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Knowledge about Acute Myocardial Infarction (AMI) and attitudes to medical care seeking—A comparison between patients and the general public

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Open Journal of Nursing 2012年第4期2卷 372-378页

作者： Catrin Henriksson Margareta Larsson Judy Arnetz Johan Herlitz jan-erik karlsson Leif Svensson Marie Thuresson Crister Zedigh Lisa Wernroth Bertil Lindahl Department of Cardiology Falu Hospital Falun Sweden Department of Cardiology Orebro University Hospital Orebro Sweden Department of Cardiology Ryhov Hospital Jonkoping Sweden Department of Clinical Science and Education Karolinska Institute Stockholm Sweden Department of Family Medicine and Public Health Sciences Wayne State University Detroit USA Department of Medical Sciences and Uppsala Clinical Research Center Uppsala University Uppsala Sweden Department of Women’s and Children’s health Uppsala University Uppsala Sweden Institution of Medicine Sahlgrenska University Hospital Gothenburg Sweden

Background: Patients with acute myocardial infarction often have long decision times before seeking medical care. The decision time is influenced by knowledge of AMI-symptoms, psychological factors and the response of people near the patient to the symptoms. Aim: To investigate and compare the knowledge of AMI, intended actions in response to AMI-symptoms and attitudes toward seeking medical care of patients and the general public. Method: This was a multicentre study with descriptive and comparative design, using questionnaires as an instrument. The population consisted of AMI-patients and representatives of the general public. Results: There was good knowledge about typical AMI-symptoms among the participants. The majority thought an AMI always starts suddenly. Patients did not know more about the time-dependency of treatment outcome than the general public. A greater proportion of the general public would contact an additional person before consulting medical professionals. Conclusions: Patients had no better knowledge about AMI than the general public, but would more commonly act appropriately in case of AMI-symptoms.

关键词： Acute Myocardial Infarction Decision Making Patient General Public Knowledge and Attitudes

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An explainable AI model for power plant NOx emission control

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Energy and AI 2024年第1期15卷 171-180页

作者： Yuanye Zhou Ioanna Aslanidou Mikael karlsson Konstantinos Kyprianidis School of Business Society and EngineeringMälardalens UniversityUniversitetsplan 172220VästeråsSweden Future Energy Centre Mälardalens UniversityUniversitetsplan 172220VästeråsSweden School of Innovation Design and EngineeringMälardalens UniversityUniversitetsplan 172220VästeråsSweden

In recent years,developing Artificial Intelligence(AI)models for complex system has become a popular research *** have been several successful AI models for predicting the Selective Non-Catalytic Reduction(SNCR)system in power plants and large ***,all these models are in essence black box models and lack of explainability,which are not able to give new *** this study,a novel explainable AI(XAI)model that combines the polynomial kernel method with Sparse Identification of Nonlinear Dynamics(SINDy)model is proposed to find the governing equation of SNCR system based on 5-year operation data from a power *** proposed model identifies the system’s governing equation in a simple polynomial format with polynomial order of 1 and only 1 independent variable among original 68 input *** addition,the explainable AI model achieves a considerable accuracy with less than 21%deviation from base-line models of partial least squares model and artificial neural network model.

关键词： Explainable AI SINDy Kernel SNCR Power plant Boiler

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Cancer-associated fibroblasts express CD1d and activate invariant natural killer T cells under cellular stress

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Cellular & Molecular Immunology 2024年第1期21卷 91-94页

作者： Shengduo Pei Jonas Sjölund Yueyun Pan Kristian Pietras Mikael C.I.karlsson Department of Microbiology Tumor and Cell BiologyKarolinska InstitutetStockholmSweden Division of Translational Cancer Research Department of Laboratory MedicineLund University Cancer CentreLund UniversityLundSweden

Invariant natural killer T(iNKT)cells are part of the family of unconventional T cells,and they recognize glycolipid antigens presented on the MHC class I like molecule CD1^([1]).In humans there are five CD1 molecules named CD1a to CD1e,whereas mice use only CD1d for lipid ***,iNKT cells can elicit both cytotoxicity similarly to conventional CD8 T cells and secrete cytokines that influence the adaptive immune response including providing direct T cell help to B cells^([2]).In the context of tumors,they can use both release of granzyme B and use Fas-mediated mechanisms for killing of tumor *** iNKT cells use a restricted TCR repertoire and CD1 molecules are non-heterogenous the risk of graft vs host disease is limited and thus these T cells have been an attractive option for off the shelf immunotherapy to treat cancer^([3]).

