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Journal of Civil Engineering and Architecture 2024年第3期18卷 141-147页

作者： jana Kosikova Brno University of Technology Faculty of Civil EngineeringInstitute of Technology of Building Materials and ComponentsVeveří331/9560200 BrnoCzech Republic

Recently the manufacture of epoxy coating and flooring materials begun to be under strong pressure to use more environmentally friendly raw materials in its *** tendency to reduce of solvents and diluents contained in the materials appeared at the end of 90´*** situation was supported by the Council of Europe in 2004 to reduce VOC emissions to zero till *** materials were thus largely replaced by solvent free materials from which the volatile substances are not released into the *** pressure continued to increase,and over the past decade began to take centre stage water-based *** the Czech market solvent based material is still occasionally used,but predominant are solvent free *** are no commonly used materials containing wastes as fillers in new water-borne and solvent-free epoxy *** identification of the waste material as a potential filler is a set of properties that determine the limits of secondary raw materials or waste as a *** paper describes the basic characteristics which must be selected to meet the requirements,to affect negatively the workability,sedimentation,properties and behavior of the final floor *** materials must comply with special requirements,such as resistance to chemicals,*** part of paper talks about utilization of polymer floors and their mechanical properties.

关键词： Industrial polymer flooring materials waster fillers building materials

Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al-Hasani Joachim Altschmied Katharina Bottermann jana Brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause Kathrin Landgraf Diana Le Duc Laura Lehmann Stefan Lehr Stephanie Pick Albert Ricken Rene Schnorr Angela Schulz Martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg Doreen Thor Simone Prömel Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with early-onset ***,we identified the adhesion GPCR latrophilin 1(ADGRL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

Trilayer anisotropic structure versus randomly oriented structure in heart valve leaflet tissue engineering

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Bio-Design and Manufacturing 2023年第4期6卷 423-438页

作者： Yuriy Snyder Soumen jana Department of Bioengineering University of MissouriColumbiaMO 65211USA

It has been hypothesized that leaflet substrates with a trilayer structure and anisotropicmechanical properties could be useful for the production of functional and long-lasting tissue-engineered *** investigate the influence of the anisotropic structural and mechanical characteristics of a substrate on cells,in this study,we electrospun trilayer anisotropic fibrous substrates and randomly oriented isotropic fibrous substrates(used as controls)from polycaprolactone ***,the random substrates had higher radial and lower circumferential tensile properties than the trilayer substrates;however,they had similar flexural *** valvular interstitial cells cultured on both substrates produced random and trilayer cell-cultured constructs,*** trilayer cell-cultured constructs had more anisotropic mechanical properties,17%higher cellular proliferation,14%more extracellular matrix(i.e.,collagen and glycosaminoglycan)production,and superior gene and protein expression,suggesting that more cells were in a growth state in the trilayer constructs than in the random ***,the random and radial layers of the trilayer constructs had more vimentin,collagen,transforming growth factor-beta 1(TGF-ß1),transforming growth factor-beta 3(TGF-ß3)gene expression than in the circumferential layer of the *** study verifies that the differences in structural,tensile,and anisotropic properties of the trilayer and random substrates influence the characteristics of the cells and ECM in the constructs.

关键词： Heart valve leaflet Trilayer Tissue engineering Fiber Electrospinning

Basic theorem as representation of heterogeneous concept lattices

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Frontiers of Computer Science 2015年第4期9卷 636-642页

作者： Jozef POCS jana POCSOVA Palacky University Olomouc Department of Algebra and Geometry Olomouc 779 00 Czech Republic Mathematical Institute Slovak Academy of Sciences Kosice 040 01 Slovakia Technical University of Kosice BERG Faculty Institute of Control and Informatization of Production Processes Ko~ice 043 84 Slovakia

We propose a method for representing heteroge- neous concept lattices as classical concept lattices. Particu- larly, we describe a transformation of heterogeneous formal context into a binary one, such that corresponding concept lattices will be isomorphic. We prove the correctness of this transformation by the basic theorem for heterogeneous as well as classical concept lattices.

