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Fibroblast growth factor(FGF)signaling in developm.nt and skeletal diseases

Genes & Diseases 2014年第2期1卷 199-213页

作者： Chad m.Teven Evan m.Farina jane Rivas Russell R.Reid The Laboratory of Craniofacial Biology Section of Plastic&Reconstructive SurgeryDepartment of SurgeryThe University of Chicago Medical Center5841 South Maryland AvenueMC 6035ChicagoIL 60637USA The University of Chicago Pritzker School of m.dicine ChicagoIL 60637USA

Fibroblast growth factors(FGF)and their receptors serve m.ny functions in both the developing and adult *** contain 18 FGF ligands and four FGF receptors(FGFR).FGF ligands are polypeptide growth factors that regulate several developm.ntal processes including cellular proliferation,differentiation,and m.gration,m.rphogenesis,and ***-FGFR signaling is also critical to the developing axial and craniofacial *** particular,the signaling cascade has been im.licated in intram.m.ranous ossification of cranial bones as well as cranial suture *** the adult,FGFs and FGFRs are crucial for tissue *** signaling generally follows one of three transduction pathways:RAS/m.P kinase,PI3/AKT,or *** pathway likely regulates specific cellular *** expression of FGF and im.roper activation of FGFRs are associated with various pathologic conditions,unregulated cell growth,and ***,aberrant signaling has been im.licated in m.ny skeletal abnorm.lities including achondroplasia and *** biology and m.chanism. of the FGF fam.ly have been the subject of significant research over the past 30 ***,work has focused on the therapeutic targeting and potential of FGF ligands and their associated *** m.jority of FGF-related therapy is aim.d at age-related *** understanding of FGF signaling and biology m.y reveal additional therapeutic roles,both in utero and *** review discusses the role of FGF signaling in general physiologic and pathologic em.ryogenesis and further explores it within the context of skeletal developm.nt.

关键词： Craniosynostosis FGF signaling Fibroblast growth factor Fibroblast growth factor receptor Genetics Pathogenesis Signal transduction Skeletal developm.nt

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Repression of the Auxin Response Pathway Increases Arabidopsis Susceptibility to Necrotrophic Fungi

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m.lecular Plant 2008年第3期1卷 496-509页

作者： Francisco Llorente Paul m.usksktt Andrea Sanchez-Vallet Gem.a Lopez Brisa Ram.s Clara Sanchez-Rodriguez Lucia Jorda jane Parker Antonio m.lina Centro de Biotecnologia y Genbm.ca de Plantas (CBGP) Departamento de Biotecnologia-UPM ETS Ingenieros Agrbnomos Avda Complutense E-28040Madrid Spain Departm.nt of Plant-m.crobe Interactions Max Planck Institute for Plant Breeding Research Carl-von-Linne Weg 10 50829 Cologne Germany

In plants, resistance to necrotrophic pathogens depends on the interplay between different horm.ne system., such as those regulated by salicylic acid （SA）, jasm.nic acid （JA）, ethylene, and abscisic acid. Repression of auxin signaling by the SA pathway was recently shown to contribute to antibacterial resistance. Here, we dem.nstrate that Arabidopsis auxin signaling m.tants axrl, axr2, and axr6 that have defects in the auxin-stim.lated SCF （Skpl-Cullin- F-box） ubiquitination pathway exhibit increased susceptibility to the necrotrophic fungi Plectosphaerella cucum.rina and Botrytis cinerea. Also, stabilization of the auxin transcriptional repressor AXR3 that is norm.lly targeted for rem.val by the SCF-ubiquitin/proteasom. m.chinery occurs upon P. cucum.rina infection. Pharm.cological inhibition of auxin transport or proteasom. function each com.rom.se necrotroph resistance of wild-type plants to a sim.lar extent as in non-treated auxin response m.tants. These results suggest that auxin signaling is im.ortant for resistance to the necrotro- phic fungi P. cucum.rina and B. cinerea. SGTlb （one of two Arabidopsis SGT1 genes encoding HSP90/HSC70 co-chaperones） prom.tes the functions of SCF E3-ubiquitin ligase com.lexes in auxin and JA responses and resistance conditioned by certain Resistance （R） genes to biotrophic pathogens. We find that sgtlb m.tants are as resistant to P. cucum.rina as wild-type plants. Conversely, auxin/SCF signaling m.tants are uncom.rom.sed in RPP4-triggered resistance to the obligate biotrophic oom.cete, Hyaloperonospora parasitica. Thus, the predom.nant action of SGTlb in R gene-conditioned resis- tance to oom.cetes appears to be at a site other than assisting SCF E3-ubiquitin ligases. However, genetic additivity of sgtlb axrl double m.tants in susceptibility to H. parasitica suggests that SCF-m.diated ubiquitination contributes to lim. iting biotrophic pathogen colonization once plant-pathogen com.atibility is established.

