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Management and outcome of hepatocellular adenoma with massive bleeding at presentation

World Journal of Gastroenterology 2017年第25期23卷 4579-4586页

作者： Anne J Klompenhouwer Robert A de Man Maarten GJ Thomeer jan nm ijzermans Department of Surgery Department of Gastroenterology and Hepatology Department of Radiology

To evaluate outcome of acute management and risk of rebleeding in patients with massive hemorrhage due to hepatocellular adenoma (HCA). METHODSThis retrospective cohort study included all consecutive patients who presented to our hospital with massive hemorrhage (grade II or III) due to ruptured HCA and were admitted for observation and/or intervention between 1999-2016. The diagnosis of HCA was based on radiological findings from contrast-enhanced magnetic resonance imaging (MRI) or pathological findings from biopsy or resection of the HCA. Hemorrhage was diagnosed based on findings from computed tomography or MRI. Medical records were reviewed for demographic features, clinical presentation, tumor features, initial and subsequent management, short- and long-term complications and patient and lesion follow-up. RESULTSAll patients were female (n = 23). Treatment in the acute phase consisted of embolization (n = 9, 39.1%), conservative therapy (n = 13, 56.5%), and other intervention (n = 1, 4.3%). Median hemoglobin level decreased significantly more on days 0-3 in the intervention group than in the patients initially treated conservatively (0.9 mmol/L vs 2.4 mmol/L respectively, P = 0.006). In total, 4 patients suffered severe short-term complications, which included hypovolemic shock, acute liver failure and abscess formation. After a median follow-up of 36 mo, tumor regression in non-surgically treated patients occurred with a median reduction of 76 mm down to 25 mm. Four patients underwent secondary (elective) treatment (i.e., tumor resection) to address HCA size of > 5 cm and/or desire for future pregnancy. One case of rebleeding was documented (4.3%). None of the patients experienced long-term complication (mean follow-up time: 36 mo). CONCLUSIONWith a 4.3% risk of rebleeding, secondary (elective) treatment of HCA after massive hemorrhage may only be considered in patients with persistent HCA > 5 cm.

关键词： Hepatocellular adenoma Management Bleeding Outcome Hemorrhage

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Machine perfusion in abdominal organ transplantation: Current use in the Netherlands

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World Journal of Transplantation 2020年第1期10卷 15-28页

作者： Elsaline Rijkse jan nm ijzermans Robert C Minnee Division of HPB and Transplant Surgery Department of Surgery Erasmus MC University Medical Center

Scarcity of donor organs and the increment in patients awaiting a transplant increased the use of organs from expanded criteria donors or donation after circulatory *** to the suboptimal outcomes of these donor organs,there is an increased interest in better preservation methods,such as ex vivo machine perfusion or abdominal regional perfusion to improve *** state-ofthe-art review aims to discuss the available types of perfusion techniques,its potential benefits and the available evidence in kidney,liver and pancreas ***,translational steps from animal models towards clinical studies will be described,as well as its application to clinical practice,with the focus on the *** the lack of evidence from randomized controlled trials,currently available data suggest especially beneficial effects of normothermic regional perfusion on biliary complications and ischemic cholangiopathy after liver *** ex vivo machine perfusion in kidney transplantation,hypothermic machine perfusion has proven to be beneficial over static cold storage in a randomized controlled trial,while normothermic machine perfusion is currently under *** ex vivo machine perfusion in liver transplantation,normothermic machine perfusion has proven to reduce discard rates and early allograft *** response to clinical studies,hypothermic machine perfusion for deceased donor kidneys has already been implemented as standard of care in the Netherlands.

关键词： Machine perfusion Review Kidney transplantation Liver transplantation Pancreas transplantation

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Interaction of immunosuppressants with HCV antivirals daclatasvir and asunaprevir: combined effects with mycophenolic acid

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World Journal of Transplantation 2018年第5期8卷 156-166页

作者： Petra E de Ruiter Yashna Gadjradj Robert J de Knegt Herold J Metselaar jan nm ijzermans Luc JW van der Laan Department of Surgery Erasmus MC-University Medical Center Department of Gastroenterology and Hepatology Erasmus MC-University Medical Center

