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Optimal C-arm angulation during transcatheter aortic valve replacement: Accuracy of a rotational C-arm computed tomography based three dimensional heart model

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World Journal of Cardiology 2016年第10期8卷 606-614页

作者： Verena Veulemans Sabine Mollus Axel Saalbach Max Pietsch Katharina Hellhammer Tobias Zeus Ralf Westenfeld Jürgen Weese Malte Kelm jan balzer Department of Medicine Division of Cardiology Pulmonary Diseases Vascular Medicine University Hospital Düsseldorf Philips Research Europe Philips GmbH Innovative Technologies Research Laboratories

AIM To investigate the accuracy of a rotational C-arm CTbased 3D heart model to predict an optimal C-arm configuration during transcatheter aortic valve replacement(TAVR). METHODS Rotational C-arm CT(RCT) under rapid ventricular pacing was performed in 57 consecutive patients with severe aortic stenosis as part of the pre-procedural cardiac catheterization. With prototype software each RCT data set was segmented using a 3D heart model. From that the line of perpendicularity curve was obtained that generates a perpendicular view of the aortic annulus according to the right-cusp rule. To evaluate the accuracy of a model-based overlay we compared model- and expert-derived aortic root diameters. RESULTS For all 57 patients in the RCT cohort diameter measurements were obtained from two independent operators and were compared to the model-based measurements. The inter-observer variability was measured to be in the range of 0°-12.96° of angular C-arm displacement for two independent operators. The model-to-operator agreement was 0°-13.82°. The model-based and expert measurements of aortic root diameters evaluated at the aortic annulus(r = 0.79, P < 0.01), the aortic sinus(r = 0.93, P < 0.01) and the sino-tubular junction(r = 0.92, P < 0.01) correlated on a high level and the Bland-Altman analysis showed good agreement. The interobserver measurements did not show a significant bias. CONCLUSION Automatic segmentation of the aortic root using an anatomical model can accurately predict an optimal C-arm configuration, potentially simplifying current clinical workflows before and during TAVR.

关键词：大动脉的狭窄成像形式退化阀门疾病 Transcatheter 大动脉的阀门代替

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Initial clinical experience using the Echo Navigator~-system during structural heart disease interventions

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World Journal of Cardiology 2015年第9期7卷 562-570页

作者： jan balzer Tobias Zeus Katharina Hellhammer Verena Veulemans Silke Eschenhagen Eva Kehmeier Christian Meyer Tienush Rassaf Malte Kelm Division of Cardiology Pneumology and Angiology Department of Medicine University Hospital Duesseldorf

AIM: To present our initial clinical experience using this innovative software solution for guidance of percutaneous structural heart disease ***: Left atrial appendage, atrial septal defect and paravalvular leak closure, transaortic valve repair and Mitra Clip procedures were performed in the catheter laboratory under fluoroscopic and echocardiographic guidance. The two-dimensional and three-dimensional images generated by the transesophageal echocardiography probe were interfaced with the fluoroscopic images in real-time using the Echo Navigator-***:The application of the novel image fusion technology was safe and led to a better appreciation of multimodality imaging guidance due to improved visualization of the complex relationship between catheter devices and anatomical ***:The Echo Navigator-system is a feasible and safe tool for guidance of interventional procedures in structural heart *** innovative technology may improve confidence of interventional cardiologists in targeting and positioning interventional devices in order to increase safety,accuracy,and efficacy of percutaneous interventions in the catheter laboratory.

关键词： Fusion imaging Interventional guidance Percutaneou

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Towards an integrated modeling of the plasma-solid interface

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Frontiers of Chemical Science and Engineering 2019年第2期13卷 201-237页

作者： Michael Bonitz Alexey Filinov jan-Willem Abraham Karsten balzer Hanno Kahlert Eckhard Pehlke Franz X.Bronold Matthias Pamperin Markus Becker Dettlef Loffhagen Holger Fehske Institute for Theoretical Physics and Astrophysics Kiel University24098 KielGermany Leibniz Institute for Plasma Research (INP) D-17489 GreifswaldGermany Joint Institute for High Temperatures RAS 125412 MoscowRussia Computing Center of Kiel University D-24118 KielGermany Institute of Physics Greifswald UniversityD-17489 GreifswaldGermany

Solids facing a plasma are a common situation in many astrophysical systems and laboratory ***,many plasma technology applications rely on the control of the plasma-surface interaction,i.e.,of the particle,momentum and energy fluxes across the plasma-solid ***,presently often a fundamental understanding of them is missing,so most technological applications are being developed via trial and *** reason is that the physical processes at the interface of a low-temperature plasma and a solid are extremely complex,involving a large number of elementary processes in the plasma,in the solid as well as fluxes across the *** accurate theoretical treatment of these processes is very difficult due to the vastly different system properties on both sides of the interface:Quantum versus classical behavior of electrons in the solid and plasma,respectively;as well as the dramatically differing electron densities,length and time ***,often the system is far from *** the majority of plasma simulations surface processes are either neglected or treated via phenomenological parameters such as sticking coefficients,sputter rates or secondary electron emission ***,those parameters are known only in some cases and with very limited ***,while surface physics simulations have often studied the impact of single ions or neutrals,so far,the influence of a plasma medium and correlations between successive impacts have not been taken into *** an approach,necessarily neglects the mutual influences between plasma and solid surface and cannot have predictive *** this paper we discuss in some detail the physical processes of the plasma-solid interface which brings us to the necessity of coupled plasma-solid *** briefly summarize relevant theoretical methods from solid state and surface physics that are suitable to contribute to such an approach and identify four *** first are

