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Carcinoid tumor of the duodenum and accessory papilla associated with polycythemia vera

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World Journal of Gastroenterology 2005年第24期11卷 3794-3796页

作者： Horng-Yuan Wang Ming-Jen chen Tsen-Long Yang Ming-Chih Chang Yu-jan Chan Division of Gastroenterology Department of Surgery Division of Hematology Department of Pathology

Carcinoid tumors have been reported in a wide range of organs but most frequently involve the gastrointestinal tract; however, duodenal carcinoid tumors are rare. We report a 50-year-old male patient complaining of multiple melenas for 3 wk. The panendoscopy and endoscopic retrograde cholangiopancreaticography revealed swelling accessory papilla with an ulcer. The biopsy taken showed a carcinoid tumor. The lesion was removed by wide resection. Patient was found to have an abnormal blood cell count during the follow-up period with elevated levels of hemoglobin and hematocrit of 21.2 g/dL and 63.5%,respectively, thrombocytosis of 501 000/μL, and leukocytosis of 20 410/μL. He was diagnosed as a polycythemia vera by a hematologist after further evaluation. He received periodic phlebotomy and hydroxyurea treatment. The response was good and his hematocrit was stabilized by periodic phlebotomy in the range of 44-49% during the last 2 years. The possible origin of UGI bleeding by a duodenal carcinoid tumor, although rare, should be considered. There has been one case report of a duodenal carcinoid tumor that involved accessory papilla of the pancreas divisum and one case report of metastatic carcinoid tumor associated with polycythemia vera. It is different in our patient as compared with the latter report, which mentioned a polycythemia vera patient who was found to have a metastatic carcinoid in the 17 years follow-up period. Chemotherapy had been given before the carcinoid tumor was revealed. Our patient had no previous chemotherapy for polycythemia vera before he was found to have duodenal carcinoid tumor; this excludes the possibility of chemotherapy induced carcinoid tumor, although it had been suspected in the previous report. In our patient, the existence of both diseases may be by predisposition of each other since both diseases have an increased incidence of other neoplasm, or they may be coexistent incidentally.

关键词： Carcinoid tumor Accessory papilla Polycythemia vera

Necrotic stercoral colitis:Importance of computed tomography findings

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World Journal of Gastroenterology 2011年第3期17卷 379-384页

作者： cheng-Hsien Wu Li-Jen Wang Yon-Cheong Wong chen-Chih Huang Chien-cheng chen Chao-jan Wang Jen-Feng Fang Chuen Hsueh Division of Emergency and Critical Care Radiology Department of Medical Imaging and InterventionChang Gung Memorial Hospital Division of Trauma and Emergency Department of SurgeryChang Gung Memorial Hospital Chang Gung University Department of Pathology Chang Gung Memorial HospitalChang Gung University

AIM: To study the computed tomography (CT) signs in facilitating early diagnosis of necrotic stercoral colitis (NSC). METHODS: Ten patients with surgically and pathologically confirmed NSC were recruited from the Clinico-Pathologic-Radiologic conference at Chang Gung Memorial Hospital, Taoyuan, Taiwan. Their CT images and medical records were reviewed retrospectively to correlate CT findings with clinical presentation. RESULTS: All these ten elderly patients with a mean age of 77.1 years presented with acute abdomen at our Emergency Room. Nine of them were with systemic medical disease and 8 with chronic constipation. Seven were with leukocytosis, two with low-grade fever, two with peritoneal sign, and three with hypotensive shock. Only one patient was with radiographic detected abnormal gas. Except the crux of fecal impaction, the frequency of the CT signs of NSC were, proximal colon dilatation (20%), colon wall thickening (60%), dense mucosa (62.5%), mucosal sloughing (10%), perfusion defect (70%), pericolonic stranding (80%), abnormal gas (50%) with pneumo-mesocolon (40%) in them, pericolonic abscess (20%). The most sensitive signs in decreasing order were pericolonic stranding, perfusion defect, dense mucosal, detecting about 80%, 70%, and 62.5% of the cases, respectively. CONCLUSION: Awareness of NSC and familiarity with the CT diagnostic signs enable the differential diagnosis between NSC and benign stool impaction.

关键词： Fecal impaction Dense mucosa Pericolonic stranding Stercoral colitis Computed tomography

Zebrafish hhex-null mutant develops an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1

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Journal of Molecular Cell Biology 2019年第6期11卷 448-462页

作者： Ce Gao Weidong Huang Yuqi Gao Li jan Lo Lingfei Luo Honghui Huang Jun chen Jinrong Peng MOE Key Laboratory for Molecular Animal Nutrition College of Animal Sciences Zhejiang University 866 Yu Hang Tang Road Hangzhou 310058 China College of Life Sciences Southwest University Chongqing 400715 China College of Life Sciences Zhejiang University 866 Yu Hang Tang Road Hangzhou 310058 China

