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Multidisciplinary approach for multifocal, bilobar hepatocellular carcinoma: A case report and literature review

World Journal of Hepatology 2019年第1期11卷 119-126页

作者： Kevin P Labadie Stephanie K Schaub Derek Khorsand Guy Johnson smith Apisarnthanarax james O Park Department of Surgery University of Washington Department of Radiation Oncology University of Washington Department of Radiology University of Washington

BACKGROUND Hepatocellular carcinoma(HCC) is the second most lethal malignancy worldwide. There has been virtually no change in the survivability of HCC in spite of improvement in therapies. Surgery is considered the ideal first, curative intervention, however most patients present in advanced stages with unresectable disease. Therefore, systemic and liver-directed non-operative therapies are initially offered to downstage the disease. To ensure optimal management, a multidisciplinary team approach is often warranted. Our case highlights the benefits of a multidisciplinary approach in a young woman with multifocal, bilobar *** SUMMARY A 36-year-old Chinese woman with untreated hepatitis B was found to have large bilobar HCC during work up for abdominal pain. Her initial serum alphafetoprotein was significantly elevated to 311136 ng/mL. Computed tomography scan demonstrated bulky bilobar liver masses, consistent with intermediate stage HCC, Barcelona Clinic Liver Cancer Stage B. Her case was discussed and a personalized care plan was developed at the Multidisciplinary Center for Advanced Minimally Invasive Liver Oncologic Therapies at the University of Washington. She initially underwent bilobar transarterial chemoembolization with partial response of the left lobar tumor. Salvage hypofractionated proton beam radiation therapy was delivered to the right lobe followed by two additional transarterial chemoembolizations to the left lobe with good ***, to remove left lobar residual disease, she was taken to the operating roomfor a left hepatectomy eleven months after her initial presentation. She continues to be without evidence of *** Coordinating the multiple HCC treatment modalities is complex and our case highlights the benefits of a multidisciplinary approach.

关键词： Hepatocellular carcinoma Liver cancer Multidisciplinary care Case report

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Characterization of the Expression of the ATP-Gated P2X7 Receptor Following Status Epilepticus and during Epilepsy Using a P2X7-EGFP Reporter Mouse

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Neuroscience Bulletin 2020年第11期36卷 1242-1258页

作者： james Morgan Mariana Alves Giorgia Conte Aida Menendez-Mendez Laura de Diego-Garcia Gioacchino de Leo Edward Beamer Jonathon smith Annette Nicke Tobias Engel Department of Physiology and Medical Physics Royal College of Surgeons in IrelandDublin D02 YN77Ireland FutureNeuro Science Foundation Ireland Research Centre for Chronic and Rare Neurological DiseasesRoyal College of Surgeons in IrelandDublin D02 YN77Ireland Walther Straub Institute of Pharmacology and Toxicology Faculty of MedicineLudwig-Maximilians-Universitat Miinchen80336 MunichGermany

Mounting evidence suggests that the ATP-gated P2X7 receptor contributes to increased hyperexcitability in the *** increased expression of P2X7 in the hippocampus and cortex following status epilepticus and during epilepsy has been repeatedly demonstrated,the cell type-specific expression of P2X7 and its expression in extra-hippocampal brain structures remains incompletely *** this study,P2X7 expression was visualized by using a transgenic mouse model overexpressing P2X7 fused to the fluorescent protein *** results showed increased P2X7-EGFP expression after status epilepticus induced by intra-amygdala kainic acid and during epilepsy in different brain regions including the hippocampus,cortex,striatum,thalamus and cerebellum,and this was most evident in microglia and *** of P2X7-EGFP with cell type-specific markers was not detected in neurons or *** data suggest that P2X7 activation is a common pathological hallmark across different brain structures,possibly contributing to brain inflammation and neurodegeneration following acute seizures and during epilepsy.

