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ProTSA: A Testing Process for Automotive Software Domain

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Journal of Software Engineering and Applications 2024年第7期17卷 571-615页

作者： Renato Rafael Arcanjo Luiz Eduardo Galvão Martins Dirceu Lavoiser fernandes Graci Department of Inovation and Science Federal University of Sao Paulo (UNIFESP) Sao Jose dos Campos Brazil Department of Automotive Electronics Faculty of Technology of Sao Paulo (Fatec) Santo Andre Brazil

This study evaluates the development of a testing process for the automotive software domain, highlighting challenges stemming from the absence of adequate processes. The research demonstrates the application of Design Science Research methodology in developing, an automotive software testing process—ProTSA, using six functional testing modules. Additionally, the study evaluates the benefits of implementing ProTSA in a specific Original Equipment Manufacturer (OEM) using an experimental single-case approach with industry professionals’ participation through a survey. The study concludes that combining testing techniques with effective communication and alignment is crucial for enhancing software quality. Furthermore, survey data indicates that implementing ProTSA leads to productivity gains by initiating tests early, resulting in time savings in the testing program and increased productivity for the testing team. Future work will explore implementing ProTSA in cybersecurity, over-the-air software updates, and autonomous vehicle testing processes. .

关键词： Verification and Validation Automotive Software Automotive Systems

Finding biomarkers of experience in animals

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Journal of Animal Science and Biotechnology 2024年第3期15卷 925-944页

作者： Sarah Babington Alan J.Tilbrook Shane K.Maloney Jill N.fernandes Tamsyn M.Crowley Luoyang Ding Archa H.Fox Song Zhang Elise A.Kho Daniel Cozzolino Timothy J.Mahony Dominique Blache School of Agriculture and Environment The University of Western AustraliaCrawleyWA 6009Australia Centre for Animal Science The Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia School of Veterinary Science The University of QueenslandGattonQLD 4343Australia School of Human Sciences The University of Western AustraliaCrawleyWA 6009Australia School of Medicine Deakin UniversityGeelongVIC 3217Australia Poultry Hub Australia University of New EnglandArmidaleNSW 2350Australia College of Animal Science and Technology Yangzhou UniversityYangzhou 225009China Centre for Nutrition and Food Sciences The Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia

At a time when there is a growing public interest in animal welfare,it is critical to have objective means to assess the way that an animal experiences a *** is critical to ensure appropriate animal welfare *** behavioural,physiological,and neurobiological indicators that are used to assess animal welfare can verify the absence of extremely negative *** welfare is more than an absence of negative outcomes and an appropriate indicator should reflect the full spectrum of experience of an animal,from negative to *** this review,we draw from the knowledge of human biomedical science to propose a list of candidate biological markers(biomarkers)that should reflect the experiential state of non-human *** proposed biomarkers can be classified on their main function as endocrine,oxidative stress,non-coding molecular,and thermobiological *** also discuss practical challenges that must be addressed before any of these biomarkers can become useful to assess the experience of an animal in real-life.

关键词： Animal experience Animal welfare Biomarker Stress Welfare assessment

Evolutionary fingerprint, phylogenetic and forest structure of tropical montane Atlantic cloud forests along an elevation gradient

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Journal of Mountain Science 2024年第4期21卷 1259-1271页

作者： Ravi fernandes MARIANO Vanessa Leite REZENDE Cléber Rodrigo de SOUZA Patrícia Vieira POMPEU Rubens Manoel dos SANTOS Carolina Njaime MENDES Aloysio Souza de MOURA Felipe Santana MACHADO Warley Augusto Caldas CARVALHO Marco Aurélio Leite FONTES Department of Forest Sciences Federal University of LavrasLavras 37200-900Brazil 2Environmental Defence Association of Minas Gerais Belo Horizonte 30360-110Brazil Department of Ecology and Conservation Federal University of LavrasLavras 37200-900Brazil Department of Forest Sciences State University of Mato Grosso do SulAquidauana 79200-000Brazil Agência Zetta Federal University of LavrasLavras 37200-900Brazil. Department of natural Sciences Federal University of São João del-ReiSão João del-Rei 36307-352Brazil.

