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Implicit Continuous User Authentication for mobile Devices based on Deep Reinforcement Learning

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Computer Systems Science & Engineering 2023年第2期44卷 1357-1372页

作者： Christy james Jose m.S.Rajasree Government Engineering College Idukki685603India APJ Abdul Kalam Technological University Thiruvananthapuram695016India

The predominant method for smart phone accessing is conﬁned to methods directing the authentication by means of Point-of-Entry that heavily depend on physiological biometrics like,ﬁngerprint or *** continuous authentication initiating to be loftier to conventional authentication mechanisms by continuously conﬁrming users’identities on continuing basis and mark the instant at which an illegitimate hacker grasps dominance of the ***,divergent issues remain *** research aims to investigate the power of Deep Reinforcement Learning technique to implicit continuous authentication for mobile devices using a method called,Gaussian Weighted Cauchy Kriging-based Continuous Czekanowski’s(GWCK-CC).First,a Gaussian Weighted Non-local mean Filter Preprocessing model is applied for reducing the noise pre-sent in the raw input face *** Kriging Regression function is employed to reduce the ***,Continuous Czekanowski’s Clas-siﬁcation is utilized for proﬁcient classiﬁcation between the genuine user and *** this way,the proposed GWCK-CC method achieves accurate authen-tication with minimum error rate and *** assessment of the pro-posed GWCK-CC method and existing methods are carried out with different factors by using UmDAA-02 Face *** results conﬁrm that the proposed GWCK-CC method enhances authentication accuracy,by 9%,reduces the authen-tication time,and error rate by 44%,and 43%as compared to the existing methods.

关键词： Deep reinforcement learning gaussian weighted non-local meanﬁlter cauchy kriging regression continuous czekanowski’s implicit continuous authentication mobile devices

PNPLA8是调控三阴性乳腺癌磷脂代谢并促进肿瘤增殖和转移的关键分子（英文）

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PNPLA8是调控三阴性乳腺癌磷脂代谢并促进肿瘤增殖和转移的关键分...

HEALTHCARE: A COmPLEX SERVICE SYSTEm

2024中国肿瘤标志物学术大会暨CACA整合肿瘤学高峰论坛暨第十七届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者：谭哲琼 Pragney Deme Keerti Boyapati Annet A.m.Duivenvoorden Ron m.A.Heeren Caitlin m.Tressler Norman james Haughey Kristine Glunde

Background Triple-negative breast cancer(TNBC) is the most aggressive breast cancer subtype and leads to the poorest patient outcomes despite surgery and chemotherapy treatment. Exploring new molecular mechanisms of TNBC that could lead to the development of novel molecular targets are critically important for improving therapeutic options for treating *** We sought to identify novel therapeutic targets in TNBC by combining genomic and functional studies with lipidomic analysis, which included mechanistic studies to elucidate the pathways that tie lipid profile to critical cancer cell properties. Our studies were performed in a large panel of human breast cancer cell lines and patient *** Comprehensive lipid profiling revealed that phospholipid metabolism is reprogrammed in TNBC cells. We discovered that patatin-like phospholipase domain-containing lipase 8(PNPLA8)is overexpressed in TNBC cell lines and tissues from breast cancer patients. Silencing of PNPLA8disrupted phospholipid metabolic reprogramming in TNBC, particularly affecting the levels of phosphatidylglycerol(PG), phosphatidylcholine(PC), lysophosphatidylcholine(LPC) and glycerophosphocholine(GPC). We showed that PNPLA8 is essential in regulating cell viability,migration and antioxidation in TNBC cells and promoted arachidonic acid and eicosanoid production, which in turn activated PI3K/Akt/Gsk3β and mAPK *** Our study highlights PNPLA8 as key regulator of phospholipid metabolic reprogramming and malignant phenotypes in TNBC, which could be further developed as a novel molecular treatment target.

关键词： PNPLA8 Breast cancer Triple negative Phospholipid metabolism reprogramming Eicosanoids migration Invasion Proliferation

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Journal of Systems Science and Systems Engineering 2009年第3期18卷 257-282页

作者： james m. TIEN Pascal J. GOLDSCHmIDT-CLERmONT Dean College of Engineering University of Miami Coral GablesFlorida USA Dean Miller School of Medicine University of Miami Coral GablesFlorida USA

Healthcare is indeed a complex service system, one requiring the technobiology approach of systems engineering to underpin its development as an integrated and adaptive system. In general, healthcare services are carried out with knowledge-intensive agents or components which work together as providers and consumers to create or co-produce value. Indeed, the engineering design of a healthcare system must recognize the fact that it is actually a complex integration of human-centered activities that is increasingly dependent on information technology and knowledge. Like any service system, healthcare can be considered to be a combination or recombination of three essential components - people （characterized by behaviors, values, knowledge, etc.）, processes （characterized by collaboration, customization, etc.） and products （characterized by software, hardware, infrastructures, etc.）. Thus, a healthcare system is an integrated and adaptive set of people, processes and products. It is, in essence, a system of systems which objectives are to enhance its efficiency （leading to greater interdependency） and effectiveness （leading to improved health）. Integration occurs over the physical, temporal, organizational and functional dimensions, while adaptation occurs over the monitoring, feedback, cybernetic and learning dimensions. In sum, such service systems as healthcare are indeed complex, especially due to the uncertainties associated with the human-centered aspects of these systems. moreover, the system complexities can only be dealt with methods that enhance system integration and adaptation.

