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Prognostic analysis of surgical treatment of peripheral cholangiocarcinoma: Two decades of experience at Chang Gung Memorial Hospital

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World Journal of Gastroenterology 2005年第12期11卷 1779-1784页

作者： Yi-Yin jan Chun-Nan Yeh Ta-Sen Yeh Tse-Ching chen Department of Surgery Department of Pathology

AIM: To analyze the prognostic factors influencing the overall survival of peripheral cholangiocarcinoma (PCC) patients undergoing surgical treatment during 25 years at a single institution. METHODS: This study retrospectively reviewed prospectively collecting data about 373 patients with historically proven PCC who underwent surgical treatment between 1977 and 2001. RESULTS: Three hundred and seventy-three PCC patients (159 men and 214 women) underwent surgical treatment from 1977 to 2001. Among them, 187 PCC patients underwent hepatectomy and 135 had curative resection (curative resectability rate: 36.2%). The follow-up duration ranged from 1.05 to 167.6 mo (mean/median = 14.1/7.2 mo). Overall cumulative survival rates at 1, 3, and 5 years were 32.5%, 9.2%, and 4.1%, respectively. Univariate log-rank analysis identified the following as adverse influences on overall survival: presence of symptoms, absence of mucobilia, elevated CEA and CA 19-9 levels, non-papillary tumor type, receiving non-hepatectomy, advanced tumor staging, lack of post-operative chemotherapy, and radiotherapy. Meanwhile, multivariate Cox's proportional hazard analysis demonstrated that absence of mucobilia, non-papillary tumor type, advanced tumor staging, non-hepatectomy, and lack of post-operative chemotherapy were the five independent prognostic factors that adversely affected overall survival. CONCLUSION: Favorable overall survival of PCC patients undergoing surgical treatment depends on early tumor stage, presence of mucobilia, papillary tumor type, hepatic resection, and post-operative chemotherapy.

关键词： Prognostic factor Surgical treatment Peripheral cholangiocarcinoma

Intermittent slipping of landslide regulated by dilatancy evolution and velocity-weakening friction law: an efficient numerical scheme

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Journal of Mountain Science 2016年第8期13卷 1333-1344页

作者： jan Chyan-deng YANG Ray-yeng HWUNG Hwung-hweng chen Wen-yau Department of Hydraulic & Ocean Engineering National Cheng Kung University International Wave Dynamics Research Center National Cheng Kung University

When a block of dense sandy soil moves downhill, the shear-induced soil dilatancy along the basal shear boundary produces a negative value of excess pore pressure that increases the basal frictional resistance. Dilatancy angle,Ψ, the degree to which the basal soil dilates due to the shear, normally evolves during slope failure. A study by other researchers shows that if Ψ is constant, the block of dense soil will remain stable(or unstable) sliding when the velocity-weakening rate of the basal friction coefficient of the block is small(or large) enough. Moreover, during unstable sliding processes, the block of dense soil exhibits "periodic" patterns of intermittent slipping. Here, we used a more efficient and accurate numerical scheme to revisit that study. We expanded their model by assuming Ψ evolves during slope failure. Consequently, we acquired completely different results. For instance, even though the velocity-weakening rate of the friction coefficient is fixed at the same smaller(or larger) value that those researchers use, the stable(or unstable) steady states of landslide they predict will inversely change to unstable(or stable) when Ψ decreases(or increases) with the increase of slide displacement to a value small(or large) enough. Particularly, in unstable processes, the soil block exhibits "aperiodic" styles of intermittent slipping, instead of "periodic". We found out that the stick states appearing later last longer(or shorter) in the case of decreasing(or increasing) Ψ. Moreover, because the basic states of landslides with impacts of dilatancy evolution are not steady nor periodic, traditional stability-analysis methods cannot be "directly" used to analyze the stability of such landslides. Here, we broke through this technical problem to a degree. We showed that combining a concept called "quasi-steady-state approximation" with a traditional stability-analysis technique can qualitatively predict the instability onset of the landslides. Through this st

关键词： Landslide Stability analysis Intermittent slipping Dilatancy angle

Global nitrogen input on wetland ecosystem:The driving mechanism of soil labile carbon and nitrogen on greenhouse gas emissions

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Environmental Science and Ecotechnology 2020年第4期4卷 26-38页

