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Evaluation of Oxidative Status of Patients with Gout Attack in a Cameroonian Urban Hospital

Open Journal of Rheumatology and Autoimmune Diseases 2017年第2期7卷 111-119页

作者： jan rené nkeck Madeleine Singwé-Ngandeu Vicky Ama Moor Jean-Pierre Chedjou Marie-Sollange Doualla Wilfred F. Mbacham Faculty of Medicine and Biomedical Sciences of the University of Yaoundé I Yaoundé Cameroon Rheumatology unit of the Yaoundé Central Hospital Yaoundé Cameroon Biochemistry laboratory of the Yaoundé University Hospital Centre Yaoundé Cameroon Biotechnology Centre of the University of Yaoundé I Yaoundé Cameroon

Background: Gout is the leading cause of microcrystalline arthritis worldwide and the most common cause of arthritis in adult men. The prevalence of cardiovascular disease, type II diabetes and metabolic syndrome is high among gout patients;one of the current hypotheses that may explain this relationship is based on oxidative stress;however, few studies have sought to investigate this relationship. Objective: The aim of this study was to determine the oxidative status of patients with gout attack. Methods: We conducted a case-control study over a 4 months period at the Rheumatology service of the Yaoundé Central Hospital. Cases were patients with an acute gout attack and controls were healthy subjects matched for sex and age. We evaluated uricemia, serum levels of Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), Catalase and Malondialdehyde (MDA). Oxidative stress was defined by an increase in MDA and/or a decrease in SOD, Catalase and GPx. Statistical analysis was performed by the S.P.S.S. 21.0 software. The Student’s T-test was used to compare means;the significance threshold was 0.05. Results: Sixty subjects were recruited of which 30 with an acute gout attack and 30 healthy subjects. The mean ages of the cases and controls were respectively 58 ± 8 years and 57.6 ± 8 years. Uricemia was statistically higher in cases (81 ± 20 mg/L) compared to controls (47 ± 11 mg/L) (p rence in serum levels of catalase, SOD and GPx between cases and controls. Conclusion: Patients with gout attack have an elevated serum level of malondialdehyde but their oxidative status seems similar to that of normal individuals.

关键词： Gout Oxidative Stress

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Electrocardiographic Safety of Daily Hydroxychloroquine 400 mg Plus Azithromycin 250 mg as an Ambulatory Treatment for COVID-19 Patients in Cameroon

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World Journal of Cardiovascular Diseases 2021年第2期11卷 106-112页

作者： Liliane Mfeukeu-Kuate William Djomo Ngatchou Mazou Ngou Temgoua Charles Kouanfack Daniel Lemoungoum Joel Noutakdie Tochie Armel Zemsi Lauriane Fomete Skinner Lekelem Sylvain Zemsi Joelle Sobngwi Thierry Ntandzi Christian Ngongang Ouankou Yves Wasnyo Antoinette Tsama Assiga jan rené nkeck Ahmadou Musa Jingi Magellan Guewo Eric Walter Pefura Yone Charlotte Moussi Omgba Paul Owono Etoundi Jean Cyr Yombi Samuel Kingue Alain Menanga Jacqueline Ze Minkande Pierre Ongolo Zogo Jean Claude Mbanya Pierre Joseph Fouda Eugène Sobngwi Central Hospital of Yaoundé Yaoundé Cameroon Department of Internal Medicine and specialities Faculty of Médicine and Biomedical Sciences of the University of Yaounde I Yaoundé Cameroon Department of Surgery University of Douala Hypertension Clinic and Cardiac Surgery Department St Pierre Hospital Université libre de Bruxelles Brussels Belgium Faculty of Medicine and Pharmaceutical Sciences of Dschang University Dschang Cameroon Hypertension Clinic and Cardiology Department Erasme Hospital University of Brussels Brussels Belgium Research-Health and Development Yaoundé Cameroon and London School of Economics and Political Sciences London UK ANRS Cameroon Yaoundé Camerroon Faculty of Health Sciences University of Bamenda Bamenda Cameroon Jamot Hospital of Yaounde Yaounde Cameroon Regional Public Health Delegation for the Centre Ministry of Public Health Cameroon Yaoundé Cameroon Department of Surgery and Specialities Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon Centre for the Development of Good Health Practices Yaoundé Cameroon