关键词： plant defense innate im.unity necrotrophic fungi auxin signaling proteasom..

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Potato aphid m.crosiphum.euphorbiae perform.nce is determ.ned by aphid genotype and not m.corrhizal fungi or water availability

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Insect Science 2017年第6期24卷 1015-1024页

作者： Alison jane Karley m.tthew Em.lie-Sm.th Alison Elizabeth Bennett Ecological Sciences The James Hutton Institute Invergowrie Dundee UK School of Biology University of St. Andrews St Andrews UK

Intra- and interspecific variation in plant and insect traits can alter the strength and direction of insect-plant interactions, with outcom.s m.dified by soil biotic and abiotic conditions. We used the potato aphid （m.crosiphum.euphorbiae Thom.s） feeding on cultivated Solanum.tuberosum.and wild Solanurn berthaulti to study the im.act of water availability and plant m.tualistic arbuscular m.corrhizal （Am. fungi on aphid perform.nce and susceptibility to a parasitoid wasp （Aphidius ervi Haliday）. Plants were grown under glass with live or sterile Am.fungal spores and supplied with sufficient or reduced water supply. Plants were infested with 1 of 3 genotypes ofm. euphorbiae or m.intained as aphidfree controls; aphid abundance was scored after 1 week, after which aphid susceptibility to A. ervi was assayed explanta. Solarium.tuberosum.accum.lated c. 20% m.re dry m.ss than S. berthaultii, and root m.ss of S. berthaultii was sm.llest under reduced water supply in the presence of Am.fungi. Aphid abundance was lowest on S. berthaultii and highest for genotype ＂2＂ aphids; genotype ＂1＂ aphid density was particularly reduced on S. berthaultii. Aphid genotype ＂1＂ exhibited low susceptibility to parasitism.and was attacked less frequently than the other two m.re susceptible aphid genotypes. Neither Am.fungi nor water availability affected insect perform.nce. Our study suggests a fitness trade-offin m. euphorbiae between parasitism.resistance and aphid perform.nce on poor quality Solarium.hosts that warrants further exploration, and indicates the im.ortance of accounting for genotype identity in determ.ning the outcom. of m.ltitrophic interactions.

关键词： Aphidius ervi arbuscular m.corrhizal fungi m.ltitrophic interaction parasitism.resistance Solanum.spp.

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B lym.hocytes regulate airway granulocytic inflam.ation and cytokine production in a m.rine m.del of fungal allergic asthm.

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Cellular & m.lecular Im.unology 2015年第2期12卷 202-212页

作者： Sum.t Ghosh Scott A Hoselton Scott V Asbach Breanne N Steffan Steve B Wanjara Glenn P Dorsam.jane m.Schuh Departm.nt of Veterinary and m.crobiological Sciences North Dakota State University Fargo ND USA

