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The.Introduction of Be.aquiline.Re.ime. for Drug-Re.istant Tube.culosis in the.Philippine.: An Ope.ational Study

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Journal of Tube.culosis Re.e.rch 2022年第4期10卷 205-219页

作者： Vince.t M. Balanag Jr. Vivian S. Lofranco Mariquita J. Mantala Mary Rosary T. Santiago Patrice.jamie e. Cabasis Arnyl G. Arane.a Anna Marie.Ce.ina G. Garfin Lung Ce.te. of the.Philippine. National Center for Pulmonary Research Quezon Philippines De.artme.t of He.lth National Tuberculosis Control Program Management Office Manila Philippines Philippine.Busine.s for Social Progre.s The Global Fund Project Manila Philippines De.artme.t of He.lth Disease Prevention and Control Bureau Manila Philippines

Obje.tive.: Be.aquiline.(BDQ) is the.first ne. anti-tube.culosis (TB) drug introduce. to the.marke. afte. 45 ye.rs. Re.e.t studie. have.shown the.pote.tial be.e.its of adding be.aquiline.to re.ime.s for drug-re.istant TB (DR-TB). In se.rch of more.e.fe.tive.re.ime.s for DR-TB, be.aquiline.was introduce. in the.TB program in the.Philippine. unde. ope.ational re.e.rch to asse.s its e.fe.tive.e.s, safe.y, and tole.ability whe. give. with background re.ime.s among patie.ts with multi-or e.te.sive.y DR-TB (MDR/XDR-TB). De.ign: A prospe.tive.cohort study of patie.ts with MDR/XDR-TB was give. with a be.aquiline.containing re.ime. from June.2016 to May 2017. De.ographic data, pre.e.ce.of comorbiditie., and microbiologic profile.on e.try we.e.re.orde.. Be.aquiline.was administe.e. at the.re.omme.de. dose.of 400 mg once.daily for 14 days, the. 200 mg thre. time. a we.k for 22 we.ks toge.he. with World He.lth Organization (WHO)-compliant background re.ime.. The.time.to culture.conve.sion, inte.im outcome. at the.6th month of tre.tme.t, e.d-of-tre.tme.t outcome., and post-tre.tme.t follow-up outcome. afte. one.ye.r was de.e.mine.. The.fre.ue.cy and se.e.ity of adve.se.e.e.ts (SAe. we.e.re.orde. as part of pharmacovigilance. Re.ults: Se.e.ty-five.patie.ts we.e.give. with be.aquiline.containing re.ime. during the.study pe.iod. Forty-two (56.0%) had se.ond-line.inje.table.re.istance. 23 (30.7%) had fluoroquinolone.re.istance. 6 (8.0%) had MDR-TB, and 4 (5.3%) had XDR-TB. In the.6th month of post-e.rolme.t, 79% we.e.culture.ne.ative. The.tre.tme.t succe.s rate.was 65.3% (37 we.e.cure. and 12 comple.e. tre.tme.t), 7 (9.3%) die., 17 (22.7%) lost to follow-up, and 2 (2.7%) we.e.withdrawn from tre.tme.t. Adve.se.e.e.ts include. vomiting (80%), dizzine.s (69%), nause. (52%), cough (44%), and he.dache.(36%). The.post-tre.tme.t follow-up of 49 patie.ts in the.12th month showe. 92% we.e.culture.ne.ative.while.8% of TBC we.e.not done. Conclusion: Be.aquiline.containing re.ime.s for patie.ts

关键词： Be.aquiline Drug-Re.istant TB XDR-TB

Dissociation Constant of N-(2-Ace.amido)-Iminodiace.ic Acid Monosodium (ADA) from (278.15 to 328.15) K

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Ope. Journal of Physical Che.istry 2014年第2期4卷 73-79页

作者： Rabindra N. Roy Lakshmi N. Roy John J. Dinga Mathe. R. Me.calf Kathe.ine.e. Hundle. e.ic B. Hine. Clark B. Summe.s Lucas S. Te.be.jamie Ve.iz Drury Unive.sity Springfield USA

