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Enhanced diagnostic workup increases pathological findings in patients with acute ischaemic stroke:results of the prospective HEBRAS study

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Stroke & Vascular Neurology 2024年第2期9卷 145-152,I0414-I0425页

作者： Simon Hellwig Thomas Krause jan f scheitz Juliane Herm Ulrike Grittner Nadja Jauert Jochen B fiebach Mario Kasner Wolfram Doehner Matthias Endres Rolf Wachter Thomas Elgeti Christian H Nolte Karl Georg Haeusler Department of Neurology with Experimental Neurology Charité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt-Universität zu BerlinBerlinGermany Center for Stroke Research Berlin BerlinGermany Berlin Institute of Health at Charité–Universitätsmedizin Berlin BIH Biomedical Innovation AcademyBerlinGermany Department of Neurology Jüdisches Krankenhaus BerlinBerlinGermany German Center for Cardiovascular Diseases(DZHK) Partner Site BerlinBerlinGermany Institute of Biometry and Clinical Epidemiology Charité-Universitätsmedizin BerlinBerlinGermany BIH Center for Regenerative Therapies(BCRT) Berlin Institute of Health at Charité–Universitätsmedizin BerlinBerlinGermany Department of Cardiology Charité-Universitätsmedizin BerlinBerlinGermany Department of Cardiology Campus Benjamin FranklinCharité-Universitätsmedizin BerlinBerlinGermany German Center for Neurodegenerative Diseases(DZNE) Partner Site BerlinBerlinGermany Department of Cardiology University Hospital LeipzigLeipzigGermany Department of Radiology Charité-Universitätsmedizin BerlinBerlinGermany Department of Neurology University Hospital WürzburgWürzburgGermany

Background Stroke aetiology remains cryptogenic in a relevant proportion of patients with acute ischaemic stroke(AIS).We assessed whether enhanced diagnostic workup after AIS yields a higher rate of prespecified pathological findings compared with routine diagnostic care *** Hospitalised patients with AIS were prospectively enrolled in the investigator-initiated observational HEart and BRain Interfaces in Acute Ischaemic Stroke(HEBRAS)study at the Charité,Berlin,*** with AIS without known atrial fibrillation(Af)underwent cardiovascular MR imaging(CMR),MR-angiography of the aortic arch and prolonged Holter-ECG monitoring on top of routine diagnostic *** Among 356 patients with AIS(mean age 66 years,37.6%female),enhanced workup yielded a higher rate of prespecified pathological findings compared with routine care(17.7%vs 5.3%;pfewer patients were classified as cryptogenic after enhanced diagnostic workup(38.5%vs 45.5%,pfully performed in 292(82.0%)patients and revealed more often a prespecified pathological finding compared with routine echocardiography(16.1%vs 5.3%).furthermore,study-related ECG monitoring(median duration 162 hours(IQR 98–210))detected Af in 16(4.5%)patients,while routine monitoring(median duration 51 hours(IQR 34–74))detected Af in seven(2.0%)*** Enhanced diagnostic workup revealed a higher rate of prespecified pathological findings in patients with AIS compared with routine diagnostic care and significantly reduced the proportion of patients with cryptogenic *** registration number NCT02142413.

关键词： routine patients prospective

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Are you suffering from a large arterial occlusion?Please raise your arm!

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Stroke & Vascular Neurology 2018年第4期3卷 215-221页

