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Temporally shifted hemodynamic response model helps to extract acupuncture-induced functional magnetic resonance imaging blood oxygenation-level dependent activities

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Chinese Medical Journal 2009年第7期122卷 823-829页

作者： Tsung-Jung Ho Jeng-Ren Duann Chun-Ming Chen Jeon-Hor Chen Wu-Chung Shen Tung-Wu Lu jan-ray liao Zen-Pin Lin Kuo-Ning Shaw Jaung-Geng Lin School of Chinese Medicine College of Chinese Medicine ChinaMedical University Taiwan China Institute for Neural Computation University of California SanDiego La Jolla CA USA Department of Radiology China Medical University HospitalTaichung Taiwan China Department of Electric Engineering National ISlaung-StnnUniversity Taichung Taiwan China Institute of Biomedical Engineering National Taiwan UniversityTaipei Taiwan China Department of Holistic Wellness MingDao University TaiwanChina Graduaie Institute of Acupuncture Science China MedicalUniversity Taiwan China ChangHwa Hospital Department of Health Executive YuanTaiwan China

Background The onsets of needling sensation introduced by acupuncture stimulus can vary widely from subject to subject. This should be explicitly accounted for by the model blood oxygenation-level dependent （BOLD） time course used in general linear model （GLM） analysis to obtain more consistent across-subject group results. However, in standard GLM analysis, the model BOLD time course obtained by convolving a canonical hemodynamic response function with an experimental paradigm time course is assumed identical across subjects. Although some added-on properties to the model BOLD time course, such as temporal and dispersion derivatives, may be used to account for different BOLD response onsets, they can only account for the BOLD onset deviations to the extent of less than one repetition time （TR）. Methods In this study, we explicitly manipulated the onsets of model BOLD time course by shifting it with -2, -1, or 1 TR and used these temporally shifted BOLD model to analyze the functional magnetic resonance imaging （fMRI） data obtained from three acupuncture fMRI experiments with GLM analysis. One involved acupuncture stimulus on left ST42 acupoint and the other two on left GB40 and left BL64 acupoints. Results The model BOLD time course with temporal shifts, in addition to temporal and dispersion derivatives, could result in better statistical power of the data analysis in terms of the average correlation coefficients between the used BOLD models and extracted BOLD responses from individual subject data and the T-values of the activation clusters in the grouped random effects. Conclusions The GLM analysis with ordinary BOLD model failed to catch the large variability of the onsets of the BOLD responses associated with the acupuncture needling sensation. Shifts in time with more than a TR on model BOLD time course might be required to better extract the acupuncture stimulus-induced BOLD activities from individual fMRI data.

关键词： acupuncture magnetic resonance imaging, functional blood oxygenation-level dependent responses

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Fourier Collocation and Reduced Basis Methods for Fast Modeling of Compressible Flows

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Communications in Computational Physics 2022年第8期32卷 595-637页

作者： Jian Yu Deep ray jan S.Hesthaven School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Laboratory of Aero-thermal Protection Technology for Aerospace Vehicles China Aerospace Science and Technology CorporationBeijing 100048China School of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA 90089USA Chair of ComputationalMathematics and Simulation Schience Ecole Polytechnique Federale de LausanneLausanne CH-1015Switzerland

A projection-based reduced order model(ROM)based on the Fourier collocation method is proposed for compressible *** incorporation of localized artificial viscosity model and filtering is pursued to enhance the robustness and accuracy of the ROM for shock-dominated ***,for Euler systems,ROMs built on the conservative and the skew-symmetric forms of the governing equation are *** ensure efficiency,the discrete empirical interpolation method(DEIM)is *** alternative reduction approach,exploring the sparsity of viscosity is also investigated for the viscous terms.A number of one-and two-dimensional benchmark cases are considered to test the performance of the proposed *** show that stable computations for shock-dominated cases can be achieved with ROMs built on both the conservative and the skew-symmetric forms without additional stabilization components other than the viscosity model and *** the same parameters,the skew-symmetric form shows better robustness and accuracy than its conservative counterpart,while the conservative form is superior in terms of efficiency.

