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Quantum feedback networks and control:A brief survey

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Chinese Science Bulletin 2012年第18期57卷 2200-2214页

作者： james Matthew r ArC Centre for Quantum Computation and Communication Technology Research School of EngineeringAustralian National UniversityCanberraACT 0200Australia

The purpose of this paper is to provide a brief review of some recent developments in quantum feedback networks and control.A quantum feedback network (QFN) is an interconnected system consisting of open quantum systems linked by free fields and/or direct physical *** network constructs,including series connections as well as feedback loops,are *** quantum feedback network theory provides a natural framework for analysis and *** properties such as dissipation,stability,passivity and gain of open quantum systems are *** system design is also discussed,primarily in the context of open linear quantum stochastic *** issue of physical realizability is discussed,and explicit criteria for stability,positive real lemma,and bounded real lemma are *** for linear quantum systems,coherent H∞ and LQG control are described.

关键词：开放量子系统反馈网络控制系统有界实引理 LQG控制网络结构反馈回路网络理论

CD8+T cell metabolic flexibility elicited by CD28-ArS2 axisdriven alternative splicing of PKM supports antitumor immunity

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Cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel Anand P.Sharda Mackenzie M.Lieberman Caitlin M.james Shivana M.Lightman Jason H.Tong Guanxi Qiao Tiffany r.Emmons Thejaswini Giridharan Shengqi Hou Andrew M.Intlekofer richard M.Higashi Teresa W.M.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.repasky Kelvin P.Lee Scott H.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present address:University of Colorado Boulder BoulderCO 80309USA Present address:Dana Farber Cancer Institute BostonMA 02215USA Present address:Massachusetts Institute of Technology BostonMA 02139USA Present address:Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

Metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ArS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mrNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ArS2 axis suppressed the expression of the M1 isoform of pyruvate kinase in favor of PKM2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,PKM alternative splicing occurred independently of CD28-driven PI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mrNA splicing CD8 T cells ArS2 PKM2

Toxicity of a seafood toxin， domoic acid， in the retina via modulation of the NrF2 and NF-κB pathways

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Food Science and Human Wellness 2024年

作者： Gabriel Mbuta Tchivelekete Yanqun Cao Mohammad Almarhoun Xinzhi Zhou Agostinho Francisco Cachapa Sebasti?o Tumitangua james reilly Patricia E.Martin Xinhua Shu Department of Biological and Biomedical Sciences， Glasgow Caledonian University Department of Marine Biology， Faculty of Natural Science， University of Namibe Puai Medical School， Shaoyang University Department of Vision Science， Glasgow Caledonian University

Domoic acid (DA)， a biotoxin， is produced by several species of marine dinoflagellate and diatom during harmful algal bloom events. DA is a neurotoxin， in humans and non-human primates， oral exposure to DA results in gastrointestinal effects， while DA at higher doses leads to neurological symptoms， seizures and memory deficiency. Exposure of humans to DA occurs mainly through consumption of contaminated seafoods containing an accumulation of the toxin. Previously， it was unclear if DA can have toxic effects on the retina. We assessed the toxicity of DA in human retinal cells (ArPE-19) and in zebrafish embryos. DA significantly lowered ArPE-19 cell viability dose-dependently， and decreased anti-oxidative capacity， increased inflammation， and promoted cell death， possibly through modulating the NrF2 and NF-κB signalling pathways. Zebrafish embryos exposed to DA for four days from one day post fertilization (dpf) had an increase in mortality and a decrease in both hatching and heartbeat rate and exhibited morphological abnormalities. DA treatment also significantly downregulated expression of antioxidant genes and upregulated expression of inflammation mediators， as well as causing photoreceptor death in zebrafish embryos. The results demonstrate that consuming seafood containing DA will have potential toxic effects in human retinas.