作者： Charith Cooray Michael V Mazya Matteo Bottai jan f scheitz Azmil H Abdul-Rahim Tiago Prazeres Moreira Robert Mikulik Antonin Krajina Miroslava Nevsimalova Danilo Toni Nils Wahlgren Niaz Ahmed Department of Clinical Neurosciences Karolinska InstitutetStockholmSweden Department of Neurology Karolinska University HospitalStockholmSweden Unit of Biostatistics Institute of Environmental MedicineKarolinska InstitutetStockholmSweden Center for Stroke Research Berlin and Department of Neurology Charité-Universitätsmedizin BerlinBerlinGermany Stroke Research Institute of Cardiovascular and Medical SciencesUniversity of GlasgowGlasgowUK International Clinical Research Center and Neurology Department St.Anne's University Hospital in Brno and Masaryk UniversityBrnoCzech Republic Department of Radiology University HospitalHradec KraloveCzech Republic Comprehensive Cerebrovascular Center HospitalČeskéBudějoviceCeske BudejoviceCzech Republic Emergency Department Stroke Unit Department of Neurology and PsychiatryHospital Policlinico Umberto I'Sapienza'UniversityRomeItaly

Background and purpose Triage tools to identify candidates for thrombectomy are of utmost importance in acute *** prognostic tool has yet gained any widespread *** compared the predictive value of various models based on National Institutes of Health Stroke Scale(NIHSS)subitems,ranging from simple to more complex models,for predicting large artery occlusion(LAO)in anterior circulation *** Patients registered in the SITS international Stroke Register with available NIHSS and radiological arterial occlusion data were *** compared 2042 patients harbouring an LAO with 2881 patients having no/distal *** binary logistic regression,we developed models ranging from simple 1 NIHSS-subitem to full NIHSS-subitems *** and specificities of the models for predicting LAO were *** The model with highest predictive value included all NIHSS subitems for predicting LAO(area under the curve(AUC)0.77),yielding a sensitivity and specificity of 69%and 76%,*** second most predictive model(AUC 0.76)included 4-NIHSS-subitems(level of consciousness commands,gaze,facial and arm motor function)yielding a sensitivity and specificity of 67%and 75%,*** simplest model included only deficits in arm motor-function(AUC 0.72)for predicting LAO,yielding a sensitivity and specificity of 67%and 72%,*** Although increasingly more complex models yield a higher discriminative performance for predicting LAO,differences between models are not *** grade of arm dysfunction along with an established stroke-diagnosis model may serve as a surrogate measure of arterial occlusion-status,thereby assisting in triage decisions.

关键词： occlusion specificity diagnosis

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Influence of a non-rotating shoulder on heat generation,microstructure and mechanical properties of dissimilar AA2024/AA7050 fSW joints

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Journal of Materials Science & Technology 2018年第1期34卷 119-127页

作者： Alessandro Barbini jan Carstensen Jorge f.dos Santos Helmholtz-Zentrum Geesthacht Institute of Materials Research Materials Mechanics Solid-State Joining Processes (WMP)

friction stir welding （fSW） and stationary shoulder friction stir welding （SSfSW） were carried out for the butt joining of dissimilar AA2024-T3 and AA7050-T7651 aluminium alloys with thicknesses of 2 mm. A comparison between the two processes was performed by varying the welding speed while keeping the rotational speed constant, Through the analysis of the force and torque produced during welding and a simple analytical model, it was possible to show that in SSfSW there is more effective coupling with the tool and the heat produced is more efficiently distributed. This process decreases both the welding area and the diffusion at the interface of the two alloys compared with fSW. The minimum microhardness occurred at the advancing side （AS） at the interface between the thermo-mechanically affected zone （TMAZ） and the stir zone （SZ） in both processes, although the decrease was more gradual in SSfSW. This interface is also where all specimens failed for both welding technologies. An increase in tensile strength was measured in SSfSW compared with standard fSW. furthermore, it was possible to establish the mechanical performance of the material in the fracture zone using digital image correlation.