作者： Mengli chen Lian Chang Junmao Zhang Fucheng Guo jan Vymazal Qiang He Yi chen College of Environment and Ecology Key Laboratory of the Three Gorges Reservoir Region’s Eco-EnvironmentMinistry of EducationChongqing UniversityChongqing400045China Key Laboratory of the Three Gorges Reservoir Region’s Eco-Environment Ministry of EducationChongqing400045China Department of Applied Ecology Faculty of Environmental SciencesCzech University of Life Sciences Prague16521Prague 6Czech Republic

Greenhouse gas emissions from wetlands are significantly promoted by global nitrogen input for changing the rate of soil carbon and nitrogen cycling,and are substantially affected by soil labile carbon and nitrogen ***,the driving mechanism by which soil labile carbon and nitrogen affect greenhouse gas emissions from wetland ecosystems under global nitrogen input is not well *** out the driving factor of nitrogen input on greenhouse gas emissions from wetlands is critical to reducing global warming from nitrogen ***,we synthesized 72 published studies(2144 paired observations)of greenhouse gas fluxes and soil labile compounds of carbon and nitrogen(ammonium,nitrate,dissolved organic carbon,soil microbial biomass nitrogen and carbon),to understand the effects of labile carbon and nitrogen on greenhouse gas emissions under global nitrogen *** the data set,nitrogen input significantly promoted carbon dioxide,methane and nitrous oxide emissions from *** particular,at lower nitrogen rates(<100 kg ha^(-1)$·yr^(-1))and with added ammonium compounds,freshwater wetland significantly promoted carbon dioxide and methane *** was the largest nitrous oxide source under these *** meta-analysis also revealed that nitrogen input stimulated dissolved organic carbon,ammonium,nitrate,microbial biomass carbon and microbial biomass nitrogen accumulation in the wetland *** variation-partitioning analysis and structural equation model were used to analyze the relationship between the greenhouse gas and labile carbon and nitrogen *** results revealed that dissolved organic carbon(DOC)is the primary factor driving greenhouse gas emission from wetlands under global nitrogen input,whereas microbial biomass carbon(MBC)more directly affects greenhouse gas emission than other labile carbon and nitrogen.

关键词： Wetland Greenhouse gas Nitrogen deposition Fertilization Soil labile compounds

IL-8,PCT及CRP联合检测在新生儿败血症诊断中的临床意义

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现代生物医学进展 2017年第11期17卷 2152-2154页

作者：沈维维吴瑛婷孙文琴张军陈慧芬同济大学附属第一妇婴保健院检验科上海200040

目的:探讨血清白细胞介素-8(IL-8)、降钙素原(PCT)及C反应蛋白(CRP)联合检测在新生儿败血症诊断中的临床意义。方法:选择2012年3月-2014年3月我院收治的89例新生儿败血症患儿为观察组,并于同期随机抽取120例在我院出生的健康新生儿为对... 详细信息

目的:探讨血清白细胞介素-8(IL-8)、降钙素原(PCT)及C反应蛋白(CRP)联合检测在新生儿败血症诊断中的临床意义。方法:选择2012年3月-2014年3月我院收治的89例新生儿败血症患儿为观察组,并于同期随机抽取120例在我院出生的健康新生儿为对照组,检测并比较两组新生儿外周血中IL-8、PCT及CRP水平。IL-8采用酶联免疫双抗体夹心法测定,血浆PCT采用免疫层析法检测,CRP采用免疫比浊法检测。结果:观察组新生儿IL-8、PCT及CRP水平均明显高于对照组,差异有统计学意义(P<0.05)。三项指标联合检测对新生儿败血症诊断的灵敏度、特异度、阳性预测值、阴性预测值和准确率分别为95.51%、98.33%、97.79%、96.72%和97.13%,均高于三项指标分别进行检测的结果,差异有统计学意义(P<0.05)。结论:通过检测外周血中IL-8、PCT及CRP水平可以有效地评估新生儿败血症的病情,三项指标联合检测有助于早期诊断新生儿败血症。

关键词： IL-8 PCT CRP 新生儿败血症诊断

Sunitinib for Taiwan Residents patients with gastrointestinal stromal tumor after imatinib treatment failure or intolerance

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World Journal of Gastroenterology 2011年第16期17卷 2113-2119页

