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Littoral landforms of Lake Hulun and Lake Buir(China and Mongolia):Wind-driven hydro-sedimentary dynamics and resulting clastics distribution

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Journal of Palaeogeography 2024年第2期13卷 309-326页

作者： Li Wang Mathieu Schuster Shi-Wei Xin Florin Zainescu Xin-Yu Xue Joep Storms jan-hendrik May Alexis Nutz Helena van der Vegt Guilherme Bozetti Zai-Xing Jiang School of Energy Resources China University of Geosciences(Beijing)Beijing100083China Universite de Strasbourg CNRSENGEESInstitut Terre et Environnement de StrasbourgUMR 70635 Rue DescartesStrasbourgFrance Tamsag Mongolia(XIX)Ltd. PetroChinaDaqing 163000China CEREGE Aix-Marseille UniversitéCNESIRDCollege de FranceINRAAix en ProvenceFrance School of Marine Science Sun Yat-sen UniversityZhuhai 519083China Delft University of Technology Department of Geoscience and EngineeringDelfthe Netherlands School of Geography Earth and Atmospheric SciencesUniversity of Melbourne253 Elgin St.CarltonVIC 3053Australia Deltares Delfthe Netherlands SCMF Faculty of GeographyUniversity of Bucharest1 N.Balcescu Blv.BucharestRomania

Two rectangular-shaped lakes,Lake Hulun and Lake Buir,located at the boundary between China and Mongolia,only c.75 km apart and therefore experiencing similar wind fields,have been studied based on satellite images and field surveys in order to compare their geomorphological and sedimentological *** wind-driven hydrodynamics,which have a significant effect on the development of littoral landforms and on sediment distribution,have been discussed for the two similar lakes that experienced a prevailing wind perpendicular to their long axis.A conceptual model related to wind-driven water bodies and sediment distribution is ***-influenced to wave-dominated deltas,beaches,spits,and eolian dune deposits develop around these two lakes,with a strikingly similar distribution *** features locally inform the longshore drift and help reconstruct the water circulation induced by wind *** the NW prevailing wind regime,the spits developed on the SW coast with a NW—SE extension,which was influenced by the NW—SE longshore *** same influence was observed in the delta extension in the NE *** differences lie in the presence of fan deltas in the NW region of Lake Hulun,but not in Lake ***,the width of the beach and eolian deposits on the downwind coast of Lake Hulun is three times greater than that of Lake Buir which were caused by the differences in sediment supply and wind fetch between the two *** Hulun and Lake Buir provide two reliable examples to understand the relationship among the wind field,provenance,hydrodynamics,landforms,and asymmetrical distribution of clastics in elongated *** also represent relevant modern analogs,which may also be of guiding significance to wind-driven sand body prediction in lacustrine basins.

关键词： Wind-driven lakes Fetch Sedimentary facies Hydrodynamics Geomorphology Spits Shoreline Lake Hulun Lake Buir

Establishing a standard method for analysing case detection delay in leprosy using a Bayesian modelling approach

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Infectious Diseases of Poverty 2023年第1期12卷 71-81页

作者： Thomas Hambridge Luc E.Coffeng Sake J.de Vlas jan hendrik Richardus Department of Public Health Erasmus MCUniversity Medical Center RotterdamRotterdamThe Netherlands

Background Leprosy is an infectious disease caused by Mycobacterium leprae and remains a source of preventable disability if left *** detection delay is an important epidemiological indicator for progress in interrupting transmission and preventing disability in a ***,no standard method exists to effectively analyse and interpret this type of *** this study,we aim to evaluate the characteristics of leprosy case detection delay data and select an appropriate model for the variability of detection delays based on the best fitting distribution *** Two sets of leprosy case detection delay data were evaluated:a cohort of 181 patients from the post exposure prophylaxis for leprosy(PEP4LEP)study in high endemic districts of Ethiopia,Mozambique,and Tanzania;and self-reported delays from 87 individuals in 8 low endemic countries collected as part of a systematic literature *** models were fit to each dataset to assess which probability distribution(log-normal,gamma or Weibull)best describes variation in observed case detection delays using leave-one-out cross-validation,and to estimate the effects of individual *** For both datasets,detection delays were best described with a log-normal distribution combined with covariates age,sex and leprosy subtype[expected log predictive density(ELPD)for the joint model:-1123.9].Patients with multibacillary(MB)leprosy experienced longer delays compared to paucibacillary(PB)leprosy,with a relative difference of 1.57[95%Bayesian credible interval(BCI):1.14-2.15].Those in the PEP4LEP cohort had 1.51(95%BCI:1.08-2.13)times longer case detection delay compared to the self-reported patient delays in the systematic *** The log-normal model presented here could be used to compare leprosy case detection delay datasets,including PEP4LEP where the primary outcome measure is reduction in case detection *** recommend the application of this modelling approach to test d