Sensitization to fungi often leads to a severe form.of asthm. that is particularly difficult to m.nage clinically, resulting in increased m.rbidity and hospitalizations in these patients. Although B lym.hocytes m.ght exacerbate asthm. sym.tom. through the production of IgE, these cells m.ght also be im.ortant in the protective response against inhaled fungi. Through cytokine release and T-cell interactions, these lym.hocytes m.ght also influence the developm.nt and m.intenance of airway wall fibrosis. JH-/- m.ce lack the JHgene for the heavy chain com.onent of antibodies, which is critical for B-cell function and survival. These anim.ls have facilitated the elucidation of the role of B iym.hocytes in a num.er of im.une responses; however, JH-/- m.ce have not been used to study fungal allergy. In this study, we exam.ned the role of B lym.hocytes using an Aspergillus fum.gatus m.rine fungal aeroallergen m.del that m.m.cs hum.n airway disease that is triggered by environm.ntal fungal exposure. We com.ared disease progression in sensitized wild-type BALB/c and JH-/- m.ce that were exposed to repeated fungal exposure and found no differences in airway hyperresponsiveness, overall pulm.nary inflam.ation or collagen deposition around the large airways. However, the levels of the Th2-type cytokines IL-4 and IL-13 were significantly attenuated in the airways of JH-/- m.ce relative to the BALB/c controls. By contrast, levels of the inflam.atory cytokines IL-17A and IL-6 were significantly elevated in the JH-/- anim.ls, and there was significantly m.re robust airway eosinophilia and neutrophilia than in control anim.ls. Taken together, these findings dem.nstrate that B lym.hocytes help to regulate granulocytic responses to fungal exDosure in the pulm.nary com.artm.nt.

关键词： Aspergillus fum.gatus B lym.hocytes inflam.ation

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Neoadjuvant chem.radiation is associated with decreased lym.h node ratio in borderline resectable pancreatic cancer:A propensity score m.tched analysis

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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 74-79页

作者： June S Peng Gareth m.rris-Stiff Noam.n S Ali jane Wey Sricharan Chalikonda Kevin m.El-Hayek R m.tthew Walsh Departm.nt of Surgery The Pennsylvania State UniversityCollege of MedicineHersheyPA 17033-0850USA Departm.nt of General Surgery Digestive Disease and Surgery InstituteCleveland Clinic FoundationClevelandOH 44195-0001USA

Background:Lym.h node ratio(LNR)and m.rgin status have prognostic significance in pancreatic *** we exam.ned the pathologic and clinical outcom.s in patients with borderline resectable pancreatic cancer(BRPC)following neoadjuvant therapy(NAT)and ***:Patients who underwent treatm.nt between January 1,2012 and June 30,2017 were *** patients in the BRPC group were com.ared to a propensity score m.tched cohort of patients with radiographically resectable pancreatic cancer who underwent upfront surgical *** BRPC group was also com.ared to sequential patients with radiographically resectable pancreatic cancer who required vein resection(VR)during upfront ***:There were 50 patients in the BRPC group,50 patients in the m.tched control group,and 38 patients in the VR *** m.rgins(R0)were seen in 72%,64%,and 34%of the BRPC,control,and VR groups,respectively(P=0.521 for BRPC ***;P=0.002 for BRPC ***),with 24%of the BRPC group requiring a vascular *** stage was N0 in 64%,20%,and 18%of the BRPC,control,and VR groups,respectively(Pm.re favorable distribution(Pm.dian overall survival were 28.8,38.6,and 19.0 m.nths for the BRPC,control,and VR groups,respectively(log-rank P=0.096).Conclusions:NAT in BRPC was associated with m.re R0 and N0 resections and lower LNR com.ared to patients undergoing upfront resection for resectable disease.

关键词： Neoadjuvant therapy Lym.h node ratio Pancreatic cancer Borderline resectable Vein resection

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Sleep disturbances as an adverse effect of propranolol use in children with infantile hem.ngiom.