关键词： Projection-based reduced order modeling Fourier collocation artificial viscosity compressible flow

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Intermittent slipping of landslide regulated by dilatancy evolution and velocity-weakening friction law: an efficient numerical scheme

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Journal of Mountain Science 2016年第8期13卷 1333-1344页

作者： jan Chyan-deng YANG ray-yeng HWUNG Hwung-hweng CHEN Wen-yau Department of Hydraulic & Ocean Engineering National Cheng Kung University International Wave Dynamics Research Center National Cheng Kung University

When a block of dense sandy soil moves downhill, the shear-induced soil dilatancy along the basal shear boundary produces a negative value of excess pore pressure that increases the basal frictional resistance. Dilatancy angle,Ψ, the degree to which the basal soil dilates due to the shear, normally evolves during slope failure. A study by other researchers shows that if Ψ is constant, the block of dense soil will remain stable(or unstable) sliding when the velocity-weakening rate of the basal friction coefficient of the block is small(or large) enough. Moreover, during unstable sliding processes, the block of dense soil exhibits "periodic" patterns of intermittent slipping. Here, we used a more efficient and accurate numerical scheme to revisit that study. We expanded their model by assuming Ψ evolves during slope failure. Consequently, we acquired completely different results. For instance, even though the velocity-weakening rate of the friction coefficient is fixed at the same smaller(or larger) value that those researchers use, the stable(or unstable) steady states of landslide they predict will inversely change to unstable(or stable) when Ψ decreases(or increases) with the increase of slide displacement to a value small(or large) enough. Particularly, in unstable processes, the soil block exhibits "aperiodic" styles of intermittent slipping, instead of "periodic". We found out that the stick states appearing later last longer(or shorter) in the case of decreasing(or increasing) Ψ. Moreover, because the basic states of landslides with impacts of dilatancy evolution are not steady nor periodic, traditional stability-analysis methods cannot be "directly" used to analyze the stability of such landslides. Here, we broke through this technical problem to a degree. We showed that combining a concept called "quasi-steady-state approximation" with a traditional stability-analysis technique can qualitatively predict the instability onset of the landslides. Through this st

关键词： Landslide Stability analysis Intermittent slipping Dilatancy angle

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Sex biased expression of hormone related genes at early stage of sex differentiation in papaya flowers

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Horticulture Research 2021年第1期8卷 2082-2094页

作者： Juan Liu Li-Yu Chen Ping Zhou Zhenyang liao Hai Lin Qingyi Yu ray Ming FAFU and UIUC Joint Center for Genomics and Biotechnology Key Laboratory of GeneticsBreeding and Multiple Utilization of CropsMinistry of EducationFujian Provincial Key Laboratory of Haixia Applied Plant Systems BiologyCollege of Life ScienceFujian Agriculture and Forestry UniversityFuzhou 350002 FujianChina Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Chinese Academy of SciencesWuhan Botanical GardenWuhan 430074China Texas A&M AgriLife Research Center at Dallas Texas A&M University SystemDallasTX 75252USA Department of Plant Pathology&Microbiology Texas A&M UniversityCollege StationTX 77843USA Department of Plant Biology School of Integrative BiologyUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Sex types of papaya are controlled by a pair of nascent sex chromosomes,but molecular genetic mechanisms of sex determination and sex differentiation in papaya are still *** performed comparative analysis of transcriptomic profiles of male and female floral buds at the early development stage before the initiation of reproductive organ primordia at which there is no morphological difference between male and female flowers.A total of 1734 differentially expressed genes(DEGs)were identified,of which 923 showed female-biased expression and 811 showed male-biased *** annotation revealed that genes related to plant hormone biosynthesis and signaling pathways,especially in abscisic acid and auxin pathways,were overrepresented in the *** factor binding motifs,such as MYB2,GAMYB,and AP2/EREBP,were enriched in the promoters of the hormone-related DEGs,and transcription factors with those motifs also exhibited differential expression between sex *** these DEGs,we also identified 11 genes in the non-recombining region of the papaya sex chromosomes and 9 genes involved in stamen and carpel *** results suggested that sex differentiation in papaya may be regulated by multiple layers of regulation and coordination and involved transcriptional,epigenetic,and phytohormone ***,especially ABA and auxin,transcription factors,and genes in the non-recombination region of the sex chromosome could be involved in this *** findings may facilitate the elucidation of signal transduction and gene interaction in sex differentiation of unisexual flowers in papaya.

