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World Journal of Gastrointestinal Endoscopy 2017年第9期9卷 448-455页

作者： Joseph J Kim james y lim Scott Q Nguyen Department of Surgery Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States

Gastrointestinal stromal tumors (GISTs) are rare tumors of the GI *** resection remains the mainstay of non-metastatic ***,the ability to provide an adequate oncologic resection using laparoscopic surgery is still an area of *** is a thorough review of the current literature,looking particularly at the use of laparoscopic surgery for larger GISTs and the long-term oncologic outcomes compared to the results of open *** resections provide an adequate oncologic result for GISTs of all sizes,including those greater than 5 cm in size.

关键词： Gastrointestinal stromal tumors Oncologic Laparoscopy Surgery

Laparoscopic surgery in the management of Crohn's disease

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World Journal of Gastrointestinal Pathophysiology 2014年第3期5卷 200-204页

作者： james y lim Joseph Kim Scott Q Nguyen Department of Surgery Icahn School of Medicine at Mount Sinai

Crohn's disease is a chronic inflammatory bowel disease with surgery still frequently necessary in its treatment. Since the 1990's, laparoscopic surgery has become increasingly common for primary resections in patients with Crohn's disease and has now become the standard of care. Studies have shown no difference in recurrence rates when compared to open surgery and benefits include shorter hospital stay, lower rates of wound infection and decreased time to bowel function. This review highlights studies comparing the laparoscopic approach to the open approach in specific situations, including cases of complicated Crohn's disease.

关键词： Crohn’s Laparoscopy Surgery Colon Ileum

The Involvement of Lipids in Alzheimer's Disease

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Journal of Genetics and Genomics 2014年第5期41卷 261-274页

作者： Wei Ling Florence lim Ian james Martins Ralph Nigel Martins School of Medical Sciences Edith Cowan University Centre of Excellence in Alzheimer's Disease Research and Care McCusker Foundation for Alzheimer's Disease Research Inc. Suite 22 Hollywood Medical Centre School of Psychiatry and Clinical Neurosciences The University of Western Australia

It has been estimated that Alzheimer＇s disease （AD）, the most common form of dementia, will affect approximately 81 million individuals by 2040. To date, the actual cause and cascade of events in the progression of this disease have not been fully determined. Furthermore, there is currently no definitive blood test or simple diagnostic method for AD. Considerable efforts have been put into proteomic approaches to develop a diagnostic blood test, but to date these efforts have not been successful. More recently, there has been a stronger focus on lipidomic studies in the hope of increasing our understanding of the underlying mechanisms leading to AD and developing an AD blood test. It is well known that the strongest genetic risk factor for AD is the e4 variant of apolipoprotein E （APOE）. Evidence suggests that the ApoE protein, a major lipid transporter, plays a key role in the pathogenesis of AD, and its role in both normal and aberrant lipid metabolism warrants further extensive investigation. Here, we review ApoE-lipid interactions, as well as the roles that lipids may play in the pathogenesis of AD.

关键词： Alzheimer's disease Lipids ApoE Oxysterols Inflammation

Elastic catenary cable element considering frictional slip effect

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Science China(Technological Sciences) 2012年第6期55卷 1489-1495页

作者： CAI JianGuo lim james FENG Jian XU yiXiang WANG Kai Key Laboratory of Concrete and Prestressed Concrete Structures of Ministry of Education Southeast UniversityNanjing 210096China National Prestress Engineering Research Center Southeast UniversityNanjing 210096China School of Planning Architecture and Civil EngineeringQueen's University Belfast BT95AGUK Department of Civil Engineering Strathclyde UniversityGlasgow G128QQUK

Conventional analysis methods of cable structures do not consider sliding of cables inside the joint,which may lead to inaccuracy of the theoretical behavior of the *** order to develop an effective method for cable sliding,a two-node cable element based on the analytical solution for an elastic catenary was *** cable sliding stiffness and the effect of friction were *** validate the proposed numerical method,analyses of two examples given in the literature were *** results demonstrated that the method given in this paper is accurate and effective,and can take into account cable sliding in cable *** addition,it was shown that the effect of cable sliding on the behavior of cable structures is *** was also shown that the friction at the support hampers the flow of the cable force,leading to unequal cable tensions on both sides of the support.