关键词： Purinergic signaling P2X7 Green fluorescence protein Status epilepticus Epilepsy Cell typespecific expression

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Preliminary age-based life history characteristics of the dogtooth tuna,Gymnosarda unicolor(Ruppell,1838),in the southwest Pacific Ocean

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Aquaculture and Fisheries 2023年第3期8卷 323-331页

作者： David J.Welch Adam K.smith Kyne Krusic-Golub Sandra Erdmann Stephen J.Newman C_(2)O Fisheries PO Box 3041CairnsQueensland4870Australia Centre for Sustainable Tropical Fisheries and Aquaculture College of Science and EngineeringJames Cook UniversityTownsville4811Australia Reef Ecologic TownsvilleQueensland4811Australia Fish Ageing Services Pty.Ltd. QueenscliffVictoria3225Australia Western Australian Fisheries and Marine Research Laboratories Department of Primary Industries and Regional DevelopmentGovernment of Western AustraliaNorth BeachWestern Australia6020Australia

Dogtooth tuna,Gymnosarda unicolor were sampled off the east coast of Australia(southwest Pacific Ocean)from 2007 to *** were determined by examining thin transverse sections of their sagittal otoliths and were based on counts of alternating opaque and translucent zones(annual growth increments).Growth was rapid during the first year of life,after which growth in length was much *** of the constrained von Bertalanffy growth function(fork length-at-age)were L∞=1164.77(mm,FL)and K=0.44 year^(-1).Preliminary estimates of longevity indicate a maximum observed age of at least 20 *** was a high degree of variation in the observed length and age of sexual maturity for *** this variation,the size at 50%maturity for female *** estimated in this study was 713 mm FL(<2 years of age).The diet of *** is very broad and covers a range of fish *** life history characteristics of *** overall,indicate that this species may be somewhat resilient to ***,reports of localised depletions,in association with heavy targeting by sports fishers,low effective population sizes and patchy recruitment indicate that this species is particularly vulnerable to overfishing.

关键词： Otoliths Age Life history Pacific ocean Diet Fisheries management

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Bilayer self-assembly on a hydrophilic, deterministically nanopatterned surface

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Nano Research 2013年第11期6卷 784-794页

作者： Gregory S. smith Seung-Yong Jung james F. Browning Jong K. Keum Nickolay V. Lavrik Mussie G. Alemseghed C. Patrick Collier Biology and Soft Matter Division Oak Ridge National Laboratory Oak Ridge TN 37831 USA Center for Nanophase Materials Sciences Oak Ridge National Laboratory Oak Ridge TN 37831 USA Chemical and Engineering Materials Division Oak Ridge National Laboratory Oak Ridge TN 37831 USA Department of Chemical and Materials Engineering University of Cincinnati Cincinnati OH 45221-0012 USA

我们现在的大小在里面 situ，在接口在之间的自我装配的 bilayer 的显微镜的建筑学一定期用中子反射计的 nanopatterned 表面和一个水的亚阶段。底层与 nanoscale 洞的一个矩形的数组是有图案的。因为模式的高质量，用中子反射计，我们... 详细信息

我们现在的大小在里面 situ，在接口在之间的自我装配的 bilayer 的显微镜的建筑学一定期用中子反射计的 nanopatterned 表面和一个水的亚阶段。底层与 nanoscale 洞的一个矩形的数组是有图案的。因为模式的高质量，用中子反射计，我们能印射有图案的硅，进模式的水的穿入，和一部扔的电影的分发的表面正常密度分发在内并且在蚀刻的洞外面。在这研究， 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC ) 单身者 bilayers 在吸水的有图案的表面上被扔。为泡熔化(VF ) 或由 Langmuir-Schaefer (L-S ) 技术扔的 bilayers，发现适合数据的最历久不渝的模型证明类脂化合物以一种实质上保角的方式象洞的底部一样在底层上形成 bilayer 涂层。然而，当 unetched 硅上有单个 bilayer 时，出现，与不平的表面一致的复杂 bimodal 结构由蚀刻生产了的洞形式的底部处理的类脂化合物涂层。这研究在外面并且在常规 nanopatterned 特征内提供卓见进电影转移。

关键词：硅表面亲水性自组装双分子层蚀刻工艺图案化沉积膜微观结构

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Review of the prevalence,diagnostics,and containment measures of the current mpox outbreak