关键词： expression flowers papaya

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Synthesis,Crystal Structure and Antibacterial Activity of Ammonium Bromide

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Chinese Journal of Structural Chemistry 2015年第5期34卷 667-672页

作者： HUO Li-Ni CHEN Rui liao Yan-Fang WEI jan-Hua LI Pei-Yuan HU Yue College of Pharmacy Guangxi University of Chinese Medicine Faculty of Chinese Medicine Science Guangxi University of Chinese Medicine Guangxi Research Institute of Chemical Industry

The new title compound N-（2-hydroxy ethyl） tetrahydropalmatine ammonium bromide has been synthesized starting from palmatine *** structure of the product was confirmed by 1H NMR,MS（ESI） and single-crystal X-ray *** title compound crystallizes in the triclinic system,space group P1 with a = 10.5887（11）,b = 10.8652（9）,c = 12.0914（12） ,β = 84.808（9）o,V = 1253.3（2） A^3,Z = 2,Dc = 1.355 g/cm^3,F（000） = 530,μ = 1.680 mm-1,the final R = 0.0833 and w R = 0.2371 for 5112 observed reflections（I 〉 2A（I））.X-ray analysis indicates that the two planar parts（C（2） C（3） C（4） C（5） C（6） C（7） N（1） C（20） C（21） C（21）） and（C（7） C（8） C（9） C（10） C（12） C（14） N（15） C（16） C（17）） are not coplanar,with the dihedral angles to be 67.9°.Weak interactions mainly between O（5）–H（5）···O from two water molecules and O（5）···Br are observed.

关键词： palmatine hydrochloride crystal structure antibacterial activities

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Prediction of the anti-inflammatory mechanisms of curcumin by module-based protein interaction network analysis

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Acta Pharmaceutica Sinica B 2015年第6期5卷 590-595页

作者： Yanxiong Gan Shichao Zheng jan P.A.Baak Silei Zhao Yongfeng Zheng Nini Luo Wan liao Chaomei Fu State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine ResourcesSchool of PharmacyChengdu University of Traditional Chinese Medicine School of Chinese Pharmacy Beijing University of Chinese Medicine Faculty of Sports Sciences and Medicine Technical University Munich

Curcumin, the medically active component from Curcuma Tonga (Turmeric), is widely used to treat inflammatory diseases. Protein interaction network (PIN) analysis was used to predict its mechanisms of molecular action. Targets of curcumin were obtained based on ChEMBL and STITCH databases. Protein protein interactions (PPIs) were extracted from the String database. The PIN of curcumin was constructed by Cytoscape and the function modules identified by gene ontology (GO) enrichment analysis based on molecular complex detection (MCODE). A PIN of curcumin with 482 nodes and 1688 interactions was constructed, which has scale-free, small world and modular properties. Based on analysis of these function modules, the mechanism of curcumin is proposed. Two modules were found to be intimately associated with inflammation. With function modules analysis, the anti-inflammatory effects of curcumin were related to SMAD, ERG and mediation by the TLR family. TLR9 may be a potential target of curcumin to treat inflammation. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

关键词： Curcumin Protein interaction network Module Anti-inflamatory Molecular mechanism Gene ontology enrichment analysis Molecular complex detection Cytoseape

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吕宋海峡海域黑潮对近惯性内波传播的调制作用研究

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中国海洋大学学报（自然科学版） 2025年第1期55卷 13-24页

作者：廖晓娴许行黄晓冬桑康凯中国海洋大学海洋与大气学院山东青岛266100 青岛海洋气象研究院山东青岛266034 中国海洋大学三亚海洋研究院海南三亚572025 中国海洋大学深海圈层与地球系统前沿科学中心物理海洋教育部重点实验室山东青岛266100

本文基于2010年8月—2011年4月吕宋海峡黑潮两侧潜标观测的流速数据,研究了台风引起的近惯性内波在黑潮调制下的传播特征。观测结果表明,台风“鲇鱼”经过吕宋海峡附近后,上层海洋有强烈的近惯性内波生成,最大近惯性流速达到0.4 m·s^(-... 详细信息

本文基于2010年8月—2011年4月吕宋海峡黑潮两侧潜标观测的流速数据,研究了台风引起的近惯性内波在黑潮调制下的传播特征。观测结果表明,台风“鲇鱼”经过吕宋海峡附近后,上层海洋有强烈的近惯性内波生成,最大近惯性流速达到0.4 m·s^(-1),黑潮东侧(太平洋)的最大近惯性动能比西侧(南海)的强2~3倍。这种空间差异与风能输入不一致,黑潮东侧的风功要弱于西侧。流速和剪切的功率谱分析结果显示,台风“鲇鱼”期间黑潮东侧明显的上层近惯性谱峰的频率在黑潮东侧明显低于黑潮西侧。黑潮形态变化引起的相应流场和涡度场变化能够对近惯性内波传播进行调制。射线追踪实验结果表明,黑潮的平流作用可以使近惯性内波远离源地,其流轴西侧正涡度阻碍近惯性内波传播,而其东侧负涡度可以使近惯性内波聚集。该结果所揭示的近惯性内波的传播过程和分布特征可为理解全球海洋近惯性内波的再分配问题提供思路。

