检索结果-南通市图书馆

进行性肾脏疾病和梗阻性肾病——临床研究概述

在线全文

学校读者我要写书评

暂无评论

中华儿科杂志 2005年第6期43卷 406-409页

作者： james c.m.chan Jonathan I.Scheinman Karl S.Roth 管娜范青锋丁洁缅因州医学中心Babara Bush儿童医院研究中心美国堪萨斯大学小儿肾脏病科美国内布拉斯加州creighton大学医学院儿科

近年来，随着分子生物学技术的应用，我们对梗阻性肾病的认识取得了很大进展。目前，对肾脏形态发生的调节机制，不同因素对胚肾发育和功能的影响，以及梗阻对肾脏产生的多方面的影响已经有了较为深入的理解。许多关于梗阻性肾病的理论... 详细信息

近年来，随着分子生物学技术的应用，我们对梗阻性肾病的认识取得了很大进展。目前，对肾脏形态发生的调节机制，不同因素对胚肾发育和功能的影响，以及梗阻对肾脏产生的多方面的影响已经有了较为深入的理解。许多关于梗阻性肾病的理论有待于从细胞培养和动物模型的研究转化为对先天性泌尿道梗阻患者的临床研究。

关键词：梗阻性肾病研究概述肾脏疾病进行性分子生物学技术泌尿道梗阻调节机制形态发生临床研究动物模型肾发育先天性

Physics-based,data-driven approach for predicting natural ventilation of residential high-rise buildings

在线全文

学校读者我要写书评

暂无评论

Building Simulation 2022年第1期15卷 129-148页

作者： Vincent J.L.Gan Boyu Wang c.m.chan A.U.Weerasuriya Jack c.P.cheng Department of Building School of Design and EnvironmentNational University of SingaporeSingapore117566 Department of civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong Kong999077China

Natural ventilation is particularly important for residential high-rise buildings as it maintains indoor human comfort without incurring the energy demands that air-conditioning *** improve a building’s natural ventilation,it is essential to develop models to understand the relationship between wind flow characteristics and the building's *** more effort is still needed for developing such reliable,accurate,and computationally economical models instead of currently the most popular physics-based models such as computational fluid dynamics(cFD)*** paper,therefore,presents a novel model developed based on physics-based modelling and a data-driven approach to evaluate natural ventilation in residential high-rise *** model first uses cFD to simulate wind pressures on the exterior surfaces of a high-rise *** the surface pressures have been obtained,multizone modelling is used to predict the air change per hour(AcH)for different flats in various ***-driven prediction models are then developed using data from the simulation and deep neural networks that are based on mean absolute error,mean absolute percentage error,and a fusion algorithm *** data-driven models are used to predict the AcH of 25 *** results from multizone modelling and data-driven modelling are *** results imply a high accuracy of the data-driven prediction in comparison with physics-based *** fusion algorithm-based neural network performs best,achieving 96%accuracy,which is the highest of all models *** study contributes a more efficient and robust method for predicting wind-induced natural *** findings describe the relationship between building design(e.g.,plan layout),distribution of surface pressure,and the resulting AcH,which serve to improve the practical design of sustainable buildings.

关键词： computational fluid dynamics data-driven prediction machine learning multizone model natural ventilation residential building

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： carina Hromada Patrick Heimel markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl james Ferguson Nicole Swiadek Xavier monforte Johannes c.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGcs). However, the use of tNGcs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGc would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGcs and compared the various features of these improved silk^(+) tNGcs with the tubes without holes(silk^(–) tNGcs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGcs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGcs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGcs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGcs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Detection of Breaking Waves Using X-Band Pulse Radar in the Nearshore Region

在线全文

学校读者我要写书评

暂无评论

china Ocean Engineering 2013年第4期27卷 549-556页

作者： Y.c.Lin c.c.chang m.c.Lee H.c.chan J.m.Leu Department of Hydraulic and Ocean Engineering National Cheng-Kung University Department of Soil and Water conservation National Chung Hsing University Department of Hospitality management Taiwan Shoufu University

An X-band pulsed Doppler microwave radar has been used to determine the characteristics of breaking waves. Field experiments were conducted at the Shuang-Si estuary in the north of Taiwan in the winter of 2005. Analyses on maxima radar cross section and Doppler frequency shift are done to characterize wave breaking zones. Based on observations of breaking waves, the wave breaking zones are shown to be located at water depths of 1.8 to 2.2 m in the experimental site. In general, the results indicate that a radar system has the potential to delineate the spatial variation of breaking waves clearly and that this is sufficient to achieve a measurement operation for near-shore air-sea interaction events.

关键词： radar Doppler effect wave breaking coastal zone

A cooperative Autonomous mechatronic System for Fault Tolerant control of material Handling Operations

在线全文

学校读者我要写书评

暂无评论

A Cooperative Autonomous Mechatronic System for Fault Tolera...

computational Biology Approaches to Plant metabolism and Photosynthesis:Applications for corals in Times of climate change and Environmental Stress

第11届粤港机械电子工程技术与应用研讨会

作者： Raymond c.m.chan Henry Y.K.Lau Department of Industrial and manufacturing Systems Engineering The University of Hong Kong Pokfulam Road Hong KongPRC

＜正＞Sustainable control of a cooperative autonomous mechatronic system is a challenging undertaking and it is one of the focuses which many researchers have been working on for *** this paper,we introduce the design of an immune-inspired decentralized sustainability control methodology for cooperative autonomous mechatronic system such as multi-agent systems （mAS） to optimize the overall performance in terns of longevity through the trade-off between maintenance activity and task *** resulting system will have favorable characteristics of good fault tolerant as well as task achievement.A design of a multi-robot system that is amenable for the experimentation of the proposed methodology is presented together with a simulation platform for investigating its performance.