关键词： cable elastic catenary friction cable sliding nonlinear analysis

Future Pharmacotherapy for Non-alcoholic Steatohepatitis (NASH): Review of Phase 2 and 3 Trials

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Journal of Clinical and Translational Hepatology 2018年第3期6卷 264-275页

作者： james J.Connolly Kohtaro Ooka Joseph K.lim Department of Internal Medicine Yale University School of MedicineNew HavenCTUSA Division of Gastroenterology Hepatology and NutritionUniversity of Pittsburgh Medical CenterPittsburghPAUSA yale Liver Center Section of Digestive DiseasesYale University School of MedicineNew HavenCTUSA

Non-alcoholic steatohepatitis(NASH)results from inflammation and hepatocyte injury in the setting of hepatic ***-alcoholic steatohepatitis increases the risk of progression to liver fibrosis and cirrhosis,and is the most rapidly growing etiology for liver failure and indication for liver transplantation in the *** loss and lifestyle modification remain the standard first-line treatment,as no USA Food and Drug Administration-approved pharmacotherapy currently *** past decade has seen an explosion of interest in drug development targeting pathologic pathways in non-alcoholic steatohepatitis,with numerous phase 2 and 3 trials currently in ***,we concisely review the major targets and mechanisms of action by class,summarize results from com-pleted pivotal phase 2 studies,and provide a detailed outline of key active studies with trial data for drugs in development,including obeticholic acid,elafibranor,cenicriviroc and selonsertib.

关键词： Fatty liver Non-alcoholic steatohepatitis Clinical trials Pharmacotherapy Obeticholic acid

Leading Approaches to Vascularize Kidney Constructs in Tissue Engineering

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Engineering 2022年第12期19卷 117-127页

作者： Diana S.lim John D.Jackson Anthony Atala james J.yoo Wake Forest Institute for Regenerative Medicine Wake Forest University School of MedicineMedical Center BoulevardNC 27157USA

There is an unprecedented need for new treatments for renal failure,as the incidence of this disease is increasing disproportionately to advancements in *** treatments are limited by the availability of viable organs,for which there is a worldwide *** treatment modalities also require a substantial amount of infrastructure,significantly limiting the access to care in most *** tissue engineering approaches promise to develop alternative solutions that address many of the inadequacies in current *** many advancements have been made—primarily in the past decade—in biofabrication and whole-organ tissue engineering,many challenges *** major hindrance to the progress of current tissue engineering approaches is establishing successful vascularization of developed engineered tissue *** review focuses on the recent advancements that address the vascular challenge,including the biofabrication of vasculature,whole-organ engineering through decellularization and recellularization approaches,microscale organogenesis,and vascularization using organoids in the context of kidney tissue *** also highlight the specific challenges that remain in developing successful strategies capable of clinical translation.

关键词： Kidney Vascularization Tissue engineering Biofabrication Organoids

FAK and Pyk2 in disease

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Frontiers in Biology 2016年第1期11卷 1-9页

作者： james M. Murphy Hyeonsoo Park Ssang-Taek Steve lim Department of Biochemistry and Molecular Biology College of Medicine University of South Alabama Mobile Alabama 36688 USA

Focal adhesion kinase （FAK） and proline-rich tyrosine kinase 2 （Pyk2） are non-receptor protein tyrosine kinases that are involved in cell proliferation, migration and survival. Current research of FAK and Pyk2 is greatly focused in cancer biology and several small molecule inhibitors are being tested under clinical development. Like cancer, certain chronic diseases such as cardiovascular disease, bone disease, fibrosis, rheumatoid arthritis, and neurological disorders, share malignant characteristics of cancer. Accumulating evidence has demonstrated that FAK and Pyk2 contribute to other proliferative and degenerative diseases. Thus, the goal of this review is to briefly highlight studies that have implicated FAK and Pyk2 as players in disease progression.

关键词： FAK Pyk2 FRNK disease

Clinical Outcome Event Adjudication in a 10-year Prospective Study of Nucleos(t)ide Analogue Therapy for Chronic Hepatitis B

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Journal of Clinical and Translational Hepatology 2020年第4期8卷 377-384页

作者： Joseph K lim Alex y Chang Atif Zaman Paul Martin Conrado M Fernandez-Rodriguez Mete Korkmaz Simona Rossi james M Ford Tamara Noonan Elizabeth Cooney Victor Navarro Luis Colombato yale University School of Medicine New HavenCTUSA Johns Hopkins School of Medicine BaltimoreMDUSA and Johns Hopkins SingaporeSingapore Oregon Health&Science University PortlandORUSA University of Miami Miller School of Medicine MiamiFLUSA Hospital Universitario Fundación Alcorcón MadridSpain OSF Saint Anthony Center for Cancer Care RockfordILUSA Einstein Healthcare Network PhiladelphiaPAUSA Stanford University School of Medicine StanfordCAUSA Bristol-Myers Squibb WallingfordCTUSA Hospital Británico UCA School of MedicineBuenos AiresArgentina

