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Chinese Journal of Polymer Science 1998年第3期16卷 261-267页

作者： GUILLET james Department of Chemistry University of Toronto Toronto M5S 3H6 Canada

Polymers of 1- and 2-vinylnaphthalene containing more than about 50 mol% sulfonic acid groups dissolve in water to form 'hypercoiled' conformations which have many of the properties of micelles. Hydrophobic molecules such as anthracene and perylene are selectively absorbed in these pseudo micellar structures, and their fluorescence emission is sensitized by energy transfer from the surrounding naphthalene chromophores. When irradiated with UV light in the presence of oxygen, the emission of perylene rapidly decreases. It is proposed that this is due to reaction of singlet oxygen with the perylene trapped in the hypercoiled polymer. (Author abstract) 3 Refs.

关键词： Sulfonated vinyl naphthalene polymers Transport of excitation energy Anthracene Perylene Tripping

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Omeprazole induces gastric transmucosal permeability to the peptide bradykinin

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World Journal of Gastroenterology 2010年第9期16卷 1097-1103页

作者： melissa Gabello mary Carmen Valenzano E Peter Zurbach james m mullin Lankenau Institute for medical Research 100 Lancaster AvenueWynnewoodPA 19096United States Department of Biology Saint Joseph's University5600 City AvenuePhiladelphiaPA 19131United States Department of Chemistry Saint Joseph's University5600 City AvenuePhiladelphiaPA 19131United States Division of Gastroenterology Lankenau Hospital100 Lancaster AvenueWynnewoodPA 19096United States

AIm:To investigate omeprazole-induced transepithelial gastric leak and its effects on the permeability of the peptides bradykinin and ***:Rat gastric corpus tissue was isolated and mounted in an Ussing chamber apparatus to evaluate the permeability of 3H-bradykinin,3H-oxytocin,and 14CEDTA in the presence or absence of *** chromatography was performed to identify any metabolic breakdown products of the peptides resulting from permeation through the gastric tissue,and thereby calculate the true flux of the ***:The flux rate ofintact 3H-bradykinin increased substantially after omeprazole addition (109.5%) compared to the DmSO vehicle control (14%).No corresponding change in flux ofintact 3H-oxytocin was observed under the same conditions (11.9% and 6.4% in the DmSO-and omeprazole-treated conditions,respectively).After exposure to omeprazole,the flux rate of 14C-EDTA also increased dramatically (122.3%) compared to the DmSO condition (36.3%).CONCLUSION:The omeprazole-induced gastric leak allows for transmucosal permeability to charged molecules as well as *** induced leak will allow certain peptides to permeate.

关键词： Proton pump inhibitor Paracellular Drug delivery Tight junction Transepithelial

Wireless data management system for environmental monitoring in livestock buildings

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Information Processing in Agriculture 2017年第1期4卷 1-17页

作者： james Gray Thomas m.Banhazi Alexander A.Kist Faculty of Health Engineering and SciencesUniversity of Southern Queensland(USQ)West StreetToowoombaQLD 4350Australia National Centre for Engineering in Agriculture(NCEA) University of Southern Queensland(USQ)West StreetToowoombaQLD 4350Australia

The impact of air quality on the health,welfare and productivity of livestock needs to be considered,especially when livestock are kept in enclosed *** monitoring of such environmental factors allows for the development of appropriate strategies to reduce detrimental effects of sub-optimal air quality on the respiratory health of both livestock and *** 2009,an environmental monitoring system was designed,developed and tested that allowed for the monitoring of a number of airborne *** limitation of the system was the manual collection of logged data from each *** paper identifies limitations of the current environmental monitoring system and suggests a range of networking technologies that can be used to increase *** is taken for the networking of environmental monitoring units,as well as the collection of recorded ***,the design and development of a software system that is used to collate and store recorded environmental data from multiple farms is *** order to design such a system,simplified software engineering processes and methodologies have been *** main steps taken in order to complete the project were requirements elicitation with clients,requirements analysis,system design,implementation and finally *** outcome of the project provided a potential prototype for improving the environmental monitoring system and analysis informing the benefit of the implementation.