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World Journal of Clinical Cases 2023年第6期11卷 1252-1260页

作者： Adekunle Sanyaolu Aleksandra Marinkovic Chuku Okorie Stephanie Prakash Nafees Haider Yashika Dixon Ricardo Izurieta Olanrewaju Badaru Stella smith Public Health Federal Ministry of HealthAbuja 083Federal Capital TerritoryNigeria Basic Science Saint James School of MedicineThe Quarter 2640Anguilla Allied Sciences Union County CollegePlainfieldNJ 07060United States Basic Science All Saints University School of MedicineRoseau 0000Dominica Basic Science Windsor University School of MedicineCayon 0000Saint Kitts and Nevis Global Communicable Diseases College of Public HealthUniversity of South FloridaTampaFL 33620United States Department of Molecular Biology and Biotechnology Nigerian Institute of Medical ResearchLagos 101245Nigeria

Monkeypox(mpox),is a disease from the Poxviridae family that can cause several serious medical *** mini-review sought to analyze the existing literature regarding the current mpox outbreak with a focus on the prevalence,diagnostics,and containment *** cases have been reported to World Health Organization(WHO)from 85 Member States in all six WHO regions during the period of January 1,2022,through August 3,*** or optimized guidelines for the clinical care of patients with mpox are limited,particularly in low-resource *** an effort to achieve guidance and meet standards,special attention should be paid to this outbreak in order to eradicate such a rare infectious disease by analyzing prevention and control *** outcomes may also be poor,and their illnesses may last for a long *** spectrum of clinical symptoms,including complications and sequelae,as well as aspects of the illness may be indicators of sickness severity and complications;therefore,its clinical presentation must be better understood to improve containment *** addition,it is important to create and evaluate a standard of care that takes a variety of parameters into account,including antiviral,immune therapies,and clinical metrics that are particular to *** global emergence of mpox has presented new challenges for public health and has called for further investigation into its epidemiological profile across international contexts.

关键词： Monkeypox virus Outbreak Prevalence Containment Epidemiology Orthopoxvirus

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Anti-onchocerca Metabolites from Cyperus articulatus:Isolation,In Vitro Activity and In Silico‘Drug-Likeness’

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Natural Products and Bioprospecting 2014年第4期4卷 243-249页

作者： Jonathan Alunge Metuge smith B.Babiaka james A.Mbah Fidele Ntie-Kang Godfred A.Ayimele Fidelis Cho-Ngwa ANDI Centre of Excellence Department of Biochemistry and Molecular BiologyFaculty of ScienceUniversity of BueaP.O.Box 63BueaCameroon Department of Chemistry Faculty of ScienceUniversity of BueaP.O.Box 63BueaCameroon Chemical and Bioactivity Information Centre Chemistry DepartmentFaculty of ScienceUniversity of BueaP.O.Box 63BueaCameroon

The aims of this investigation were to isolate active ingredients from the roots/rhizomes of Cyperus articulatus used as herbal medicine in Cameroon for the treatment of human onchocerciasis and to assess the efficacy of the metabolites on the Onchocerca *** antifilarial activity was evaluated in vitro on microfilariae(Mfs)and adult worms of the bovine derived Onchocerca ochengi,a close relative of Onchocerca *** was assessed in vitro on monkey kidney epithelial *** structures of the active compounds were determined using spectroscopic methods and their drug-likeness evaluated using Lipinski *** secondary metabolites,AMJ1[containing mustakone(1)as the major component]and linoleic acid or(9Z,12Z)-octadeca-9,12-dienoic acid(2)were *** compounds were found to kill both the microfilariae and adult worms of *** in a dose dependent *** IC50s for AMJ1 were 15.7 lg/mL for Mfs,17.4 lg/mL for adult males and 21.9 lg/mL for adult female worms while for linoleic acid the values were,15.7 lg/mL for Mfs,31.0 lg/mL for adult males and 44.2 lg/mL for adult *** present report provides the first ever evidence of the anti-Onchocerca efficacy of AMJ1 and linoleic ***,these secondary metabolites may provide a lead for design and development of new antifilarial agents.

