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Vitamin D, selenium in type 2 diabetes and Hashimoto's thyroiditis: Is it effective?

World Journal of Diabetes 2024年第5期15卷 1048-1050页

作者： Kotha Sugunakar reddy Vishakha Jain Sakthivadivel Varatharajan janardhana reddy pallavali Department of General Medicine All India Institute of Medical SciencesTelanganaHyderabad 508126India

The study by Feng et al,explores treatment approaches for these coexisting *** emphasizes the potential advantages of selenium and vitamin D supplementation but also raises methodological and patient selection *** indicate a complex interplay between interventions and disease markers,prompting the need for further *** limitations,the study offers valuable insights into managing the intricate relationship between type 2 diabetes mellitus and Hashimoto's *** authors'contributions shed light on potential treatment avenues,although careful consideration of study design and patient characteristics is warranted for future investigations in this domain.

关键词： Vitamin D Selenium Type 2 diabetes Mellitus Hashimoto’s thyroiditis

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The efect of the couple stress parameter and Prandtl number on the transient natural convection flow over a vertical cylinder

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Acta Mechanica Sinica 2013年第5期29卷 649-656页

作者： H.P.Rani G.janardhana reddy Chang Nyung Kim Department of Mathematics National Institute of TechnologyWarangal-506004 AP India Department of Mechanical Engineering College of Advanced Technology (Industrial Liaison Research Institute)Kyung Hee UniversityGyeonggi-do 446-701 Korea

An analysis is performed to study transient free convective boundary layer flow of a couple stress fluid over a vertical cylinder, in the absence of body couples. The solution of the time-dependent non-linear and coupled governing equations is carried out with the aid of an unconditionally stable Crank-Nicolson type of numerical scheme. Numerical results for the steady-state velocity, temperature as well as the time histories of the skin-friction coefficient and Nus- selt number are presented graphically and discussed. It is seen that for all flow variables as the couple stress control parameter, Co, is amplified, the time required for reaching the temporal maximum increases but the steady-state decreases.

关键词： Couple stress fluid Natural convection Vertical cylinder Finite difference method

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Transient analysis of Casson fluid thermo-convection from a vertical cylinder embedded in a porous medium: Entropy generation and thermal energy transfer visualization

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Journal of Central South University 2019年第5期26卷 1342-1361页

作者： janardhana reddy G BHASKERreddy Kethireddy MAHESH Kumar ANWAR BEG O Department of Mathematics Central University of KarnatakaKalaburagi585367India Fluid Mechanics Aeronautical and Mechanical Engineering DepartmentSchool of ComputingScience and EngineeringUniversity of SalfordManchester M54WTUK

Thermal transport in porous media has stimulated substantial interest in engineering sciences due to increasing applications in filtration systems,porous bearings,porous layer insulation,biomechanics,geomechanics *** by such applications,in this article,a numerical study of entropy generation impacts on the heat and momentum transfer in time-dependent laminar incompressible boundary layer flow of a Casson viscoplastic fluid over a uniformly heated vertical cylinder embedded in a porous medium is ***’s law is used to simulate bulk drag effects at low Reynolds number for an isotropic,homogenous porous *** line visualization is also *** mathematical model is derived and normalized using appropriate transformation *** resulting non-linear time-dependent coupled governing equations with associated boundary conditions are solved via an implicit finite difference method which is efficient and unconditionally *** outcomes show that entropy generation and Bejan number are both elevated with increasing values of Darcy number,Casson fluid parameter,group parameter and Grashof *** analyze the heat transfer process in a two-dimensional domain,plotting heat lines provides an excellent approach in addition to streamlines and *** is remarked that as the Darcy number increases,the deviations of heat lines from the hot wall are reduced.

关键词： vertical cylinder entropy generation Casson fluid finite difference method heat function porous medium

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Novel pharmaceutical rationale against human lymphatic filarial parasite:An oxidative premise

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Asian Pacific Journal of Tropical Medicine 2009年第1期2卷 30-34页

作者： R.D.Sharma P.B.janardhana D.Gajalakshmi M.V.R.reddy K.Goswami Jamnalal Bajaj Tropical Disease Research Centre & Department of Biochemistry Mahatma Gandhi Institute of Medical SciencesSevagram-442102India.

Objective:Mandate from WHO has boosted up anti-filarial drug *** citrate(DEC) was not known for any direct effect on filarial ***,recent report proposed its direct apoptotic *** stress has been implicated in apoptotic impact.A study was designed to explore the possibility of oxidative rationale to be operative in the direct anti-filarial effect of ***:Various doses of DEC and potent oxidant H_2O_2 alone were used in vitro to check for the effects on *** microfilariae,followed by the use of DEC in combination with H_2O_*** of the oxidative impact of the drug was tested using the antioxidant,vitamin C and also lipid peroxidation levels in the post incubation culture supematants were ***:As expected,DEC alone failed to record any anti-filarial effect.H_2O_2 alone also failed to show any significant effect until a very high dose was ***,in combination significant anti-filarial effect was noticed,which allowed even 44%reduction in the dose of H_2O_*** significant lipid peroxidation was not *** C demonstrated 30%inhibitory ***:DEC and H_2O_2 combination being able to educe synergistic anti-filarial effect and inhibition of the same by vitamin C hinted towards covert oxidative component in the mechanism of *** implication of non-significant lipid peroxidation was addressed in the perspective of subtle oxidative nexus that seems to be operative in observed anti-filarial effect. Exploration of such rationale might lead to novel drug development.

关键词： DEC H_2O_2 Vitamin C Oxidative stress Anti-filarial drug

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