehydration solution calcium-sensing receptor Gene knockout

Integrating flood depth and plant resistance with chlorantraniliprole seed treatments for management of rice water weevil, Lissorhoptrus oryzophilus （coleoptera： curculionidae）

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Insect Science 2015年第5期22卷 679-687页

作者： Srinivas K. Lanka David c. Blouin Michael J. stout Department of Entomology Louisiana State University Agricultural Center Baton Rouge LA 70803 USA

chlorantraniliprole seed treatments in rice provide effective suppression of rice water weevil populations in the United States; however, heavy reliance on prophylac- tic insecticide treatments as a sole strategy could destabilize management programs for this insect. The present research evaluated the compatibility of seed treatments with two other potential management tactics--plant resistance and shallow flooding-by conducting two split-plot experiments in 2009 and 2011. In both experiments, no substantial antago- nism was found among the 3 different tactics. Statistical interactions in these experiments arose from the strong and persistent effects of chlorantraniliprole on larval densities rather than incompatibility of tactics. In 2009, weevil densities differed among varieties and were significantly lower on the cultivar ＂Jefferson.＂ In 2011, weevil densities were reduced sig- nificantly in shallow-flooded plots compared to deep-flooded plots. Significant reductions in weevil numbers by chlorantraniliprole seed treatments, even at application rates 5 fold lower than commercially recommended rates, demonstrated the potential to reduce appli- cation rates of this highly potent larvicide. These latter results suggest that future studies on the relationship between chlorantraniliprole seed treatment rate and weevil fitness are warranted.

关键词： chlorantraniliprole compatibility integrated management plant resistance rice water weevil seed treatments

Evaluation of a Wireless Solar Powered Personal Weather Station

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Agricultural Sciences（农业科学） 2024年第1期

作者： Robert J.Lascano Timothy S.Goebel Dennis c.Gitz III John E.stout

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Objects observed

Enhancing Private Healthcare Effectiveness in Lagos State, Nigeria: An Overview of the Effect of Quality Improvement Initiatives and Implications for Sustainable Healthcare Delivery

作者： John c. stout.

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Health 2024年第2期16卷 93-104页

作者： Nnenna Mba-Oduwusi Ifesinachi Eze Tochukwu Osuji Maxwell Obubu Tolulope Oyekanmi Oluwatosin Kolade Ozioma Oguguah jane Martins Nkata chuku Alozie Ananaba Rodio Diallo Firdausi Umar Sadiq Emmanuella Zamba Abiola Idowu InSiGHt Health consulting Limited Ikeja Nigeria Health Systems consult Limited Abuja Nigeria Bill & Melinda Gates Foundation Abuja Nigeria Lagos State Health Management Agency (LASHMA) Lagos Nigeria Health Facility Monitoring and Accreditation Agency (HEFAMAA) Ikeja Nigeria

Background: Nigeria, a nation grappling with rapid population growth, economic intricacies, and complex healthcare challenges, particularly in Lagos State, the economic hub and most populous state, faces the challenge of ensuring quality healthcare access. The overview of the effect of quality improvement initiatives in this paper focuses on private healthcare providers in Lagos State, Nigeria. The study assesses the impact of donor-funded quality improvement projects on these private healthcare facilities. It explores the level of participation, perceived support, and tangible effects of the initiatives on healthcare delivery within private healthcare facilities. It also examines how these initiatives influence patient inflow and facility ratings, and bring about additional benefits and improvements, provides insights into the challenges faced by private healthcare providers in implementing quality improvement projects and elicits recommendations for improving the effectiveness of such initiatives. Methods: Qualitative research design was employed for in-depth exploration, utilizing semi-structured interviews. Private healthcare providers in Lagos involved in the SP4FP Quality Improvement Project were purposively sampled for diversity. Face-to-face interviews elicited insights into participation, perceived support, and project effects. Questions covered participation levels, support perception, changes observed, challenges faced, and recommendations. Thematic analysis identified recurring themes from interview transcripts. Adherence to ethical guidelines ensured participant confidentiality and informed consent. Results: Respondents affirmed active involvement in the SP4FP Quality Improvement Project, echoing literature emphasizing private-sector collaboration with the public sector. While acknowledging positive influences on facility ratings, respondents highlighted challenges within the broader Nigerian healthcare landscape affecting patient numbers. Respondents c

关键词： Private Healthcare Quality Improvement Projects Donor-Funded Initiatives Healthcare Delivery Lagos State Nigeria