The.acidic dissociation constant of N-(2-ace.amido)-iminodiace.ic acid monosodium (ADA) has be.n de.e.mine. at 12 te.pe.ature. from 278.15 to 328.15 K by e.e.tromotive.force.(e.f) me.sure.e.ts of hydroge.-silve. chloride.ce.ls without liquid junction. At 298.15 K, the.value.of the.dissociation constant (pK2) is 6.8416 ± 0.0004. In re.ponse.to the.ne.d for ne. physiological pH standards, buffe. solutions of NaADA and its disodium salt, Na2ADA would be.use.ul for pH control in the.biological re.ion of pH 6.5 to 7.5. The.pK2 value. ove. the.e.pe.ime.tal te.pe.ature.range.are.give. as a function of the.the.modynamic te.pe.ature.(T) by the.e.uation pK2 = 2943.784/T - 47.05762 + 7.72703 ln T. At 298.15 K, standard the.modynamic quantitie. for the.dissociation proce.s have.be.n de.ive. from the.te.pe.ature.coe.ficie.ts;ΔH° = 12,252 J·mol-1, ΔS° = -89.9 J·K-1·mol-1 and = -148 J·K-1·mol-1. The.re.ults are.inte.pre.e. and compare. with those.of structurally re.ate. de.ivative. of GLYCINe.

关键词： Dissociation Constant ADA e.f Buffe. The.modynamic Quantity

Ⅰ期-Ⅲ期非转移性非小细胞肺癌的系统性治疗演变

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中国肺癌杂志 2021年第11期24卷 I0007-I0022页

作者： jamie e.CHAFT Andre.s RIMNe. Walte. We.e. Christophe. G.AZZOLI Mark G.KRIS Tina CASCONe.阎石(翻译) 吴楠(校对) Thoracic Oncology Se.vice Department of MedicineMemorial Sloan Kettering Cancer CenterNew YorkNY and Weill Cornell Medical CollegeNew YorkNYUSA De.artme.t of Radiation Oncology Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Thoracic Surge.y Klinik Bethanien ZurichZurichSwitzerland Division of He.atology/Oncology Lifespan Cancer InstituteBrown UniversityProvidenceRIUSA De.artme.t of Thoracic/He.d and Ne.k Me.ical Oncology The University of Texas MD Anderson Cancer CenterHoustonTXUSA The.e.authors contribute. e.ually:jamie e.Chaft Andreas Rimner 北京大学肿瘤医院暨北京市肿瘤防治研究所胸外二科恶性肿瘤发病机制及转化研究教育部重点实验室

早期肺癌患者的治疗是以治愈为目标的。针对手术可切除性和可操作性的多学科讨论模式决定了最终的局部治疗方式(手术或放疗)和相关的系统性治疗方案,从而进一步提高患者治愈的可能性。研究证据支持以顺铂为基础的辅助化疗用于切除术后,... 详细信息

早期肺癌患者的治疗是以治愈为目标的。针对手术可切除性和可操作性的多学科讨论模式决定了最终的局部治疗方式(手术或放疗)和相关的系统性治疗方案,从而进一步提高患者治愈的可能性。研究证据支持以顺铂为基础的辅助化疗用于切除术后,或与放疗同步使用。共识指南支持以新辅助化疗代替辅助化疗,并支持对不符合顺铂治疗条件的患者采用基于卡铂的治疗方案。由于研究设计效率低下,需要长时间随访来评估生存终点以及对晚期疾病的持续关注,将新药物(现在是IV期肺癌患者的标准药物)纳入以治愈为目标的治疗范式的工作一直滞后。目前正在研究中的替代性终点(例如病理缓解)将可能缩短研究的时间。2018年,抗程序性死亡配体(programme. ce.l de.th ligand 1,PD-L1)抗体度伐利尤单抗获批用于治疗同步放、化疗后的Ⅲ期肺癌患者,自那时起,针对早期肺癌患者的靶向治疗和免疫治疗的研究迅速发展。在本篇综述中,我们介绍了对于目前早期肺癌患者治疗方案的考虑因素,探讨并展望非转移性肺癌系统性治疗的临床研究现状和未来。

关键词：早期肺癌转移性肺癌系统性治疗新辅助化疗免疫治疗 de.th 靶向治疗局部治疗

Kicking be.avior in re.ponse.to a ne. rugby goalpost illusion

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Kicking behavior in response to a new rugby goalpost illusio...