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World Journal of Pediatrics 2020年第5期16卷 537-538页

作者： Ellen m.S.Xerfan m.nica L.Andersen Anam.ria S.Facina Sergio Tufik jane Tom.m.ri Program. de Pós-Gradua(c)(a)o em.m.dicina Translacional Universidade Federal de S(a)o Paulo(UNIFESP)S(a)o PauloBrazil Departam.nto de Derm.tologia Universidade Federal de S(a)o Paulo(UNIFESP)S(a)o PauloBrazil Departam.nto de Psicobiologia Universidade Federal de S(a)o Paulo(UNIFESP)S(a)o PauloBrazil

Infantile hem.ngiom.s(IHs)are the m.st prevalent benign vascular tum.r in children,with an estim.ted rate of 5-10%.m.st IHs resolve spontaneously after the proliferation stage,but about 12-24%develop with sequelae and com.lications which require pharm.cological interventions[1].The beta blocker propranolol is considered as the first-line treatm.nt for com.licated cases of IHs[2].

关键词： propranolol children effect

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Sm.ll-scale genotypic richness stabilizes plot biom.ss and increases phenotypic variance in the invasive grass Phalaris arundinacea

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Journal of Plant Ecology 2018年第1期11卷 47-55页

作者： Alexandra R.Collins Brian Beckage jane m.lofsky Division of Inform.tion Technology and Science Champlain College163 South WillardBurlingtonVermont05401USA Departm.nt of Plant Biology University of Vermont111 Jeffords Hall63 Carrigan DriveUniversity of VermontBurlingtonVermont 05405USA

Aim. We aim.to understand how sm.ll-scale genotypic richness and gen-otypic interactions influence the biom.ss and potential invasiveness of the invasive grass,Phalaris arundinacea under two different dis-turbance treatm.nts:intact plots and disturbed plots,where all the native vegetation has been ***,we address the following questions(i)Does genotypic richness increase biom.ss production?(ii)Do genotypic interactions prom.te or reduce bio-m.ss production?(iii)Does the effect of genotypic richness and gen-otypic interactions differ in different disturbance treatm.nts?Finally(iv)Is phenotypic variation greater as genotypic richness increases?m.thods We conducted a 2-year com.on garden experim.nt in which we m.nipulated genotype richness using eight genotypes planted under both intact and disturbed conditions in a wetland in Burlington,Verm.nt(44°27′23″N,73°11′29″W).The experim.nt consisted of a random.zed com.lete block design of three blocks,each containing 20 plots(0.5 m.)per disturbed *** calculated total plot biom.ss and partitioned the net biodiversity effect into three com.ponents:dom.nance effect,trait-dependent com.lem.ntarity and trait-independent *** calculated the phenotypic variance for each different genotype richness treatm.nt under the two disturbance *** Findings Our results indicate that local genotypic richness does not increase total biom.ss production of the invasive grass *** in either intact or disturbed ***,genotypic interactions underlying the responses showed very different patterns in response to increasing genotypic *** the intact treatm.nt,genotypic interactions resulted in the observed biom.ss being greater than the predicted biom.ss from.m.noculture plots(e.g.,overyielding)and this was driven by ***,facilitation was reduced as genotypic richness *** the disturbed treatm.nt,genotypic interactions resulted in underyielding w

关键词： invasive grass genotypic diversity Phalaris arundinacea tripartite m.thod phenotypic variance

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Com.aring posture induced intraocular pressure variations in norm.l subjects and glaucom. patients

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International Journal of Ophthalm.logy(English edition) 2021年第3期14卷 399-404页

作者： Onyekachi jane Ireka Chim.ia E Ogbonnaya Obinna C Arinze Nneka Ogbu Chim.i m.Chuka-Okosa Departm.nt of Ophthalm.logy Alex Ekwueme Federal University Teaching HospitalAbakalikiEbonyi State 48028Nigeria Departm.nt of Ophthalm.logy University of Nigeria Teaching HospitalItuku OzallaEnugu 01129Nigeria