Background and Aims:In the REALM (Randomized, Obser-vational Study of Entecavir to Assess Long-Term Outcomes Associated with Nucleoside/Nucleotide Monotherapy for Pa-tients with Chronic HBV Infection) study, 12,378 patients with chronic hepatitis B virus (HBV) infection received up to 10 years of randomized therapy with entecavir or another HBV nucleos(t)ide analogue. Monitored clinical outcome events (COEs) included malignant neoplasms, HBV disease progres-sion events, and deaths. An external event adjudication com-mittee (EAC) was convened to provide real-time review of reported COEs to optimize data quality, and minimize poten-tial adverse effects of the large cohort, interdisciplinary out-come assessments, geographic scope, and long duration. Methods:The EAC comprised an international group of hep-atologists and oncologists with expertise in diagnosis of tar-geted COEs. The EAC reviewed and adjudicated COEs according to prospectively defined diagnostic criteria cap-tured in the EAC charter. Operational processes, including da-ta collection and query procedures, were implemented to optimize efficiency of data recovery to maximize capture of adjudicated COEs, the primary study outcome measure. Results: A total of 1724 COEs were reported and 1465 of these events were adjudicated by the EAC as reported by the investigators (85.0% overall concordance). Concordance by COE type varied: deaths, 99.6%;hepatocellular carcino-ma (HCC), 83.3%;non-HCC malignancies, 88.0%;non-HCC HBV disease progression, 68.2%. Reasons for lack of con-cordance were most commonly lack of adequate supporting data to support an adjudicated diagnosis or evidence that the event pre-dated the study. Conclusions: The REALM EAC performed a critical role in ensuring data quality and consis-tency;EAC performance was facilitated by well-defined diag-nostic criteria, effective data capture, and efficient operational processes. Trial registration: *** NCT00388674.

关键词： Hepatitis B Antiviral therapy Clinical outcomes Event adjudication Liver cirrhosis

Non-invasive splenic parameters of portal hypertension:Assessment and utility

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World Journal of Hepatology 2020年第11期12卷 1055-1066页

作者： Ayesha Karim Ahmad Sebastiana Atzori james Maurice Simon D Taylor-Robinson Adrian KP lim Liver Unit Department of DigestionMetabolism&ReproductionFaculty of MedicineImperial College LondonLondon W21NYUnited Kingdom Liver Unit Department of DigestionMetabolism&ReproductionImperial College LondonLondon W21NYUnited Kingdom Liver Unit and Imaging Department of DigestionMetabolism&ReproductionImperial College LondonLondon W21NYUnited Kingdom

BACKGROUND Portal hypertension is a major complication of cirrhosis that is associated with significant morbidity and *** present gold-standard method to risk stratify and observe cirrhosis patients with portal hypertension is hepatic venous pressure gradient measurement or ***,these methods are invasive,carry a risk of complications and are associated with significant patient ***,non-invasive splenic parameters are of clinical interest as potential useful markers in determining the presence of portal ***,diagnostic accuracy and reproducibility remains *** To assess the diagnostic accuracy of spleen stiffness,area and diameter in predicting the presence of portal *** Of 50 patients with varying liver disease pathologies were prospectively recruited from the ***’s Hospital Liver Unit in London;25 with evidence of portal hypertension and 25 with no evidence of portal *** stiffness,spleen stiffness,spleen diameter and spleen area were measured using the Philips Affiniti 70 elastography point quantification point shear wave elastography *** aspartate aminotransferase-to-platelet-ratio-index(APRI)score was also *** measures,univariate and multivariate logistic regression were used to evaluate demographic,clinical and elastography *** correlation coefficient was used to determine the reproducibility of splenic area and *** On univariate and individual performance,platelet count[area under the receiver operating characteristic(AUROC)0.846,P valueying the presence of portal *** multivariate logistic regression models constructed,the combination of spleen area greater than 57.90 cm2 and platelet count less than 126×10^9 had 63.2%sensitivity and 100%specificity

关键词： Portal hypertension Esophageal varices Point shear wave elastography Spleen stiffness Spleen area Non-invasive

Computational Finite Element Modelling of Structural Behaviours of Precast Sandwiched Foamed Concrete Slab

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Open Journal of Civil Engineering 2015年第2期5卷 220-227页

作者： Kingsley Ukanwa Noridah Mohamad james B. P. lim Department of Civil and Environmental Engineering University of Auckland Auckland New Zealand Department of Civil and Environmental Engineering University Tun Hussein Onn Malaysia

The structural behaviour of Precast Lightweight Foamed Concrete Panel (PLFP) under flexural load is investigated by using ABAQUS 6.13. The PLFP is made up of two Whyte’s with a polystyrene insulator placed in between them using a double shear truss connector of diameter 6mm placed at an angle 45°. The panel is reinforced with both vertical and horizontal steel reinforcement of 9 mm diameter. Four panels with varying dimensions are simulated to investigate their Ultimate Strength and Load-deflection profile. The results show that the length to thickness ratio of the panel is the major contributing factor to the ultimate strength of the PLFP. From the load deflection curve, the panel with the least deflection has the highest thickness which also results in a high ultimate strength recorded at 34.43 KN.

关键词： Foamed Concrete Flexural Behaviour Finite Element ABAQUS