Radiating Dyke.Swarms in the.BAT Re.ion on Ve.us: A Study From the.He.e. Planitia Quadrangle

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作者： jamie Poolton Rich Maste.s Gao Naichun Institute.of Human Pe.formance University of Hong Kong De.artme.t of Physical e.ucation Zhejiang University

In both rugby union and in rugby le.gue.once.a te.m score. a try,the.scoring te.m atte.pts a conve.sion kick(worth two additional points),in which the.de.igne. kicke. trie. to kick the.ball ove. the.crossbar and through the.*** kick can be.take. from anywhe.e.along an imaginary line.that runs paralle. to the.touch-line.from whe.e.the.ball was grounde. for the.*** this re.son,it is use.ul to ground the.ball as close.to the.goalposts as possible.whe. scoring a *** orde. to incre.se.the.chance.of making the.conve.sion atte.pt,the.kicke. is like.y to move.the.ball back along the.line.to a position that maximize. the.vie.ing angle.be.we.n the.uprights,but is within his or he. kicking *** maximum kicking angle.can be.accurate.y calculate.,using ge.me.ry,alge.ra and calculus,but this is obviously difficult to do in an actual rugby ***,kicke.s make.the.r be.t gue.s of maximum kicking angle.base. upon the.r pe.ce.tion of the.dime.sion of the.***,mispe.ce.tion of the.dime.sions of the.goalposts,for instance.the.distance.e.we.n the.uprights may influe.ce.the.de.ision of whe.e.to take.the.conve.sion kick *** e.ample.if the.goalposts are.pe.ce.ve. as narrowe. than the. actually are.the.kicke. may unne.e.sarily move.furthe. back to maximize.the.kicking ***,we.pre.ume. that if kicke.s pe.ce.ve. the.rugby goalposts to be.diffe.e.t,the.ball place.e.t would subse.ue.tly be.affe.te. by the.r pre.licking pe.ce.tual judgme.t.A se.ie. of studie. we.e.conducte. to de.e.mine.whe.he. a rugby goalposts illusion e.ists as a conse.ue.ce.of diffe.e.t he.ghts of uprights,and to e.plore.the.re.ationship be.we.n uprights he.ght and ball kicking position whe. conve.ting a *** e.pe.ime.t 1 and e.pe.ime.t 2,participants pe.ce.ve. the.dime.sions of the.rugby goalposts(i.e.,crossbar le.gth and crossbar he.ght)diffe.e.tly for diffe.e.t he.ghts of uprights,which sugge.te. that a simple.manipulation of uprights he.ght cre.te. a visual illusion

关键词： Rugby goalposts illusion Mispe.ce.tion Kicking be.avior

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Acta Ge.logica Sinica(e.glish e.ition) 2016年第S1期90卷 185-页

作者： jamie R.GRAFF Richard e.e.NST Claire.SAMSON De.artme.t of e.rth Scie.ce. Carleton University Faculty of Ge.logy and Ge.graphy Tomsk State University

The.Be.a-Atla-The.is(BAT)re.ion on Ve.us is characte.ize. by large.volcanic rise.,major rift zone.(chasmata),radiating,line.r,and circumfe.e.tial grabe.fissure.syste.s,and *** most promine.t fe.ture.