关键词： basic theorem heterogeneous concept lattice,representation

Preparation of LDPE-Acetylated/Butyrylated Starch Blend Blow Films and Characterization

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Chinese Journal of Polymer Science 2014年第3期32卷 268-279页

作者： Sangeeta Garg Asim Kumar jana Department of Chemical Engineering National Institute of TechnologyJalandhar Department of Biotechnology National Institute of TechnologyJalandhar

Development of modified plastics has been studied through the LDPE-acylated starch blend films to examine the effect of different acyl groups and degrees of substitution （DS） on properties of films. Corn starch was modified with acetyl and hutyryl groups and films were prepared by blending acylated starch with low density polyethylene （LDPE）. Systematic studies were done to observe the effect of acyl groups, DS and starch concentration on the properties and biodegradability of the blend films. It was observed that blend films containing 5% acetylated and butyrylated starches of high DS （2.5, 1.7） maintained 75% and 83% of tensile strength of LDPE films. Thermal analysis results indicated that acetylated and butyrylated starch blend films decomposed at 370℃ and 389℃ which were higher than the decomposition temperature of native starch film （349℃）. Scanning electron micrographs of blend films containing high DS acylated starch showed well dispersed starch particles due to improvement in dispersion between starch and LDPE. Water absorption capacity of high DS acetylated and butyrylated starch blend films （4.18% and 3.76%, respectively） was lower than that of native starch films （5%）. This study has an advantage because of blown films prepared can be integrated with the present manufacturing systems without any other requirement.

关键词： Acylated starch LDPE-starch blend films Mechanical properties Water absorption capacity Biodegradability.

Evaluation of the expression of sperm proteins in normozoospermic and asthenozoospermic men using monoclonal antibodies

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Asian Journal of Andrology 2016年第1期18卷 108-113页

作者： jana Capkova Alena Kubatova Lukas Ded Olina Tepla jana Peknicova Laboratory of Reproductive Biology Institute of Biotechnology Academy of Sciences of the Czech Republic v. v. i. Prague Czech Republic Clinic Center IVF ISCARE Prague Czech Republic

Recent studies have shown that infertility affects estimated 15% of all couples. Male infertility is the primary or contributory cause in 60% of these cases. Consequently, the application of assisted reproduction is increasing. These methods could benefit from an extended evaluation of sperm quality. For this reason, we analyzed sperm proteins from 30 men with normal spermiograms and 30 men with asthenozoospermia. Ejaculates of both groups were tested by flow cytometry （FCM） and fluorescence with a set of well-characterized anti-human sperm Hs-monoclonal antibodies （MoAbs）, which were generated in our laboratory. No statistically significant differences were found between normospermics and asthenospermics in the expression of the sperm surface protein clusterin, evaluated with Hs-3 MoAb, and semenogelin, evaluated with Hs-9 MoAb. However, FCM revealed quantitative differences in the acrosomal proteins between normozoospermic and asthenozoospermic men, namely, in glyceraldehyde-3-phosphate dehydrogenase, evaluated with Hs-8 MoAb, valosin-containing protein, evaluated with Hs-14 MoAb, and ATP synthase （cAMP-dependent protein kinase II, PRKAR2A）, evaluated with MoAb Hs-36. Asthenozoospermic men displayed a highly reduced expression of intra-acrosomal proteins, with a likely decrease in sperm quality, and thus a negative impact on successful reproduction. Asthenozoospermia seems to be a complex disorder involving intra-acrosomal proteins.

