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Sensory-motor responses to mechanical stimulation of the esophagus after sensitization with acid

World Journal of Gastroenterology 2005年第28期11卷 4367-4374页

作者： Asbjφrn Mohr Drewes Hariprasad Reddy Camilla Staahl jan pedersen Peter Funch-Jensen Lars Arendt-Nielsen Hans Gregersen Center for Biomechanics and Pain Department of Gastroenterology Aalborg HospitalAarhus University HospitalAalborgDenmark Department of Surgical Gastroenterology L Aarhus University Hospital AarhusDenmark Center for Sensory-Motor Interactions (SMI) Department of Health Science and Technology Aalborg UniversityAalborgDenmark

AIM: Sensitization most likely plays an important role in chronic pain disorders, and such sensitization can be mimicked by experimental acid perfusion of the *** current study systematically investigated the sensory and motor responses of the esophagus to controlled mechanical stimuli before and after ***: Thirty healthy subjects were *** of the distal esophagus with a balloon was performed before and after perfusion with 0.1 mol/L hydrochloric acid for 30 min. An impedance planimetry system was used to measure cross-sectional area,volume, pressure, and tension during the distensions. A new model allowed evaluation of the phasic contractions by the tension during contractions as a function of the initial muscle length before the contraction (comparable to the Frank-Starling law for the heart). Length-tension diagrams were used to evaluate the muscle tone before and after relaxation of the smooth muscle with ***: The sensitization resulted in allodynia and hyperalgesia to the distension volumes, and the degree of sensitization was related to the infused volume of acid. Furthermore, a nearly 50% increase in the evoked referred pain was seen after sensitization. The mechanical analysis demonstrated hyper-reactivity of the esophagus following acid perfusion, with an increased number and force of the phasic contractions, but the muscle tone did not ***: Acid perfusion of the esophagus sensitizes the sensory pathways and facilitates secondary *** new model can be used to study abnormal sensorymotor mechanisms in visceral organs.

关键词： Esophagus Mechanical Sensitization Motility Reflux Pain

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Lattice distortion releasing local surface strain on high-entropy alloys

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Nano Research 2022年第6期15卷 4775-4779页

作者： Christian M.Clausen Jack K.pedersen Thomas A.A.Batchelor jan Rossmeisl Department of Chemistry University of Copenhagen2100 KøbenhavnØDenmark

High-entropy alloys(HEAs)have the potential to be a paradigm-shift for rational catalyst discovery but this new type of alloy requires a completely new approach to predict the surface *** addition to the ligand effect perturbing the surface–adsorbate bond,the random configuration of elements in the surface will also induce local strain effects due to the varying radii of neighboring *** modelling of HEA surface reactivity requires an estimate of this effect:To what degree is the adsorption of intermediates on these lattice distorted atomic environments affected by local strain?In this study,more than 3,500 density functional theory(DFT)calculated adsorption energies of*OH and*O adsorbed on the HEAs IrPdPtRhRu and AgAuCuPdPt are statistically analyzed with respect to the lattice constants of the alloys and the surfaces of each individual binding *** is found that the inherent distortion of the lattice structure in HEAs releases the local strain effect on the adsorption energy as the atomic environment surrounding the binding atom(s)settles into a relaxed *** is even observed to be true for clusters of atoms of which the sizes deviate significantly from the atomic environment in which they are *** elucidates an important aspect of binding site interaction with the neighboring atoms and thus constitutes a step towards a more accurate theoretical model of estimating the reactivity of HEA surfaces.

关键词： high-entropy alloys surface reactivity strain effect surface strain electrocatalysis oxygen reduction reaction

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SPECIFICATIONS AND GUIDELINES FOR PRODUCTION OF AAR RESISTANT CONCRETE IN NORWAY

SPECIFICATIONS AND GUIDELINES FOR PRODUCTION OF AAR RESISTAN...

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第十二届国际混凝土碱集料反应会议

作者： Per Arne Dahl jan Lindgrd Svein Willy Danielsen Cecilie Hagby Reidar Kompen Brd pedersen Terie F.R■nning SINTEF Civil and Environmental Engineering NO-7465 TrondheimNorway SINTEF Civil and Environmental Engineering NO-7465 TrondheimNorway Dr.ing.S.W.Danielsen P.O.Box 144 TillerNO-7476 TrondheimNorway Control Council for Concrete Products P.O.Box 53 BlindernNO-0313 OsloNorway Norwegian Public Roads Administration P.O.Box 8142NO-0033 OsloNorway NorBetong AS P.O.Box 15NO-5847 BergenNorway Norcem P.O.Box 38NO-3991 BrevikNorway