关键词： Stationary shoulder friction stir welding friction stir welding Dissimilar welded joints Process analysis Microstructure analysis Mechanical behaviour

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Halogen versus halide electronic structure

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Science China Chemistry 2010年第1期53卷 210-215页

作者： Willem-jan van Zeist f.Matthias Bickelhaupt Department of Theoretical Chemistry and Amsterdam Center for Multiscale Modeling Scheikundig Laboratorium der Vrije UniversiteitDe Boelelaan 1083NL-1081 HV AmsterdamThe Netherlands

Halide anions X-are known to show a decreasing proton affinity(PA),as X descends in the periodic table along series f,Cl,Br and *** it is also well-known that,along this series,the halogen atom X becomes less electronegative(or more electropositive).This corresponds to an increasing energy of the valence np atomic orbital(AO) which,somewhat contradictorily,suggests that the electron donor capability and thus the PA of the halides should increase along the series f,Cl,Br,*** reconcile these contradictory observations,we have carried out a detailed theoretical analysis of the electronic structure and bonding capability of the halide anions X-as well as the halogen radicals X-,using the molecular orbital(MO) models contained in Kohn-Sham density functional theory(DfT,at SAOP/TZ2P as well as OLYP/TZ2P levels) and ab initio theory(at the Hf/TZ2P level).We also resolve an apparent intrinsic contradiction in Hartree-fock theory between orbital-energy and PA *** results of our analyses are of direct relevance for understanding elementary organic reactions such as nucleophilic substitution(SN2) and base-induced elimination(E2) reactions.

关键词： bond theory halogen hydrogen-atom affinity orbital energy proton affinity reactivity

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Comparative Study of Plasma Parameters in Magnetic Pole Enhanced Inductively Coupled Argon Plasmas

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Plasma Science and Technology 2013年第4期15卷 329-334页

作者： f.jan A.W. KHAN A.SAEED M.ZAKAULLAH Department of Physics Quaid-i-Azam University Department of Physics Gomal University

Langmuir probe measurements of radio frequency （Rf） magnetic pole enhanced inductively coupled （MaPE-ICP） argon plasma were accomplished to obtain the electron number densities and electron temperatures. The measurements were carried out with a fixed Rf frequency of 13.56 MHz in a pressure range of 7.5 mTorr to 75 mTorr at an applied Rf power of 10 W and 100 W. These results are compared with a global （volume average） model. The results show good agreement between theoretical and experimental measurements. The electron number density shows an increasing trend with both Rf power and pressure while the electron temperature shows decreasing trend as the pressure increases. The difference in the plasma potentiM and floating potential as a function of electron temperature measured from the electrical probe and that obtained theoretically shows a linear relation with a small difference in the coefficient of proportionality. The intensity of the emission line at 750.4 nm due to 2pl → 1s2 （Paschen＇s notation） transition closely follows the variation of ne with Rf power and filling gas pressure. Measured electron energy probability function （EEPf） shows that electron occupation changes mostly in the high-energy tail, which highlights close similarity of 750.4 nm argon line to he.

关键词： MaPE-ICP Langmuir probe global model

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Intestinal barrier in inflammatory bowel disease

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World Journal of Gastroenterology 2014年第5期20卷 1165-1179页

作者： Lena Antoni Sabine Nuding jan Wehkamp Eduard f Stange Margarete fischer-Bosch-Institute of Clinical Pharmacology Stuttgart University of Tübingen Eduard f Stange Department of Internal Medicine I Robert-Bosch-Hospital

A complex mucosal barrier protects as the first line of defense the surface of the healthy intestinal tract from adhesion and invasion by luminal microorganisms. In this review, we provide an overview about the major components of this protective system as for example an intact epithelium, the synthesis of various antimicrobial peptides (AMPs) and the formation of the mucus layer. We highlight the crucial importance of their correct functioning for the maintenance of a proper intestinal function and the prevention of dysbiosis and disease. Barrier disturbances including a defective production of AMPs, alterations in thickness or composition of the intestinal mucus layer, alterations of pattern-recognition receptors, defects in the process of autophagy as well as unresolved endoplasmic reticulum stress result in an inadequate host protection and are thought to play a crucial role in the pathogenesis of the inflammatory bowel diseases Crohn’s disease and ulcerative colitis.