作者： Yen-Yang chen Chun-Nan Yeh Chi-Tung cheng Tsung-Wen chen Kun-Ming Rau Yi-Yin jan Miin-Fu chen Division of Hematology-Oncology Department of Internal MedicineChang Gung Memorial HospitalKaohsiung Medical Center GIST team Department of SurgeryChang Gung Memorial Hospital and University

AIM:To report preliminary results of the efficacy and safety of sunitinib in the management of Taiwan Residents gastrointestinal stromal tumors (GIST) patients facing imatinib mesylate (IM) intolerance or ***:Between 2001 and May 2010,199 Taiwan Residents patients with metastatic GIST were treated at Chang Gung Memorial *** them,23 (11.6%) patients receiving sunitinib were ***:Sixteen male and 7 female patients with a median age of 59 years (range:24-83 years) received ***-two GIST patients changed to sunitinib because of IM failure and 1 because of *** median duration of sunitinib administration was 6.0 mo (range:2-29 mo).The clinical benefit was 65.2% [2 complete response (CR),4 partial response (PR),and 9 stationary disease (SD);15/23].In 12 patients harboring mutations of the kit gene at exon 11,the clinical benefit rate (CR,PR,and SD) was 75.0% and 6 patients with tumors containing kit exon 9 mutations had a clinical benefit of 50.0% (not significant,P=0.344).The progression free survival (PFS) and overall survival (OS) did not differ between patients whose GISTs had wild type,KIT exon 9,or KIT exon 11 ***-foot syndrome was the most common cause of grade Ⅲ adverse effect (26.1%),followed by anemia (17.4%),and neutropenia (13.0%).During the median 7.5-mo follow-up after sunitinib use,the median PFS and OS of these 23 GIST patients after sunitinib treatment were 8.4 and 14.1 mo,***:Sunitinib appears to be an effective treatment for Taiwan Residents with IM-resistant/intolerant GISTs and induced a sustained clinical benefit in more than 50% of Taiwan Residents advanced GIST patients.

关键词： Suintinib Gastrointestinal stromal tumors Imaitinib Failure or intolerance

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人血清白蛋白及其重组表达研究进展

生物技术通讯 2016年第4期27卷 572-575页

作者：刘丹丹刘思国陈建泉许小琴成国祥上海杰隆生物工程股份有限公司上海200000 扬州大学兽医学院江苏扬州225009

人血清白蛋白在医疗方面有广泛的应用,其可作为血容量扩张剂和辅助治疗剂、培养基组分和保护剂、药物制剂、诊断试剂和医疗器械包被剂等。基因重组技术提供了一种规模制备人血清白蛋白的有效途径,并已建立了多种人血清白蛋白的重组表达... 详细信息

人血清白蛋白在医疗方面有广泛的应用,其可作为血容量扩张剂和辅助治疗剂、培养基组分和保护剂、药物制剂、诊断试剂和医疗器械包被剂等。基因重组技术提供了一种规模制备人血清白蛋白的有效途径,并已建立了多种人血清白蛋白的重组表达系统。本文综述了重组人血清白蛋白在细菌、真菌、转基因植物和转基因动物等表达系统中的发展和应用概况。

关键词：重组人血清白蛋白医疗表达系统乳腺反应器

Virome identification in wheat in the Czech Republic using small RNA deep sequencing

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Journal of Integrative Agriculture 2020年第7期19卷 1825-1833页

作者： Khushwant SINGH jana JAROSOVA jan FOUSEK chen Huan Jiban Kumar KUNDU Plant Virus and Vector Interactions Group Division of Crop Protection and Plant HeatthCrop Research InstitutePrague 16106Czech Republic Zhejiang Tianke High-Technology Development Co. Ltd.Hangzhou 310012P.R.China