AIM To investigate the specific effects of immunosuppressants on the antiviral action of daclatasvir and *** The antiviral activity of daclatasvir(DCV) and asunaprevir(ASV) combined with immunosuppressants was tested using two in vitro models for hepatitis C virus(HCV) *** Tacrolimus, rapamycin and cyclosporine did not negatively affect the antiviral action of DCV or ASV. Mycophenolic acid(MPA) showed additive antiviral effects combined with these direct acting antivirals(DAAs). MPA induces interferon-stimulated genes(ISGs) and is a potent GTP synthesis inhibitor. DCV or ASV did not induce ISGs expression nor affected ISG induction by MPA. Rather, the combined antiviral effect of MPA with DCV and ASV was partly mediated via inhibition of GTP *** Immunosuppressants do not negatively affect the antiviral activity of DAAs. MPA has additive effect on the antiviral action of DCV and ASV. This combined benefit needs to be confirmed in prospective clinical trials.

关键词： Immunosuppressant Hepatitis C Daclatasvir Asunaprevir Liver Transplantation

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Solid Bi_(2)O_(3)-derived nanostructured metallic bismuth with high formate selectivity for the electrocatalytic reduction of CO_(2)

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 803-811页

作者： Xiaoyan Wang Safeer jan Zhiyong Wang Xianbo Jin College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power SourcesWuhan UniversityWuhan 430072China Engineering Research Center of Organosilicon Compounds&Materials Ministry of EducationWuhan 430072China

CO_(2) electrochemical reduction(CO_(2)ER)is an important research area for carbon ***,available catalysts for CO_(2) reduction are still characterized by limited stability and ***,metallic bismuth(Bi)has emerged as a promising catalyst for CO_(2) ***,we report the solid cathode electroreduction of commercial micronized Bi2O3as a straightforward approach for the preparation of nanostructured ***-1.1 V versus reversible hydrogen electrode in a KHCO3aqueous electrolyte,the resulting nanostructure Bi delivers a formate current density of~40 mA·cm^(-2) with a current efficiency of~86%,and the formate selectivity reaches97.6% at-0.78 *** nanosized Bi2O3as the precursor can further reduce the primary particle sizes of the resulting Bi,leading to a significantly increased formate selectivity at relatively low *** high catalytic activity of nanostructured Bi is attributable to the ultrafine and interconnected Bi nanoparticles in the nanoporous structure,which exposes abundant active sites for CO_(2) electrocatalytic reduction.

关键词： bismuth carbon dioxide electrocatalysis formate solid electroreduction

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Individual effect of Y and Nd on the microstructure formation of Mg-Y-Nd alloys processed by severe plastic deformation and their effect on the subsequent mechanical and corrosion properties

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Journal of Magnesium and Alloys 2023年第2期11卷 509-521页

作者： Maria Zemkova Peter Minarik jan Dittrich jan Bohlen Robert Kral Charles University Department of Physics of MaterialsKe Karlovu 512116PragueCzechia University of Zilina Research CentreUniverzitna8215/1Zilina01026Slovakia Institute of Material and Process Design Helmholtz-Zentrum Hereon21502GeesthachtGermany

This work investigated the effect of sole yttrium and neodymium alloying on the microstructure formation during severe plastic deformation by equal channel angular pressing(ECAP) and an impact on the mechanical strength and corrosion resistance of binary Mg-3Y and Mg-3Nd *** results are compared with a ternary Mg-4Y-3Nd alloy,which represents a simplified version of the commercially successful WE43 *** extensive study comprises a thorough microstructural analysis performed by scanning and transmission electron microscopy,including electron backscatter diffraction and texture analysis performed by X-ray *** is shown that the presence of Nd primarily caused precipitation during the processing of the Mg-3Nd alloy,while Y remained dissolved in the magnesium matrix in the Mg-3Y *** difference resulted in a significantly smaller average grain size in the Mg-3Y alloy(~0.77 nm) than in the Mg-3Nd alloy(~1.3 μm) after the final step of the processing and formation of a slightly different ***,the composition and the processing affected the mechanical and corrosion properties of the investigated materials,measured by compression deformation tests,microhardness measurement,and electrochemical impedance *** study shows that the ECAP-processed W3 sample exhibits a surprisingly good combination of ultrafine-grain structure,weak crystallographic texture,high strength,and high corrosion resistance compared with the other investigated *** attributes make this material very interesting for utilisation in the industry and/or medicine.

关键词： Magnesium Rare earth elements Microstructure Texture Mechanical strength Corrosion

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SYNTHESIS,CHARACTERIZATION AND ENHANCED ELECTRICAL PROPERTIES OF CTAB-DIRECTED POLYANILINE NANOPARTICLES

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Chinese Journal of Polymer Science 2011年第2期29卷 181-190页

作者： Lal Said jan Mohamed Ahmed Siddig Department of Physics Postgraduate College Mardan23200Khyber PakhtunkhwaPakistan School of Physics and Applied Physics Faculty of Science and TechnologyEL Neelain UniversityKhartoumSudan

Inverse microemulsion system of cetyltrimethylammonium bromide（CTAB） molecules is utilized for virtually monodispersed and controlled growth of HCl polyaniline（PANI） nanoparticles at room temperature（ca.300 K）.The templated electroconductive polymer reveals lamellar crystalline structure under X-ray diffraction signifying marked sub-chain alignment of the polymerized *** nanostructured polymer has spherically symmetric morphology in a size range of 2.0 nm to 6.0 nm under electron microscope *** permeation chromatography gives polydispersity index of 1.02 for nanostructured polymer in agreement with the size monodispersity transpired by electron *** *** conductivityσ_（dc） of PANI at room temperature is 10.11 S/cm whereas the variation of conductivity with temperature in the range 227-303 *** that the conducting mechanism can be considered as three-dimensional variable-range-hopping（3D-VRH）.UV-Vis spectrum indicates two broad absorption bands due to polaron formation that contributes to enhanced electrical conductivity of the *** fundamental absorption edge in the polymer is formed by direct allowed transitions to the extent that the optical band gap value was found to be 2.35 *** crystalline nanostructure and homogeneous doping attained in the cationic template of amphiphile are argued as contributing factors to the enhanced conductivity of the polymer.

关键词： Polyaniline Nanostructured Band gap energy Electrical conductivity

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Is Chloroplast Movement in Tobacco Plants Influenced Systemically after Local Illumination or Burning Stress?

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Journal of Integrative Plant Biology 2008年第10期50卷 1292-1299页

作者： jan Nau Monika Rolencov Vladimíra Hlavkov Laboratory of Biophysics Department of Experimental Physics Palacky' University tr. Svobody 26 77146 Olomouc Czech Republic

Chloroplast movement has been studied in many plants mainly in relation to the local light, mechanical or stress effects. Here we investigated possible systemic responses of chloroplast movement to local light or burning stress in tobacco plants （Nicotisna tabacum cv. Samsun）. Chloroplast movement was measured using two independent methods： one with a SPAD 502 Chlorophyll meter and another by collimated transmittance at a selected wavelength （676 nm）. A sensitive periodic movement of chloroplasts was used in high or low （2 000 or 50 μmol/m2 per s photosynthetically active radiation, respectively） cold white light with periods of 50 or 130 min. Measurements were carried out in the irradiated area, in the non-irradisted area of the same leaf or in the leaf located on the stem below the irradiated or bumed one. No significant changes in systemic chloroplast movement in non-irradiated parts of the leaf and in the non-treated leaf were detected. Our data indicate that chloroplast movement in tobacco is dependent dominantly on the intensity and spectral composition of the incident light and on the local stimulation and state of the target tissue. No systemic signal was strong enough to evoke a detectable systemic response in chloroplast movement in distant untreated tissues of tobacco plants.

关键词： buming chloroplast movement irradiance systemic response tobacco.

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Buses retrofitting with diesel particle filters: Real-world fuel economy and roadworthiness test considerations

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Journal of Environmental Sciences 2018年第5期30卷 273-286页

作者： Rafael Fleischman Ran Amiel jan Czerwinski ANDreas Mayer Leonid Tartakovsky Faculty of Mechanical Engineering Technion–Israel Institute of Technology Labs for IC-Engines & Exhaust Emission Control(AFHB) Berne University of Applied Sciences VERT Association TTM

Retrofitting older vehicles with diesel particulate filter（DPF） is a cost-effective measure to quickly and efficiently reduce particulate matter emissions. This study experimentally analyzes real-world performance of buses retrofitted with CRT DPFs. 18 in-use Euro III technology urban and intercity buses were investigated for a period of 12 months. The influence of the DPF and of the vehicle natural aging on buses fuel economy are analyzed and discussed. While the effect of natural deterioration is about 1.2%–1.3%, DPF contribution to fuel economy penalty is found to be 0.6% to 1.8%, depending on the bus type. DPF filtration efficiency is analyzed throughout the study and found to be in average 96% in the size range of 23–560 nm. Four different load and non-load engine operating modes are investigated on their appropriateness for roadworthiness tests. High idle is found to be the most suitable regime for PN diagnostics considering particle number filtration efficiency.

关键词： Diesel particle filter Ultrafine particles Diesel bus Fuel economy Vehicle natural aging Roadworthiness tests

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Do mowing regimes affect plant and soil biological activity in the mountain meadows of Southern Poland?

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Journal of Mountain Science 2018年第11期15卷 2409-2421页

作者： JóZEFOWSKA Agnieszka ZALESKI Tomasz ZARZYCKI jan FRACZEK Krzysztof Institute of Soil Science and Agrophysics Department of Soil Science and Soil Protection University of Agriculture in Krakow Department of Ecology Climatology and Air Protection University of Agriculture in Krakow Department of Microbiology University of Agriculture in Krakow

The soil biological activity of mountain meadows is a significant factor that determines the health and utility of these regions. The climax stage of this area is forest, but to maintain semi-natural grassland, which is characterised by high biodiversity,low-intensity land use(mowing or grazing) is necessarily required. To understand the effect of various mowing regimes on the soil biological activity and plants, the soil microbial activity(microbial biomass carbon, dehydrogenase activity and number of the cultivable fraction of soil microbial community),annelids community(density and species composition earthworms and enchytraeids) and plant species composition were investigated. The study area was located in the Pieniny National Park in the Carpathian Mountains, in a meadow belonging to the association Dactylis glomerata-Poa trivialis. The investigated variants were divided according to mowing regime:traditional scything – hand mowing(HM), mechanical mowing(MM), or the abandonment of mowing – nonmowing(nm). The microbial activities(expressed by,e.g. microbial biomass carbon and the number of phosphorus bacteria) were affected by the mowing regime. The density of earthworms was higher in the HM and MM than in the nm variants. The largest changes in plant species composition were caused by the abandonment of mowing(nm). The mean number of plant species was positively correlated with soil moisture, earthworm density, and microbial activity(expressed indirectly by dehydrogenases activity). The soil microbial community, such as vegetative bacteria forms and ammonifying bacteria,were positively associated with pH value, and the microbial and total organic carbon content. The results presented here indicate that there is no single form of optimal management for all living *** about mowing regimes, or abandonment of use, should be preceded by multi-aspect studies,including plants and soil biota.

关键词： Mowing techniques Grassland management Earthworms Enchytraeids Microorganisms Biodiversity

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Comparative Study of Plasma Parameters in Magnetic Pole Enhanced Inductively Coupled Argon Plasmas

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Plasma Science and Technology 2013年第4期15卷 329-334页

作者： F.jan A.W. KHAN A.SAEED M.ZAKAULLAH Department of Physics Quaid-i-Azam University Department of Physics Gomal University

Langmuir probe measurements of radio frequency （RF） magnetic pole enhanced inductively coupled （MaPE-ICP） argon plasma were accomplished to obtain the electron number densities and electron temperatures. The measurements were carried out with a fixed RF frequency of 13.56 MHz in a pressure range of 7.5 mTorr to 75 mTorr at an applied RF power of 10 W and 100 W. These results are compared with a global （volume average） model. The results show good agreement between theoretical and experimental measurements. The electron number density shows an increasing trend with both RF power and pressure while the electron temperature shows decreasing trend as the pressure increases. The difference in the plasma potentiM and floating potential as a function of electron temperature measured from the electrical probe and that obtained theoretically shows a linear relation with a small difference in the coefficient of proportionality. The intensity of the emission line at 750.4 nm due to 2pl → 1s2 （Paschen＇s notation） transition closely follows the variation of ne with RF power and filling gas pressure. Measured electron energy probability function （EEPF） shows that electron occupation changes mostly in the high-energy tail, which highlights close similarity of 750.4 nm argon line to he.

关键词： MaPE-ICP Langmuir probe global model

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