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mRNA expression of DOK1-6 in human breast cancer

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World Journal of Clinical Oncology 2014年第2期5卷 156-163页

作者： Tamara ghanem james Bracken Abdul Kasem Wen g Jiang Kefah Mokbel London Breast Institute Princess Grace Hospital Metastasis and Angiogenesis Research group University Department of Surgery Cardiff University

AIM:To examine the expression of downstream of tyrosine kinase(DOK)1-6 genes in normal and breast cancer tissue and correlated this with several clinicopathological and prognostic ***:DOK1-6 m RNA extraction and reverse transcription were performed on fresh frozen breast cancer tissue samples(n = 112) and normal background breast tissue(n = 31). Tissues were collected between 1991 and 1996 at two centres and all patients underwent mastectomy and ipsilateral axillary node dissection. All tissues were randomly numbered and the details were only made known after all analyses were completed. Transcript levels of expression were determined using real-time polymerase chain reaction and analyzed against TNM stage, tumour grade and clinical outcome over a 10-year follow-up ***:DOK-2 and DOK-6 expression decreased with increasing TNM stage. DOK-6 expression decreased with increasing Nottingham Prognostic Index(NPI) [NPI-1 vs NPI-3(mean copy number 15.4 vs 0.22, 95%CI:2.7-27.6, P = 0.018) and NPI-2 vs NPI-3(mean copy number 7.6 vs 0.22, 95%CI:0.1-14.6, P = 0.048)]. After a median follow up period of 10 years, higherlevels of DOK-2 expression were found among patients who remained disease-free compared to those who developed local or distant recurrence(mean copy number 3.94 vs 0.0000096, 95%CI:1.0-6.85, P = 0.0091), and distant recurrence(mean copy number 3.94 vs 0.0025, 95%CI:1.0-6.84, P = 0.0092). Patients who remained disease-free had higher levels of DOK-6 expression compared to those who died from breast ***:Decreasing expression levels of DOK-2 and DOK-6 with increased breast tumour progression supports the notion that DOK-2 and DOK-6 behave as tumour suppressors in human breast cancer.

关键词： Adaptor protein Breast cancer Downstream of tyrosine kinase-2 Downstream of tyrosine kinase-6 Mitogen-activated protein kinase Tyrosine kinase,Tumour suppressor

Intraductal papillary mucinous neoplasms and other pancreatic cystic lesions

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World Journal of gastroenterology 2008年第19期14卷 2977-2979页

作者： Hugh james Freeman Department of Medicine (gastroen-terology) University of British Columbia

Pancreatic cystic neoplasms are being increasingly recognized, even in the absence of symptoms, in large part, due to markedly improved imaging modalities such as magnetic resonance imaging (MRI)/magnetic resonance cholangio pancreatography (MRCP) and computer tomography (CT) scanning. During the past 2 decades, better imaging of these cystic lesions has resulted in definition of different types, including pancreatic intraductal papillary mucinous neoplasms (IPMN). While IPMN represent only a distinct minority of all pancreatic cancers, they appear to be a relatively frequent neoplastic form of pancreatic cystic neoplasm. Moreover, IPMN have a much better outcome and prognosis compared to pancreatic ductal adenocarcinomas. Therefore, recognition of this entity is exceedingly important for the clinician involved in diagnosis and further evaluation of a potentially curable form of pancreatic cancer.

关键词： Pancreatic cancer Pancreatic intraductal papillary mucinous neoplasms Mucinous cystic neoplasm of pancreas Serous cystadenoma Pancreatic cysticlesions

Reproductive changes associated with celiac disease

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World Journal of gastroenterology 2010年第46期16卷 5810-5814页

作者： Hugh james Freeman Department of Medicine (gastroenterology) University of British Columbia Hospital

Celiac disease is a mucosal disorder of the small intestine that may be triggered by dietary exposure to gluten in genetically-susceptible *** disorder is often associated with diarrhea,malabsorption and weight loss along with other extra-intestinal *** changes have been described,including impaired fertility and adverse pregnancy outcomes possibly related to immune-mediated mechanisms or nutrient *** possible pathogenetic factors that may alter placental function include maternal celiac disease autoantibodies binding to placental transglutaminase,and genetic mutations that may facilitate microthrombus *** noting activation during pregnancy or the puerperium may be important,and suggest that celiac disease may also be hypothetically precipitated by maternal exposure to one or more fetal antigens.