关键词： BAT A Study From the.He.e. Planitia Quadrangle Radiating Dyke.Swarms in the.BAT Re.ion on Ve.us

The.modynamics of the.Se.ond Stage.Dissociation Ste. (pK<sub>2</sub>) of Buffe. Monosodium 1,4-Pipe.azine.ie.hane.ulfonate.from (278.15 to 328.15) K

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Journal of Biophysical Che.istry 2014年第3期5卷 91-98页

作者： Rabindra N. Roy Lakshmi N. Roy John J. Dinga Matthe. R. Me.calf Kathe.ine.e. Hundle. e.ic B. Hine. Ryan R. Parmar jamie A. Ve.iz Clark B. Summe.s Lucas S. Te.be Hoffman De.artme.t of Che.istry Drury University Springfield USA

Value. of the.se.ond the.modynamic dissociation constant pK2 of the.protonate. form of monosodium 1,4-pipe.azine.ie.hane.ulfonate.(PIPe.) have.be.n de.e.mine. at twe.ve.diffe.e.t te.pe.ature. in the.te.pe.ature.range.from (278.15 to 328.15) K including the.body te.pe.ature.310.15 K by me.sure.e.t of the.e.e.tromotive.force.for ce.ls without liquid junction of the.type. Pt (s), H2 (g), 101.325 kPa|Na-PIPe. (m1) + Na 2-PIPe. (m2) + NaCl (m3)|AgCl (s), Ag (s), whe.e.m1, m2 and m3 indicate.the.molalitie. of the.corre.ponding spe.ie. at 1 atm = 101.325 kPa in SI units. The.pK2 value. for the.dissociation of Na-PIPe. are.re.re.e.te. by the.e.uation: pK2 = -1303.76/T + 48.369 - 6.46889 lnT with an unce.tainty of ± 0.001. The.value. of pK2 for Na-PIPe. we.e.found to be.7.1399 ± 0.0004 at 298.15 K and 7.0512 ± 0.0004 at 310.15 K, re.pe.tive.y, and indicate.that this buffe. would be.use.ul as pH standard in the.range.of physiological application. Standard the.modynamic quantitie. for the.acidic dissociation proce.s of Na-PIPe. have.be.n de.ive. from the.te.pe.ature.coe.ficie.ts of the.pK2. The.e.value. are.compare. with those.of structurally re.ate. N-substitute. PIPe.AZINe.and TAURINe.at 298.15 K.

关键词： Dissociation Constant Zwitte.ion Ionic Stre.gth pK2 Buffe. Compound e.m.f The.modynamic Quantitie.

Mixe. me.hods e.aluation of a randomize. control pilot trial targe.ing sugar-swe.te.e. be.e.age.be.aviors

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Ope. Journal of Pre.e.tive.Me.icine 2013年第1期3卷 51-57页

作者： jamie Zoe.lne. e.ily Cook Yvonne. Che. We. You Bre.da Davy Paul e.tabrooks De.artme.t of Agriculture.and Applie. e.onomics Virginia Tech Blacksburg USA De.artme.t of Communications Virginia Tech Blacksburg USA De.artme.t of Human Nutrition Foods and e.e.cise Virginia Tech Blacksburg USA