关键词： killer CD1d Cancer

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“4R-4M”试验方法论在国家重大科技基础设施实验装置设计和建设中的应用与思考

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科学通报 2024年第20期69卷 2838-2843页

作者：孙冬柏杨纯臻孟凡强周舟倪木一崔艺涛 Ulf karlsson 中山大学材料科学与工程学院广州510006 中山大学材料学院深圳518107 中山大学中法核工程技术学院珠海519082 中山大学物理学院广州510275 深圳综合粒子设施研究院深圳518107

当今世界科技强国之间的竞争,比拼的是国家战略科技力量.党的十八大以来,以习近平同志为核心的党中央坚持把科技创新摆在国家发展全局的核心位置,以前所未有的力度加强国家战略科技力量建设.国家重大科技基础设施是为促进科技创新、技... 详细信息

当今世界科技强国之间的竞争,比拼的是国家战略科技力量.党的十八大以来,以习近平同志为核心的党中央坚持把科技创新摆在国家发展全局的核心位置,以前所未有的力度加强国家战略科技力量建设.国家重大科技基础设施是为促进科技创新、技术变革提供极限研究手段的大型、复杂的科学研究系统,是提高我国高新技术研发和关键核心技术突破的重要平台[1].目前,我国在建和运行的重大科技基础设施项目总量达77个.完善和利用这些重大科技基础设施解决重点领域和战略产品“卡脖子”问题,对进一步推动解决关键核心技术、引领相关产业发展具有重要研究意义.

关键词：重大科技基础设施关键核心技术党的十八大以来实验装置设计应用与思考世界科技强国高新技术研发方法论

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Direct generation of linearly polarized photon emission with designated orientations from site-controlled InGaN quantum dots

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Light(Science & Applications) 2014年第1期3卷 323-329页

作者： Anders Lundskog Chih-Wei Hsu K Fredrik karlsson Supaluck Amloy Daniel Nilsson Urban Forsberg Per Olof Holtz erik janzen Department of Physics Chemistry and Biology(IFM) Linkoping UniversitySE-58183 LinkopingSweden Department of Physics Faculty of ScienceThaksin UniversityPhattalung 93110Thailand

Semiconductor quantum dots(QDs)have been demonstrated viable for efficient light emission applications,in particular for the emission of single photons on ***,the preparation of QDs emitting photons with predefined and deterministic polarization vectors has proven *** to linearly polarized photons is essential for various *** this report,a novel concept to directly generate linearly-polarized photons is *** concept is based on InGaN QDs grown on top of elongated GaN hexagonal pyramids,by which the predefined elongation determines the polarization vectors of the emitted photons from the *** growth scheme should allow fabrication of ultracompact arrays of photon emitters,with a controlled polarization direction for each individual emitter.

关键词： GaN InGaN photoluminescence polarized emission quantum dot

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A novel feature extraction methodology using Siamese convolutional neural networks for intrusion detection

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Cybersecurity 2018年第1期1卷 847-859页

作者： Serafeim Moustakidis Patrik karlsson AIDEAS OU Narva mnt 5TallinnHarju maakondEstonia

Intrusion detection systems(IDS)can play a significant role in detecting security threats or malicious attacks that aim to steal information and/or corrupt network *** deal with the dynamic and complex nature of cyber-attacks,advanced intelligent tools have been applied resulting into powerful and automated IDS that rely on the latest advances of machine learning(ML)and deep learning(DL).Most of the reported effort has been devoted on building complex ML/DL architectures adopting a brute force approach towards the maximization of their detection ***,just a limited number of studies have focused on the identification or extraction of user-friendly risk indicators that could be easily used by security *** papers have explored various dimensionality reduction algorithms,however a large number of selected features is still required to detect the attacks successfully,which humans cannot intuitively or immediately *** enhance user’s trust and understanding on data without sacrificing on accuracy,this paper contributes to the transformation of the available data collected by IDS into a single actionable and easy-to-understand risk *** achieve this,a novel feature extraction pipeline was implemented consisting of the following components:(i)a fuzzy allocation scheme that transforms raw data to fuzzy class memberships,(ii)a novel modality transformation mechanism for converting feature vectors to images(Vec2im)and(iii)a dimensionality reduction module that makes use of Siamese convolutional neural networks that finally reduces the input data dimensionality into a 1-d feature *** performance of the proposed methodology was validated with respect to detection accuracy,dimensionality reduction performance and execution time on the NSL-KDD dataset via a thorough comparative analysis that demonstrated its effectiveness(86.64%testing accuracy using only one feature)over a number of well-known feature selection(FS)and extracti

关键词： Feature extraction Siamese convolutional neural networks Machine learning Intrusion detection

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Surrogate potency assays:Comparison of binding profiles complements dose response curves for unambiguous assessment of relative potencies

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Journal of Pharmaceutical Analysis 2018年第2期8卷 138-146页

作者： Robert karlsson Veronica Fridh Asa Frostell Purification and Analysis GE Healthcare Life SciencesUppsalaSweden