关键词： Sensors Environmental monitoring Networking Software engineering

Performance, emission and combustion characteristics of CI engine fuelled with diesel and hydrogen

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Frontiers in Energy 2015年第4期9卷 486-494页

作者： R. Senthil KUmAR m. LOGANATHAN E. james GUNASEKARAN Department of mechanical Engineering Annamalai University Chi- dambaram 608002 India

Hydrogen （H2） is being considered as a primary automotive fuel and as a replacement for conventional fuels. Some of the desirable properties, like high flame velocity, high calorific value motivate us to use hydrogen fuel as a dual fuel mode in diesel engine. In this experiment, hydrogen was inducted in the inlet manifold with intake air. The experiments were conducted on a four stroke, single cylinder, water cooled, direct injection （DI）, diesel engine at a speed of 1500r/min. Hydrogen was stored in a high pressure cylinder and supplied to the inlet manifold through a water-and-air-based flame arrestor. A pressure regulator was used to reduce the cylinder pressure from 140 bar to 2 bar. The hydrogen was inducted with a volume flow rate of 41 pm, 61 pm and 81 pm, respectively by a digital volume flow meter. The engine performance, emission and combustion parameters were analyzed at various flow rates of hydrogen and compared with diesel fuel operation. The brake thermal efficiency （BTE） was increased and brake specific fuel consumption （BSFC） decreased for the hydrogen flow rate of 81 pm as compared to the diesel and lower volume flow rates of hydrogen. The hydrocarbon （HC） and carbon monoxide （CO） were decreased and the oxides of nitrogen （NOx） increased for higher volume flow rates of hydrogen compared to diesel and lower volume flow rates of hydrogen. The heat release rate and cylinder pressure was increased for higher volume flow rates of hydrogen compared to diesel and lower volume flow rates of hydrogen.

关键词： hydrogen brake thermal efficiency crankangle compressed ignition (CI)

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Timings of early crustal activity in southern highlands of mars:Periods of crustal stretching and shortening

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Geoscience Frontiers 2019年第3期10卷 1029-1037页

作者： Trishit Ruj Goro Komatsu Jan Hendrik Pasckert james m.Dohm International Research School of Planetary Sciences Università d'Annunzio Department of Earth and Planetary Science School of Science University of Tokyo Institut für Planetologie Westf?lische Wilhelms-Universit?t Foundation for Advancement of International Science

Extensional and compressional structures are globally abundant on mars. Distribution of these structures and their ages constrain the crustal stress state and tectonic evolution of the planet. Here in this paper, we report on our investigation over the distribution of the tectonic structures and timings of the associated stress fields from the Noachis-Sabaea region. Thereafter, we hypothesize possible origins in relation to the internal/external processes through detailed morphostructural mapping. In doing so, we have extracted the absolute model ages of these linear tectonic structures using crater size-frequency distribution measurements, buffered crater counting in particular. The estimated ages indicate that the tectonic structures are younger than the mega impacts events(especially Hellas) and instead they reveal two dominant phases of interior dynamics prevailing on the southern highlands, firstly the extensional phase terminating around3.8 Ga forming grabens and then compressional phase around 3.5-3.6 Ga producing wrinkle ridges and lobate scarps. These derived absolute model ages of the grabens exhibit the age ca. 100 ma younger than the previously documented end of the global extensional phase. The following compressional activity corresponds to the peak of global contraction period in Early Hesperian. Therefore, we conclude that the planet wide heat loss mechanism, involving crustal stretching coupled with gravitationally driven relaxation(i.e.,lithospheric mobility) resulted in the extensional structures around Late Noachian(around 3.8 Ga). Lately cooling related global contraction generated compressional stress ensuing shortening of the upper crust of the southern highlands at the Early Hesperian period(around 3.5-3.6 Ga).

