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Prospective Evaluation of Post-Traumatic Vasospasm and Post-Injury Functional Outcome Assessment: Is Cerebral Ischemia Going Unrecognized in Patients with Traumatic Brain Injury?

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Journal of Behavioral and Brain Science 2017年第8期7卷 338-347页

作者： Cherisse Berry jamila Torain Joseph A. Kufera Peter F. Hu Thomas M. Scalea Deborah M. Stein Program in Trauma University of Maryland School of Medicine R Adams Cowley Shock Trauma Center Baltimore MD USA

Background: Secondary injury processes such as posttraumatic vasospasm (PTV) play a critical role in the development of cerebral ischemia/infarction after traumatic brain injury (TBI). The objectives of this study were to evaluate the incidence of cerebral vasospasm in patients with moderate to severe TBI and to assess post-injury functional outcome. Study Design: A prospective observational study was conducted in patients with moderate and severe blunt TBI. Transcranial Doppler (TCD) ultrasound was performed within the first 72 hours and then daily for up to 7 days. Patient characteristics and outcome data including functional outcome as assessed by the Extended Glasgow Outcome Scale (GOS-E) were collected and compared between patients with and without PTV. Results: Twenty-three patients met our inclusion criteria. While there was a 47.8% incidence of vasospasm as detected by TCD, there was no significant difference in hospital LOS or mortality between patients with and without PTV. Of the two patients with PTV who died, both had a cerebral infarct or cerebral ischemia. In evaluating overall GOS-E among patients with a cerebral focal injury, patients with PTV had a significantly higher GOS-E score when compared to patients without PTV (8.0 vs. 6.8, p = 0.01). Conclusions: The high incidence of PTV and the role of clinically significant vasospasm after TBI remain unclear. While functional outcome was better in patients with a focal injury and vasospasm, patients who died had cerebral ischemia or infarction. We hypothesize that there is an interaction between impaired cerebral autoregulation, PTV and poor outcomes in patients with TBI.

关键词： Traumatic Brain Injury Vasospasm Cerebral Ischemia

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Evaluating implicit gender bias at Canadian otolaryngology meetings through use of professional title

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 12-17页

作者： Kylen Van Osch Agnieszka Dzioba Khadija Ahmed Andrew MacDonald jamila Skinner Harley Williams Julie E.Strychowsky M.Elise Graham Department of Otolaryngology-Head&Neck Surgery Schulich School of Medicine&DentistryWestern UniversityLondonOntarioCanada Department of Otolaryngology London Health Sciences Centre Children's HospitalLondonOntarioCanada Faculty of Medicine Schulich School of Medicine&DentistryWestern UniversityLondonOntarioCanada

Objectives:Increasing numbers of women enter medical school *** number of female physicians in leadership positions has been much slower to *** are also well‐documented differences in the treatment of women as compared to men in professional *** presenters are less likely to be introduced by their professional title(“Doctor”)for grand rounds and conferences,especially with a man performing the *** study reviewed the Canadian Society of Otolaryngology–Head and Neck Surgery(CSOHNS)meetings from 2017 to 2020 to determine the proportion of presenters introduced by their professional title and whether this varied by ***:Recordings from CSOHNS meetings were reviewed and coded for introducer and presenter demographics,including leadership positions and ***‐squared tests of proportion and multivariate logistic regression was used to compare genders and identify factors associated with professional versus unprofessional forms of ***:No significant association was found between professional title use and introducer or presenter *** presenters were introduced with professional title 69.6%of the time,while male presenters were introduced with professional title 67.6%of the time(P=0.69).Residents were introduced with a professional title with the most frequency(75.8%),while attending staff were introduced with a professional title with the least frequency(63.0%)(P=0.02).Conclusions:The lack of gender bias in speaker introductions at recent CSOHNS meetings demonstrates progress in achieving gender equity in *** efforts should continue to define additional forms of unconscious bias that may be contributing to gender inequity in leadership positions.