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High incidences and similar patterns of Wolbachia infection in fig wasp communities from three different continents

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Insect Science 2010年第2期17卷 101-111页

作者： Lin-Lin Chen james M. cook Hui Xiao Hao-Yuan Hu Li-Ming Niu Da-Wei Huang Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Beijing China Graduate University of Chinese Academy of Sciences Beijing China School of Biological Sciences University of Reading Reading UK College of Plant Protection Shandong Agricultural University Tai'an Shandong Province China

Wolbachia are endosymbiotic bacteria that infect numerous arthropod species. Previous studies in Panama and Australia revealed that the majority of fig wasp species harbor Wolbachia infections, but that similar patterns of incidence have evolved inde- pendently with different wasp species and Wolbachia strains on the two continents. We found Wolbachia infections in 25/47 species （53%） of fig wasp associated with 25 species of Chinese figs. Phylogenetic analyses of Wotbachia wsp sequences indicated that very similar strains are not obviously found in either closely related or ecologically linked fig wasps species. The extremely high prevalence of Wolbachia in fig wasps （over 50% of species infected） is not constrained by geographical origin and is a recurrent theme of fig wasp/Wolbachia interactions.

关键词： fig wasps horizontal transmission Wolbachia wsp

Compressing local atomic neighbourhood descriptors

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npj Computational Materials 2022年第1期8卷 1593-1605页

作者： james P.Darby james r.Kermode Gábor Csányi Engineering Dept University of CambridgeTrumpington StCambridgeCB21PZUK Warwick Centre for Predictive Modelling School of EngineeringUniversity of WarwickCoventryCV47ALUK

Many atomic descriptors are currently limited by their unfavourable scaling with the number of chemical elements S *** length of body-ordered descriptors,such as the SOAP power spectrum(3-body)and the(ACE)(multiple body-orders),scales as(NS)^(ν)whereν+1 is the body-order and N is the number of radial basis functions used in the density *** introduce two distinct approaches which can be used to overcome this scaling for the SOAP power ***,we show that the power spectrum is amenable to lossless compression with respect to both S and N,so that the descriptor length can be reduced from O(N^(2)S^(2))to O(NS).Secondly,we introduce a generalised SOAP kernel,where compression is achieved through the use of the total,element agnostic density,in combination with radial *** ideas used in the generalised kernel are equally applicably to any other body-ordered descriptors and we demonstrate this for the(ACSF).

关键词： SOAP scaling kernel

Matrilinear hierarchy in the American black bear (Ursus americanus)

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Integrative Zoology 2022年第1期17卷 139-155页

作者： Benjamin KILHAM james r.SPOTILA Kilham Bear Center LymeNew HampshireUSA Department of Biodiversity Earth and Environmental ScienceDrexel UniversityPhiladelphiaPennsylvaniaUSA

The American black bear(Ursus americanus)was long thought to be solitary and its social organization has not been well ***,we present new data on black bear social *** objectives of the study were to make detailed observations of the behavior of wild black bears to determine their social interactions and *** tested whether black bears interacted socially beyond mating and competing for resources,if black bears tracked relationships and interacted regularly even when resources were not limited,and whether the social structure of a population of black bears was based on a matrilinear *** collected data by direct observation of bears from 1993 to *** of 1210 social interactions at a provisioning site indicated that females compete and form matrilinear *** bears established a hierarchy for food,control of space,and control of younger *** interaction scent marking took place,which suggested that dominant females were conditioning subordinates to their scent *** behavior occurred between related and unrelated bears and helped to establish the social structure of the bear *** on our data,human–bear conflicts can be reduced by behavioral modifications by humans when they encounter *** of bear behavior and the matrilinear hierarchy provide a basis for non-lethal management of bears that find themselves in a bear–human conflict situation.