关键词： Intestinal barrier, Antimicrobial peptide, Mucus layer, Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Goblet cell, Paneth cell

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Experimental results of the tribology of aluminum measured with a pin-on-disk tribometer: Testing configuration and additive effects

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friction 2016年第2期4卷 124-134页

作者： S.M.H.AHMER L.S.jan M.A.SIDDIG S.f.ABDULLAH Department of Physics GS Faculty Yanbu University College Yanbu al Sinayiah 41912 Kingdom of Saudi Arabia Department of Physics Faculty of Science and Technology al Neelain University Khartoum 11111 Sudan Mechanical Engineering Department UNITEN Kajang 43009 Malaysia

The friction coefficient, wear rate, and wear coefficient of the aluminum metal surface were measured at room temperature ( approximately 300 K) with a pin-on-disk machine at a fixed load of 196.2 N. Two different testing configurations were adopted: (1) aluminum pin vs. Helix oil-on-steel disk (AHS) and (2) aluminum pin vs. 10% Polytron plus 90% helix oil-on-steel disk (APS). In the AHS configuration, the wear of the aluminum surface was found to be approximately 70 mu m; however, in the APS configuration the wear dropped to 20 mu m, revealing a marked decrement of one-third of the wear of aluminum. The volume wear rate of the metal in the unaided Helix oil was estimated to be 1.2810 super(-3) mm super(3)/min. The additive minimized the volume wear rate of the aluminum metal by orders of magnitude to 6.0810 super(-5) mm super(3)/min. Similarly, the wear coefficient of the aluminum pin, calculated in the AHS configuration, rendered a value of 1.2710 super(-10) m super(2)/N. In the APS configuration, the same parameter was 4.2210 super(-11) m super(2)/N, that is to say, an order of magnitude lower than the preceding value. The observed coefficient of friction for aluminum is 0.012 in Helix oil and falls to a remarkably lower value of 0.004 through the Polytron additive. The experimental findings demonstrate that Polytron additive substantially lessens the wear of the aluminum surface; in effect, the wear coefficient and the wear rate decline linearly. This singularity may be linked to the ability of Polytron to impregnate the crystal structure of the metal due to its ionic character and the consequent adherence to the metallic surface as a hard surface layer.

关键词： antiwear Polytron additive aluminum metal lubrication friction

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A Multi-match Approach to the Author Uncertainty Problem

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Journal of Data and Information Science 2019年第2期4卷 1-18页

作者： Stephen f.Carley Alan L.Porter jan L.Youtie Search Technology Inc Georgia Institute of Technology Enterprise Innovation Institute Georgia Institute of Technology

Purpose: The ability to identify the scholarship of individual authors is essential for performance evaluation. A number of factors hinder this endeavor. Common and similarly spelled surnames make it difficult to isolate the scholarship of individual authors indexed on large databases. Variations in name spelling of individual scholars further complicates matters. Common family names in scientific powerhouses like China make it problematic to distinguish between authors possessing ubiquitous and/or anglicized surnames(as well as the same or similar first names). The assignment of unique author identifiers provides a major step toward resolving these difficulties. We maintain, however, that in and of themselves, author identifiers are not sufficient to fully address the author uncertainty problem. In this study we build on the author identifier approach by considering commonalities in fielded data between authors containing the same surname and first initial of their first name. We illustrate our approach using three case ***/methodology/approach: The approach we advance in this study is based on commonalities among fielded data in search results. We cast a broad initial net—i.e., a Web of Science(WOS) search for a given author's last name, followed by a comma, followed by the first initial of his or her first name(e.g., a search for ‘John Doe' would assume the form: ‘Doe, J'). Results for this search typically contain all of the scholarship legitimately belonging to this author in the given database(i.e., all of his or her true positives), along with a large amount of noise, or scholarship not belonging to this author(i.e., a large number of false positives). from this corpus we proceed to iteratively weed out false positives and retain true positives. Author identifiers provide a good starting point—e.g., if ‘Doe, J' and ‘Doe, John' share the same author identifier, this would be sufficient for us to conclude these are one and the same individual. We fin