关键词： attitude of health personnel gender identity Otolaryngology women

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Evaluation of Efficacy of Insecticides and Long-Lasting Insecticidal Nets for Control of Culex quinquefasciatus Say Populations from Northern Nigeria

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Advances in Entomology 2022年第2期10卷 186-203页

作者： jamila A. Datti Muhammad M. Mukhtar Maimuna T. Usman Bilkisu I. Abba Binta G. Kurfi Sulaiman S. Ibrahim Department of Biochemistry Bayero University Kano Nigeria Department of Pharmacology and Therapeutics Bayero University Kano Nigeria Department of Vector Biology Liverpool School of Tropical Medicine Pembroke Place UK

Information on Culex mosquitoes (vectors of filarial worm and viral encephalitis) from northern Nigeria is scanty, hindering evidence-based control. Here, two Culex populations (Kano and Kaduna) were characterized. Culex quinquefasciatus and Culex pipiens were found breeding in sympatry, with some hybrid individuals identified. Larval bioassays revealed high temephos resistance (LC50s = 1.34 mg/mL and 3.01 mg/mL for Kano and Kaduna, respectively). Larvae were more sensitive to α-cypermethrin (LC50s = 0.026 mg/mL and 0.067 mg/mL for Kano and Kaduna). WHO adult tube bioassays revealed high pyrethroid and DDT resistance, with mortalities of 44.01% ± 6.79%, 35.83% ± 12.58%, 29.69% ± 9.97% and 52.47% ± 4.34% for permethrin, deltamethrin, α-cypermethrin and DDT, respectively. Highest resistance was observed with bendiocarb (mortality = 13.58% ± 3.98%). High resistance was obtained with fenitrothion and malathion (mortalities = 21% ± 4.76% and 56.47% ± 8.67%, respectively), while a full susceptibility was observed with pirimiphos-methyl. Pre-exposure to piperonylbutoxide (PBO) significantly recovered α-cypermethrin susceptibility (mortality = 82% ± 5.16%, χ2 = 50.99, p < 0.0001), compared with the conventional bioassay (mortality = 32 ± 7.30). Mortalities of <20% were obtained in cone bioassays with Yorkool, DuraNet and PermaNet3.0 (side panels) nets, suggesting a loss of efficacy of conventional long-lasting insecticidal nets. However, mortalities of 99% and 86% were obtained in Kano and Kaduna populations using the roof of PermaNet3.0 (containing PBO and deltamethrin). Despite the high frequency of the 1014F VGSC knockdown resistance mutation allele (0.90), no correlation was observed between the 1014F kdr genotype and resistance phenotype. Sequencing of fragments of the acetylcholinesterase-1 gene detected no G119S mutation, in malathion-alive and malathion-dead females. These suggest a preeminent role of metabolic resistance in these Cu

关键词： Culex quinquefasciatus Metabolic Resistance Insecticides LLINs PBO P450s

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组织透明:研究述评与展望

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外国经济与管理 2019年第6期41卷 43-58页

作者：陈建安佳美拉·鲁斯兰陈武武汉大学经济与管理学院湖北武汉430072 江西师范大学商学院江西南昌330022

组织透明成为人文社科领域炙手可热的研究主题之一,在深度和广度方面均被不断推进。遵循系统文献综述法,整合不同研究视角的组织透明文献,对拓展相关研究具有重要的意义。研究发现:内涵界定存在工具论(信息披露观和社交互动观)和伦理论... 详细信息

组织透明成为人文社科领域炙手可热的研究主题之一,在深度和广度方面均被不断推进。遵循系统文献综述法,整合不同研究视角的组织透明文献,对拓展相关研究具有重要的意义。研究发现:内涵界定存在工具论(信息披露观和社交互动观)和伦理论两大派系,其中工具论把组织透明当做自我调节的一种管理手段,伦理论则认为组织透明是展示诚实、真诚和美德的一种管理实践;透明前因包括信息特征、组织特性、利益相关者特征和外部环境四大类,并在组织—利益相关者互动过程中分别影响组织透明意愿的动机触发和组织透明实现的产生条件;组织透明带来的影响涉及组织自身和利益相关者的'双刃剑'效应,均存在'利之刃'和'伤之刃'两种内在矛盾机制。最后,展望了未来的研究方向。

关键词：组织透明利益相关者动机触发 “双刃剑”效应

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Patient Experience at Endoscopy Centers in Three West African Countries during the COVID-19 Pandemic

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Open Journal of Gastroenterology 2023年第4期13卷 161-169页