＜正＞ AAR was recognised as a durability challenge in Norway some 15 years ago. Since then, several comprehensive national research projects on this subject have been carried out. These projects have strongly focused on test methods and corresponding criteria for the prediction of AAR as observed on Norwegian concrete structures. In 1996 the Norwegian Concrete Association produced a publication giving guidelines for handling AAR in Norway. Based on technological knowledge obtained after 1996, and the fact that the publication now shall be a harmonised normative reference document to the new concrete materials standard, NS-EN 206, a revised version of the publication will be provided in September *** 2004 edition is divided into two major parts. Part 1 is in formal terms describing the mandate and the use of the publication, and how concrete constituents and concrete recipes shall be tested and evaluated with respect to potential AAR. Individual aggregates and blends of aggregates shall be evaluated by petrographical analyses as a first step. The evaluation based on result from these analyses can be reassessed by a mortar bar expansion test, while a concrete prism expansion test can be used to reassess the evaluation from any of these tests. For the evaluation of binders and concrete compositions, only the concrete prism expansion test can be used. Part 2 gives advisory guidelines for how the concrete industry can fulfil the requirements given in the Part 1 specifications. More complementary descriptions of the test methods and corresponding evaluation criteria are presented and illustrated by examples. Part 2 also provides a survey of binders and corresponding alkali contents documented to be suited for production of AAR resistant concrete containing all types and amounts of Norwegian reactive aggregates. This survey will be updated whenever new binders obtain satisfactory documentation. The revised publication will be a valuable and updated tool for handling AAR

关键词： Alkali-aggregate reactivity Concrete materials Specifications

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Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults:Big Data from Seven Randomized Controlled Trials Worldwide

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Health Data Science 2021年第1期2021卷 174-183页

作者： Tao Huang Zhenhuang Zhuang Yoriko Heianza Dianjianyi Sun Wenjie Ma Wenxiu Wang Meng Gao Zhe Fang Emilio Ros Liana C.Del Gobbo Jordi Salas-Salvadó Miguel A.Martínez-González jan Polak Markku Laakso Arne Astrup Dominique Langin Jorg Hager Gabby Hul Torben Hansen Oluf pedersen Jean-Michel Oppert Wim H.M.Saris Peter Arner Montserrat Cofán Sujatha Rajaram Jaakko Tuomilehto Jaana Lindström Vanessa D.de Mello Alena Stancacova Matti Uusitupa Mathilde Svendstrup Thorkild I.A.Sørensen Christopher D.Gardner Joan Sabaté Dolores Corella J.Alfredo Martinez Lu Qi Department of Epidemiology&Biostatistics School of Public HealthPeking UniversityChina Department of Global Health School of Public HealthPeking UniversityChina Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education China Global Health Institute Peking University China Department of Epidemiology School of Public Health and Tropical MedicineTulane UniversityNew OrleansLAUSA Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMAUSA Department of Endocrinology&Nutrition Institut d’Investigacions Biomèdiques August Pi SunyerHospital ClínicBarcelonaSpain CIBER Fisiopatologia de la Obesidad y Nutrición(CIBERobn) Instituto de Salud Carlos III(ISCIII)MadridSpain Stanford Prevention Research Center Stanford UniversityStanford CAUSA Human Nutrition Unit Faculty of Medicine and Health SciencesPere Virgili Health Research InstituteRovira i Virgili UniversityReusSpain University of Navarra Department of Preventive Medicine and Public HealthMedical School&IDISNAPamplonaSpain Department for the Study of Obesity and Diabetes Third Faculty of MedicineCharles UniversityPragueCzech Republic Department of Medicine University of Eastern FinlandKuopioFinland University of Copenhagen Department of NutritionExercise and SportsFaculty of ScienceCopenhagenDenmark Institut National de la Santéet de la Recherche Médicale(Inserm) UMR1048Institute of Metabolic and Cardiovascular DiseasesUniversity of Toulouse and Paul Sabatier UniversityToulouseFrance NestléInstitute of Health Sciences LausanneSwitzerland Department of Human Biology NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Medical Centre+MaastrichtNetherlands Section of Metabolic Genetics Novo Nordisk Foundation Center for Basic Metabolic ResearchFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark Sorbonne Université Institute of Cardiometabolism and Nutrition(ICAN)Department of NutritionPitié-Salpêtrière HospitalAssistance Publique-