Objective: To determine the early electrocardiographic changes in a cohort of ambulatory cameroonian COVID-19 patients treated with hydroxychlo- roquine and Azithromycin. Design: Prospective study. Setting: Treatment centres of the city of Yaounde, Cameroon, from May 7th to 24th 2020. Participants: We enrolled 51 consecutive confirmed COVID-19 on RT-PCR who having mild forms of COVID-19 and treated by hydroxychloroquine 200 mg twice daily during seven #days plus Azithromycin 500 mg the first day and 250 mg the remaining 4 days as per national standard. Main Outcomes Measures: The primary end-point was the change in QTc interval between day 0 (D0), day 3 (D3) and day 7 (D7). Secondary endpoints were changes in all other cardiac electrical conductivity patterns and the occurrence of clinical arrhythmic events during the course of treatment. Results: The population (29 men and 22 women) was aged 39 ± 11 years (range 17 to 61 years

关键词： Early Electrocardiographic Changes COVID-19 Hydroxychloroquine Azithromycin Cameroon

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Increased Risk of Arterial Stiffness in Rhumatoid Arthritis Patients in a Sub-Saharan African Setting

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World Journal of Cardiovascular Diseases 2023年第6期13卷 313-326页

作者： Asongwed Achu Reid Joshua Njimbuc Walinjom Collins Chenwi Eho Emerentia Achu Achiri Roosevelt Daniel Tchamdeu jan rene nkeck Marie Solange Doualla Daniel Lemogoum Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon Medical Unit Douala General Hospital Douala Cameroon Hô pital Erasme Université Libre de Bruxelles Bruxelles Belgium

Background: Analysis of arterial stiffness (AS) is a good marker of early arterial disease and an important determinant of cardiovascular risk, independent of other traditional cardiovascular risk factors. Carotid-femoral pulse wave velocity (CfPWV) is the gold standard to evaluate arterial stiffness. There is evidence that patients with rheumatoid arthritis (RA) have a higher arterial stiffness than their age-matched healthy counterparts and thus have higher cardiovascular (CV) risk. However, data on arterial stiffness in African rheumatoid arthritis patients is scarce. Objectives: To determine the patterns of arterial stiffness in rheumatoid arthritis patients in a sub-Saharan African setting, using CfPWV and Augmentation index (AIx). Method: We conducted a case-control study, at the Douala general hospital over four months (February to May 2018) on 63 subjects among which 31 RA patients matched for age and sex with 32 healthy subjects. AIx and CfPWV were determined non-invasively by radial pulse wave analysis and carotid femoral wave analysis respectively, using a sphygmocor Atcor device (SphygmoCor, PWV Medical, Sydney, Australia). Results: The mean age of RA patients was 47 ± 14 years with most of them being females (n = 26, 83.9%). CfPWV was significantly higher in RA patients compared to the control group (mean: 8.85 ± 2.1 vs 7.45 ± 1.38;p ≤ 0.01) as well as was AIx (Median: 33 [26 - 43] vs 26 [20 - 31];p = 0.01). RA (OR: 6.105;95% CI: 1.52 - 24.54;p 1.34;95% CI: 1.14 - 5.17;p = 0.05), elevated CRP levels (OR: 4.01;95% CI: 1.16 - 13.68;p = 0.03) and Hypertension (OR: 5.75;95% CI: 1.24 -11.60;p Conclusion: Arterial stiffness, a well-recognized marker of cardiovascular risk is increased among patients suffering from rheumatoid arthritis when compared to a healthy control group.

关键词： Rheumatoid Arthritis Arterial Stiffness CfPWV Augmentation Index

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Burden, Type, and Associated Factors of Thyroid Dysfunction in Patients with Heart Failure in Sub-Saharan Africa: A Cross-Sectional Study

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World Journal of Cardiovascular Diseases 2021年第11期11卷 485-497页

作者： Liliane Mfeukeu-Kuate Honoré Kemnang Yemele Ahmadou Musa Jingi Martine Etoa jan rene nkeck Jerome Boombhi Sylvie Ndongo Amougou Chris Nadege Nganou-Gninjio Mesmin Yefou Dehayem Ama Moor Vicky Faculty of Medicine and Biomedical Sciences The University of Yaounde Yaounde Cameroun The Yaounde Central Hospital Yaounde Cameroun Faculty of Health Sciences The University of Bamenda Bamenda Cameroon Faculty of Medicine and Pharmaceutical Sciences The University of Douala Douala Cameroun The Yaounde General Hospital Yaounde Cameroon The Yaounde University Teaching Hospital Yaounde Cameroun