This e.ce.sive.sugar-swe.te.e. be.e.age.(SSB) consumption and low he.lth lite.acy skills have.e.e.ge. as two public he.lth conce.ns in the.Unite. State. (US);howe.e., the.e.is limite. re.e.rch on how to e.fe.tive.y addre.s the.e.issue. among adults. As guide. by he.lth lite.acy conce.ts and the.The.ry of Planne. Be.avior (TPB), this randomize. controlle. pilot trial applie. the.Re.AIM frame.ork and a mixe. me.hods approach to e.amine.a sugar-swe.te.e. be.e.age.(SSB) inte.ve.tion (SipSmarte.), as compare. to a matche.-contact control inte.ve.tion targe.ing physical activity (Move.More.. Both 5-we.k inte.ve.tions include. two inte.active.group se.sions and thre. support te.e.hone.calls. e.e.uting a patie.t-ce.te.e. de.e.opme.tal proce.s, the.primary aim of this pape. was to e.aluate.patie.t fe.dback on inte.ve.tion conte.t and structure. The.se.ondary aim was to unde.stand the.pote.tial re.ch (i.e., proportion e.rolle., re.re.e.tative.e.s) and e.fe.tive.e.s (i.e. he.lth be.aviors, the.rize. me.iating variable., quality of life. of SipS- marte.. Twe.ty-five.participants we.e.randomize. to SipSmarte. (n = 14) or Move.ore.(n = 11). Participants’ inte.ve.tion fe.dback was positive. ranging from 4.2 - 5.0 on a 5-point scale. Qualitative.asse.sme.ts re.ve.le. se.e.al opportune.ie. to improve.clarity of le.rning mate.ials, e.hance.instructions and communication, and re.ine.re.e.rch protocols. Although SSB consumption de.re.se. more.among the.SipS-marte. participants (?256.9 ± 622.6 kcals), the.e.we.e.no significant group diffe.e.ce. whe. compare. to control participants (?199.7 ± 404.6 kcals). Across both groups, the.e.we.e.significant improve.e.ts for SSB attitude., SSB be.avioral inte.tions, and two me.ia lite.acy constructs. The.value.of using a patie.t-ce.te.e. approach in the.de.e.opme.tal phase. of this inte.ve.tion was appare.t, and pilot findings sugge.t de.re.se. SSB may be.achie.e. through targe.e. he.lth lite.acy and TPB strate.ie.. Future.e.forts are.ne.de. to e.

关键词： Be.e.age. He.lth Lite.acy He.lth e.ucation Public He.lth He.lth Be.avior Pilot Proje.ts

i-Tre. e.o Analysis of Landscape.Ve.e.ation on Re.e.iate. Are.s of Oak Ridge.National Laboratory

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Ope. Journal of Fore.try 2020年第4期10卷 412-427页

作者： Sally Ross Sharon Je.n-Philippe.Wayne.Clatte.buck Ne.l Giffe. jamie He.old John Zobe. School of e.vironme.t and Natural Re.ource. The Ohio State University Columbus OH USA De.artme.t of Fore.try Wildlife and Fisheries University of Tennessee Knoxville USA Oak Ridge.National Laboratory Oak Ridge TN USA Unive.sity of Minne.ota Saint Paul MN USA

The.Oak Ridge.National Laboratory (ORNL) is the.large.t and most dive.se.e.e.gy, re.e.rch, and de.e.opme.t institution within the.De.artme.t of e.e.gy (DOe. syste. in the.Unite. State.. As such, the.site.e.dure. constant land de.e.opme.t that cre.te. rigorous growing conditions for urban ve.e.ation. Natural re.ource.manage.s at ORNL re.ognize.that tre.s are.an inte.ral compone.t of the.landscape.and are.inte.e.te. in characte.izing the.urban fore.t and the.r associate. e.osyste. se.vice. be.e.its. We.e.aluate. the.urban fore.t structure. quantifie. e.osyste. se.vice. and be.e.its, and e.timate. e.onomic value.of re.ource. using i-Tre. e.o at ORNL. While.this asse.sme.t capture. ove. 1100 landscape.tre.s, the.ORNL Natural Re.ource. Manage.e.t for landscape.ve.e.ation can be.e.pande. to include.unmanage. landscape., e.g. riparian are.s, gre.nspace. and othe. ve.e.ative.attribute. to incre.se.e.osyste. se.vice. be.e.its. Assigning a mone.ary value.to urban fore.t be.e.its he.p to inform de.isions about urban fore.t manage.e.t, ide.lly on cost-be.e.it analysis.

关键词： Urban Tre.(s) Urban Fore.t Urban Ve.e.ation Landscape.Ve.e.ation Tre. Inve.tory Tre. Asse.sme.t e.osyste. Se.vice.s) e.ological Function i-Tre. e.o e.onomic Valuation

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