关键词： asthenozoospermia flow cytometry fluorescence microscopy monoclonal antibodies sperm proteins

Microtubule affinity regulating kinase(MARK/Par1)isoforms differentially regulate Alzheimer-like TAU missorting and Aβ-mediated synapse pathology

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Neural Regeneration Research 2023年第2期18卷 335-336页

作者： jana Chudobová Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital Cologne Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

Importance of TAU protein for dementia syndromes:Dementia currently affects about 55 million people worldwide,with Alzheimer's disease(AD)being the most prevalent *** one crucial pathological hallmark of AD that correlates best with loss of synapses and cognitive decline are the so-called intracellular neurofibrillary tangles composed of mislocalized/missorted and hyperphosphorylated TAU protein(Naseri et al.,2019).Many other neurodegenerative diseases,both genetic and nongenetic,are characterized by neurofibrillary ta ngles or pathological accumulation of the protein TAU and are thus termed"tauopathies".

关键词： Alzheimer diseases

Compromising Solution of Geometric Programming Problem with Bounded Parameters

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Journal of the Operations Research Society of China 2017年第3期5卷 377-390页

作者： Mrinal jana Geetanjali Panda University of Petroleum and Energy Studies Dehradun 248007India Department of Mathematics Faculty of MathematicsIndian Institute of Technology KharagpurKharagpur 721302West BengalIndia

This paper addresses a geometric programming problem,where the objective function and constraints are interval-valued *** concept of acceptable feasible region is introduced,and a methodology is developed to transform this model to a general optimization problem,which is free from interval ***ship between the solution of the original problem and the transformed problem is *** methodology is illustrated through numerical *** by the proposed method and previous methods are analyzed.

关键词： Interval-valued function Partial ordering Nonlinear programming Geometric programming Decision making

Online Induction of Probabilistic Real-Time Automata

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Journal of Computer Science & Technology 2014年第3期29卷 345-360页

作者： jana Schmidt Stefan Kramer Technische Universitt Mnchen Institut fr Informatik/I12Boltzmannstr. 385748 Garching b. MnchenGermany Johannes Gutenberg-Universitt Mainz Institute for Computer ScienceStaudingerweg 955128 MainzGermany

The probabilistic real-time automaton （PRTA） is a representation of dynamic processes arising in the sciences and industry. Currently, the induction of automata is divided into two steps： the creation of the prefix tree acceptor （PTA） and the merge procedure based on clustering of the states. These two steps can be very time intensive when a PRTA is to be induced for massive or even unbounded datasets. The latter one can be efficiently processed, as there exist scalable online clustering algorithms. However, the creation of the PTA still can be very time consuming. To overcome this problem, we propose a genuine online PRTA induction approach that incorporates new instances by first collapsing them and then using a maximum frequent pattern based clustering. The approach is tested against a predefined synthetic automaton and real world datasets, for which the approach is scalable and stable. Moreover, we present a broad evaluation on a real world disease group dataset that shows the applicability of such a model to the analysis of medical processes.

关键词： probabilistic real-time automata online induction maximum frequent pattern based clustering

Survey of control techniques to alleviate repercussions of shock-wave and boundary-layer interactions

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Advances in Aerodynamics 2022年第1期4卷 569-598页

作者： Tamal jana Mrinal Kaushik Department of Aerospace Engineering JAIN(Deemed-to-be University)Bangalore560069India Department of Aerospace Engineering Indian Institute of Technology KharagpurKharagpur721302India

The primary focus of the present survey is to categorize the results of various investigations on the Shock/Boundary-Layer Interactions(SBLIs),their repercussions,and the effective ways to control *** interactions of shock waves with the boundary layer are an important area of research due to their ubiquity in several applications ranging from transonic to hypersonic ***,there is a need for a detailed inspection to understand the phenomena to predict its characteristics with certain *** this in mind,this article presents some key features of the physical nature of SBLIs,their consequences,and the control techniques in a sequential manner;in particular,the passive control techniques for the supersonic and hypersonic intakes are reviewed in detail.

关键词： Oblique shock Boundary layer Separation bubble Surface bump Porous cavity Micro-vortex generator(MVG) Plasma jet