作者： Alice Nanelin Guingané Euloge Houndonougbo jamila Abdouramane Soli Léonce Steve Zoungrana Sandrine Soudré Aboubacar Coulibaly Sosthène Somda Roger Sombié Appolinaire Sawadogo Alain Bougouma Service d’hépato-Gastroentérologie CHU Bogodogo Ouagadougou Burkina Faso Service d’hépato-Gastroentérologie Hopital saint jean de Dieu Tanguiéta Bénin Service d’hépato-Gastroentérologie Hopital général de référence de Niamey Niamey Niger Service d’hépato-Gastroentérologie CHU Ouahigouya Ouagadougou Burkina Faso Service d’hépato-Gastroentérologie CHU Tengandogo Tengandogo Burkina Faso Service d’hépato-Gastroentérologie CHU Yalgado Ouédraogo Ouagadougou Burkina Faso Service d’hépato-Gastroentérologie CHU Sourou Sanou Bobo-Dioulasso Burkina Faso

Corona virus infection and the risk of contagiousness to medical personnel or patients during endoscopy necessitated further measures in the endoscopy rooms. The objective of this study was to assess the experience of patients in endoscopy rooms during the COVID-19 epidemic in West Africa. Patients and Methods: This was a multicenter cross-sectional study that took place over a period of 3 months (June to August 2020) in endoscopy centers in Burkina Faso, Benin and Niger. An online questionnaire was sent to patients who had performed upper digestive endoscopies, in 8 digestive endoscopy centers including private, public and religious structures. Depending on the choice of patients, questionnaires were either sent electronically or completed in the endoscopy room with the help of field investigators. The choice of centers was random from the list of centers and descriptive analyses were carried out. Results: A total of 294 patients responded to the online questionnaire. There were 37 lower and 257 upper gastrointestinal endoscopies. The female sex represented 52.1%. The wait times for obtaining an endoscopy appointment were considered satisfactory by 281 patients 95.6%. In the endoscopy departments, 112 patients, or 38.1%, were questioned about the risk factors for contamination of SARS-CoV-2. Among the risk factors found, 6 patients (2.0%) would have traveled abroad in the 2 weeks preceding the examination, 4 patients 1.4% had already been in contact with a subject at risk. The most frequent symptoms were chest pain (80 cases;27.2%), flu-like syndrome (29 cases;9.9%), cough (40 cases;13.6%), fever (46 cases;15.6%). In contrast, ageusia (7 cases;2.4%) and anosmia (5 cases;1.7%) were only found in very few patients. Twenty-two patients (7.5%) felt highly exposed to COVID-19 during the endoscopy examination and 144 patients (48.9%) rated the examination as satisfactory. Conclusion: Gastrointestinal symptoms initially described as rare are being reported with increasing

关键词： Endoscopy COVID-19 Patients Exposure Symptoms

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Emergency Obstetric Hysterectomy in a Low Resources Country: An Eight-Year Retrospective Cohort Study from a Secondary Care Hospital in Niger

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Open Journal of Obstetrics and Gynecology 2024年第10期14卷 1611-1627页

作者： Amadou Issa Abdou Hamidou Soumana Diaouga Zalika Salifou Lankoandé Souley Ibrahim Lailata Maina Oumara Harouna Salifou jamila Salamatou Guédé Younsou Ganda Moussa Boukari Oumarou Garba Souleymane Hamissou Souley M. Noury Madi Nayama Department of Obstetrics & Gynecology Mother and Child Health Centre Dan Dicko Dankoulodo University of Maradi Maradi Niger Department of Obstetrics & Gynecology Issaka Gazoby Maternity Hospital Abdou Moumouni University in Niamey Niamey Niger Department of Obstetrics & Gynecology Mother and Child Health Centre Andre Salifou University of Zinder Zinder Niger Department of Obstetrics & Gynecology General Referal Hospital Abdou Moumouni University in Niamey Niamey Niger Department of Anesthesia Referal Hospital in Maradi Maradi Niger

