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Autism, an area that needs public attention and investment

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Science China(Life Sciences) 2015年第10期58卷 931-932页

作者： jane Y.WU Department of Neurology Center for Genetic Medicine Lurie Cancer Center Northwestern University Feinberg School of Medicine State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences

I would like to dedicate this special issue to children and adults who are affected by autism or related developmental disorders, as well as to their families and friends. I am indebted to the clinicians and care providers who have made tremendous effort in supporting these patients. They have inspired me to invest a significant amount of my energy to adventure into this area. I greatly appreciate all the contributing authors around the world whose hard work made this special issue possible.

关键词：自闭投资公众成年人

Satisfaction with patient-doctor relationships in inflammatory bowel diseases:Examining patient-initiated change of specialist

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World Journal of Gastroenterology 2012年第18期18卷 2212-2218页

作者： Daniel R van Langenberg jane M Andrews Department of Gastroenterology and Hepatology Royal Adelaide HospitalSchool of MedicineUniversity of AdelaideSouth Australia 5000Australia Department of Gastroenterology and Hepatology Eastern Health Clinical SchoolMonash UniversityVictoria 3128Australia

AIM:To assess the reasons for,and factors associated with,patient-initiated changes in treating specialist in inflammatory bowel diseases(IBD).METHODS:Prospectively identified IBD patients(n = 256) with ≥ 1 encounter at a metropolitan hospital were surveyed,including whether they had changed treating specialist and *** reasons included loss of confidence,disagreement,and/or personality clash with the ***:Of 162 respondents,70(43%) had ever changed specialists;30/70(43%) for negative reasons,52/70(74%) in the preceding *** with negative reasons for changing(n = 30) were younger(median,35.2 years vs 45.3 years),had higher IBD knowledge(median,5.0 years vs 4.0 years),yet had lower medication adherence and satisfaction scores(median,19.0 years vs 22.0 years,14.0 years vs 16.0 years respectively,Mann-Whitney tests,all P < 0.05),compared to all other responders(n = 132).Patients with a recent change(for any reason) were more likely to have Crohn's disease,currently active disease,previous bowel resection and recent hospitalization [OR 2.6,95% CI(1.3-5.4),2.2(1.0-4.7),5.56(1.92-16.67),2.0(1.3-3.0),eachP < 0.05].CONCLUSION:Changing specialist appears associated with patient-related(age,nonadherence) and contemporaneous disease-related factors(recent relapse) which,where modifiable,may enhance patient-doctor relationships and therefore quality of care.

关键词： Inflammatory bowel disease Patient-doctor relationship Quality of care Disease outcomes Quality of life

The Animals of China in the Eighteenth-Century British Imagination

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Fudan Journal of the Humanities and Social Sciences 2015年第2期8卷 167-177页

作者： jane Spencer College of Humanities University of Exeter Queen's Building The Queen's DriveExeter EX4 4QH UK

In eighteenth-century Britain, knowledge about animals from around the world was rapidly increasing. This paper focuses on what the British knew and imagined about the animals of China from reading the works of European travellers and natural historians. Whereas the animals of Africa and America served to foster a growing sense of European mastery of less civilized parts of the world through trade and possession, those of China were understood as embedded in a highly advanced civilization and therefore as sources of knowledge about that civilization. This paper examines the way in which British understandings of China were mediated through accounts of Chinese animals and of human-animal relations in China. Looking at works of popular natural history and at Oliver Goldsmith＇s fictional letters of a ＂Chinese philosopher＂ in The Citizen of the World （1762）, I argue that the animals of China bore several messages about their country. Focusing on the particular examples of the golden pheasant, the horse, the cormorant, and the cat, I suggest that British writing about Chinese animals served as a way of expressing mixed feelings about the value of advanced civilizations, whether Chinese or European.

