Preconditioned calves have greater marketvalue per unit weight than normal-weaned calves. Development of a low cost forage-based preconditioning system allows producers to add value to their calf-crop. This study eval...
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Preconditioned calves have greater marketvalue per unit weight than normal-weaned calves. Development of a low cost forage-based preconditioning system allows producers to add value to their calf-crop. This study evaluated calf performance in three forage-based weaning systems;early-weaned calves were backgrounded in legume/grass forage plots and supplemented with commercial preconditioning feed (Treatment 1) or an on-farm corn-mix (Treatment 2). Control (Treatment 3) calves suckled for an additional 45 days. Supplements provided2.17 kgTDN/calf/ day. Weights were collected on days -30, 0 and 45 with respect to early weaning, from135 inyear 1 and 150 calves in each of the two subsequent years. Effects of treatment, age of dam, sex of calf and their interactions on calf weight gain were analyzed by analysis of covariance using GLM procedures of SAS. Marginal effects of treatment and feed cost were used to evaluate economic feasibility. Sensitivity analyses were evaluated for anticipated market fluctuations in feed costs and calf premiums. Data are reported as least squares means. Calf weight gains differed (P < 0.001) among treatments and averaged 1.16, 1.03 and1.04 kg/calf/day for commercial supplement, corn-mix and controls, respectively. Calves from 2-year-old cows gained less (P < 0.001) weight compared to those from cows 3 - 4 and ≥5 years of age (44.8, 48.9 and51.5 kg, respectively). Steers calves gained more (P < 0.001) weight compared to heifer calves (51.2 vs.45.7 kg, respectively). Net returns for corn mix were greater than those for commercial feed ($1.48 vs. $1.35/kg weight gain, respectively). Sensitivity analyses indicated that selection of preconditioning treatment to a large degree was less sensitive to significant changes in market conditions due to the large gap in marginal costs between the two treatments. In conclusion, forage-based weaning systems can be utilized to precondition calves providing an economical means for calf weight gain and profit
AIM: To show a new paradigm of simultaneously testing whether breast cancer therapies impact other causes of death. METHODS: MA.14 allocated 667 postmenopausal women to 5 years of tamoxifen 20 mg/daily ± 2 years of o...
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AIM: To show a new paradigm of simultaneously testing whether breast cancer therapies impact other causes of death. METHODS: MA.14 allocated 667 postmenopausal women to 5 years of tamoxifen 20 mg/daily ± 2 years of octreotide 90 mg, given by depot intramuscular injections monthly. Event-free survival was the primary endpoint of MA.14; at median 7.9 years, the tamoxifen+octreotide and tamoxifen arms had similar event-free survival(P = 0.62). Overall survival was a secondary endpoint, and the two trial arms also had similar overall survival(P = 0.86). We used the median 9.8 years follow-up to examine by intention-to-treat, the multivariate time-to-breast cancer-specific(Br Ca) and other cause(OC) mortality with log-normal survival analysis adjusted by treatment and stratification factors. We tested whether baseline factors including Insulin-like growth factor 1(IGF1), IGF binding protein-3, C-peptide, body mass index, and 25-OH vitamin D were associated with(1) all cause mortality, and if so; and(2) cause-specific mortality. We also fit step-wise forward cause-specific adjusted ***: The analyses were performed on 329 patients allocated tamoxifen and 329 allocated tamoxifen+octreotide. The median age of MA.14 patients was 60.1 years: 447(82%) < 70 years and 120(18%) ≥ 70 years. There were 170 deaths: 106(62.3%) BrC a; 55(32.4%) OC, of which 24 were other malignancies, 31 other causes of death; 9(5.3%) patients with unknown cause of death were excluded from competing risk assessments. BrC a and OC deaths were not significantly different by treatment arm(P = 0.40): tamoxifen patients experienced 50 BrC a and 32 OC deaths, while tamoxifen + octreotide patients experienced 56 Br Ca and 23 OC deaths. Proportionately more deaths(P = 0.004) were from BrC a for patients< 70 years, where 70% of deaths were due to Br Ca, compared to 54% for those ≥ 70 years of age. The proportion of deaths from OC increased with increasing body mass index(BMI)(P = 0.02). Higher pathol
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