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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse w.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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中国高龄老人健康状况和死亡率变动趋势

人口学

Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

人口学 2017年第6期 22-32页

作者：曾毅冯秋石 Therese Hesketh Kaare Christensen james w.vaupel

文章对“中国老年健康影响因素跟踪调查”近两万名80～105岁高龄老人的数据分析发现，社会经济发展使得2008年高龄老人存活概率和自评日常生活自理能力比1998年有显著改善。医疗条件进步使健康较差高龄老人被“救”存活率提高，使2008... 详细信息

文章对“中国老年健康影响因素跟踪调查”近两万名80～105岁高龄老人的数据分析发现，社会经济发展使得2008年高龄老人存活概率和自评日常生活自理能力比1998年有显著改善。医疗条件进步使健康较差高龄老人被“救”存活率提高，使2008年高龄老人客观量测的躯体功能和认知功能比10年前显著下降；这给社会和亿万家庭带来严峻挑战。研究表明，经济社会发展和人类寿命提高带来效益的同时，也会产生一定成本；但它不是以往不少国际文献解释这一现象时所称的“胜利的失败”，所以没有必要为此恐慌，而需要全社会积极应对，努力实现人口健康老龄化。

关键词：高龄老人生活自理能力躯体功能认知功能健康老龄化 oldest old activities of daily living physical performance cognitive function healthy aging

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles w.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

Sea Nine 211 as antifouling biocide: A coastal pollutant of emerging concern

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Journal of Environmental Sciences 2017年第11期29卷 68-79页

作者： Lianguo Chen james C.w.Lam State Key Laboratory in Marine Pollution City University of Hong Kong Department of Science and Environmental Studies The Education University of Hong Kong

Sea Nine 211, with 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one（DCOIT） being the biocidal ingredient, is a widely-used antifouling agent to deter the undesirable biofouling phenomenon. It is commercially promoted as an environmentally acceptable antifoulant mainly due to its claimed rapid degradation in marine environment. However, increasing researches document varying degradative kinetics in different environments, proving that Sea Nine 211 is actually not degraded equally fast around the world（half-life between〈 1 day and 13.1 days）. Large-scale application of Sea Nine 211 in antifouling coatings has also caused global contamination of marine environment in various compartments. For example, accumulation of Sea Nine 211 is detected as high as 3700 ng/L in Spanish seawater and 281 ng/g dry weight in Korean sediment. Considering that Sea Nine 211 is highly toxic against non-target marine organisms, environmental risk assessment finds that most marine organisms are endangered by Sea Nine 211 in worst-case scenario. Its endocrine disrupting and reproductive impairing effects at environmentally worst-case concentrations further constitute a long-term threat to the maintenance of population ***, in the light of the varying degradability, environmental pollution and high toxicity, especially the endocrine disruption, Sea Nine 211 as an antifouling agent is likely to cause non-negligible damages to the marine ecosystem. There is an urgency to perform a systematic ecological risk assessment of Sea Nine 211 to prevent the potential impacts on the health of marine environment. A regular monitoring also becomes necessary to place the usage of antifouling biocides under control.

关键词： Sea Nine 211 Antifouling agent Degradation Environmental occurrences Ecological risks Endocrine disruption

Intentional and unintentional impacts of anaesthesia： insights from experiments in pain and injury

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Neural Regeneration Research 2017年第12期12卷 1985-1986页

作者： james w.M.Kang Department of Anatomy and Histology School of Medical SciencesUniversity of Sydney Sydney NSW Australia

The study of brain function in the presence of pain and injury is a rapidly expanding field of experimental ***,the presence of pain and injury is often accompanied by reports of behavioural change and altered *** in a highly controlled environment such as the surgical operating theatre postoperative behavioural changes including posttraumatic stress disorder,depression,chronic fatigue,

关键词： Intentional unintentional impacts anaesthesia insights from experiments pain and injury

Governing for the Global Good the Greening of Diverse Responsibilities

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学术界 2017年第3期 257-265页

作者： james w.Skillen Center for Public Justice of U.S.A.

This paper discusses methods for governing the global good. It holds that justice for both people and non-human creatures requires a change at the foundations of our view of life. what is needed is not only a few more government regulations or a little more international cooperation based on the unquestioned presupposition of the priority of national sovereignty and economic growth,but also a different perspective on our responsibilities for the wellbeing of the commons, recognizing that increasingly the environmental commons is global in scope and requires some transnational means of governance. It also holds that a"responsibilities"approach calls for the greening of all kinds of responsibility and not only those of national governments and international organizations.