关键词： Services healthcare system integration system adaptation system complexity system of systems customization co-production decision informatics real-time decision making

A CASE FOR SERVICE SYSTEmS ENGINEERING

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Systems Science and Systems Engineering 2003年第1期12卷 13-38页

作者： james m.TIEN Daniel BERG Department of Decision Sciences and Engineering Systems Rensselaer Polytechnic Institute Troy New York 12110-3590U.S.A.Department of Decision Sciences and Engineering Systems Rensselaer Polytechnic Institute TroyNew York 12110-3590U.S.A.

A case is made for further developing a branch of systems engineering that focuses on problems and issues which arise in the service sector. We promulgate this special focus not only because of the size and importance of the service sector but also because of the unique opportunities that systems engineering can exploit in the design and joint production and delivery of services. We begin by considering the economic, technological and demographic contexts within which the service sector has flourished; we then address both services, especially emerging services, and systems engineering, followed by a discussion of how to advance the field of service systems engineering, and concluding with several remarks. In particular, a number of service systems engineering methods are identified to enhance the design and production/delivery of services, especially taking advantage of the unique features that characterize services - namely, services, especially emerging services, are information-driven, customer-centric, e-oriented, and productivity-focused.

关键词： Service sector systems engineering information technology decision technologies customer-centric productivity

Comparison of Energy Harvesting Systems for Wireless Sensor Networks

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International Journal of Automation and computing 2008年第4期5卷 334-347页

作者： james m.Gilbert Farooq Balouchi Department of Engineering University of Hull

Wireless sensor networks (WSNs) offer an attractive solution to many environmental,security,and process monitoring ***,one barrier to their fuller adoption is the need to supply electrical power over extended periods of time without the need for dedicated *** harvesting provides a potential solution to this problem in many *** paper reviews the characteristics and energy requirements of typical sensor network nodes,assesses a range of potential ambient energy sources,and outlines the characteristics of a wide range of energy conversion *** then proposes a method to compare these diverse sources and conversion mechanisms in terms of their normalised power density.

关键词： Energy harvesting energy scavenging wireless sensor networks (WSNs) energy management

Vertebrate pesticide risk assessment by indigenous communities in New Zealand

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Integrative Zoology 2010年第1期5卷 37-43页

作者： Shaun C.OGILVIE james m.ATARIA james WAIWAI james DOHERTY Aroha mILLER james G.ROSS Charles T.EASON Ecology Department Lincoln UniversityLincolnCanterburyNew Zealand Landcare Research LincolnCanterburyNew Zealand Lake Waikaremoana Hapu Restoration Trust TuaiNew Zealand Tuhoe Tuawhenua Trust MuruparaNew Zealand

In New Zealand,the vertebrate pesticide sodium fluoroacetate(Compound 1080)is aerially applied in baits for control of the brush-tailed possum Trichosurus vulpecula(Kerr,1792).maori,the indigenous people of New Zealand,have raised concerns about 1080 impacts on culturally-important ***,we outline two steps taken to help maori assess 1080 ***,field research was undertaken to determine if naturally-occurring plants utilized by a maori community for food and medicine would take up 1080 from *** baits were placed at the base of individual plants of two species,pikopiko(Asplenium bulbiferum)and karamuramu(Coprosma robusta).Plants were sampled at various times up to 56 days,and samples were analyzed for 1080 *** 1080 was detected in any of the pikopiko samples,whereas 1080 was detected in karamuramu,at a maximum concentration of 5 ppb after seven days,and 2.5 ppb after 14 *** concentration decreased to 0 at 28 days,indicating that 1080 was not *** results of the present study suggest there is negligible risk of humans being poisoned by consum-ing plants that have taken up 1080 from *** allay community concerns that minute concentrations of 1080 might influence the medicinal properties of plants,it is suggested that a withholding period of 30 days after 1080 control operations could be ***,after further consultation we undertook a review of the scientific literature relating to 1080 impacts on additional non-target species of cultural importance to *** information was presented on an interactive foodweb database that allowed the collection and presentation of a large volume of complex information about 1080 in a holistic and pictorial *** database was presented to many maori communities throughout New Zealand,and feedback was overwhelmingly *** database is likely to play a key role in informing these communities about 1080,and is seen as an important new tool to help these communities

关键词： 1080 indigenous communities maori risk assessment sodium fluoroacetate

Thiopurine use associated with reduced B and natural killer cells in inflammatory bowel disease

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World Journal of Gastroenterology 2017年第18期23卷 3240-3251页