Introduction: Emergency obstetric hysterectomy (EOH) is a lifesaving procedure that is performed as a last resort in cases of severe postpartum haemorrhage. Objective: The objective of this study was to determine the incidence, socio-demographic profile of patients, indications, management and maternal-fetal outcomes of EOH in a maternity hospital with limited resources in Niger. Methodology: This was an eight-year retrospective cohort study involving the analysis of medical records from patients who underwent emergency obstetric hysterectomies between 1 January 2015 and 31 December 2022 at the Mother and Child Health Centre (MCHC) in Maradi, Niger. The epidemiological data, indications, and outcomes of EOH were collated and subjected to analysis using the statistical software package SPSS 21.0. Comparisons were made using the Chi-squared test. A p-value of less than 0.05 was considered statistically significant. Results: During the study period, 239 cases of emergency obstetric hysterectomy were recorded out of 269,710 deliveries, representing a frequency of 0.89%. The mean age of the patients was 32.41 years (range: 17 - 50 years). The patients were identified as married (239 cases, 100%), unemployed (228 cases, 95.4%), and not attending school (215 cases, 90%). The largest number of cases were observed in large multiparous women (i.e., those with more than five children), representing 58.6% of the total number of cases (140 patients). The average parity among this group was 6.15 children. The majority of patients (229 patients, 95.82%) had undergone in utero transfer, with 169 patients (70.71%), originating from peripheral maternity units in the Maradi region. Upon admission, 116 patients (48.53%) exhibited active genital haemorrhage, while 58 patients (24.26%) were in shock. The primary indications for hysterectomy were uterine rupture (153 patients, 64%), uterine atony (77 patients, 32.2%), and placental accreta (six patients, 2.5%). Hysterectomy was performed

关键词： Emergency Obstetrical Hysterectomy Postpartum Hemorrhage Maternal Mortality Niger

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一种改进的指针安全分析算法

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武汉大学学报（理学版） 2010年第2期56卷 170-174页

作者：郭曦何炎祥张焕国胡颖加米拉.沙塔尔武汉大学计算机学院湖北武汉430072 武汉大学空天信息安全与可信计算教育部重点实验室湖北武汉430072 新疆维吾尔自治区民族语言文字工作委员会新疆乌鲁木齐830001

指针的安全性是C语言程序中的常见问题,它严重影响到系统的安全性.针对指针静态分析中的精度问题,比较分析了目前常见的5种指针分析算法的优缺点,提出了一种基于流不敏感的改进指针静态分析算法.该算法是在Steensgaard算法的基础上,对... 详细信息

指针的安全性是C语言程序中的常见问题,它严重影响到系统的安全性.针对指针静态分析中的精度问题,比较分析了目前常见的5种指针分析算法的优缺点,提出了一种基于流不敏感的改进指针静态分析算法.该算法是在Steensgaard算法的基础上,对程序的控制流图进行改进,通过该算法可以得到比常见的数据流不敏感算法更为精确的指针分析结果.在实验室开发的国内首款商用编译器中实现了该算法,实验结果表明该算法可以提高指针分析的精度.

关键词：指针安全数据流分析 Steensgaard算法精度

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可信网络连接中一种基于可信度的细粒度授权模型

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武汉大学学报（理学版） 2010年第2期56卷 147-150页

作者：邹冰玉张焕国郭曦胡颖加米拉.沙塔尔武汉大学计算机学院湖北武汉430072 武汉大学空天信息安全与可信计算教育部重点实验室湖北武汉430072 新疆维吾尔自治区民族语言文字工作委员会新疆乌鲁木齐830001

针对可信网络连接架构中所定义的访问控制粒度粗、对于如何评估访问请求者的可信级别,如何实施授权访问没有定义等问题,提出了根据请求者的行为及其平台计算环境特征评估其信任级别的方法,研究了具有反馈功能的动态访问授权模型,并在构... 详细信息

针对可信网络连接架构中所定义的访问控制粒度粗、对于如何评估访问请求者的可信级别,如何实施授权访问没有定义等问题,提出了根据请求者的行为及其平台计算环境特征评估其信任级别的方法,研究了具有反馈功能的动态访问授权模型,并在构建可信网络连接原型系统的基础上,实现了从连接到授权的接入控制和动态调整.