关键词： Celiac disease Infertility Pregnancy Post-partum celiac disease Fetal outcome

Recent advances in nanomaterials for high-performance Li–S batteries

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Journal of Energy Chemistry 2020年第8期29卷 86-106,I0004页

作者： james E.Knoop Seongki Ahn Joint School of Nanoscience and Nanoengineering North Carolina Agricultural and Technical State UniversityGreensboroNC 27401USA Research Organization for Nano and Life Innovation Waseda University513WasedatsurumakichoShinjuku-kuTokyo 162-0041Japan

This article reviews nanotechnology as a practical solution for improving lithium-sulfur batteries. Lithiumsulfur batteries have been widely examined because sulfur has many advantageous properties such as a high crustal abundance, low environmental impact, low cost, high gravimetric(2600 W h kg-1) and volumetric(2800 W h L-1) energy densities, assuming complete conversion of sulfur to lithium sulfide(Li2S)upon lithiation. However, lithium-sulfur batteries have not yet reach commercialization due to demerits involving the formation of soluble lithium polysulfides(Li2Sn, n=3–8), low electrical conductivity, and low loading density of sulfur. These issues arise mainly due to the polysulfide shuttle phenomenon and the inherent insulating nature of sulfur. To overcome these issues, strategies have been pursued using nanotechnology applied to porous carbon nanocomposites, hollow one-dimensional carbon nanomaterials, graphene nanocomposites, and three-dimensional carbon nanostructured matrices. This paper aims to review various solutions pertaining to the role of nanotechnology in synthesizing nanoscale and nanostructured materials for advanced and high-performance lithium–sulfur batteries. Furthermore, we highlight perspective research directions for commercialization of lithium–sulfur batteries as a major power source for electric vehicles and large-scale electric energy storage.

关键词： Nanotechnology Lithium–sulfur batteries Carbon nanomaterials Nanocomposite sulfur 3D nanostructured materials

Two-dimensional near-infrared photonic crystal fabrication by generation of void channels in solid resin

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Chinese Optics Letters 2003年第12期1卷 719-721页

作者： Michael james Ventura Centre for Micro-Phtonics and the Centre for Ultrahigh-Highwidth Devices for Optical Systems School of Biophysical Sciences and Electrical Engineering Swinburne University of Technology PO Box 218 Hawthorn Victoria 3122 Australia

Two-dimensional (2D) triangular void channel photonic crystals with different lattice constants stacked in two different directions were fabricated by using femtosecond laser micro-explosion in solid polymer material. Fundamental and higher-order stop gaps were observed both in the infrared transmission and reflection spectra. There is an approximately linear relationship between the gap position and the lattice constant. The suppression of the fundamental gap is as high as 70% for 24-layer structures stacked in the T-M direction.

关键词： of as Two-dimensional near-infrared photonic crystal fabrication by generation of void channels in solid resin by that were for with

Analysis of the Oscillatory Flows of Multiple Shock Waves in a Constant Area Duct

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Journal of Thermal Science 2024年第3期33卷 794-806页

作者： K james Jintu KIM Heuy Dong Department of Mechanical Engineering Andong National UniversityAndong36729Republic of Korea CAD-IT Korea Co. Ltd.Seoul08591Republic of Korea

The oscillatory response of multiple shock waves to downstream perturbations in a supersonic flow is studied numerically in a rectangular *** shock waves are formed inside the duct at a shock Mach number of *** duct has an exit height of H,and the effect of duct resonance on multiple shock oscillations is investigated by attaching exit ducts of lengths 0H,50H,and *** downstream disturbance frequency varied from 10 Hz to 200 Hz to explore the oscillation characteristics of the multiple shock *** oscillatory response of shock waves under self-excited and forced oscillation conditions are analyzed in terms of wall static pressure,shock train leading-edge location,shock train length,and the size of the separation *** extent of the initial shock location increases with an increase in exit duct length for the self-excited oscillation *** analysis of the shock train leading edge and the spectral analysis of wall static pressure variations are *** variation in the shock train length is analyzed using the pressure ratio method for self-excited as well as forced *** RMS amplitude of the normalized shock train length(ζ_(ST))increases with an increase in the exit duct length for the self-excited oscillation *** the downstream perturbation frequency is increased,ζ_(ST)is decreased for exit duct *** all exit duct designs and downstream forcing frequencies,the size of the separation bubble grows and shrinks during the shock oscillations,demonstrating the dependence on duct resonance and forced oscillations.

关键词： shock train downstream disturbance supersonic flow shock wave boundary layer interaction duct resonance flow separation

Insurance coverage for male infertility care in the United States

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Asian Journal of Andrology 2016年第3期18卷 339-341,I0006页

作者： james M Dupree Department of Urology Divisions of Andrology and Health Services Research and Department of Obstetrics and Gynecology University of Michigan 1500 E Medical Center Drive 3875 Taubman Center SPC 5330 Ann Arbor M148109-5330 USA.