作者： james D Lord Donna m Shows Translational Research Program Benaroya Research Institute Gastroenterology Division Virginia Mason Medical Center

To identify which blood and mucosal lymphocyte populations are specifically depleted by thiopurine use in *** thiopurines azathioprine and 6-mercaptopurine have been a mainstay of inflammatory bowel disease (IBD) therapy for decades, but their mechanism of action in vivo remains obscure. Although thiopurines are lymphotoxic at high doses, and have been reported to cause T cell apoptosis in vitro, their ability to control IBD at lower doses suggests that they may selectively deplete particular lymphocyte populations. Blood cells from 19 IBD patients on a thiopurine, 19 IBD patients not on a thiopurine, and 38 matched healthy control subjects were analyzed by multiple multi-color flow cytometry panels to quantify the immune cell subsets contained therein, both as a percent of cells, and as an absolute cell count. Similar analyses were performed on colon biopsies from 17 IBD patients on a thiopurine, 17 IBD patients not on a thiopurine, and 49 healthy screening colonoscopy *** blood counts revealed lower lymphocyte, but not monocyte or granulocyte, counts in IBD patients who were taking thiopurines at the time of sampling. This reduction was restricted to CD3-negative lymphocytes, wherein both natural killer (NK) and B cells were significantly reduced among thiopurine recipients. Among CD19+ B cells, the transitional B cells were particularly depleted, being nearly absent in both blood and colon biopsies of thiopurine recipients. No differences were associated with thiopurine use in CD8+ T cells, mucosa-associated invariant T (mAIT) cells, invariant natural killer T (iNKT) cells, gamma/delta T cells, Th1, Th17, regulatory T cells (Tregs) or naïve CD4+ T cells. However, patients with IBD had significantly more circulating FOXP3+, Helios+ Tregs and fewer iNKT and mAIT cells than healthy *** use is associated with reduced B and NK cell, but not T cell, subpopulations in the blood of IBD patients.

关键词： Thiopurine Azathioprine mercaptopurine Lymphocyte Natural killer cell Transitional B cell Inflammatory bowel disease

Perspectives on the clinical development of mmunotherapy in prostate cancer

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Asian Journal of Andrology 2018年第3期20卷 253-259页

作者： Lisa m Cordes james L Gulley Ravi A madan Clinical Center National Institutes of Health Bethesda MD 20892 USA Genitourinary malignancies Branch Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD 20892 USA

Despite impressive survival benefits with immunotherapy in patients with various solid tumors, the full potential of these agents in prostate cancer has yet to be realized. SipuleuceI-T demonstrated a survival benefit in this population, indicating that prostate cancer is an immunoresponsive disease; however, these results have not been matched by other agents. A large trial with ipilimumab in prostate cancer failed to meet its primary objective, and small trials with PD-1/PD-L1 inhibitors did not yield a significant improvement in overall response. However, several late-stage clinical trials are underway with other vaccines in prostate cancer. Reports of clinical benefit with immunotherapies, particularly when used in combination or a select population, have provided the framework to develop sound clinical trials. Understanding immunogenic modulation, antigen spread, biomarkers, and DNA-repair defects will also help mold future strategies. Through rational patient selection and evidence-based combination approaches, patients with prostate cancer may soon derive durable survival benefits with immunotherapies.

关键词： checkpoint inhibitor immunotherapy prostate cancer therapeutic vaccine

Flu channel drug resistance:a tale of two sites

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Protein & Cell 2010年第3期1卷 246-258页

作者： Rafal m.Pielak james J.Chou Department of Biological Chemistry and molecular Pharmacology Harvard Medical SchoolBostonMA 02115USA Program in Biological and Biomedical Sciences Harvard Medical SchoolBostonMA 02115USA

The m2 proteins of influenza A and B virus,Am2 and Bm2,respectively,are transmembrane proteins that oligomerize in the viral membrane to form proton-selective *** conductance of the m2 proteins is required for viral replication;it is believed to equilibrate pH across the viral membrane during cell entry and across the trans-Golgi membrane of infected cells during viral *** addition to the role of m2 in proton conductance,recent mutagenesis and structural studies suggest that the cytoplasmic domains of the m2 proteins also play a role in recruiting the matrix proteins to the cell surface during virus *** viral ion channels of minimalist architecture,the membrane-embedded channel domain of m2 has been a model system for investigating the mechanism of proton ***,as a proven drug target for the treatment of influenza A infection,m2 has been the subject of intense research for developing new anti-flu ***2 is the target of two anti-influenza A drugs,amantadine and rimantadine,both belonging to the adamantane class of ***,resistance of influenza A to adamantane is now widespread due to mutations in the channel domain of *** review summarizes the structure and function of both Am2 and Bm2 channels,the mechanism of drug inhibition and drug resistance of Am2,as well as the development of new m2 inhibitors as potential anti-flu drugs.

关键词： m2 Bm2 influenza proton channel amantadine rimantadine