关键词： martian dynamics Southern highlands Extensional tectonics Compressional tectonics Age of structures Buffer crater counting

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Retrospective analysis of hepatitis C infected patients treated through an integrated care model

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World Journal of Gastroenterology 2016年第38期22卷 8558-8567页

作者： james m Levin Shabnam Dabirshahsahebi mindy Bauer Eric Huckins Department of Infectious Disease Dean Clinic

AIm To determine if our health system's integrated model reflects sustained virologic response(SVR) outcomes similar to those in clinical trial data, maximizes adherence, and averts drug *** Subjects with chronic hepatitis C had their medical records reviewed from November 1st, 2014 through march 1st, 2016. Patients eligible for treatment were entered into an integrated care model therapy algorithm. The primary outcome was SVR12 based on intention to treat(ITT) analysis. Inclusion criteria consisted of both treatment na?ve and experienced patients over the age of 18 who were at least twelve weeks post-therapy completion with any genotype(GT) or mETAVIR score. Secondary outcomes included adherence, adverse events, and number of drug interaction *** At the time of analysis, 133 patients had reached twelve weeks post therapy with ITT. In the ITT analysis 70 patients were GT 1a, 26 GT 1b, 23 could not be differentiated between GT 1a or 1b, 8 GT 2, 4 GT 3, and 2 patients with multiple genotypes. The ITT treatment regimens consisted of 97 sofosbuvir(SOF)/ledipasvir(LDV), 8 SOF/LDV and ribavirin(RBV), 7 SOFand Simeprevir(SmV), 6 3D and RBV, 1 3D, 11 SOF and RBV, and 1 SOF, peg interferon alpha, and RBV. The overall SVR12 rate was 93% in the ITT analysis with a total of 6 patients relapsing. In patients with cirrhosis, 89% obtained SVR12. All 33 patients who were previous treatment failures achieved SVR12. Drug-drug interactions were identified in 56.4% of our patient population, 69 of which required interventions made by the pharmacist. The most common side effects were fatigue(41.4%), headache(28.6%), nausea(18.1%), and diarrhea(8.3%). No serious adverse effects were *** Dean Health System's integrated care model successfully managed patients being treated for hepatitis C virus(HCV). The integrated care model demonstrates high SVR rates amongst patients with different levels of fibrosis, genotypes, and HCV treatment histo

关键词： Hepatitis C medication adherance Direct acting antiviral Sustained viral response Integrated care model

Cancer risk in primary sclerosing cholangitis: Epidemiology,prevention, and surveillance strategies

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World Journal of Gastroenterology 2019年第6期25卷 659-671页

作者： Brian m Fung Keith D Lindor james H Tabibian UCLA-Olive View Internal medicine Residency Program Olive View-UCLA Medical Center Office of the University Provost Arizona State University Division of Gastroenterology Department of MedicineOlive View-UCLA Medical Center

Primary sclerosing cholangitis(PSC) is a rare cholestatic liver disease characterized by progressive fibroinflammatory destruction of the intra-and/or extrahepatic biliary ducts. While its features and disease course can be variable,most patients with PSC have concurrent inflammatory bowel disease and will eventually develop liver cirrhosis and end-stage liver disease, with liver transplantation representing the only potentially curative option. Importantly,PSC is associated with a significantly increased risk of malignancy compared to the general population, mainly cholangiocarcinoma, gallbladder carcinoma,hepatocellular carcinoma, and colorectal cancer, with nearly 50% of deaths in patients with PSC being due to cancer. Therefore, robust surveillance strategies are needed, though uncertainty remains regarding how to best do so. In this review, we discuss the epidemiology, prevention, and surveillance of cancers in patients with PSC. Where evidence is limited, we present pragmatic approaches based on currently available data and expert opinion.

关键词： Bile duct diseases Cholangiocarcinoma Gallbladder carcinoma Hepatocellular carcinoma Colorectal cancer Chemoprotection Inflammatory bowel disease

Quaternion Quasi-Chebyshev Non-local means for Color Image Denoising

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Chinese Journal of Electronics 2023年第3期32卷 397-414页

作者： XU Xudong ZHANG Zhihua m.james C.Crabbe School of mathematics Shandong University Wolfson College University of Oxford