Infertility is a common condition experienced by many men and women, and treatments are expensive. The World Health Organization and American Society of Reproductive Medicine define infertility as a disease, yet private companies infrequently offer insurance coverage for infertility treatments. This is despite the clear role that healthcare insurance plays in ensuring access to care and minimizing the financial burden of expensive services. In this review, we assess the current knowledge of how male infertility care is covered by insurance in the United States. We begin with an appraisal of the costs of male infertility care, then examine the state insurance laws relevant to male infertility, and close with a discussion of why insurance coverage for male infertility is important to both men and women. Importantly, we found that despite infertility being classified as a disease and males contributing to almost half of all infertility cases, coverage for male infertility is often excluded from health insurance laws. Excluding coverage for male infertility places an undue burden on their female partners. In addition, excluding care for male infertility risks missing opportunities to diagnose important health conditions and identify reversible or irreversible causes of male infertility. Policymakers should consider providing equal coverage for male and female infertility care in future health insurance laws.

关键词： health policy insurance male infertility public policy

Watershed science:Linking hydrological science with sustainable management of river basins

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Science China Earth Sciences 2021年第5期64卷 677-690页

作者： Chansheng HE L.Allan james Department of geography Western Michigan UniversityKalamazooM149008USA Center for Dryland Water Resources Research and Watershed Science Key Laboratory of West China’s Environmental System(Ministry of Education)College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Department of geography University of South CarolinaColumbiaSC 29208USA

Over the past decades,a number of water sciences and management programs have been developed to better understand and manage the water cycles at multiple temporal and spatial scales for various purposes,such as ecohydrology,global hydrology,sociohydrology,supply management,demand management,and integrated water resources management(IWRM).At the same time,rapid advancements have also been taking place in tracing,mapping,remote sensing,machine learning,and modelling technologies in hydrological *** those programs and advancements,a water crisis is intensifying *** missing link is effective interactions between the hydrological research and water resource management to support implementation of the UN Sustainable Development goals(SDgs)at multiple spatial *** the watershed is the natural unit for water resources management,watershed science offers the potential to bridge this missing *** study first reviews the advances in hydrological research and water resources management,and then discusses issues and challenges facing the global water ***,it describes the core components of watershed science:(1)hydrological analysis;(2)water-operation policies;(3)governance;(4)management and *** framework takes into account water availability,water uses,and water quality;explicitly focuses on the storage,fluxes,and quality of the hydrological cycle;defines appropriate local water resource thresholds through incorporating the planetary boundary framework;and identifies specific actionable measures for water resources *** provides a complementary approach to the existing water management programs in addressing the current global water crisis and achieving the UN SDgs.

关键词： Water crisis Hydrology Watershed science Integrated water resources management(IWRM)

A spatiotemporal analysis of the impact of lockdown and coronavirus on London’s bicycle hire scheme:from response to recovery to a new normal

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geo-Spatial Information Science 2023年第4期26卷 664-684页

作者： Xiaowei gao Huanfa Chen james Haworth SpaceTimelab Department of CivilEnvironmental and Geomatic EngineeringUniversity College LondonLondonUnited Kingdom Centre for Advanced Spatial Analysis University College LondonLondonUnited Kingdom

The coronavirus pandemic that started in 2019 has had wide-ranging impacts on many aspects of people’s daily *** the peak of the outbreak,lockdown measures and social distancing changed the ways in which cities *** particular,they had profound impacts on urban transportation systems,with public transport being shut down in many *** share systems(BSS)were widely reported as having experienced an increase in demand during the early stages of the pandemic before returning to pre-pandemic ***,the studies published to date focus mainly on the first year of the pandemic,when various waves saw continual relaxing and reintroductions of ***,they fall short of exploring the role of BSS as we move to the post-pandemic *** address this gap,this study uses origin-destination(O-D)flow data from London’s Santander Cycle Hire Scheme from 2019-2021 to analyze the changing use of BSS throughout the first two years of the pandemic,from lockdown to recovery.A gaussian mixture model(gMM)is used to cluster 2019 BSS trips into three distinct clusters based on their duration and *** clusters are used as a reference from which to measure spatial and temporal change in 2020 and *** agreement with previous research,BSS usage was found to have declined by nearly 30%during the first *** then saw a sharp increase as restrictions were lifted,characterized by longer,less direct trips throughout the afternoon rather than typical peak commuting *** the aggregate number of BSS trips appeared to return to normal by October 2020,this was against the backdrop of continuing restrictions on international travel and work from home *** period between July and December 2021 was the first period that all government restrictions were *** this time,BSS trips reached higher levels than in ***-temporal analysis indicates a shift away from the traditional morning and evening peak to a more diffuse p

关键词： COVID-19 micro-mobility restrictive measures bicycle share system