*** strongest locus which associated with type 2 diabetes(T2D)by the common variant rs7903146 is the transcription factor 7-like 2 gene(TCF7L2).We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TCF7L2 rs7903146 on glycemic traits,body weight,or waist circumference in overweight or obese adults in several randomized controlled trials(RCTs).*** October 2016 to May 2018,a large collaborative analysis was performed by pooling individualparticipant data from 7 *** RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese *** treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all *** the joint analysis,a total of 7 eligible RCTs were included(n=4,114).Importantly,we observed a significant effect modification of diet/lifestyle-related interventions on the TCF7L2 variant rs7903146 and changes in fasting *** with the control group,diet/lifestyle interventions were related to lower fasting glucose by-3.06(95%CI,-5.77 to-0.36)mg/dL(test for heterogeneity and overall effect:I^(2)=45:1%,p<0:05;z=2:20,p=0:028)per one copy of the TCF7L2 T risk ***,regardless of genetic risk,diet/lifestyle interventions were associated with lower waist ***,there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of TCF7L2 risk *** findings suggest that carrying the TCF7L2 T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults.

关键词： TCF7L2 weight finding

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深圳能源大厦

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建筑实践 2019年第6期 26-33页

作者： Bjarke Ingels Andreas Klok pedersen Martin Voelkle He Song Andre Schmidt Alessio Zenaro Alina Tamosiunaite Alysen Hiller Ana Merino Andreas Geisler Johansen Annette Jensen Armor Rivas Balaj IIulian Brian Yang Baptiste Blot Buster Christiansen Cecilia Ho Christian Alvarez Christin Svensson Claudia Hertrich Claudio Moretti Cory Mattheis Dave Brown Dennis Rasmussen Doug Stechschulte Eskild Nordbud Felicia Guldberg Fred Zhou Gaetan Brunet Gül Ertekin Henrik Kania Iris Van der Heide James Schrader jan Magasanik jan Borgstr?m Jeppe Ecklon Jelena Vucic Jo?o Albuquerque Jonas M?nster Karsten Hansen Malte Kloe Mikkel Marcker Stubgaard Michael Andersen Michal Kristof Min Ter Lim Oana Simionescu Nicklas A. Rasch Philip Sima Rasmus pedersen Rune Hansen Rui Huang Sofia Gaspar Stanley Lung Sun Ming Lee Takuya Hosokai Todd Bennett Xi Chen Xing Xiong Xiao Lu Xu Li Yijie Dan Zoltan Kalaszi BIG

深圳能源公司办公楼项目总建筑面积为96000m2,旨在让人在深圳的文化、政治和商业中心感到亲切的同时,在城市主轴线上建造一座可持续的新公共地标。本项目的体量和高度由中心区城市总体规划决定。主体建筑由两座塔楼组成,北楼高220m,南楼... 详细信息

深圳能源公司办公楼项目总建筑面积为96000m2,旨在让人在深圳的文化、政治和商业中心感到亲切的同时,在城市主轴线上建造一座可持续的新公共地标。本项目的体量和高度由中心区城市总体规划决定。主体建筑由两座塔楼组成,北楼高220m,南楼高120m,两座塔楼与邻近建筑的塔楼一起在深圳的中心形成一个连续的弧形天际线。在建筑底部,两座塔楼通过一个34m长,包括大厅、会议中心、自助餐厅和展览空间功

关键词： Michael 建筑面积建筑实践

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提尔皮茨博物馆

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城市环境设计 2019年第2期118卷 128-141页

作者： David Zahle Andreas K.pedersen Snorre Emanuel Nash J?rgensen Michael Andersen Hugo Soo Marcella Martinez Geoffrey Eberle Adam Busko Hanna Johansson Jakob Andreassen Charlotte Cocco Mikkel Marcker Stubgaard Michael Sch?nemann Jensen Alejandro Mata Gonzales Kyle Thomas David Tousant Jesper Boye Andersen Alberte Danvig jan Magasanik Enea Michelesio Alina Tamosiunaite Ryohei Koike Brigitta Gulyás Katarzyna Krystyna Siedlecka Andrea Scalco Tobias Hjortdal Maria Teresa Fernandez Rojo Rasmus Hjortshoj 运小红

新落成的提尔皮茨博物馆是沙漠中的一处庇佑所,它的存在就像是对曾经发生在丹麦西海岸的战争历史的一次平静的隔空对话。这座面积为2 800m2的"隐形博物馆"开创性地将德国二战时期的战壕延伸转变为一个文化容器,其中的四个展厅,运用简单... 详细信息