Surface plasmon resonance(SPR) systems are widely used for detailed characterization of antibody activities including antigen and Fc-receptor binding. During the later stages of development, where the focus is to ensure that established critical quality attributes(CQAs) are maintained during cell culture,purification and formulation processes, analysis is simplified, and relative potencies are often determined. Here, simulation of binding data revealed that relative potency values, determined via parallel line analysis(PLA) and half maximal effective concentration(EC50) analysis accurately reflect changes in active concentration only if binding kinetics remain unchanged. Changes in the association rate constant shifted dose response curves, and therefore relative potencies, in the same way as changes in analyte concentration do. However, for interactions characterized by stable binding, changes in the dissociation rate constant did not result in any shift, suggesting that this type of change may go unnoticed in the dose response curve. Thus, EC50 and PLA analyses of dose response curves obtained with an anti-TNF-α antibody were complemented with the Biacore functionality for sensorgram comparison analysis, whereby changes in antigen and Fc-receptor binding profiles could be detected. Next, analysis of temperature stressed TNF-α antibody revealed that calibration free concentration analysis(CFCA) data correlated perfectly with relative potency values. Together, these results demonstrate that combinations of SPR based dose response curves, sensorgram comparison and CFCA can be used to strengthen the confidence in relative potency assessments, and suggest that SPR can potentially be used as a surrogate potency assay in the quality control of biotherapeutic medicines.

关键词： Surface plasmon resonance EC50 Sensorgram comparison Calibration free concentration analysis Surrogate potency assay TNF-a

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Low Porosity in Cast Magnesium Welds by Advanced Laser Twin-Spot Welding

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Materials Sciences and Applications 2019年第1期10卷 53-64页

作者： Karl Fahlstrom Jon Blackburn Leif karlsson Lars-erik Svensson Swerea KIMAB KistaSweden University West TrollhattanSweden TWI Ltd. CambridgeUK

Porosity is reported to be a major issue when welding cast magnesium. Therefore, it is important to understand the pore formation mechanisms and find procedures that could be used to reduce porosity. This study investigated the possibility of using twin-spot optics for reducing the porosity in laser welded cast magnesium. Two twin-spot welding setups were compared using either a beam splitter or twin-spot welding with primary and secondary (placed in front of the primary optic) optics. The results showed that welding with a dual optic setup with a defocused secondary beam reduced the volumetric porosity in the weld to 5%. The highest levels of volumetric porosity were 30%, and were a result of using the dual optic setup, but with a defocused primary beam. No clear relation between the level of porosity and power or welding speed was found. It was found that the amount of porosity depended on the balance of the energy input (controlled by defocusing) between the two beams. Porosity formation can be reduced if the energy from the first beam results in the nucleation and initial growth of pores. Reheating by the second beam then allows the pores to grow and escape from the molten material without melting additional base material. Furthermore, twin-spot welding is shown to be a promising combination of a production friendly solution and high quality welding.

关键词： Laser Welding Cast Magnesium Twin-Spot Metallurgy Porosity Automotive AM50 Alloy

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Experimental evaluation of autonomous map-based Spot navigation in confined environments

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Biomimetic Intelligence & Robotics 2022年第1期2卷 50-58页

作者： Anton Koval Samuel karlsson George Nikolakopoulos Robotics&AI Team Deparment of ComputerElectrical and Space Engineering.Luled University of TechunologyLuled SE-97187Sweden

In this article,we address the task of experimental evaluation of autonomous map-based navigation of a Boston Dynamics Spot quadruped robot in confined environments equipped with the developed autonomy package that incorporates a 3D lidar,an IMU,and an onboard *** that,we propose an integrated software and hardware system that is considered as an enabler for robot localization and risk-aware path planning,based on the known *** system design itself is modular and incorporates the perception capabilities required for autonomous *** Spot robot first is utilized to build the offline map of the environment by utilizing the Google Cartographer simultaneous localization and mapping(SLAM)*** the next step,the online environmental information from the autonomy package sensors and the offline map are provided to the onboard computer to localize the robot on the known map by utilizing means provided by ***,the occupancy information is provided to the online grid-based path planner that generates risk-aware *** extensive experimental evaluation of the proposed system is performed in corridors and SubT environments.

关键词： Spot SubT Map-based navigation 3D lidar Autonomy package

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New Horizons in Sexual Selection Research

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Current Zoology 2013年第4期59卷 553-557页

作者： Kenyon B. MOBLEY Kristina karlsson GREEN Guest Editors Max Planck Institute for Evolutionary Biology Department of Evolutionary Ecology August-Thienemarm-StraBe 2 24306 P16n Germany Metapopulation Research Group Department of Biosciences PO Box 65 (Viikinkaari 1) FI-00014 University of Helsinki Finland Kristina

1 Introduction One of the most important decisions that a sexually reproducing organism must make in its lifetime is with whom shall it mate？ From an evolutionary perspective, the importance of this decision is paramount： make the right choice and your offspring will continue your genetic legacy; make the wrong choice and your lineage will be at a disadvantage or worse,

关键词：视野有性繁殖生物体

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