关键词： plasma physics surface science plasmasurface modeling DFT nonequilibrium Green functions

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专家系统组织导论(续)

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计算机科学 1985年第4期 35-44页

作者： Mark Stefik jan Aikins Robert balzer John Benoit Lawrence Birnbaum Frederick Hayes-Roth Earl Sacerdoti 中原

情况6——子问题的不固定划分当应用中每个范例问题通常可以划分成一些相同的子问题时,就应考虑前一节所描述的组织方式。在具有各种各样问题的应用中,子问题的不固定集可以提供有用的抽象。例如,象出差(errand running)(见〔22〕)之类... 详细信息

情况6——子问题的不固定划分当应用中每个范例问题通常可以划分成一些相同的子问题时,就应考虑前一节所描述的组织方式。在具有各种各样问题的应用中,子问题的不固定集可以提供有用的抽象。例如,象出差(errand running)(见〔22〕)之类的规划定义域要求富有结构性的计划。为了使抽象发挥作用,它们必须体现计划结构的变动。

关键词：问题求解程序知识编译临界值人工智能子问题产生式规则调度程序操作系统知识源单词相关回溯专家系统搜索空间似然推理序列半序关系

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No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors

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Translational Neurodegeneration 2019年第1期8卷 127-133页

作者： Franziska Hopfner Stefanie HMüller Dagmar Steppat Joanna Miller Nele Schmidt Klaus-Peter Wandinger Frank Leypoldt Daniela Berg Andre Franke Wolfgang Lieb Lukas Tittmann Monika balzer-Geldsetzer Simon Baudrexel Richard Dodel Ruediger Hilker-Roggendorf Elke Kalbe jan Kassubek Thomas Klockgether Inga Liepelt-Scarfone Brit Mollenhauer Petra Neuser Kathrin Reetz Oliver Riedel Claudia Schulte Jörg BSchulz Annika Spottke Alexander Storch Claudia Trenkwalder Hans-Ulrich Wittchen Karsten Witt Ullrich Wüllner Günther Deuschl Gregor Kuhlenbäumer Department of Neurology University Hospital Schleswig HolsteinArnold-Heller Str.324105 KielGermany Center of Blood Transfusion University Hospital Schleswig HolsteinKiel&LübeckGermany Department of Clinical Chemistry University Hospital Schleswig-HolsteinKielGermany Institute of Clinical Molecular Biology University Hospital Schleswig-HolsteinKielGermany Institute of Epidemiology University Hospital Schleswig-HolsteinKielGermany Chair of Geriatric Medicine University Hospital EssenEssenGermany Department of Neurology Philipps-University MarburgMarburgGermany Department of Neurology Goethe UniversityFrankfurt/MainGermany Brain Imaging Center Goethe UniversityFrankfurt/MainGermany Department of Medical Psychology|Neuropsychology and Gender Studies&Center for Neuropsychological Diagnostics and Intervention(CeNDI) University Hospital CologneCologneGermany Psychological Gerontology Institute of GerontologyUniversity of VechtaVechtaGermany Department of Neurology University of UlmUlmGermany Department of Neurology University of Bonnand German Center for Neurodegenerative Diseases(DZNE)BonnGermany Center for Neurology Hertie Institute for Clinical Brain ResearchDepartment of Neurodegenerative DiseasesUniversity of TübingenTübingenGermany DZNE German Center for Neurodegenerative DiseasesTübingenGermany Paracelsus-Elena-Klinik KasselGermany Institute of Neuropathology and Department of Neurosurgery University Medical Center GöttingenGöttingenGermany Coordinating Centre for Clinical Trials Philipps-UniversityMarburgGermany Department of Neurology RWTH Aachen UniversityAachenGermany JARA-BRAIN Institute of Molecular Neuroscience and Neuroimaging Forschungszentrum Jülich GmbH and RWTH Aachen UniversityAachenGermany Leibniz Institute for Prevention Research and Epidemiology-BIPS Achterstrasse 3028359 BremenGermany Department of Neurology Technische Universität Dresden01307 DresdenGermany German Center for Neurodegenerative Diseases(DZNE) Research Site Rostock18147 RostockGerma

Background:IgG-class autoantibodies to N-Methyl-D-Aspartate(NMDA)-type glutamate receptors define a novel entity of autoimmune *** examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting *** measured NMDA antibodies in a large,well phenotyped sample of Parkinson patients without and with cognitive impairment(n=296)and controls(n=295)free of neuropsychiatric *** phenotyping and large numbers allowed statistically meaningful correlation of antibody status with diagnostic subgroups as well as quantitative indicators of disease severity and cognitive ***:NMDA antibodies were analysed in the serum of patients and controls using well established validated *** used anti-NMDA antibody positivity as the main independent variable and correlated it with disease status and phenotypic ***:The frequency of NMDA IgA/IgM antibodies was lower in Parkinson patients(13%)than in controls(22%)and higher than in previous studies in both *** IgA/IgM antibodies were neither significantly associated with diagnostic subclasses of Parkinson disease according to cognitive impairment,nor with quantitative indicators of disease severity and cognitive impairment.A positive NMDA antibody status was positively correlated with age in controls but not in Parkinson ***:It is unlikely albeit not impossible that NMDA antibodies play a significant role in the pathogenesis or progression of Parkinson disease *** Parkinson disease with dementia,while NMDA IgG antibodies define a separate disease of its own.

关键词： NMDA antibody NMDA IgA/IgM antibodies Parkinson disease Cognitive impairment

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