Environmental conditions can change markedly over geographical distances along elevation gradients,making them natural laboratories to study the processes that structure *** work aimed to assess the influences of elevation on Tropical Montane Cloud Forest plant communities in the Brazilian Atlantic Forest,a historically neglected *** evaluated the phylogenetic structure,forest structure(tree basal area and tree density)and species richness along an elevation gradient,as well as the evolutionary fingerprints of elevation-success on phylogenetic lineages from the tree *** do so,we assessed nine communities along an elevation gradient from 1210 to 2310 m *** large elevation *** relationships between elevation and phylogenetic structure,forest structure and species richness were investigated through Linear *** occurrence of evolutionary fingerprint on phylogenetic lineages was investigated by quantifying the extent of phylogenetic signal of elevation-success using a genus-level molecular *** results showed decreased species richness at higher elevations and independence between forest structure,phylogenetic structure and *** also verified that there is a phylogenetic signal associated with elevation-success by *** concluded that the elevation is associated with species richness and the occurrence of phylogenetic lineages in the tree communities evaluated in Mantiqueira *** the other hand,elevation is not associated with forest structure or phylogenetic ***,closely related taxa tend to have their higher ecological success in similar ***,we highlight the fragility of the tropical montane cloud forests in the Mantiqueira Range in face of environmental changes(*** warming)due to the occurrence of exclusive phylogenetic lineages evolutionarily adapted to environmental conditions(*** temperature)associated with each elevation range.

关键词： Atlantic Forest Cloud forest Conservation Community ecology Montane forests Phylogenetic diversity Phylogenetic signal

Active packaging for lipid foods and development challenges for marketing

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Food Bioscience 2022年第1期45卷 20-33页

作者： Erica da Costa Moncao Cristiani Viegas Brandao Grisi janaína de Moura fernandes Priscila Santos Souza Antonia Lucia de Souza Programa de Pos-Graduacao Em Ciencia e Tecnologia de Alimentos Universidade Federal da ParaíbaJoao PessoaPB58051Brazil Programa de Pos-Graduacao Em Tecnologia Agroalimentar Universidade Federal da ParaíbaBananeiras-PB58220-000Brazil Programa de Pos-Graduacao Em Química Universidade Federal da ParaíbaJoao PessoaPB58051Brazil

Consumer demand for natural products with low concentration of additives and controlled environmental impact has been a major challenge for the lipid food packaging *** of this fact,active packaging such as oxygen absorbers and antioxidant releasers are trends in the *** this work,research developed on oxygen absorbing packaging and antioxidant-releasing packaging will be *** work will also reveal the challenges to *** that slows down lipid oxidation in food presents satisfactory results and greater efficacy than vacuum *** challenges for the development of active packaging that consist of biopolymers and natural additives are related to the physical and mechanical properties of the *** research should develop biodegradable active packaging that are resistant to industrial ***,there are plenty of natural resources not yet studied and that may be applicable for the development of active oxygen-absorbing and antioxidant active packaging for food.

关键词： Oxygen absorbers Antioxidants Food packaging Lipids Oxidation

Is there a window of opportunity for the therapeutic use of vitamin D in multiple sclerosis?

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Neural Regeneration Research 2022年第9期17卷 1945-1954页

作者： Sofia Fernanda gonçalves Zorzella-Pezavento Luiza Ayumi Nishiyama Mimura Marina Bonifácio Denadai William Danilo fernandes de Souza Thais Fernanda de Campos Fraga-Silva Alexandrina Sartori Department of Chemical and Biological Sciences Institute of BiosciencesSão Paulo State University(UNESP)BotucatuSão PauloBrazil

Multiple sclerosis is an autoimmune treatable but not curable *** are a multiplicity of medications for multiple sclerosis therapy,including a class entitled disease-modifying drugs that are mainly indicated to reduce the number and severity of disease *** all patients respond well to these therapies,and minor to severe adverse effects have been *** D,called sunshine vitamin,is being studied as a possible light at the end of the *** this review,we recapitulated the similar immunopathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis,the immunomodulatory and neuroprotective potential of vitamin D and the state-of-art concerning its supplementation to multiple sclerosis ***,based on our and other groups’experimental findings,we analyzed the need to consider the relevance of the route and the different time-point administration aspects for a more rational indication of this vitamin to multiple sclerosis patients.