The hepatopancreatic duct (HPD) system links the liver and pancreas to the intestinal tube and is composed of the extrahepatic biliary duct, gallbladder, and pancreatic duct. Haematopoietically expressed-homeobox (Hhex) protein plays an essential role in the establishment of HPD;however, the molecular mechanism remains elusive. Here, we show that zebrafish hhex-null mutants fail to develop the HPD system characterized by lacking the biliary marker Annexin A4 and the HPD marker sox9b. The hepatobiliary duct part of the mutant HPD system is replaced by an intrahepatic intestinal tube characterized by expressing the intestinal marker fatty acid-binding protein 2a (fabp2a). Cell lineage analysis showed that this intrahepatic intestinal tube is not originated from hepatocytes or cholangiocytes. Further analysis revealed that cdx1b and pdx1 are expressed ectopically in the intrahepatic intestinal tube and knockdown of cdx1b and pdx1 could restore the expression of sox9b in the mutant. Chromatin-immunoprecipitation analysis showed that Hhex binds to the promoters of pdx1 and cdx1b genes to repress their expression. We therefore propose that Hhex, Cdx1b, Pdx1, and Sox9b form a genetic network governing the patterning and morphogenesis of the HPD and digestive tract systems in zebrafish.

关键词： liver development hepatopancreatic duct (HPD) hhex pdx1 cdxlb

Cross-sectional associations of dietary habits with asthma and wheeze in childhood:confounding for avoidance behaviors

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Science Bulletin 2015年第23期60卷 2080-2082页

作者： Wei Liu chen Huang Yu Hu Zhijun Zou Louise B.Weschler Li Shen jan Sundell Department of Building Environment and Energy Engineering School of Environment and Architecture University of Shanghai for Science and Technology Tongji Architectural Design (Group) Company Limited (TJAD) 161 Richdale Road Colts Neck NJ 07722 USA R&B Technology (Shanghai) Company Limited Department of Building Science Tsinghua University

The prevalence of childhood asthma has increased rapidly in China[1].In Shanghai,the prevalence has increased from 2.1%in 1990 to 10.2%in 2011 in 3-to 7-year-old children[2].Various environmental and lifestyle factors have been suspected of association with the increasing prevalence of asthma in childhood[3,4].Numerous studies have investigated possible associations between

关键词：儿童哮喘饮食习惯行为混杂协会患病率生活方式

Measuring a dynamical topological order parameter in quantum walks

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Light(Science & Applications) 2020年第1期9卷 1932-1942页

作者： Xiao-Ye Xu Qin-Qin Wang Markus Heyl jan Carl Budich Wei-Wei Pan Zhe chen Munsif jan Kai Sun Jin-Shi Xu Yong-Jian Han Chuan-Feng Li Guang-Can Guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Max-Planck-Institut fur Physik komplexer Systeme Nöthnitzer Straße 38D-01187 DresdenGermany Institute of Theoretical Physics Technische Universitat Dresden01062 DresdenGermany

Quantum processes of inherent dynamical nature,such as quantum walks,defy a description in terms of an equilibrium statistical physics *** now,identifying the general principles behind the underlying unitary quantum dynamics has remained a key ***,we show and experimentally observe that split-step quantum walks admit a characterization in terms of a dynamical topological order parameter(DTOP).This integer-quantized DTOP measures,at a given time,the winding of the geometric phase accumulated by the wavefunction during a quantum *** observe distinct dynamical regimes in our experimentally realized quantum walks,and each regime can be attributed to a qualitatively different temporal behavior of the *** identifying an equivalent manybody problem,we reveal an intriguing connection between the nonanalytic changes of the DTOP in quantum walks and the occurrence of dynamical quantum phase transitions.

关键词： quantum dynamical topological

Epidemiology of insertional and midportion Achilles tendinopathy in runners:A prospective cohort study

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Journal of Sport and Health Science 2024年第2期13卷 256-263页

作者： Wenbo chen Kyra L.A.Cloosterman Sita M.A.Bierma-Zeinstra Marienke van Middelkoop Robert-jan de Vos Department of Orthopaedic Surgery and Sports Medicine Erasmus MC University Medical CenterRotterdam 3015GDthe Netherlands Department of General Practice Erasmus MC University Medical CenterRotterdam 3015GDthe Netherlands Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China

Background:Achilles tendinopathy(AT)is a common problem among *** is only limited evidence for risk factors for AT,and most studies have not defined the AT *** study has compared the incidence and risk factors between insertional AT and midportion AT,though they are considered *** study aimed to assess incidence and risk factors of AT based on data from a large prospective *** secondary aim was to explore differences in risk factors between insertional and midportion ***:Participants were recruited from among registered runners at registration for running *** were completed at baseline,1 month before the event,1 week before the event,and 1 month after the *** concerning demographics,training load,registered events,and running-related injuries were collected at *** follow-up questionnaires collected information about new injuries.A pain map was used to diagnose midportion and insertional *** primary outcome was the incidence of *** logistic regression analysis was applied to identify risk factors for the ***:We included 3379 participants with a mean follow-up of 20.4 *** incidence of AT was 4.2%.The proportion of insertional AT was 27.7%and of midportion AT was 63.8%;the remaining proportion was a combined type of insertional and midportion *** had a significantly higher incidence(5%,95%confidence interval(95%CI):4.1%-6.0%)than women(2.8%,95%CI:2.0%-3.8%).AT in the past12 months was the most predominant risk factor for new-onset AT(odds ratio(OR)=6.47,95%CI:4.27-9.81).This was similar for both subcategories of AT(insertional:OR=5.45,95%CI:2.51-11.81;midportion:OR=6.96,95%CI:4.24-11.40).Participants registering for an event with a distance of 10/10.55 km were less likely to develop a new-onset AT(OR=0.59,95%CI:0.36-0.97)or midportion AT(OR=0.47,95%CI:0.23-0.93).Higher age had a significant negative association with insertional AT(OR=0.97,95%CI:0.9