关键词：吕宋海峡近惯性内波台风黑潮射线追踪

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Development of Teacher Attitudes, Behaviors, and Skills Related to Elementary Science

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Psychology Research 2015年第3期5卷 172-178页

作者： Pascale Creek Pinner jan ray Hilo Intermediate School Hilo United States University of Hawaii at Hilo Hilo United States

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Synthesis and Electrical Properties of Li-modified Bi_(0.5)Na_(0.5)TiO_3-BaTiO_3 Lead-free Piezoelectric Ceramics

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Journal of Materials Science & Technology 2009年第6期25卷 777-780页

作者： Yunweu liao Dingquan Xiao Institute of Applied Chemistry China West Normal University Nanchong 637002 China Department of Materials Science Sichuan University Chengdu 610064 China

Lead-free piezoelectric ceramics （1-y）Bi0.5（Na1-xLix）0.5TiO3-yBaTiO3 with x=0-0.125 and y=0.02-0.12 were fabricated by a solid-state reaction process, and their dielectric, piezoelectric and ferroelectric properties were investigated. The results show that the addition of Li^＋ significantly improves the sintering performance and piezoelectric properties of the ceramics. X-ray diffraction （XRD） patterns indicate that the ceramics possess pure perovskite structure. At room temperature, the ceramics provide high piezoelectric charge constant d33 （up to 210 pC/N）, high planar electromechanical coupling factor kp （34.5%）, large remanent polarization Pr （up to 40 μC/cm^2）, and low coercive field Ec （3.0 kV/mm）, which indicates that （1-y）Bi0.5（Na1-xLix）0.5TiO3-yBaTi03 is a good lead-free piezoelectric ceramic.

关键词： Lead-free piezoelectric ceramic Bi0.5Na0.5TiO3 Microstructure Piezoelectricity

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Optimization of ferroelectricity and endurance of hafnium zirconium oxide thin films by controlling element inhomogeneity

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Journal of Advanced Ceramics 2024年第7期13卷 1023-1031页

作者： Fei Yan Ke Cao Yang Chen Jiajia liao Min liao Yichun Zhou Shaanxi Key Laboratory of High-Orbits-Electron Materials and Protection Technology for Aerospace School of Advanced Materials and NanotechnologyXidian UniversityXi’an 710126China Xi’an Key Laboratory of Reconfigurable Chip and Materials School of Advanced Materials and NanotechnologyXidian UniversityXi’an 710126China Frontier Research Center of Thin Films and Coatings for Device Applications Academy of Advanced Interdisciplinary ResearchXidian UniversityXi’an 710126China

Ferroelectric thin films based on HfO_(2) have garnered increasing attention worldwide,primarily due to their remarkable compatibility with silicon and scalability,in contrast to traditional perovskite-structured ferroelectric ***,significant challenges remain in their widespread commercial utilization,particularly concerning their notable wake-up effect and limited *** address these challenges,we propose a novel strategy involving the inhomogeneous distribution of Hf/Zr elements within thin films and explore its effects on the ferroelectricity and endurance of Hf_(0.5)Zr_(0.5)O_(2) thin *** techniques such as grazing incidence X-ray diffraction,transmission electron microscopy,and piezoresponse force microscopy,we investigated the structural characteristics and domain switching behaviors of these *** experimental results indicate that the inhomogeneous distribution of Hf/Zr contributes to improving the frequency stability and endurance while maintaining a large remnant polarization in Hf_(0.5)Zr_(0.5)O_(2) ferroelectric thin *** adjusting the distribution of Zr/Hf within the Hf_(0.5)Zr_(0.5)O_(2) thin films,significant enhancements in the remnant polarization(2P_(r)>35μC/cm2)and endurance(>109)along with a reduced coercive voltage can be ***,the fabricated ferroelectric thin films also exhibit high dielectric tunability(≥26%)under a low operating voltage of 2.5 V,whether in the wake-up state or *** study offers a promising approach to optimize both the ferroelectricity and endurance of HfO_(2)-based thin films.

关键词： ferroelectric capacitors thin films ferroelectricity hafnium zirconium oxide

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