关键词： Natural history Enlightenment Buffon Du Halde Goldsmith Animals Cormorant Cat Horse

From cradle to grave: neurogenesis, neuroregeneration and neurodegeneration in Alzheimer’s and Parkinson’s diseases

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Neural Regeneration Research 2022年第12期17卷 2606-2614页

作者： Debia Wakhloo jane Oberhauser Angela Madira Sameehan Mahajani Deparment of Neuropathology Stanford UniversitySchool of MedicineStanfordCAUSA

Two of the most common neurodegenerative disorders-Alzheimer’s and Parkinson’s diseases-are characterized by synaptic dysfunction and degeneration that culminate in neuronal loss due to abnormal protein *** intracellular aggregation of hyper-phosphorylated tau and the extracellular aggregation of amyloid beta plaques form the basis of Alzheimer’s disease *** major hallmark of Parkinson’s disease is the loss of dopaminergic neurons in the substantia nigra pars compacta,following the formation of Lewy bodies,which consists primarily of alpha-synuclein ***,the discrete mechanisms that contribute to neurodegeneration in these disorders are still poorly *** neuronal loss and impaired adult neurogenesis have been reported in animal models of these *** these findings remain subject to frequent debate due to a lack of conclusive evidence in post mortem brain tissue from human *** some publications provide significant findings related to axonal regeneration in Alzheimer’s and Parkinson’s diseases,they also highlight the limitations and obstacles to the development of neuroregenerative *** this review,we summarize in vitro and in vivo findings related to neurogenesis,neuroregeneration and neurodegeneration in the context of Alzheimer’s and Parkinson’s diseases.

关键词： alpha-synuclein amyloid beta plaques autophagy dopaminergic neurons human iPSCs mitochondrial dysfunction scRNA sequencing synaptic dysfunction Tau Wallerian degeneration

Decoding degeneration:the implementation of machine learning for clinical detection of neurodegenerative disorders

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Neural Regeneration Research 2023年第6期18卷 1235-1242页

作者： Fariha Khaliq jane Oberhauser Debia Wakhloo Sameehan Mahajani Department of Biomedical Engineering and Sciences(BMES) National University of Science and TechnologyIslamabadPakistan Department of Neuropathology School of MedicineStanford UniversityStanfordCAUSA

Machine learning represents a growing subfield of artificial intelligence with much promise in the diagnosis,treatment,and tracking of complex conditions,including neurodegenerative disorders such as Alzheimer’s and Parkinson’s *** no definitive methods of diagnosis or treatment exist for either disease,researchers have implemented machine learning algorithms with neuroimaging and motion-tracking technology to analyze pathologically relevant symptoms and *** learning algorithms such as neural networks and complex combined architectures have proven capable of tracking disease-linked changes in brain structure and physiology as well as patient motor and cognitive symptoms and responses to ***,such techniques require further development aimed at improving transparency,adaptability,and *** this review,we provide an overview of existing neuroimaging technologies and supervised and unsupervised machine learning techniques with their current applications in the context of Alzheimer’s and Parkinson’s diseases.

关键词： Alzheimer’s disease clinical detection deep learning machine learning neurodegenerative disorders neuroimaging Parkinson’s disease

Cryptomycota: the missing link

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Protein & Cell 2012年第3期3卷 161-162页

作者： Krishna Bolla Elizabeth jane Ashforth Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100190China􀀍

Fungi have been well studied for 150 years and it was thought that there was a good understanding of the major evolutionary groups,but new findings by UK researchers from the University of Exeter have radically changed this *** a local pond near the Exeter University,UK,they discovered a diverse and deep evolutionary branch of fungi named Cryptomycota(Greek:crypto,hidden;mycota,fungi)that has now doubled our knowledge of fungal diversity.