关键词： Achilles tendon injury Incidence Risk factor Running-related injury

Solid-pseudopapillary tumor of the pancreas: Clinical experience and literature review

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World Journal of Gastroenterology 2005年第9期11卷 1403-1409页

作者： Hsueh-Lien Huang Shou-Chuan Shih Wen-Hsiung Chang Tsang-En Wang Ming-Jen chen Yu-jan Chan Division of Gastroenterology

AIM: To evaluate the clinical presentations of solidpseudopapillary tumor of the pancreas (SPT) and examine the diagnosis, treatment, low grade malignant potential of this rare ***: We retrospectively reviewed a series of seven patients with SPT managed in our hospital between July 1990 and October 2003. Six females and one male with mean age of 31 years (range 13 to 50 years) were diagnosed with SPT at our ***: Clinical presentation included a palpable abdominal mass in two patients and vague abdominal discomfort in another two. Two patients were asymptomatic;their tumors were found incidentally on abdominal sonographic examination for other reasons. The final patient was admitted with hemoperitoneum secondary to tumor rupture. The mean diameter of the tumors in the seven patients was 10.5 cm (range 5 to 20 cm). The lesions were located in the body and tail in five cases and in the head of the pancreas in two. Surgical procedures included distal pancreatectomy (3), distal pancreatectomy with splenectomy (2), pancreaticoduodenectomy (1) and a pylorus-preserving Whipple procedure (1). There were gross adhesions or histological evidence of infiltration to the adjacent pancreas and/or splenic capsule in four cases. None of the patients received adjuvant *** mean follow up was 7 years (range 0.5 to 14 years).One patient developed multiple liver metastases after 14 years of follow ***: SPT is a rare tumor that behaves less aggressively than other pancreatic tumor. However, in cases with local invasion, long-term follow up is advisable.

关键词： Solid-pseudopapillary tumor of the pancreas Distal pancreatectomy Pancreaticoduodenectomy

Interaction between Bms1 and Rcl1,two ribosome biogenesis factors,is evolutionally conserved in zebrafish and human

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Journal of Genetics and Genomics 2016年第7期43卷 467-469页

作者： Yong Wang Qinfang Zhu Ling Huang Yanqing Zhu Jun chen Jinrong Peng Li jan Lo MOE Key Laboratory for Molecular Animal -Nutrit-ion College of Animal Sciences Zhejiang University Hangzhou 310058 China College of Life Sciences Zhejiang University Hangzhou 310058 China

Ribosomes are large RNA and protein complexes that function as the machinery for translation protein synthesis （Boisvert et al., 2007; Ben-Shem et al., 2011： Henras et al., 2015： Kbatter et al., 2015; McCann et al., 2015）. The eukaryotic ribosome is composed of two subunits, the 60S large subunit （LSU） and the 40S small sub- unit （SSU）, which collectively comprise of four different ribosomal RNA （rRNA） species and more than 70 proteins （Ben-Sbem et al., 2011： Henras et al., 2015; Khatter et al., 2015）. The LSU contains the 28S, 5.8S and 5S rRNAs and the SSU contains the 18S rRNA. The assembly of each subunit is initiated in the nucleolus using the respective rRNAs as backbones （Ben-Shem et al., 2011; Henras et al., 2015; Khatter et al., 2015）.

关键词： ribosome evolutionally human

Hepatocytes in a normal adult liver are derived solely from the embryonic hepatocytes

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Journal of Genetics and Genomics 2018年第3期45卷 173-175页

作者： Ce Gao Zhihui Zhu Yuqi Gao Li jan Lo Jun chen Lingfei Luo Jinrong Peng College of Animal Sciences Zhejiang University College of Life Sciences Zhejiang University College of Life Sciences Southwest University

In vertebrates,body weight increases many folds as a consequence of body growth from the childhood to adulthood（e.g.,～20 folds for a mouse）.Considering the fact that the liver-to-body weight ratio（LBR）stays relatively constant within species（Weglarz and Sandgren,2000;Kan et al.,2009）,the cell number in a liver must therefore keep increasing along with the growth of an individual organism. For example, during the growth of the zebrafish from 5 days post-fertilization （dpf） to 1.5 years old, the number of liver cells increased -900 folds （Figs. 1A and S1 ）.

关键词： In Hepatocytes in a normal adult liver are derived solely from the embryonic hepatocytes ERT RSG