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IPY计划“大西洋中部海岭系（Mohns海岭和Knipovich海岭）与Bear岛区的大陆边缘动力学”

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海洋地质 2008年第3期24卷 52-53页

作者： Johannes Schweitzer Aleksander Guterch Frank Kruger Meehita Schmidt- Aursch Rolf Mjelde Marek Grad jan inge faleide 孙桂华（译）邱燕（校对）挪威地震研究中心波兰科学院德国波茨坦大学德国阿尔弗雷德·魏格纳研究所挪威卑尔根大学波兰华沙大学挪威奥斯陆大学不详

2007年，我们发起了一个主动地震和被动地震的地震学实验，实验地点是Bear岛附近的巴伦支海大陆边缘、Mohns海岭和Knipovich海岭之间的结合部和大西洋东北部的扩张轴。2007～2008年间的野外实验主要是安装几台地震仪器，实施相关的野外... 详细信息

2007年，我们发起了一个主动地震和被动地震的地震学实验，实验地点是Bear岛附近的巴伦支海大陆边缘、Mohns海岭和Knipovich海岭之间的结合部和大西洋东北部的扩张轴。2007～2008年间的野外实验主要是安装几台地震仪器，实施相关的野外操作。这项研究的目标是大陆边缘沉积盖层至上地幔的地球结构和动力学机制，因为该大陆边缘包含一个非常厚的沉积楔和至少一个古断裂带。

关键词：大西洋中部动力学机制大陆边缘海岭野外实验沉积盖层被动地震巴伦支海

PETROBAR-巴伦支海地区石油地质研究

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海洋地质 2008年第3期24卷 69-69页

作者： jan inge faleide 吴峧歧（译）邱燕（校对）挪威奥斯陆大学不详

PETROBAR（巴伦支海区域性石油地质研究）是一个由挪威研究理事会（NFR）及StatoilHydro赞助的、PETROMAKS项目下属的大型跨学科研究课题。参与这个研究课题的有：地学部（项目负责）、地球物理研究所（PGP）、奥斯陆大学、地球科学部... 详细信息

PETROBAR（巴伦支海区域性石油地质研究）是一个由挪威研究理事会（NFR）及StatoilHydro赞助的、PETROMAKS项目下属的大型跨学科研究课题。参与这个研究课题的有：地学部（项目负责）、地球物理研究所（PGP）、奥斯陆大学、地球科学部、卑尔根大学、斯塔瓦格国际研究所（IRIS）、挪威地质调查局以及火山盆地石油研究所（VBPR）。我们也将与俄罗斯的科学家和研究机构合作。

关键词：石油地质巴伦支海地球物理研究所海地地球科学部地质调查局火山盆地研究机构

Ghrelin's second life:From appetite stimulator to glucose regulator

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World Journal of Gastroenterology 2012年第25期18卷 3183-3195页

作者： Pieter-jan Verhulst inge Depoortere Translational Research Center for Gastrointestinal Disorders Catholic University of Leuven3000 LeuvenBelgium

Ghrelin,a 28 amino acid peptide hormone produced by the stomach,was the first orexigenic hormone to be discovered from the *** octanoyl modification at Ser3,mediated by ghrelin O-acyltransferase(GOAT),is essential for ghrelin's biological *** stimulates food intake through binding to its receptor(GRLN-R) on neurons in the arcuate nucleus of the *** is widely expressed throughout the body;accordingly,it is implicated in several other physiological functions,which include growth hormone release,gastric emptying,and body weight *** and GRLN-R expression are also found in the pancreas,suggesting a local physiological ***,several recent studies now point towards an important role for ghrelin and its receptor in the regulation of blood glucose homeostasis,which is the main focus of this *** mechanisms of this regulation by ghrelin have been proposed,and one possibility is through the regulation of insulin *** some controversy,most studies suggest that ghrelin exerts an inhibitory effect on insulin secretion,resulting in increased circulating glucose *** may thus be a diabetogenic ***-related type2 diabetes has become an increasingly important health problem,almost reaching epidemic proportions in the world;therefore,antagonists of the ghrelin-GOAT signaling pathway,which will tackle both energy-and glucose homeostasis,may be considered as promising new therapies for this disease.