High-throughput deep-sequencing technology and bioinformatics analysis of the small RNA(sRNA)population isolated from plants allows universal virus detection and complete virome reconstruction for a given *** the present sRNA deep-sequencing analysis of virus-infected wheat samples in the Czech Republic,samples were firstly tested for barley yellow dwarf viruses(BYDVs),wheat streak mosaic virus(WSMV)and wheat dwarf virus(WDV)using ELISA,RT-PCR and *** sRNA sequencing of these samples yielded more than^60 million single-end 50-bp reads with high confidence for nine field samples of ***,16.5%of reads were virus-specific and 83.5%were mapped to the *** 21-nt reads(-7.7E+06 reads)were found than 24-nt(~6.20E+06 reads)or 22-nt(-4.30E+06 reads)*** novo assembly of the high-quality contigs revealed the presence of three earlier repoted viruses in the Czech Republic:BYDVs(31.48%),WSMV(24.23%)and WDV(2666%).We also showed the presence of cereal yellow dwarf virus(14.33%;two species CYDV-RPS and CYDV-RPV family Luteoviridae/Polerovirus)and wheat yellow dwarf virus(WYDV,3.30%;Luteoviridae).Phylogenetic analysis showed CYDV and WYDV grouped separately from ***,several recombination breakpoints were found among the groups of yellow dwarf viruses(BYDVs,CYDV,and WYDV).Using RNA deep sequencing,we confirmed the presence of the three known viruses(BYDVs,WSMV,and WDV)and the first record of two species of CYDV and WYDV in wheat in the Czech Republic.

关键词： NGS sRNA BYDVs CYDV WSMV WYDV WDV

Identification of differentially-expressed genes of rice in overlapping responses to bacterial infection by Xanthomonas oryzae *** and nitrogen deficiency

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Journal of Integrative Agriculture 2015年第5期14卷 888-899页

作者： YU Chao chen Hua-min TIAN Fang BI Yong-mei Rothstein J Steven Leach E jan HE chen-yang State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural Sciences Department of Molecular and Cellular Biology College of Biological ScienceUniversity of Guelph Department of Bioagricultural Sciences and Pest Management Colorado State University

Bacterial blight of rice caused by Xanthomonas oryzae ***（Xoo） is one of high nitrogen（N） responsive *** plants became more disease resistant with decreasing N suggesting that the crosstalk between disease resistance and N utilization pathways might ***,the co-regulatory components in such crosstalk have not been ***,we comparatively analyzed the gene expression profiling of rice under Xoo inoculation,low N treatment,or a combination of both stresses,and identified the differentially-expressed genes（DEGs） in overlapping *** DEGs were involved in different biological processes,including innate immunity and nitrogen *** randomly-selected DEGs expression was validated by quantitative real-time PCR *** expression of six genes from different functional categories suggested that N condition was the dominant factor when both stresses were *** DEGs identified provide novel insights into the coordinated regulatory mechanism in biotic and abiotic stress responses in rice.

关键词： Xanthomonas differentially overlapping abiotic blight responsive crosstalk pathogen encoding validated

Multifunctional antiperovskites driven by strong magnetostructural coupling

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npj Computational Materials 2021年第1期7卷 890-898页

作者： Harish K.Singh Ilias Samathrakis Nuno MFortunato jan Zemen chen Shen Oliver Gutfleisch Hongbin Zhang Institute of Materials Science Technische Universität DarmstadtDarmstadtGermany Faculty of Electrical Engineering Czech Technical UniversityPragueCzech Republic Department of Physics Blackett LaboratoryImperial College LondonLondonUK Materials Recycling and Resource Strategies Fraunhofer IWKSHanauGermany

Based on density functional theory calculations,we elucidated the origin of multifunctional properties for cubic antiperovskites with noncollinear magnetic ground states,which can be attributed to strong isotropic and anisotropic magnetostructural *** 54 stable magnetic antiperovskites M_(3)XZ(M=Cr,Mn,Fe,Co,and Ni;X=selected elements from Li to Bi except for noble gases and 4f rare-earth metals;and Z=C and N),14 are found to exhibit the Γ_(4g)/Γ_(5g)(i.e.,characterized by irreducible representations)antiferromagnetic magnetic configurations driven by frustrated exchange coupling and strong magnetocrystalline *** the magnetic deformation as an effective proxy,the isotropic magnetostructural coupling is characterized,and it is observed that the paramagnetic state is critical to understand the experimentally observed negative thermal expansion and to predict the magnetocaloric ***,the piezomagnetic and piezospintronic effects induced by biaxial strain are *** is revealed that there is not a strong correlation between the induced magnetization and anomalous Hall conductivities by the imposed ***,the anomalous Hall/Nernst conductivities can be significantly tailored by the applied strain due to the fine-tuning of the Weyl points energies,leading to promising spintronic applications.

关键词： deformation coupling structural