Background: Various thyroid abnormalities have been reported during heart failure (HF). The present study aimed to evaluate the burden, type, and associated factors of thyroid disorders in Cameroonian patients with heart failure. Materials and Methods: We conducted a cross-sectional study from January to May 2020, involving volunteer adults followed for heart failure at the Yaoundé Central Hospital. Those receiving treatment that could cause thyroid dysfunction were excluded. Thyroid hormone levels (TSH, free T3, and free T4) were measured by enzyme-linked immunosorbent assay. Results: A total of 63 patients (30 women;47.6%) were included. The median age was 65 (IQR: 56 - 70) years. The main etiology of heart failure was hypertension (52.4%) followed by valvular heart disease (14.3%). Thyroid dysfunction was seen in 38 (60.3%, [95% CI: 47.2 - 72.4]) patients, of which 30 (79%) had hypothyroidism and 8 (21%) had hyperthyroidism. The most frequent thyroid dysfunction was Low T3 syndrome in 27% (95% CI: 16.6 - 39.7) of the study population followed sub-clinical hypothyroidism in 19.1% (95% CI: 10.3 - 30.9) of patients. Patients with HF and reduced ejection fraction (HFrEF) were more likely to have hypothyroidism than those with preserved ejection fraction (OR: 3.5, [95% CI: 1.2 - 9.9], p = 0.016). Also, patients with more than one hospital admission in the past 12 mo

关键词： Thyroid Dysfunction Heart Failure Sub-Saharan Africa

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活动性肺结核患者糖尿病的全球患病率:2300万肺结核患者数据的系统回顾与Meta分析

活动性肺结核患者糖尿病的全球患病率:2300万肺结核患者数据的系...

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作者： Jean Jacques Noubiap Jobert Richie Nansseu Ulrich Flore Nyaga jan rene nkeck Francky Teddy Endomba Arnaud D Kaze Valirie N Agbor Jean Joel Bigna 张烨冰 Department of Medicine Groote Schuur Hospital and University of Cape Town Faculty of Medicine University of Paris Sud XI

背景:尽管糖尿病和血糖控制不佳显着地增加了患结核病的风险,并不利地影响结核病的治疗结果,但在结核病背景下的全球糖尿病负担仍然未知。目的:我们做了一个系统的审查和meta分析,以估计在全球、区域和国家各级肺结核患者的糖尿病患病... 详细信息

背景:尽管糖尿病和血糖控制不佳显着地增加了患结核病的风险,并不利地影响结核病的治疗结果,但在结核病背景下的全球糖尿病负担仍然未知。目的:我们做了一个系统的审查和meta分析,以估计在全球、区域和国家各级肺结核患者的糖尿病患病率。方法:我们搜索了PubMed,Excerpta Medica数据库,Web of Science和Global Index Medicus,以确定1986年1月1日至2017年6月15日期间发表的关于活动性肺结核患者糖尿病患病率的研究,这些研究没有语言限制。肺结核和糖尿病的诊断标准与世卫组织准则一致,并评估了符合条件的研究的方法学质量,通过随机效应模型荟萃分析获得了全球活动性结核病患者合并糖尿病的总体估计值。通过Cochran Q统计量的χ检验评估了异质性(I)。结果:我们筛选了7565条记录,其中200项研究(活动性结核病2291571人)纳入了荟萃分析。合并糖尿病患病率为15.3%(95%预测区间2.5-36.1;I:99.8%),从拉脱维亚的0.1%到马绍尔群岛的45.2%不等。通过亚组和元回归分析确定异质性来源表明,四个国际糖尿病联合会(IDF)地区(北美和加勒比[19.7%],西太平洋[19.4%],东南亚[19.0%],中部东非和北非[17.5%])的患病率估计值明显高于其他三个(非洲[8.0%],南美和中美洲[7.7%]和欧洲[7.5%];P<0.0001)。此外,在男性以及结核病负担低的国家,患病率随年龄增长而增加。在低收入和低人类发展指数得分的国家中,糖尿病的患病率降低了。在活动性结核病患者中,结核病感染的形式和HIV的存在似乎并不影响糖尿病的患病率。结论:这项研究表明,活动性肺结核患者的糖尿病负担很高,但因年龄、性别、地区、国家收入水平和发展程度不同而存在差异。降低活动性肺结核患者糖尿病负担的成本效益策略是必要的。

关键词：糖尿病活动性结核病患病率回顾元分析

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