关键词： Name disambiguation Author identifiers Multi-match approach

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Improved patient reported outcomes with functional articulating spacers in two-stage revision of the infected hip

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World Journal of Orthopedics 2020年第12期11卷 595-605页

作者： Ewout S Veltman Dirk jan f Moojen Rudolf W Poolman Department of Orthopaedic and Trauma Surgery OLVGAmsterdam 1091ACNetherlands Orthopaedic and Trauma Surgery OLVGAmsterdam 1091ACNetherlands Department of Orthopaedic Surgery and Joint Research OLVGAmsterdam 1091ACNetherlands

BACKGROUND Two-stage revision arthroplasty with an antibiotic-loaded spacer is the treatment of choice in chronically infected total hip *** spacers can be functional articulating or *** results of these spacers have scarcely been *** To compare retrospectively the patient reported outcome and infection eradication rate after two-stage revision arthroplasty of the hip with the use of a functional articulating or prefabricated *** All patients with two-stage revision of a hip prosthesis at our hospital between 2003 and 2016 were included in this retrospective cohort *** were divided into two groups;patients treated with a functional articulating spacer or with a prefabricated *** completed the Hip Osteoarthritis Outcome Score and the EQ-5D-3L(EQ-5D)and the EQ-5D quality of life thermometer(EQVAS)*** outcomes were patient reported outcome and infection eradication after two-stage *** results of both groups were compared to the patient acceptable symptom state for primary arthroplasty of the *** outcomes were complications during spacer treatment and at final *** statistics,mean and range are used to represent the demographics of the *** numerical variables,students’t-tests were used to assess the level of significance for differences between the groups,with 95%confidence intervals;for binary outcome,we used fisher’s exact *** We consecutively treated 55 patients with a prefabricated spacer and 15 patients with a functional articulating spacer of the *** infection eradication rates for functional articulating and prefabricated spacers were 93%and 78%,respectively(P>0.05).With respect to the functional outcome,the Hip Osteoarthritis Outcome Score(HOOS)and its subscores(all Pficantly better for patients successfully treated with a functional articulating

关键词： Two-stage revision Periprosthetic joint infection Hip arthroplasty functional articulating spacer Prefabricated spacer Patient reported outcome

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Cavitation and grain boundary sliding during creep of Mg-Y-Nd-Zn-Mn alloy

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中国有色金属学会会刊：英文版 2008年第A01期18卷 64-68页

作者： V.janíK f.HNILICA P.ZUNA V.OENEK I.STULíKOV Department of Materials Engineering Faculty of Mechanical EngineeringCzech Technical University in PraguePragueCzech Republic Research Institute for Metals Panenské BrezanyCzech Republic faculty of Mathematics and Physics Charles UniversityPragueCzech Republic

Creep of squeeze-cast Mg-3Y-2Nd-1Zn-1Mn alloy was investigated at the constant load in the stress range of 30-80 MPa. Tensile creep tests were performed at 300℃up to the final *** tests at 50 MPa were interrupted after reaching the steady state creep;and another set of creep tests was interrupted after the onset of ternary *** of cavitated dendritic boundaries was evaluated using optical *** of grain boundary sliding by observation of the offset of marker lines was carried out on the surface of the crept specimens after the test interruption by scanning electron microscopy and by confocal laser scanning *** results show that the dominant creep mechanism in this alloy is dislocation creep with minor contribution of the grain boundary *** failure took place by the nucleation,growth and coalescence of creep cavities on the boundaries predominantly oriented perpendicular to the applied *** amount of cavitated boundaries with time of creep exposure supports the mechanism of continuous cavity nucleation and growth.

关键词：镁合金锌合金锰合金高温测试

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