新落成的提尔皮茨博物馆是沙漠中的一处庇佑所,它的存在就像是对曾经发生在丹麦西海岸的战争历史的一次平静的隔空对话。这座面积为2 800m2的"隐形博物馆"开创性地将德国二战时期的战壕延伸转变为一个文化容器,其中的四个展厅,运用简单的结构体系无缝嵌入大地。初到这里,参观者首先将看到的是原有的战壕,直到他们穿过荒草丛生的小径,才会渐渐感知这些深深刻入沙丘的墙体,从各个方向

关键词：卫生间博物馆群 Section 提尔皮茨

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丹麦国家海事博物馆

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城市环境设计 2019年第2期118卷 142-159页

作者： John Pries Jensen Henrik Kania Ariel Joy Norback Wallner Rasmus pedersen Annette Jensen Dennis Rasmussen jan Magasanik Jeppe Ecklon Karsten Hammer Hansen Rasmus Rodam Rune Hansen Alina Tamosiunaite Alysen Hiller Ana Merino Armen Menendian Andy Yu Andreas Johansen Baptiste Blot Christian Alvarez Christin Svensson Claudia Hertrich Claudio Moretti Cory Mattheis Eskild Nordbud Felicia Guldberg Finn N?rkj?r Gül Ertekin jan Borgstr?m James Schrader Johan Cool Jonas M?nster Kirstine Ragnhild Malte Kloe Michael Andersen Michal Kristof Marc Jay Maria Mavriku Masatoshi Oka Oana Simionescu Pablo Labra Peter Rieff Qianyi Lim Sara Sosio Sebastian Latz Tina Lund H?jgaard Tina Troster Todd Bennet Xi Chen Xing Xiong Xu Li Zoltan Kalaszi Iwan Baan Rasmus Hjortshoj Luca Santiago Mora Dragoer Luftfoto Jens Lindhe Lorenzon Boddi Thiks Wolzak 陈子钰

丹麦海事博物馆位于独特的历史和空间环境中:在丹麦最重要和最著名的建筑之一克伦堡城堡和文化庭院——一个新的、雄心勃勃的文化中心之间。BIG建议将博物馆放在地下,就在船坞的墙壁外侧,以便将船坞保留为开放的户外展示空间,保存其强... 详细信息

丹麦海事博物馆位于独特的历史和空间环境中:在丹麦最重要和最著名的建筑之一克伦堡城堡和文化庭院——一个新的、雄心勃勃的文化中心之间。BIG建议将博物馆放在地下,就在船坞的墙壁外侧,以便将船坞保留为开放的户外展示空间,保存其强有力的结构作为海事博物馆中心。将博物馆这样设置,使它在成为与克伦堡城堡和邻近的文化庭院相联系的文化环境的一部分的同时,彰显自身,成为一个独立

关键词：海事博物馆铝覆层 Section 重钢结构

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音乐屋——奥尔堡创意中心

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城市环境设计 2020年第4期126卷 174-185页

作者：沃尔夫·狄·普瑞克斯 Marcelo Bernardi Jesper Bork Bo Stjerne Hansen Roberta Jiraschek Daniel Krüger Carsten Laursen Martin Oberascher Florian Pfeifer Robert Pippan Marita Schnepper Sigrid Svensson Eva Wolf Carola B?ker Moa Carlson Isak Foged Annina G?hwiler Patricia Gola Robin Heather Per Kruse Win Man Ruth Mandl Aline Müller Tenna Olsen Anke Pasolt Annemarie pedersen Eva Ravnborg Carolin Schmitz-Remberg Tim Seidl Guro Sollid Michele Zanella jan-Ruben Fischer Markus Pillhofer Markus Baumann Robin Heather Anja Sorger Bo Stjerne Thomsen Anna Wasserthal Philip Wilck Blaine Lepp Talya Kozminsky Hannes Walzl Morten Grau Jensen Stephanie Neufeld Tyler Bornstein Laura Githa Julia G?rtner Jenny Draxlbauer Duccio Malagamba Martin Schubert

项目大事记/CHRONOLOGY竞赛（第一名）/Competition （1st Place）:2003一期规划设计/Layout Planning Ho M I:2003—2005项目延期/Postponement of the Project:2006—2007二期规划设计/Start of Layout Planning Ho M II:2008二期动工/Start of Construction Ho M II:2010二期竣工/Completion Ho M II:2014项目参数/PROJECT DATA建筑净面积/Net Floor Area:17 637m2建筑毛面积/Gross Floor Area:20 257m2音乐厅/Concert Hall:1 298座/1 289 Seats

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