关键词： Leprosy Case detection delay Neglected tropical diseases Epidemiological methods Bayesian approach Statistical model

Approximating multi-purpose AC Optimal Power Flow with reinforcement trained Artificial Neural Network

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能源与人工智能(英文) 2022年第1期7卷 131-141页

作者： Zhenqi Wang jan-hendrik Menke Florian Schäfer Martin Braun Alexander Scheidler Department of Energy Management and Power System Operation University of KasselWilhelmshöher Allee 7334121 KasselGermany Fraunhofer Institute for Energy Economics and Energy System Technology Königstor 5934119 KasselGermany

Solving AC-Optimal Power Flow(OPF)problems is an essential task for grid operators to keep the power system safe for the use cases such as minimization of total generation cost or minimization of infeed curtailment from renewable DERs(Distributed Energy Resource).Mathematical solvers are often able to solve the AC-OPF problem but need significant computation *** neural networks(ANN)have a good application in function approximation with outstanding computational *** this paper,we employ ANN to approximate the solution of AC-OPF for multiple *** novelty of our work is a new training method based on the reinforcement learning concept.A high-performance batched power flow solver is used as the physical environment for training,which evaluates an augmented loss function and the numerical action *** augmented loss function consists of the objective term for each use case and the penalty term for constraints *** training method enables training without a reference OPF and the integration of discrete decision variable such as discrete transformer tap changer position in the constrained *** improve the optimality of the approximation,we further combine the reinforcement training approach with supervised training labeled by reference *** benchmark results show the high approximation quality of our proposed approach while achieving high computational efficiency on multiple use cases.

关键词： OPF Artificial neural network Reinforcement learning Grid planning and operation Grid congestion management

Combination of cold drawing and cryogenic turning for modifying surface morphology of metastable austenitic AISI 347 steel

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Journal of Iron and Steel Research(International) 2019年第11期26卷 1188-1198页

作者： hendrik Hotz Benjamin Kirsch Steven Becker Ralf Miiller jan CAurich Institute for Manufacturing Technology and Production Systems University of Kaiserslautern67663 KaiserslauternGermany Institute of Applied Mechanics University of Kaiserslautern67663 KaiserslauternGermany

The application of components often depends to a large extent on the properties of the surface layer.A novel process chain for the production of components with a hardened surface layer from metastable austenitic steel was *** investigated metastable austenitic AISI 347 steel was cold-drawn in solution annealed condition at cryogenic temperatures for pre-hardening,followed by post-hardening via cryogenic *** increase in hardness in both processes was due to strain hardening and deformation-induced phase transformation from y-austenite to^-*** turning experiments were carried out with solution annealed AISI 347 steel as well as with solution annealed and subsequently cold-drawn AISI 347 *** thermomechanical load of the workpiece surface layer during the turning process as well as the resulting surface morphology was *** forces and temperatures were higher in turning the cold-drawn AISI 347 steel than turning the solution annealed AISI 347 *** cryogenic turning of the solution annealed material,deformation-induced phase transformation and a significant increase in hardness were detected in the near-surface *** contrast,no additional phase transformation was observed after cryogenic turning of the cold-drawn AISI 347 *** maximum hardness in the surface layer was similar,whereas the hardness in the core of the cold-drawn AISI 347 steel was higher compared to that in the solution annealed AISI 347 steel.

关键词： Surface layer hardening Cryogenic turning Cold drawing Metastable austenitic steel Deformation-induced phase transformation

Timings of early crustal activity in southern highlands of Mars:Periods of crustal stretching and shortening

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Geoscience Frontiers 2019年第3期10卷 1029-1037页

作者： Trishit Ruj Goro Komatsu jan hendrik Pasckert James M.Dohm International Research School of Planetary Sciences Università d'Annunzio Department of Earth and Planetary Science School of Science University of Tokyo Institut für Planetologie Westf?lische Wilhelms-Universit?t Foundation for Advancement of International Science