关键词： bear matrilinear hierarchy New Hampshire rank social behavior Ursus

用nr改良海氏法则及PALT评估药物性肝损伤研究进展

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中国药物警戒 2024年第1期21卷 117-120页

作者：詹姆斯·布坎南 Covilance LLC 美国加利福尼亚州贝尔蒙特市

与药物、草药和其他补充或替代疗法相关的肝毒性一直是全球安全专业人员和监管机构关注的问题。在临床开发和上市后阶段及时识别肝损伤仍是一项挑战。目前,用于识别最有可能发展为肝衰竭或死亡的肝毒性病例标准已经取得最新进展,并建立... 详细信息

与药物、草药和其他补充或替代疗法相关的肝毒性一直是全球安全专业人员和监管机构关注的问题。在临床开发和上市后阶段及时识别肝损伤仍是一项挑战。目前,用于识别最有可能发展为肝衰竭或死亡的肝毒性病例标准已经取得最新进展,并建立了可用于评估与肝损伤相关肝细胞损失程度的新方法。本文将对这些新方法及其在相关肝毒性持续监测和评估中的应用进行回顾。

关键词：药物性肝损伤(DILI) 草药补充疗法替代疗法海氏法则药物引起严重肝毒性的四象限评价图表 r值 nr值谷丙转氨酶的P值

Is activation of GDNF/rET signaling the answer for successful treatment of Parkinson's disease?A discussion of data from the culture dish to the clinic

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Neural regeneration research 2022年第7期17卷 1462-1467页

作者： james A.Conway Edgar r.Kramer Institute of Translational and Stratified Medicine Peninsula Medical SchoolFaculty of HealthUniversity of PlymouthDevonUK

The neurotrophic signaling of glial cell line-derived neurotrophic factor(GDNF)with its canonical receptor,the receptor tyrosine kinase rET,coupled together with the GDNF family receptor alpha 1 is important for dopaminergic neuron survival and physiology in cell culture experiments and animal *** prompted the idea to try GDNF/rET signaling as a therapeutic approach to treat Parkinson’s disease with the hallmark of dopaminergic cell death in the substantia nigra of the *** several clinical trials with GDNF in Parkinson’s disease patients,which mainly focused on optimizing the GDNF delivery technique,benefits were only seen in a few *** general,the endpoints did not show significant *** suggests that it will be helpful to learn more about the basic biology of this fascinating but complicated GDNF/rET signaling system in the dopaminergic midbrain and about recent developments in the field to facilitate its use in the *** we will refer to the latest publications and point out important open questions in the field.

关键词： α-synuclein clinical trials dopaminergic neurons glial cell line-derived neurotrophic factor GFrα1 gut-brain axis Nedd4 Parkin Parkinson’s disease rET

Effect of wall rougheners on cross-sectional flow characteristics for non-spherical particles in a horizontal rotating cylinder

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Particuology 2014年第1期12卷 44-53页

作者： Guang Lu james r.Third Christoph r.Müller ETH Zürich Department of Mechanical and Process Engineering Institute of Energy Technology Laboratory of Energy Science and Engineering8092 Zürich Switzerland

Discrete-element-method （DEM） simulations have been performed to investigate the cross-sectional flow of non-spherical particles in horizontal rotating cylinders with and without wall rougheners. The non-spherical particles were modeled using the three-dimensional super-quadric equation. The influence of wall rougheners on flow behavior of grains was studied for increasing particle blockiness. Moreover, for approximately cubic particles （squareness parameters [555]）, the rotational speed, gravitational acceleration and particle size were altered to investigate the effect of wall rougheners under a range of operating conditions. For spherical and near-spherical particles （approximately up to the squareness parameters [344]）, wall rougheners are necessary to prevent slippage of the bed against the cylinder wall. For highly cubic particle geometries （squareness parameters larger than [3441）, wall rougheners resulted in a counter-intuitive decrease in the angle of repose of the bed. In addition, wall rougheners employed in this study were demonstrated to have a higher impact on bed dynamics at higher rotational speeds and lower gravitational accelerations. Nevertheless, using wall rougheners had a comparatively small influence on particle-flow characteristics for a bed composed of finer grains.

关键词： Granular flowNon-spherical particlesrotating cylinderDiscrete element method (DEM)Kiln