关键词： multi-agent system artificial immune systems robotic control

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2010年第8期52卷 698-703页

作者： m.james c.crabbe LIRANS Institute for Research in the Applied Natural Sciences Faculty of Creative ArtsTechnologies and ScienceUniversity of BedfordshireLutonUK

Knowledge of factors that are important in reef resilience helps us to understand how reef ecosystems react following major anthropogenic and environmental disturbances. The symbiotic relationship between the photosynthetic zooxanthellae algal cells and corals is that the zooxanthellae provide the coral with carbon, while the coral provides protection and access to enough light for the zooxanthellae to photosynthesise. This article reviews some recent advances in computational biology relevant to photosynthetic organisms, including Beyesian approaches to kinetics, computational methods for flux balances in metabolic processes, and determination of clades of zooxanthallae. Application of these systems will be important in the conservation of coral reefs in times of climate change and environmental stress.

关键词： computational Biology Approaches to Plant metabolism and Photosynthesis

Differential signaling of Flt3 activating mutations in acute myeloid leukemia:a working model

在线全文

学校读者我要写书评

暂无评论

Protein & cell 2011年第2期2卷 108-115页

作者： Perry m.chan Neuroscience Research Partnership Biomedical Sciences Instituteaffiliated with Institute of Molecular and Cell BiologyASTARSingapore 138673Singapore

Receptor tyrosine kinases couple a wide variety of extracellular cues to cellular *** class III subfamily comprises the platelet-derived growth factor receptor,c-Kit,Flt3 and c-Fms,all of which relay cell proliferation signals upon ligand ***,mutations in these proteins that confer ligand-independent activation are found in a subset of *** mutations cluster in the juxtamembrane(Jm)and catalytic tyrosine kinase domain(TKD)*** the case of acute myeloid leukemia(AmL),the juxtamembrane(named ITD for internal tandem duplication)and TKD Flt3 mutants differ in their spectra of clinical *** the mechanism of aberrant activation has been largely elucidated by biochemical and structural analyses of mutant kinases,the differences in disease presentation cannot be attributed to a change in substrate specificity or signaling strength of the catalytic *** review discusses the latest literature and presents a working model of differential Flt3 signaling based on mis-localized juxtamembrane autophosphorylation,to account for the disease *** will have bearing on therapeutic approaches in a complex disease such as AmL,for which no efficacious drug yet exists.

关键词： acute myeloid leukemia receptor tyrosine kinase oncogenic mutation autoinhibition intracellular traf-ficking

Diagnosis and management of testosterone deficiency

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2015年第2期17卷 177-186,I0006页

作者： james A mcBride culley c carson Robert m coward Department of Urology University of North Carolina School of Medicine NC USA.

Testosterone supplementation therapy （TST） use has dramatically increased over the past decade, due to the availability of newer agents, aggressive marketing, and an increasing incidence of testosterone deficiency （TD）. Despite the increase in TST, a degree of ambiguity remains as to the exact diagnostic criteria of TD, and administration and monitoring of TST. One explanation for this phenomenon is the complex role testosterone plays in multiple physiologic pathways. Numerous medical co-morbidities and medications can alter testosterone levels resulting in a wide range of nonspecific clinical signs and symptoms of TD. The diagnosis is also challenging due to the lack of a definitive serum total testosterone level that reliably correlates with symptoms. This observation is particularly true in the aging male and is exacerbated by inconsistencies between different laboratory assays. Several prominent medical societies have developed guideline statements to clarify the diagnosis, but they differ from each other and with expert opinion in several ways. Aside from diagnostic dilemmas, there are numerous subtle advantages and disadvantages of the various testosterone agents to appreciate. The available TST agents have changed significantly over the past decade similar to the trends in the diagnosis of TD. Therefore, as the usage of TST increases, clinicians will be challenged to maintain an up-to-date understanding of TD and TST. The purpose of this review is to provide a clear description of the current strategies for diagnosis and management of TD.

关键词： androgens erectile dysfunction hormones hypogonadism testosterone

Assessment of cOVID-19 aerosol transmission in a university campus food environment using a numerical method

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2022年第6期13卷 265-278页

作者： m.Zhao c.Zhou T.chan c.Tu Y.Liu m.Yu Laboratory of Aerosol Science and Technology China Jiliang UniversityHangzhouChina Department of mechanical Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina college of modern Science China Jiliang UniversityHangzhouChina

With the prevalence of cOVID-19,the phenomenon of viruses spreading through aerosols has become a focus of *** in university dining halls have a high risk of exposure to respiratory droplets from others without the protection of face masks,which greatly increases the risk of cOVID-19 ***,the transmission mechanism of respiratory droplets in extremely crowded dining environments should be *** this study,a numerical simulation of coughing at dining tables under two conditions was performed,namely the presence and absence of protective partitions,and the evaporation and condensation of aerosol droplets in the air were *** using the numerical method,we analyzed and verified the isolation effect of dining table partitions in the propagation of aerosol *** effect of changes in room temperature on the diffusion of coughed aerosols when partitions were present was *** demonstrated how respiratory droplets spread through coughing and how these droplets affect ***,we proposed a design for a dining table partition that minimizes the transmission of cOVID-19.

关键词： cOVID-19 transmission University dining hall cough Table partition computational fluid dynamics