关键词：责任绿化国际合作经济增长国家主权全球范围国际组织人生观

A new fractal algorithm to model discrete sequences

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Chinese Physics B 2010年第9期19卷 274-278页

作者：翟明岳 Heidi Kuzuma james w. Rector School of EE Engineering North China Electric Power University Department of Civil Engineering University of California Lawrence Berkeley Laboratory

Employing the properties of the affine mappings, a very novel fractal model scheme based on the iterative function system is proposed. we obtain the vertical scaling factors by a set of the middle points in each affine transform, solving the difficulty in determining the vertical scaling factors, one of the most difficult challenges faced by the fractal interpolation. The proposed method is carried out by interpolating the known attractor and the real discrete sequences from seismic data. The results show that a great accuracy in reconstruction of the known attractor and seismic profile is found, leading to a significant improvement over other fractal interpolation schemes.

关键词： fractal interpolation the vertical scaling factors iterative function system seismic data

Guidelines for the use of accelerated pavement testing data in autonomous vehicle infrastructure research

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第3期6卷 273-281页

作者： wynAND J.vdM.Steyn james w.Maina Department of Civil Engineering University of Pretoria

There is much research conducted on the vehicle technologies required for operation of autonomous vehicles(AV) on public roads, as well as analysis of the interaction between AV and the road environment. However, limited research exists on the impact of AV on road pavement structures. The research includes issues such as the effect of more channelized traffic loading, shorter inter-vehicle following distances and potential higher traffic volumes of more uniform vehicle types and loads. This paper discusses the application of existing and generation of new, relevant accelerated pavement testing(APT) data in understanding the effects of AV on pavement infrastructure. The paper presents development of provisional guidelines for the use and application of APT data to ensure that road pavement structures cope with anticipated increase in AV use. It is concludes that the use of AV fleets on existing road pavement infrastructure may lead to different behaviors and responses than what became the norm under non-autonomous vehicle fleets;appropriate analysis of existing APT data will contribute to the improved understanding of these expected changes in behaviors and responses; appropriate planning of AV operations-focused APT is possible with existing technology to contribute to the provision of economic and durable road pavement infrastructure in future.

关键词： Autonomous vehicles Accelerated pavement testing Vehicle-pavement interaction Road infrastructure

Upper range limit establishment after wildfire of an obligateseeding montane forest tree fails to keep pace with 20th century warming

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Journal of Plant Ecology 2018年第2期11卷 200-207页

作者： John w.Morgan james D.Vincent james S.Camac Research Centre for Applied Alpine Ecology Department of EcologyEnvironment and EvolutionLa Trobe UniversityKingsbury DriveBundooraVIC 3086Australia Department of Biological Sciences Macquarie UniversityBalaclava RoadNorth RydeNew South Wales 2109Australia

Aims How species respond to climate change at local scales will depend on how edaphic and biological characteristics interact with species physiological limits and traits such as *** seeders,those species that depend on fire for recruitment,have few and epi-sodic opportunities to track a changing climate *** such cases,long-distance seed dispersal will be necessary to take advan-tage of rare recruitment *** examine recruitment patterns and seedling growth below,at and above the timberline of an obligate-seeding Australian montane forest tree(Eucalyptus delegatensis)after stand-replacing fire,and place these changes in the context of regional *** we use two methods to detect whether *** can estab-lish and persist above the timberline after stand-replacing wildfire in montane forests in south-east ***,we examine estab-lishment patterns by using belt transects at six sites to quantify how changes in post-fire recruit density with increasing distance above the timberline seven years ***,to determine whether dispersal or physiological constraints determine post-fire establish-ment patterns,we transplanted seedlings and saplings into bare ground above(100 m elevation),at,and below(50 m elevation)timberline 18-months after *** monitored seedling growth and survival for one growing *** Findings There was minimal upslope migration of the species after fire with most saplings observed near seed-bearing timberline trees,with only occasional outpost *** seedlings and saplings sur-vived equally well across one growing season when planted above existing timberlines,relative to saplings at or below the *** and sapling growth rates also did not differ across these location,although seedlings grew at much faster rates than *** findings suggest that upslope growing season conditions are unlikely to limit initial range expansion of trees aft

关键词： climate change dispersal limitation growth rates regeneration niche timberline