Extensional and compressional structures are globally abundant on Mars. Distribution of these structures and their ages constrain the crustal stress state and tectonic evolution of the planet. Here in this paper, we report on our investigation over the distribution of the tectonic structures and timings of the associated stress fields from the Noachis-Sabaea region. Thereafter, we hypothesize possible origins in relation to the internal/external processes through detailed morphostructural mapping. In doing so, we have extracted the absolute model ages of these linear tectonic structures using crater size-frequency distribution measurements, buffered crater counting in particular. The estimated ages indicate that the tectonic structures are younger than the mega impacts events(especially Hellas) and instead they reveal two dominant phases of interior dynamics prevailing on the southern highlands, firstly the extensional phase terminating around3.8 Ga forming grabens and then compressional phase around 3.5-3.6 Ga producing wrinkle ridges and lobate scarps. These derived absolute model ages of the grabens exhibit the age ca. 100 Ma younger than the previously documented end of the global extensional phase. The following compressional activity corresponds to the peak of global contraction period in Early Hesperian. Therefore, we conclude that the planet wide heat loss mechanism, involving crustal stretching coupled with gravitationally driven relaxation(i.e.,lithospheric mobility) resulted in the extensional structures around Late Noachian(around 3.8 Ga). Lately cooling related global contraction generated compressional stress ensuing shortening of the upper crust of the southern highlands at the Early Hesperian period(around 3.5-3.6 Ga).

关键词： Martian dynamics Southern highlands Extensional tectonics Compressional tectonics Age of structures Buffer crater counting

Scalable and controlled self-assembly of aluminum-based random plasmonic metasurfaces

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Light(Science & Applications) 2017年第1期6卷 692-699页

作者： Radwanul Hasan Siddique jan Mertens hendrik Hölscher Silvia Vignolini Institute for Microstructure Technology Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 1Eggenstein-LeopoldshafenKarlsruhe 76344Germany Department of Chemistry University of CambridgeLensfield RoadCambridge CB21EWUK Department of Physics NanoPhotonics GroupKapitza BuildingCavendish LaboratoryUniversity of CambridgeCambridge CB30HEUK

Subwavelength metal-dielectric plasmonic metasurfaces enable light management beyond the diffraction ***,a costeffective and reliable fabrication method for such structures remains a major challenge hindering their full ***,we propose a simple yet powerful manufacturing route for plasmonic metasurfaces based on a bottom-up *** fabricated metasurfaces consist of a dense distribution of randomly oriented nanoscale scatterers composed of aluminum(Al)nanohole-disk pairs,which exhibit angle-independent scattering that is tunable across the entire visible *** macroscopic response of the metasurfaces is controlled via the properties of an isolated Al nanohole-disk pair at the *** addition,the optical field confinement at the scatterers and their random distribution of sizes result in a strongly enhanced Raman signal that enables broadly tunable excitation using a single *** unique combination of a reliable and lithography-free methodology with the use of aluminum permits the exploitation of the full potential of random plasmonic metasurfaces for diagnostics and coloration.

关键词： aluminum plasmonics plasmonic metasurfaces polymer blends self-assembly SERS structural color

Topology impacts TRAIL therapy: Differences in primary cancer growth and liver metastasis between orthotopic and subcutaneous xenotransplants of pancreatic ductal adenocarcinoma cells

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Hepatobiliary & Pancreatic Diseases International 2021年第3期20卷 279-284页

作者： Bastian Kettler Anna Trauzold Christian Röder jan-hendrik Egberts Holger Kalthoff Clinic for General- Abdominal-and Transplant-SurgeryMedical School HannoverCarl-Neuberg-Str.130625 HannoverGermany Institute for Experimental Cancer Research University of Kiel and University Clinic of Schleswig-HolsteinCampus KielHs.U30Arnold-Heller-Str.324105 KielGermany Clinic for General VisceralThoracicTransplantation-and Pediatric SurgeryUniversity Clinic of Schleswig-HolsteinCampus KielHs.CArnold-Heller-Str.324105 KielGermany

Background: To study novel treatment modalities for pancreatic ductal adenocarcinoma(PDAC), we need to transfer the knowledge from in vitro to in vivo. It is important to mirror the clinical characteristics of the typically local invasive growth of pancreatic cancer and the distant spread resulting in liver metastasis. Notably, for xenotransplant studies using human specimen, two models, i.e. subcutaneous(s.c.) and orthotopic(o.t.) transplantation are widely used. Methods: The subcutaneously and orthotopically inoculated Colo357 Bcl-x L cell-derived tumors were directly compared with and without TNF-related apoptosis inducing ligand(TRAIL) treatment. The size of primary tumors, number of liver metastasis and the histologic markers Ki67, M30, TNF-α and CD31 were assessed. Results: Upon TRAIL treatment, the primary tumors did not change their size, neither in the s.c. nor in the o.t. approaches. But when s.c. was compared to o.t., the size of the s.c. tumors was more than twofold bigger than that of the o.t. tumors( P<0.01). However, mice with orthotopically inoculated PDAC cells developed liver metastasis upon TRAIL treatment much more frequently( n=13/17) than mice with subcutaneously inoculated PDAC cells( n=1/11)( P<0.01). As a likely driving force for this increased metastasis, a higher TNF-α staining intensity in the o.t. tumors was observed by immunohistochemistry. Conclusions: These data from a direct side-by-side comparison underline the importance of the proper inoculation site of the PDAC cells. Local invasion and liver metastases are a hallmark of PDAC in the clinic;the o.t. model is clearly superior in reflecting this setting. Moreover, a serious side-effect of a possible new therapeutic compound became obvious only in the o.t. model.