关键词： doubled branch Cry

Corneal endothelial cell density and morphology in low and moderate myopic Chinese eyes

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International Journal of Ophthalmology(English edition) 2013年第4期6卷 467-470页

作者： Samaneh Delshad jane Mei Chun National Institute of Ophthalmic Sciences School of OptometryLot 2Lorong Utara BPetaling Jaya 46200Darul EhsanSelangorMalaysia

AIM:To describe and compare the corneal endothelial cell density and morphology in young,low and moderate myopic Chinese adults in Malaysian Chinese population.·METHODS:Non-contact specular microscopy(Topcon SP3000P,Tokyo,Japan) was performed in low(n =78;21.22±1.51 years) and moderate(n =78;21.82±1.40 years)myopic *** mean of three consecutive measurements of endothelial cell density(MCD),coefficient of variation(CV) in the cell size,and hexagonal appearance of the cell were obtained.·RESULTS:In low myopic eyes the MCD was 3 063.0±176.2/mm2,the mean CV was 33.4 ±4.0% and the mean hexagonal appearance of the cell was 57.9 ±2.7%.In moderate myopic eyes the MCD was 2961.6 ±159.0/mm2,the mean CV was 33.9 ±3.6% and mean hexagonal appearance of the cell was 56.2 ±4.7%.There were statistically significant differences in MCD(P <0.000) and hexagonal appearance of the cell(P <0.005) between low and moderate myopic eyes.·CONCLUSION:The corneal endothelial cell layer in more myopic eyes tends to have less MCD and cell hexagonality compared to lower myopic ***,there is no significant difference in CV between low and moderate myopic eyes.

关键词： cornea myopic eyes specular microscopy endothelial cell density morphology

2D Centroidal Voronoi Tessellations with Constraints

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Numerical Mathematics(Theory,Methods and Applications) 2010年第2期3卷 212-222页

作者： jane Tournois Pierre Alliez Olivier Devillers INRIA Sophia Antipolis-Mediterranee

We tackle the problem of constructing 2D centroidal Voronoi tessellations with constraints through an efficient and robust construction of bounded Voronoi diagrams, the pseudo-dual of the constrained Delaunay *** exploit the fact that the cells of the bounded Voronoi diagram can be obtained by clipping the ordinary ones against the constrained Delaunay *** clipping itself is efficiently computed by identifying for each constrained edge the(connected) set of triangles whose dual Voronoi vertices are hidden by the *** resulting construction is amenable to Lloyd relaxation so as to obtain a centroidal tessellation with constraints.

关键词： Centroidal Voronoi tessellation bounded Voronoi diagram constrained Delaunay triangulation.

DOCK8 regulates signal transduction events to control immunity

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Cellular & Molecular Immunology 2017年第5期14卷 406-411页

作者： Conor J Kearney Katrina L Randall jane Oliaro Immune Defence Laboratory Cancer Immunology Division The Peter MacCallum Cancer Centre East Melbourne Victoria 3002 Australia Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria 3052 Australia Department of Immunology and Infectious Disease The John Curtin School of Medical Research Australian National University Acton Australian Capital Territory 2601 Australia Australian National University Medical School Australian National University Acton Australian Capital Territory 2605 Australia

Genetic mutations in the gene encoding DOCK8 cause an autosomal recessive form of hyper immunoglobulin E syndrome （AR-HIES）, referred to as DOCK8 deficiency. DOCK8 deficiency in humans results in the onset of combined immunodeficiency disease （CID）, clinically associated with chronic infections with diverse microbial pathogens, and a predisposition to malignancy. It is now becoming clear that DOCK8 regulates the function of diverse immune cell sub-types, particularly lymphocytes, to drive both innate and adaptive immune responses. Early studies demonstrated that DOCK8 is required for lymphocyte survival, migration and immune synapse formation, which translates to poor pathogen control in the absence of DOCK8. However, more recent advances have pointed to a crucial role for DOCK8 in regulating the signal transduction events that control transcriptional activity, cytokine production and functional polarization of immune cells. Here, we summarize recent advances in our understanding of DOCK8 function, paying particular attention to an emerging role as a signaling intermediate to promote immune responses to diverse external stimuli.

关键词： DOCK8 immunodeficiency lymphocytes NK Cells signal transduction