Quaternion non-local means(QNLm) denoising algorithm makes full use of high degree self-similarities inside images to suppress the noise, so the similarity metric plays a key role in its denoising *** this study, two improvements have been made for the QNLm: 1) For low level noise, the use of quaternion quasi-Chebyshev distance is proposed to measure the similarity of image patches and it has been used to replace the Euclidean distance in the QNLm algorithm. Since the quasi-Chebyshev distance measures the maximal distance in all color channels, the similarity of color images measured by quasi-Chebyshev distance can capture the structural similarity uniformly for each color channel; 2) For high level noise, quaternion bilateral filtering has been proposed as the preprocessing step in the QNLm algorithm. Denoising simulations were performed on 110 images of landscape, people, and architecture at different noise levels. Compared with QNLm, quaternion non-local total variation(QNLTV), and non-local means(NLm)variants(NLTV, NLm after wavelet threshold preprocessing, and the color adaptation of NLm), our novel algorithm not only improved PSNR/SSIm(peak signal to noise rate/structural similarity) and figure of merit values by an average of 2.77 dB/8.96% and 0.0491 respectively, but also reduced processing time.

关键词： Image color analysis Filtering Quaternions Noise reduction Color Euclidean distance Filtering algorithms

Going only half the way:cell cycle exit after the G1 restriction point

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Signal Transduction and Targeted Therapy 2024年第1期9卷 1-2页

作者： Lisa muller Tony Gutschner mechthild Hatzfeld Department of Pathobiochemistry Institute of Molecular MedicineMartin Luther University Halle-WittenbergCharles Tanford Protein Research CenterHalleGermany Department of RNA Biology and Pathogenesis Institute of Molecular MedicineMartin Luther University Halle-WittenbergCharles Tanford Protein Research CenterHalleGermany

In a recent article published in Nature,james *** et *** that cyclin A2 levels determine whether cells will make an entrance into mitosis or whether cells will leave the cell cycle after having passed the G1/restriction(R)-point implicating that the decision is fully reversible(Fig.1).This ground-breaking study could impact future approaches for cancer treatment by targeting the mitotic clock.

关键词： point cycle

Polyplex interaction strength as a driver of potency during cancer immunotherapy

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Nano Research 2018年第10期11卷 5642-5656页

作者： Shannon d. Tsai james I. Andorko Xiangbin Zeng Joshua m. Gammon Christopher m. dewell Fischell Department of Bioengineering University of Marylond 8278 Paint Branch Drive College Park MD 20742 USA Robert E. Fischell Institute for Biomedicol Devices University of Maryland 8278 Paint Branch Drive College Park MD 20742 USA United States Department of Veterans Affairs Maryland VA Health Care System 10 North Greene Street Baltimore MD 21201 USA Deportment of microbiology and Immunology University of Maryland Medical School 685 West Baltimore Street Baltimore MD 21201 USA marlene and Stewart Greenebaum Cancer Center 22 South Greene Street Baltimore MD 21201 USA

many experimental cancer vaccines are exploring toll-like receptor agonists （TLRas） such as CpG, a DNA motif that agonizes toll-like receptor 9 （TLR9）, to trigger immune responses that are potent and molecularly-specific. The ability to tune the immune response is especially important in the immunosuppressive microenvironments of tumors. Because TLR9 is located intracellularly, CpG must be internalized by immune cells for functionality. Polyplexes can be self- assembled through electrostatics using DNA （anionic） condensed by a positively charged carrier. These structures improve cell delivery and have been widely explored for gene therapy. In contrast, here we use cationic poly （^-amino esters）（PBAEs） to assemble polyplexes from CpG as an adjuvant to target and improve immune stimulation in cells and mouse models. Polyplexes were formed over a range of PBAE：CpG ratios, resulting in a library of complexes with increasingly positive charge and stronger binding as PBAE：CpG ratio increased. Although higher PBAE：CpG ratios exhibited improved CpG uptake, lower ratios of PBAE：CpG--which condensed CpG more weakly, activated DCs and tumorspecific T cells more effectively. In a mouse melanoma model, polyplexes with lower binding affinities improved survival more effectively compared with higher binding affinities. These data demonstrate that altering the polyplex interaction strength impacts accessibility of CpG to TLRs in immune cells. Thus, physiochemical properties, particularly the interplay between charge, uptake, and affinity, play a key role in determining the nature and efficacy of the immune response generated. This insight identifies new design considerations that must be balanced for engineering effective immunotherapies and vaccines.

关键词： cancer immunotherapy nanoparticle vaccine polyplex