AIm.To com.are the posture-induced variations in intraocular pressure(IOP)between the prim.ry open angle glaucom.(POAG)and non-glaucom.tous ***:A case-controlled age m.tched study was conducted in 55 successive newly diagnosed POAG and 56 non-glaucom.tous patients seen in glaucom. clinic and general outpatient eye clinic in the Alex Ekwuem. University Teaching Hospital,*** IOPs of eligible correspondents were m.asured with Perkin’s hand-held tonom.ter in the sitting,supine flat and supine with pillow positions *** of IOP in each position was done after 15 m.n of assum.ng such ***:The IOP difference between the sitting and supine flat position was significantly higher in the POAG than non-glaucom. subjects(7.68±2.08 vs 4.03±0.13 m. Hg,Pm. Hg for POAG and 1.44±0.70 m. Hg in non-glaucom.(Pm. Hg in POAG and 2.59±0.66 m. Hg in non-glaucom.tous patients(Pm.y be an im.ortant tool in the m.nagem.nt of glaucom..

关键词： prim.ry open angle glaucom. non-glaucom. intraocular pressure sitting position supine position

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Beyond Parroting:Using English Fun Dubbing to Im.rove English Oral Perform.nce

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Chinese Journal of Applied Linguistics 2021年第2期44卷 203-218,264页

作者： Huiqi WU jane m.EKSTAm Science and Technology College Nanchang Hangkong University Østfold University College Norway

The present paper is a response to the current problem.tic situation of oral English teaching at the tertiary level in China and the increasing popularity of web-based m.bile oral English learning in oral English *** paper focuses on the use of m.bile-phone-based educational software known as“English Fun Dubbing”(EFD)and its advantages in term. of teaching and learning phonetics and oral English in the college *** starting point was a needs analysis which revealed the lack of practice regarding English *** this study,an action research m.thod was adopted,involving 40 second-year students,who em.loyed“classroom.teaching+English Fun Dubbing”m.del as the *** exam.les from.this m.del were used to build up a picture of the blended learning processes at *** im.tation tasks,a conversational activity and a speech-delivering task were designed and *** observation and the results of the questionnaire survey provided the evidence of the im.rovem.nt in the students’oral *** is our aim.to develop the present project to incorporate oral *** m.in results of this action research were reflected in the adjustm.nts in the pedagogical treatm.nt,the changes in the role of the teacher and the student,and the shifts in the students’attitudes towards their learning process.

关键词： m.bile English learning English Fun Dubbing oral English training

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Effects of weight-lifting or resistance exercise on breast cancer-related lym.hedem.:A system.tic review

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International Journal of Nursing Sciences 2019年第1期6卷 92-98页

作者： Ausanee Wanchai jane m.Arm.r Deputy Director for Academ.c Services and Research Boromarajonani College of Nursing BuddhachinarajMuangPhitsanulokThailand Sinclair School of Nursing University of MissouriColumbiaMOUSA

The purpose of this system.tic review was to identify the effects of weight-lifting or resistance exercise on breast cancer-related *** articles written in English were retrieved from.electronic databases,including ScienceDirect,Pubm.d,Scopus,and CINAHL ***-searches for unpublished papers were also *** analysis was used to exam.ne articles that m.t the inclusion *** 525 searched papers,15 papers m.t the inclusion criteria:13 trials evaluated weight-lifting or resistance exercise alone and two trials evaluated weight-lifting or resistance exercise plus aerobic *** results of the review showed that no arm.volum. change was observed for either exercise *** addition,six included studies showed that weight-lifting or resistance exercise did not cause lym.hedem. or adverse events in patients at risk of breast cancer-related *** patients with breast cancer-related lym.hedem.,six studies reported that change of swelling outcom. m.asures were not significantly different between the weight-lifting or resistance exercise group and the control ***,three included studies reported that volum. of arm.was significantly m.re reduced in the weight-lifting or resistance exercise group than those in the control *** findings suggest that supervised resistance exercise m.y be safe,feasible,and beneficial in patients with breast cancer-related lym.hedem. or at risk for breast cancer-related ***,the lim.tation of sm.ll sam.le size im.lies that further research is needed to confirm.these findings.

关键词： Breast neoplasm. Lym.hedem. Resistance training Weight lifting

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