关键词： Pancreatic cancer Animal models Immunohistochemistry Subcutaneous metastasis

Catastrophic total costs in tuberculosisaffected households and their determinants since Indonesia’s implementation of universal health coverage

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Infectious Diseases of Poverty 2018年第1期7卷 30-43页

作者： Ahmad Fuady Tanja A.J.Houweling Muchtaruddin Mansyur jan hendrik Richardus Department of Public Health Erasmus MCUniversity Medical Center RotterdamP.O.Box 20403000CA RotterdamThe Netherlands Department of Community Medicine Faculty of MedicineUniversitas IndonesiaJakartaIndonesia

Background:As well as imposing an economic burden on affected households,the high costs related to tuberculosis(TB)can create access and adherence *** highlights the particular urgency of achieving one of the End TB Strategy’s targets:that no TB-affected households have to face catastrophic costs by *** Indonesia,as elsewhere,there is also an emerging need to provide social protection by implementing universal health coverage(UHC).We therefore assessed the incidence of catastrophic total costs due to TB,and their determinants since the implementation of ***:We interviewed adult TB and multidrug-resistant TB(MDR-TB)patients in urban,suburban and rural areas of Indonesia who had been treated for at least one month or had finished treatment no more than one month *** the WHO recommendation,we assessed the incidence of catastrophic total costs due to *** also analyzed the sensitivity of incidence relative to several thresholds,and measured differences between poor and non-poor households in the incidence of catastrophic *** linear mixed-model analysis was used to identify determinants of the catastrophic total ***:We analyzed 282 TB and 64 MDR-TB *** TB-related services,the median(interquartile range)of total costs incurred by households was 133 USD(55-576);for MDR-TB-related services,it was 2804 USD(1008-4325).The incidence of catastrophic total costs in all TB-affected households was 36%(43%in poor households and 25%in non-poor households).For MDR-TB-affected households,the incidence was 83%(83%and 83%).In TB-affected households,the determinants of catastrophic total costs were poor households(adjusted odds ratio[aOR]=3.7,95%confidence interval[CI]:1.7-7.8);being a breadwinner(aOR=2.9,95%CI:1.3-6.6);job loss(aOR=21.2;95%CI:8.3-53.9);and previous TB treatment(aOR=2.9;95%CI:1.4-6.1).In MDR-TB-affected households,having an income-earning job before diagnosis was the only determinant of catastrophic to

关键词： Tuberculosis Catastrophic total cost Determinant Indonesia

Spatial heterogeneity of flesh-cell osmotic potential in sweet cherry affects partitioning of absorbed water

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Horticulture Research 2020年第1期7卷 2104-2113页

作者： Eckhard Grimm Daniel Pflugfelder jan Hahn Moritz Jonathan Schmidt hendrik Dieckmann Moritz Knoche Institut für Gartenbauliche Produktionssysteme Leibniz Universität HannoverAbteilung ObstbauHerrenhäuser Straße 2D-30419 HannoverGermany Forschungszentrum Jülich IBG-2:PflanzenwissenschaftenWilhelm-Johnen-StraßeD-52428 JülichGermany Laser Zentrum Hannover e.V. Hollerithallee 8D-30419 HannoverGermany

A fleshy fruit is commonly assumed to resemble a thin-walled pressure vessel containing a homogenous carbohydrate *** sweet cherry(Prunus avium L.)as a model system,we investigate how local differences in cell water potential affect H2O and D2O(heavy water)*** partitioning of H2O and D2O was mapped nondestructively using magnetic resonance imaging(MRI).The change in size of mesocarp cells due to water movement was monitored by optical coherence tomography(OCT,non-destructive).Osmotic potential was mapped using microosmometry(destructive).Virtual sections through the fruit revealed that the H2O distribution followed a net pattern in the outer mesocarp and a radial pattern in the inner *** patterns align with the disposition of the vascular bundles.D2O uptake through the skin paralleled the acropetal gradient in cell osmotic potential gradient(from less negative to more negative).Cells in the vicinity of a vascular bundle were of more negative osmotic potential than cells more distant from a vascular *** revealed net H2O uptake was the result of some cells loosing volume and other cells increasing volume.H2O and D2O partitioning following uptake is non-uniform and related to the spatial heterogeneity in the osmotic potential of mesocarp cells.

关键词： potential Spatial bundle