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COG1-A master transcription factor regulating photosynthesis

Molecular Plant 2023年第12期16卷 1890-1892页

作者： jan ferdinand penzler Tatjana Kleine Dario Leister Plant Molecular Biology Faculty of BiologyLudwig-Maximilians-University(LMU)MunichMartinsried-Planegg82152 MunichGermany

COG1 CANENHANCE PHOTOSYNTHESIS AND PLANT GROWTH Recently,Wei et al.(2023)report that overexpression or a gain-offunction mutation of COGWHEEL1(COG1)gene,which encodes a transcription factor belonging to the DNA binding with one finger(Dof)protein family,can increase growth and biomass in Arabidopsis thaliana.Similarly,overexpression of any of its six paralogs,CYCLING DOF FACTORS 1-6,also leads to increased growth and biomass production,implying that these seven Dof proteins have partially redundant functions.Accordingly,several of the seven Dof genes must be knocked out to significantly reduce growth and biomass production;the septuple mutants show severely reduced growth but are still viable.COG1 positively modulates the accumulation of transcripts of several photosynthetic genes and,in turn,the corresponding proteins and binds to the promoters of most LHC genes.Changes in gene expression related to photosynthesis increase the efficiency of photosynthesis.Overexpression of two closely related Brassica rapa COG1 homologs in A.thaliana or Arabidopsis COG1 in Nicotiana benthamiana,could cause an increase in growth and biomass production.These results indicate that the effects of COG1 are not confined to a specific species.

关键词： species. functions. Arabidopsis

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Intrahepatic cholestasis without jaundice

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Hepatobiliary & Pancreatic Diseases International 2009年第1期8卷 103-105页

作者： Thomas Namdar Andreas Raffel Stefan Andreas Topp jan Schulte am Esch Günther Fürst Wolfram Trudo Knoefel Claus ferdinand Eisenberger Department of General Visceral and Pediatric Surgery Heinrich-Heine University Institute of Diagnostic Radiology Heinrich-Heine University

BACKGROUND:Cholangiocarcinoma(CC),the most common biliary tract malignancy,is frequently seen in advanced unresectable stages and is typically localized extrahepatically.Early diagnosis is unusual because of nonspecific symptoms.Painless jaundice is usually the first sign of tumor. METHOD:We present a patient with a CC(Klatskin tumor) with a complete biliary drainage by an aberrant bile duct without jaundice. RESULTS:A 67-year-old woman presented with persisting elevation of liver parameters.Diagnostic tests showed a Klatskin tumor typeⅡ.A curative right hepatic trisegmentectomy was performed after liver volume augmentation by preoperative vein embolization. CONCLUSIONS:A direct drainage of the right posterior bile duct into the common bile duct as an aberrant hepatic duct is a rare variation and is present in less than 5%of the population.In case of persistently perturbed liver function tests,an aberrant bile duct can cover up severe intrahepatic cholestasis and even obscure the diagnosis of a Klatskin tumor.Up to now it has not been described in the literature.

关键词： Klatskin tumor hyperbilirubinemia cholangiocarcinoma

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Current-induced degradation and lifetime prediction of 310 nm ultraviolet light-emitting diodes

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Photonics Research 2019年第7期7卷 14-18页

作者： jan Ruschel Johannes Glaab Batoul Beidoun Neysha Lobo Ploch Jens Rass Tim Kolbe Arne Knauer Markus Weyers Sven Einfeldt Michael Kneissl ferdinand-Braun-Institut Leibniz-Institut fur HochstfrequenztechnikGustav-Kirchhoff-Str.412489 BerlinGermany Technische Universitat Berlin Institut fur FestkorperphysikHardenbergstr.36EW6-710623 BerlinGermany

The impact of operation current on the degradation behavior of 310 nm UV LEDs is investigated over 1000 h of stress. It ranges from 50 to 300 mA and corresponds to current densities from 34 to 201 A/cm^2.To separate the impact of current from that of temperature, the junction temperature is kept constant by adjusting the heat sink temperature. Higher current was found to strongly accelerate the optical power reduction during operation. A mathematical model for lifetime prediction is introduced.It indicates that lifetime is inversely proportional to the cube of the current density, suggesting the involvement of Auger recombinati on.

关键词： degradation light-emitting diodes lifetime

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