关键词： Ghrelin Blood glucose Pancreas Diabetes Insulin

Early detection of neuropathy in leprosy:a comparison of five tests for field settings

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Infectious Diseases of Poverty 2017年第1期6卷 1034-1042页

作者： inge Wagenaar Erik Post Wim Brandsma Dan Ziegler Moshiur Rahman Khorshed Alam jan Hendrik Richardus Department of Public Health Erasmus MCRotterdamThe Netherlands KIT Health Royal Tropical InstituteAmsterdamThe Netherlands Independent leprosy consultant AmsterdamThe Netherlands Institute for Clinical Diabetology German Diabetes Center at Heinrich Heine UniversityLeibniz Center for Diabetes ResearchDusseldorfGermany Department of Endocrinology and Diabetology Medical FacultyHeinrich Heine UniversityDüsseldorfGermany Rural Health Program The Leprosy Mission International-BangladeshNilphamariBangladesh

Background:Early detection and treatment of neuropathy in leprosy is important to prevent disabilities.A recent study showed that the Nerve Conduction Studies(NCS)and Warm Detection Thresholds(WDT)tests can detect leprosy neuropathy the *** two tests are not practical under field conditions,however,because they require climate-controlled rooms and highly trained staff and are *** assessed the usefulness of alternative test methods and their sensitivity and specificity to detect neuropathy at an early ***:Through a literature search we identified five alternative devices that appeared user-friendly,more affordable,portable and/or battery-operated:the Neuropad^(■),Vibratip^(TM),NC-Stat^(■)DPNCheck^(TM),NeuroQuick and the Thermal Sensibility Tester(TST),assessing respectively sweat function,vibration sensation,nerve conduction,cold sensation and warm *** leprosy patients in Bangladesh,the posterior tibial and sural nerves that tested normal for the monofilament test and voluntary muscle test were assessed with the NCS and WDT as reference standard *** alternative devices were then tested on 94 nerves with abnormal WDT and/or NCS results and on 94 unaffected *** and specificity were the main ***:The NeuroQuick and the TST showed very good sensitivity and *** the sural nerve,the NeuroQuick had both a sensitivity and a specificity of 86%.The TST had a sensitivity of 83%and a specificity of 82%.Both the NC-Stat^(■)DPNCheck^(TM)and Vibratip^(TM)had a high specificity(88%and 100%),but a low sensitivity(16%and 0%).On the posterior tibial nerve,the NeuroQuick and the TST also showed good sensitivity,but the sensitivity was lower than for the sural *** Neuropad^(■)had a sensitivity of 56%and a specificity of 61%.Conclusions:The NeuroQuick and TST are good candidates for further field-testing for reliability and *** feasibility of production on a larger scale should be exami

关键词： Leprosy Neuropathy Detection Subclinical Field use

A physically active lifestyle is related to a lower level of skin autofluorescence in a large population with chronic-disease(LifeLines cohort)

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Journal of Sport and Health Science 2022年第2期11卷 260-265页

作者： Saskia Corine van de Zande Jeroen Klaas de Vries inge van den Akker-Scheek Johannes Zwerver Andries jan Smit Department of Internal Medicine Division of Vascular MedicineUniversity of GroningenUniversity Medical Center GroningenGroningen9700 RBthe Netherlands Department of Internal Medicine Antonius Hospital SneekSneek8601 ZKthe Netherlands Department of Orthopaedics University of GroningenUniversity Medical Center GroningenGroningen9700 RBthe Netherlands Center for Human Movement Sciences University of GroningenUniversity Medical Center GroningenGroningen9700 RBthe Netherlands Sports Valley Gelderse Vallei HospitalEde6716 RPthe Netherlands

Background:Physical activity(PA)has substantial health benefits and is important in combatting chronic diseases,which have been associated with elevated levels of advanced glycation endproducts(AGEs).AGEs play a role in the aging process,and an association between PA and AGEs has been *** aimed to investigate the relationship between PA and AGE accumulation in a general population and in a population with chronic ***:This large cross-sectional population study used data from adult participants in the LifeLines project,with participant information drawn from the LifeLines database as well data from patients with diabetes mellitus or renal and/or cardiovascular *** AGE accumulation was assessed non-invasively by skin-autofluorescence(SAF)using an AGE reader(DiagnOptics Technologies BV,Groningen,the Netherlands).PA was assessed using the short questionnaire to assess health-enhancing physical activity(SQUASH).Multivariate linear regression analyses were adjusted for age,body mass index,sex,and smoking ***:Data from 63,452 participants(general population n=59,177,chronic disease n=4275)were *** general population was significantly younger(43.58±11.77 years,mean±SD)and had significantly lower SAF(1.90±0.42 arbitrary units(AU))compared to the population with chronic disease(age:55.51±12.07 years;SAF:2.27±0.51 AU).In the group with chronic disease,more hours of moderate to vigorous physical activities per week were associated with lower SAF(β=-0.002,95%confidence interval(95%CI):-0.002 to-0.001).For the general population,there was no association between hours of moderate to vigorous activity and SAF(β=3.2×10^(-5),95%CI:0.000-0.001,p=0.742).However,there was an association in the general population between total hours of PA per week and SAF(β=4.2×10^(-4),95%CI:0.000-0.001,p<0.001),but this association was not found in the chronic disease population(β=-3.2×10^(-4),95%CI:-0.001 to 0.000,p=0.347).Conclusion:Our study demons

关键词： Advanced glycation endproducts Chronic disease population General population Physical activity Skin autofluorescence

Changing insights in the diagnosis and classification of autosomal recessive and dominant von Willebrand diseases 1980-2015

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World Journal of Hematology 2016年第3期5卷 61-74页

作者： jan Jacques Michiels Angelika Batorova Tatiana Prigancova Petr Smejkal Miroslav Penka inge Vangenechten Alain Gadisseur Goodheart Institute and Foundation in Nature Medicine and Health Blood Coagulation and Vascular Medicine Research Center Blood Coagulation Research Laboratory University Hospital Antwerp National Hemophilia Center Department of Hematology and Blood TransfusionFaculty of Medicine of Comenius University University Hospital Department of Clinical Hematology University Hospital and Department of Laboratory Methods Faculty of Medicine Masaryk University Hemostasis Research Unit Antwerp University Hospital

The European Clinical Laboratory and Molecular(ECLM) criteria define 10 distinct Willebrand diseases(VWD) recessive type 3, severe 1, 2C and 2N; dominant VWD type 1 secretion/clearance defect, 2A, 2B, 2E, 2M and 2D; and mild type 1 VWD(usually carriers of recessive VWD). Recessive severe 1 and 2C VWD are characterized by secretion and multimerization defects caused by mutations in the D1-D2 domain. Recessive 2N VWD is a mild hemophilia due to D'-FVIII-von Willebrand factor(VWF) binding site mutations. Dominant 2E VWD caused by heterozygous missense mutations in the D3 domain is featured by a secretion-clearancemultimerization VWF defect. Dominant VWD type 2M due to loss of function mutations in the A1 domain is characterized by decreased ristocetin-induced platelet aggregation and VWF RCo, normal VWF multimers and VWF CB, a poor response of VWF RCo and good response of VWF CB to desmopressin(DDAVP). Dominant VWD type 2A induced by heterozygous mutations in the A2 domain results in hypersensitivity of VWF for proteolysis by ADAMTS13 into VWF degradationproducts, resulting in loss of large VWF multimers with triplet structure of each individual VWF band. Dominant VWD type 2B due to a gain of function mutation in the A1 domain is featured by spontaneous interaction between platelet glycoprotein Ib(GPIb) and mutated VWF A1 followed by increased proteolysis with loss of large VWF multimers and presence of each VWF band. A new category of dominant VWD type 1 secretion or clearance defect due to mutations in the D3 domain or D4-C1-C5 domains consists of two groups Those with normal or smeary pattern of VWF multimers.

关键词： Von Willebrand disease Von Willebrand factor ADAMTS13 DDAVP Von Willebrand factor assays Von Willebrand gene mutations

曲古抑菌素A对外周血自然杀伤细胞活性和功能的影响

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山东大学学报（医学版） 2009年第8期47卷 50-54页

作者：王向玲纪春岩 Magnus Nordenskjld jan-inge Henter 郑成云山东大学齐鲁医院血研室济南250012 瑞典卡罗林斯卡大学医院临床分子医学中心斯德哥尔摩17176 瑞典卡罗林斯卡大学医院小儿癌症研究中心斯德哥尔摩17176 山东大学第二医院血液科济南250033

目的探讨曲古抑菌素A(TSA)对正常人外周血自然杀伤细胞(NK)活性和功能的影响。方法从正常人外周血单个核细胞(PBMCs)分离淋巴细胞(PBLs)(主要包括T细胞和NK细胞)或纯化NK细胞。体外应用白介素-2(IL-2)诱导PBLs 72 h产生淋巴因子激活的杀... 详细信息

目的探讨曲古抑菌素A(TSA)对正常人外周血自然杀伤细胞(NK)活性和功能的影响。方法从正常人外周血单个核细胞(PBMCs)分离淋巴细胞(PBLs)(主要包括T细胞和NK细胞)或纯化NK细胞。体外应用白介素-2(IL-2)诱导PBLs 72 h产生淋巴因子激活的杀伤(LAK)细胞。将PBLs,LAK或NK细胞进行体外培养,给予不同浓度的TSA处理122、44、8 h。流式细胞术检测NK细胞和T细胞的凋亡;采用51Cr释放试验检测NK细胞的杀伤功能。结果TSA以剂量和时间依赖方式诱导PBLs和LAK细胞凋亡,TSA处理组淋巴细胞及LAK细胞凋亡百分率明显高于对照组(P<0.05);TSA同样可诱导静止期NK细胞的凋亡,0.1μmol/L TSA作用于NK细胞24 h后,36%NK细胞凋亡,显著高于未处理组(P<0.05);0.1μmol/L TSA作用于NK细胞12 h后,其杀伤白血病细胞的能力明显低于对照组(P<0.01)。结论TSA能够诱导人外周血静止期NK细胞及LAK细胞发生凋亡,并影响NK细胞的细胞毒作用。

关键词：组蛋白去乙酰化酶抑制剂自然杀伤细胞凋亡细胞毒作用

重症禽流感病毒A(H_5N_1)感染的细胞毒疗法

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中国处方药 2006年第11期5卷 41-43页

作者： jan-inge Henter Chun-Bong Chow Chi-Wai Leung Yu-Lung Lau 于丽

据文献报道,禽流感病毒AH5N1亚型感染的死亡率仍然很高,现在WHO报道的数据是大约50%。事后分析发现,感染患者的噬血细胞现象与噬血细胞性淋巴组织增生症(HLH)患者相似。这种噬血细胞现象可能是H5N1感染后的一个显著特征。在临床表现方面... 详细信息

据文献报道,禽流感病毒AH5N1亚型感染的死亡率仍然很高,现在WHO报道的数据是大约50%。事后分析发现,感染患者的噬血细胞现象与噬血细胞性淋巴组织增生症(HLH)患者相似。这种噬血细胞现象可能是H5N1感染后的一个显著特征。在临床表现方面,H5N1感染与HLH也有相似,比如血细胞减少以及急性脑炎。据报道,其他重症病毒感染且有可能并发继发性HLH、重症EB病毒相关噬血细胞性淋巴组织增生症(Epstein-Barrvirus-associatedhemophagocyticlymphohistiocytosis,EBV-H的LH)患者,若早期即开始给予特异性的HLH治疗(包括细胞毒药物和促进凋亡的药物),存活率会由50%升至90%。由于生存率有如此明显的升高,特异性的HLH治疗(包括细胞毒药物治疗)可被作为重症禽流感病毒A感染并发继发性HLH患者的治疗方法。

关键词： A(H5N1) 细胞毒药物感染患者禽流感病毒重症流感病毒A感染噬血细胞性组织增生症

曲古抑菌素A对外周血自然杀伤细胞的活性和功能影响的研究

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曲古抑菌素A对外周血自然杀伤细胞的活性和功能影响的研究