关键词：可信计算可信网络连接可信度访问授权模型

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Lower Extremity Arterial Disease in Patients with Type 2 Diabetes: Prevalence and Associated Factors at the Libreville University Hospital Center

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World Journal of Cardiovascular Diseases 2024年第5期14卷 295-308页

作者： Allognon Mahutondji Christian Ayo Bivigou Elsa Ntoutoume Mvé Dylan Anthony N’nang Jean-Fidel Kinga Armel Mpori jamila Myrtille Akagah Kondé Christelle Ndoume Obiang Francis Yékini Carole Fadylath Ndjibah Alakoua Cajole Ludvine Babongui Boussougou Latifah Mipinda Jean-Bruno Moubamba Franck Ecke Nzengue Jean-Emmanuel Houenassi Dèdonougbo Martin Boguikouma Jean-Bruno Department of Medicine and Medical Specialties Health Sciences University (USS) Libreville Gabon Cardiology Service Libreville University Hospital Center (CHUL) Libreville Gabon Department of Physiology Health Sciences University Libreville Gabon Amissa Bongo Regional Hospital Franceville Gabon Mother-Child Hospital Center Jeanne Ebori Foundation Libreville Gabon Medicine Service Owendo University Hospital Center Owendo Gabon

Introduction: Lower extremity arterial disease in diabetic patients has distinct characteristics. Objectives: To study the hospital frequency of lower extremity arterial disease and identify associated factors in diabetic patients at the Libreville University Hospital Center (CHUL). Materials and Methods: This was a cross-sectional study conducted from July 1, 2023, to January 31, 2024, in the endocrinology department of the CHUL. All patients with type 2 diabetes over the age of 18 admitted to this department, regardless of the reason for hospitalization, who provided informed consent, were included. Socio-demographic data and cardiovascular risk factors were recorded. Personal and family cardiovascular history and functional symptoms were investigated. The physical examination included measuring blood pressure, heart rate, and the ankle-brachial index in all patients. Results: A total of 219 patients were included, of whom 75 had lower extremity arterial disease, representing a prevalence of 34.24%. It was compensated in 28 cases (37.33%) and decompensated in 39 patients (52%). In eight cases (10.67%), there was critical chronic ischemia. Cardiovascular risk factors associated with diabetes were physical inactivity (89.5%), hypertension (55.25%), overweight (49.77%), obesity (22.84%), and smoking (10.04%). In multivariate analysis, only hypertension (OR = 2.09;95% CI: 1.05 - 4.17;p = 0.035) and LDL cholesterol (OR = 2.75;95% CI: 1.10 - 6.85;p = 0.03) were significantly associated with lower extremity arterial disease in diabetics at the University Hospital of Libreville. Conclusion: Lower extremity arterial disease is common in diabetic patients at the University Hospital of Libreville. It is often asymptomatic, thus requiring systematic screening.[-rId11-]

关键词： Lower Extremity Arterial Disease Diabetes Hypertension Ankle-Brachial Index Gabon

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细胞粘附位点的talin蛋白FERM结构域在细胞膜调控下的开关转换新机制

细胞粘附位点的talin蛋白FERM结构域在细胞膜调控下的开关转换新...

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中国晶体学会第五届全国会员代表大会暨学术大会（大分子分会场）

作者：宋先强杨骏 jamila Hirbawi 叶盛 H Dhanuja Perera Esen Goksoy Pallavi Dwivedi Edward F Plow 张荣光和秦军中国科学院生物物理研究所美国克利夫兰医学中心勒纳研究所分子心脏病学系

细胞质蛋白talin对异源二聚体跨膜受体整合素的激活在与细胞粘附相关的多种生物学过程例如凝血,组织的重塑以及癌细胞的扩散中发挥着重要作用。该激活过程是通过talin分子的N端的FERM结构域同时结合到细胞膜内表面以及整合素β亚基的胞...

细胞质蛋白talin对异源二聚体跨膜受体整合素的激活在与细胞粘附相关的多种生物学过程例如凝血,组织的重塑以及癌细胞的扩散中发挥着重要作用。该激活过程是通过talin分子的N端的FERM结构域同时结合到细胞膜内表面以及整合素β亚基的胞内尾段来完成的,但这种结合是如何在时空上被调控的,目前还不清楚。我们解析了talin自抑制状态下的复合物晶体结构,该结构中talin尾部的棒状结构域片段(talin-RS)通过一个很大的接触面掩

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