关键词： central nervous system cytokines experimental autoimmune encephalomyelitis immunomodulation immunopathogenesis inflammation multiple sclerosis neuroprotection regulatory T cells vitamin D

科技型中小企业专业培训对研发人员离职倾向的影响研究——以工作嵌入为中介变量

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西华大学学报（哲学社会科学版） 2024年第2期43卷 64-87页

作者：谷昊 Alexandra fernandes 丁奕文电子科技大学经济与管理学院四川成都611731 University Institute of Lisbon Lisbon 1649-026 成都信息工程大学管理学院四川成都610103

为寻求降低科技型中小企业研发人员离职倾向的路径,文章构建“专业培训—工作嵌入—离职倾向”的研究框架,并考虑员工性别、教育程度和职位层级的调节作用,采用大规模调查问卷的实证方法,通过数据分析发现:专业培训显著降低了研发人员... 详细信息

为寻求降低科技型中小企业研发人员离职倾向的路径,文章构建“专业培训—工作嵌入—离职倾向”的研究框架,并考虑员工性别、教育程度和职位层级的调节作用,采用大规模调查问卷的实证方法,通过数据分析发现:专业培训显著降低了研发人员离职倾向,工作嵌入发挥了中介作用,不同特征的员工接受专业培训的效果不同。文章的研究成果丰富了专业培训、工作嵌入等理论内涵并拓展其应用情境,系统地剖析了专业培训针对不同特征研发人员离职倾向的作用机制,具有深刻的理论与实践价值。

关键词：专业培训离职倾向工作嵌入员工特征科技型中小企业

Effect of drug therapies on self-reported chemosensory outcomes after COVID-19

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： Marco A.Fornazieri Bruno M.Cunha Samuel P.Nicácio Lucas K.Anzolin JoséL.B.da Silva Aristides fernandes Neto Deusdedit Brandão Neto Richard L.Voegels Fábio D.R.Pinna Department of Surgery Londrina State UniversityLondrinaBrazil Department of Medicine Pontifical Catholic University of ParanáLondrinaBrazil Department of Otorhinolaryngology University of São PauloSao PauloBrazil Department of Otorhinolaryngology:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of this study was to assess the relative efficacy of medications used following severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection on self-reported alterations in taste and/or smell ***:Seven hundred and fourteen persons with self-reported postcoronavirus disease 2019(post-COVID-19)chemosensory disorders were personally interviewed regarding specific medications they were administered following the acute phase of the *** dependent measure—self-reported total recovery of chemosensory symptoms—was subjected to stepwise logistic *** predictors included demographic and clinical variables,in addition to specific medications used to mitigate disease symptoms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibuprofen,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoagulants,and zinc).Results:The median time between COVID-19 symptom onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)reported total recovery of their chemosensory function;437(61.2%)had at least one treatment since the beginning of the *** and those with more comorbidities had undergone more *** recovery rates of the treated and nontreated groups did not differ ***,respondents who had used nitazoxanide tended to have a higher rate of self-reported taste or smell *** who took oral zinc were less likely to ***:No medication employed during the first months after SARS-CoV-2 infection had a clear positive effect on returning self-reported smell or taste function to normal,although nitrazoxide trended in a positive *** zinc had a negative effect on the reported recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVID-19 drug therapy SARS-CoV-2 smell loss taste loss

Effect of Turbidity on Semi-Automatic Analysis of Copepod Size and Abundance Distribution in the Water Column

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Advances in Bioscience and Biotechnology 2024年第6期15卷 380-395页

作者： Thiago da Silva Matos Carolina Siqueira dos Reis Laura de Andrade Moura Márcio Abreu Ricardo Coutinho Lohengrin fernandes IEAPM/UFF Marine Biotechnology Post-Graduate Program Arraial do Cabo Brazil Instituto de Estudos do Mar Almirante Paulo Moreira Arraial do Cabo Brazil

Automated image systems to characterize aquatic organisms improve research and enable fast response to environmental risk situations. In November 2015, a dam in Mariana City-MG (Brazil) collapsed and led to the disposal of mud tailings from the mining process to the Doce River. The accident resulted in several casualties and incalculable damage to surrounding communities and the environment. The mud increased water turbidity, an essential condition to the functioning of the image analysis systems, and directly affected the characterization of the organisms, making it impossible to distinguish copepods in the mud, due to the blurred outline. To get a quick response evaluating environmental situations, this work aimed to develop and test different algorithms characterizing and classifying copepods by their size (length and area) using in situ images acquired by the Lightframe On-Sight Keyspecies Investigation device. Field tests were carried out under different turbidity levels throughout the gradient observed in the coastal zone adjacent to the Doce River. The best algorithm reduced nearly 50% of the noise in some images when compared with manual treatment and led to 96% accuracy in measurement and counting. Semi-automated devices that perform post-processing corrections are suitable for fast environmental evaluation under high turbidity scenarios.

关键词： Imaging Zooplankton Doce River LOKI Copepod

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan Juan Alec C.Bancroft Ji Hae Choi Chase A.Pagani Aysel A.fernandes Michael Woodard Juhoon Lee Sowmya Ramesh Aaron W.James David Hudson Kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell Rna sequencing(scRna-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRna-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant