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Self-reported participation restrictions in normal hearing individuals in thyroid ontogeny: Evidence of subclinical changes

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Journal of Otology 2019年第1期14卷 6-11页

作者： Caio Le?nidas Oliveira de Andrade Gabriela Carvalho Machado Luan Paulo Franco Magalh?es Elen Pereira de Jesus Elaine alves Matias Taíse Lima de Oliveira Cerqueira Hélida Braga de Oliveira Luciene da Cruz fernandes Helton Estrela Ramos Crésio de Arag?o Dantas alves Postgraduate Program in Interactive Processes of Organs and Systems Institute of Health Science–Federal University of Bahia Department of Life Sciences University of the State of Bahia Social Services Sister Dulce Institute of Health Science–Federal University of Bahia Department of Speech Therapy Institute of Health Science–Federal University of Bahia Department of Bioregulation Health & Sciences Institute Federal University Bahia (UFBA) Medical School Institute of Health Science–Federal University of Bahia

Purpose: To verify evidence of subclinical alterations through self-reported participation restrictions in normal hearing individuals and congenital hypothyroidism ***: An analytical, quantitative, cross-sectional exploratory study with a 1:1 ratio, consisting of a convenience sample of 86 normal hearing individuals with(n = 42) and without(n = 44) congenital hypothyroidism diagnosis. All participants underwent tonal and speech audiometry, immitance and distortion product otoacoustic emissions. The researchers excluded people with hearing loss, genetic syndromes and metabolic diseases. The instrument used for evaluate of self-reported participation restrictions was the HHIE-adapted questionnaire, composed of 25 questions, 12 of which were social domain and 13 emotional domain. Student's ttest and chi-square test were used for statistical analysis at a significance level of 5%.Results: There was a significant(p < 0.001) self-reported participation restrictions in CH(61.9%), with a greater relevance for the social domain(p = 0.002). There was a greater frequency of mild/moderate(40.5%)and higher prevalence of association with clinical factors and adherence to ***: The findings indicate that self-reported participation restrictions in normal hearing individuals with congenital hypothyroidism was more significant than in the non-exposed group, suggesting evidence of subclinical auditory abnormalities in this population.

关键词： Hearing Hearing loss Auditory perception Congenital hypothyroidism Surveys and questionnaires

Obstructive Sleep Apnea Hypopnea Syndrome and Pulmonary Embolism： Warfarin Versus Positive Airway Pressure as Determinant

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Chinese Medical Journal 2016年第2期129卷 251-252页

作者： Filipa Ramalho fernandes Dulce Apolinario Antonio M Esquinas Department of Pneumoloqv Unidade Local de Saude da Guarda EPE - Sousa Martins Hospital Guarda Portugal Department of Pneumology Centro Hospitalar de Tras-os-Montes e Alto Douro EPE - Sao Pedro de Vila Real Hospital Vila Real Portugal Intensive Care and Non Invasive Ventilatory Unit Hospital Morales Meseguer Murcia Spain

To the Editor： Xie et al, analyzed warfarin doses in pulmonary embolism （PE） and its adverse effects in patients with obstructive sleep apnea hypopnea syndrome （OSAHS）. The key findings were that OSAHS patients required a significantly higher dose of warfarin than their non-OSAHS counterparts （4.73 mg vs. 3.61 mg, P 〈 0.001） and that PE recurrence was higher in OSAHS than in non-OSAHS groups after withdrawal ofwarfarin （21.43% vs. 6.78%, P = 0.047）.

关键词： analyzed warfarin pulmonary embolism great interest

Maternal low protein diet induces persistent expression changes in metabolic genes in male rats

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World Journal of Diabetes 2020年第5期11卷 182-192页

作者： Allan de Oliveira Lira JoséLuiz de Brito alves Mariana Pinheiro fernandes Diogo Vasconcelos David Filipe Santana João Henrique da Costa-Silva Béatrice Morio Carol Góis Leandro Luciano Pirola Department of Nutrition Federal University of PernambucoVitoria de Santo AntãoPernambuco 55608680Brazil Department of Nutrition Federal University of ParaíbaJoao Pessoa 74556060Brazil Henrique da Costa-Silva Luciano PirolaDepartment of Physical Education and Sport SciencesFederal University of PernambucoVitoria de Santo AntãoPernambuco 55608680Brazil Carmen(Cardiology Metabolism and Nutrition)LaboratoryINSERM U1060Lyon-1 UniversitySouth Lyon Medical FacultyPierre Benite 69310France

BACKGROUND Perinatal exposure to a poor nutritional environment predisposes the progeny to the development of metabolic disease at the adult age,both in experimental models and *** adaptive responses to maternal protein restriction have been reported in metabolic ***,the expression of glucose/fatty acid metabolism-related genes in adipose tissue and liver needs to be *** To evaluate the metabolic impact of perinatal malnutrition,we determined malnutrition-associated gene expression alterations in liver and adipose *** In the present study,we evaluated the alterations in gene expression of glycolytic/Krebs cycle genes(Pyruvate dehydrogenase kinase 4 and citrate synthase),adipogenic and lipolytic genes and leptin in the adipose tissue of offspring rats at 30 d and 90 d of age exposed to maternal isocaloric low protein(LP)diet throughout gestation and *** also evaluated,in the livers of the same animals,the same set of genes as well as the gene expression of the transcription factors peroxisome proliferator-activated receptor gamma coactivator 1,forkhead box protein O1 and hepatocyte nuclear factor 4 and of gluconeogenic *** In the adipose tissue,we observed a transitory(i.e.,at 30 d)downregulation of pyruvate dehydrogenase kinase 4,citrate synthase and carnitine palmitoyl transferase 1b gene *** transcriptional changes did not persist in adult LP rats(90 d),but we observed a tendency towards a decreased gene expression of leptin(P=0.052).The liver featured some gene expression alterations comparable to the adipose tissue,such as pyruvate dehydrogenase kinase 4 downregulation at 30 d and displayed other tissue-specific changes,including citrate synthase and fatty acid synthase upregulation,but pyruvate kinase downregulation at 30 d in the LP group and carnitine palmitoyl transferase 1b downregulation at 90 *** gene alterations,together with previously described changes in gene expression in

关键词： Metabolic adaptation Phenotype plasticity Liver Adipose tissue Metabolism Maternal protein undernutrition Rats

Temporal Variation of the Concentration of Carbon Monoxide in the Center West of Brazil

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Atmospheric and Climate Sciences 2014年第4期4卷 563-568页

作者： Amaury de Souza Flavio Aristones Gustavo Becker Modesto Silva Widinei alves fernandes Catia Braga Federal University of Mato Grosso do Sul Institute of Physics Campo Grande MS Brazil CEMTEC—Monitoring Center of Weather Campo Grande MS Brazil

South Mato Grosso has been developing very rapidly in recent decades, and it is clearly leaving behind the status of being solely an agricultural region to become an important state in the areas of commerce and industry. Nevertheless, it is still possible to observe the harmful effects of atmospheric pollution due to biomass burning activities, even if those actions are being systematically reduced in the state throughout the past several years. This kind of pollution persists not only due to local activities but also due to the pollution of other states and even other border countries. Satellite remote sensing has proven to be an important tool of environmental control vis-à-vis the ease of data acquisition, accuracy and wide temporal range. A study has been conducted of spatial and temporal concentration of carbon monoxide (CO) in the state of South Mato Grosso from 2001 through 2012 using the MOPITT sensor onboard the TERRA satellite. The carbon monoxide comes principally from the incomplete combustion of vehicles engines and biomass burnings. A direct correlation of the CO concentration in the state of South Mato Grosso is observed precisely during the months of drought (August to October), for which the number of fire outbreaks is the highest of the year.

关键词： Carbon Monoxide MOPITT Biomass Burning

Peroxisome proliferator-activated receptors as targets to treat metabolic diseases:Focus on the adipose tissue,liver,and pancreas

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World Journal of Gastroenterology 2023年第26期29卷 4136-4155页

作者： Henrique Souza-Tavares Carolline Santos Miranda Isabela Macedo Lopes Vasques-Monteiro Cristian Sandoval Daiana Araujo Santana-Oliveira Flavia Maria Silva-Veiga Aline fernandes-da-Silva Vanessa Souza-Mello Department of Anatomy Rio de Janeiro State UniversityRio de Janeiro 20551030Brazil Escuela de Tecnología Médica Facultad de SaludUniversidad Santo TomásOsorno 5310431Chile Departamento de Ciencias Preclínicas Universidad de la FronteraTemuco 4780000Chile

The world is experiencing reflections of the intersection of two pandemics:Obesity and coronavirus disease *** prevalence of obesity has tripled since 1975 worldwide,representing substantial public health costs due to its *** adipose tissue is the initial site of obesity *** excessive energy intake,it undergoes hyperplasia and hypertrophy until overt inflammation and insulin resistance turn adipocytes into dysfunctional cells that send lipotoxic signals to other *** pancreas is one of the organs most affected by *** lipotoxicity becomes chronic,there is an increase in insulin secretion by pancreatic beta cells,a surrogate for type 2 diabetes mellitus(T2DM).These alterations threaten the survival of the pancreatic islets,which tend to become dysfunctional,reaching exhaustion in the long *** for the liver,lipotoxicity favors lipogenesis and impairs beta-oxidation,resulting in hepatic *** silent disease affects around 30%of the worldwide population and can evolve into end-stage liver *** therapy for hepatic steatosis remains to be defined,peroxisome proliferator-activated receptors(PPARs)activation copes with T2DM *** PPARs are transcription factors found at the intersection of several metabolic pathways,leading to insulin resistance relief,improved thermogenesis,and expressive hepatic steatosis mitigation by increasing mitochondrial *** review aimed to update the potential of PPAR agonists as targets to treat metabolic diseases,focusing on adipose tissue plasticity and hepatic and pancreatic remodeling.

关键词： Obesity Insulin resistance Peroxisome proliferator-activated receptors Pancreas Hepatic steatosis Adipose tissue

Ana-HEp2 pattern evaluation in pancreatic cancer:What can the autoantibodies tell us?

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Hepatobiliary & Pancreatic Diseases International 2023年第1期22卷 104-106页

作者： Amanda PB Albuquerque Amanda R fernandes Angela LBP Duarte Henrique de Ataide Mariz José GCA Júnior Luiz A Mattos Maira Galdino da Rocha Pitta Moacyr JBM Rego Laboratory of Immunomodulation and New Therapeutical Approaches Research Centre for Therapeutic Innovation Suely Galdino(NUPIT-SG)Federal University of PernambucoRecifePEBrazil Rheumatology Service Hospital das ClínicasRecifePEBrazil General Surgery Service Hospital das ClínicasRecifePEBrazil Oncology Service Hospital das ClínicasRecifePEBrazil

To the Editor:Pancreatic neoplasms are mainly diagnosed by imaging methods and confirmed by biopsies[1].Imaging techniques and the tumor markers carbohydrate antigen 19-9(CA19-9)or carcinoembryonic antigen(CEA)used fo... 详细信息

关键词： neoplasms pattern specificity

Second-line treatment of advanced hepatocellular carcinoma:Time for more individualized treatment options?

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World Journal of Hepatology 2022年第6期14卷 1074-1086页

作者： Senthil Rajappa Kun-Ming Rau Palanki Satya Dattatreya Anant Ramaswamy Philana fernandes Aarohan Pruthi Rebecca Cheng Mariusz Lukanowski Yi-Hsiang Huang Department of Medical Oncology Basavatarakam Indo-American Cancer Hospital and Research InstituteHyderabad 500034TelanganaIndia College of Medicine I-Shou UniversityKaohsiung 822Taiwan Department of Oncology Omega HospitalHyderabad 500034India Department of Oncology Tata Memorial HospitalMumbai 400012India Global Scientific Communications Eli Lilly and Company LtdCork 48006CorkIreland Medical Affairs Eli Lilly IndiaHaryana 122001India Medical Affairs Eli Lilly TaiwanTaipei 10543Taiwan Medical Affairs Eli LillyHerlev 2370Denmark Division of Gastroenterology and Hepatology Department of MedicineTaipei Veterans General HospitalInstitute of Clinical MedicineNational Yang-Ming Yang Ming Chiao Tung University School of MedicineTaipei 112Taiwan

Hepatocellular carcinoma(HCC)is the most frequently diagnosed primary tumor of the liver and is usually detected as advanced *** is an aggressive disease that often progresses rapidly when it fails to respond to *** such,patients have limited opportunities to try different subsequent-line treatment *** the last 5 years,the number of agents and/or regimens available for the treatment of advanced HCC has significantly increased,which has made treatment choices for this patient population increasingly *** the secondline setting,several phase III trials of regorafenib(RESORCE),ramucirumab(REACH/REACH-2),and cabozantinib(CELESTIAL)have demonstrated clinically meaningful survival benefits in patients with the ***,the median overall survival of patients with advanced HCC remains unchanged at approximately 12 mo from the start of systemic second-line therapy,with a limited duration of *** from the REACH/REACH-2 trials demonstrated for the first time that baseline alpha-fetoprotein(AFP)levels can be used as an identification factor to select those who are likely to benefit the most from ramucirumab *** is both well tolerated and efficacious and has a clinically acceptable safety ***,it should be considered an option for patients with AFP levels≥400 ng/mL.

关键词： Hepatocellular carcinoma Alpha-fetoprotein Prognostic factor Ramucirumab Second-line treatment Survival

Peripheral nerve regeneration with conduits:use of vein tubes

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Neural Regeneration Research 2015年第4期10卷 529-533页

作者： Rodrigo Guerra Sabongi Marcela fernandes Joao Baptista Gomes dos Santos Department of Orthopedics and Traumatology Escola Paulista de MedicinaFederal University of Sao Paulo Division of Hand Surgery Department of Orthopedics and TraumatologyEscola Paulista de MedicinaFederal University of Sao Paulo

Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the com-plexity of the neurobiological nerve regenerating process. There is a greater challenge when the transected nerve ends are not amenable to primary end-to-end tensionless neurorraphy. When facing a segmental nerve defect, great effort has been made to develop an alternative to the au-tologous nerve graft in order to circumvent morbidity at donor site, such as neuroma formation, scarring and permanent loss of function. Tubolization techniques have been developed to bridge nerve gaps and have been extensively studied in numerous experimental and clinical trials. The use of a conduit intends to act as a vehicle for moderation and modulation of the cellular and molecular ambience for nerve regeneration. Among several conduits, vein tubes were validated for clinical application with improving outcomes over the years. This article aims to address the investigation and treatment of segmental nerve injury and draw the current panorama on the use of vein tubes as an autogenous nerve conduit.

关键词： peripheral nerve injury nerve graft nerve conduit Wallerian degeneration neurotrophic factors veins autografts nerve regeneration

Tapir health and conservation medicine

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Integrative Zoology 2012年第4期7卷 331-345页

作者： Paulo Rogerio MANGINI Emilia Patrícia MEDICI Renata Carolina fernandes-SANTOS Lowland Tapir Conservation Initiative IPÊ-Institute for Ecological ResearchNazaréPaulistaSão PauloBrazil Brazilian Institute for Conservation Medicine-TRÍADE RecifePernambucoBrazil IUCN/SSC Tapir Specialist Group(TSG) GlandSwitzerland IUCN/SSC Wildlife Health Specialist Group(WHSG) New YorkNYUSA IUCN/SSC Peccary Specialist Group(PSG) GlandSwitzerland Escola Superior de Conservação Ambiental e Sustentabilidade(ESCAS/IPÊ) NazaréPaulistaSão PauloBrazil IUCN/SSC Conservation Breeding Specialist Group(CBSG) Brazil NetworkCampo GrandeBrazil

Tapirs have unique nutritional needs,as well as anatomical,physiological,behavioral and ecological adapta-tions that must be considered when managing their health,both in the wild and in *** about how tapirs live in their natural habitats can provide crucial knowledge to prevent many of the health problems found in captivity such as infectious and parasitic diseases,reproductive issues and nutritional and behavior-al ***,proper management in captivity can significantly contribute to in situ conservation *** medicine is a science created to address the global health crisis that jeopardizes biodiver-sity causing imbalances among ecosystem,human,animal and vegetal *** this context,common threats to tapir health and conservation,such as isolated and small populations surrounded by human activity,chemical pollution,domestic animals and their pathogenic agents,need to be better *** manuscript provides information about the health of tapirs both in captivity and in the wild and aims to encourage tapir conservation-ists worldwide to gather information about pathogen and disease dynamics and manifestation,as well as impli-cations for tapir conservation.

关键词： captive management conservation medicine tapirs wildlife health