关键词： Cyperus articulates Linoleic acid Microfilariae Mustakone Onchocerca ochengi Onchocerca volvulus

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Biomedical and Environmental Sciences 2021年第9期34卷 734-738页

作者： james B.Hittner Folorunso O.Fasina Almira L.Hoogesteijn Renata Piccinini Dawid Maciorowski Prakasha Kempaiah Stephen D.smith Ariel L.Rivas Department of Psychology College of CharlestonCharlestonSouth CarolinaUnited States of America29424 Food and Agriculture Organization Dar es SalamTanzania&Department of Veterinary Tropical DiseasesUniversity of PretoriaSouth Africa0010 Human Ecology Centro de Investigación y de Estudios Avanzados(CINVESTAV)MéridaMéxico97133 Department of Veterinary Medicine University of MilanMilanItaly20122 Loyola University Medical Center ChicagoIllinoisUnited States of America60153 Institute for Resource Information Science College of AgricultureCornell UniversityIthacaUnited States of America14853 Center for Global Health Department of Internal MedicineMedical SchoolUniversity of New MexicoAlbuquerqueNew MexicoUnited States of America87131

The COVID-19 pandemic has wreaked havoc around the globe and caused significant disruptions across multiple domains[1].Moreover,different countries have been differentially impacted by COVID-19—a phenomenon that is d... 详细信息

关键词： Strongly COV Death

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High Intensity Interval Training in Healthy Males Does not Improve Markers of Insulin Sensitivity

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Journal of Sports Science 2015年第2期3卷 49-56页

作者： Douglas james Oberlin Jason smith Kevin Ritsche Laurie Wideman Department of Kinesiology University of North Carolina Greensboro Greensboro NC 27412 USA Department of Human Performance and Sport Science Winston-Salem State University Winston-Salem NC 27110 USA

Purpose: Determine if three weeks of HIT (high-intensity interval training) improves fasting insulin sensitivity in healthy males. Methods: Participants were recreationally active ( ≥ 10 hours per week) men between 18 and 35 years of age (Ht: 180 ± 1.44 cm; Wt: 85 ± 2.95 kg; BMI: 26.1 ± 0.59 kg/m2; body fat: 19.7 ± 1.76%). HIT training occurred 3 days weekly for 3 weeks, at intensities equivalent to 7.5% of body mass. Training volume increased weekly as follows: three sprints per session (week 1), four sprints per session (week 2), and five sprints per session (week 3). Fasting blood samples were collected at baseline and after each week and tested for glucose and insulin. A repeated measures ANOVA was used to measure changes in both fasting glucose and insulin concentrations as well as HOMA(IR) (homeostatic model assessment) and QUICKI (quantitative insulin sensitivity check index). Results: Values were in the normal range throughout the study and there were no significant improvements in glucose (P = 0.346), insulin (P = 0.680), HOMA (P = 0.567), or QUICKI (P = 0.186), as a result of HIT. Conclusion: While HIT may be useful in maintaining insulin sensitivity in healthy males, 3-weeks of HIT did not further improve insulin sensitivity in this group.

关键词：运动科学体育运动体育锻炼科学方法

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Potato aphid Macrosiphum euphorbiae performance is determined by aphid genotype and not mycorrhizal fungi or water availability

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Insect Science 2017年第6期24卷 1015-1024页

作者： Alison Jane Karley Matthew Emslie-smith Alison Elizabeth Bennett Ecological Sciences The James Hutton Institute Invergowrie Dundee UK School of Biology University of St. Andrews St Andrews UK

Intra- and interspecific variation in plant and insect traits can alter the strength and direction of insect-plant interactions, with outcomes modified by soil biotic and abiotic conditions. We used the potato aphid （Macrosiphum euphorbiae Thomas） feeding on cultivated Solanum tuberosum and wild Solanurn berthaulti to study the impact of water availability and plant mutualistic arbuscular mycorrhizal （AM） fungi on aphid performance and susceptibility to a parasitoid wasp （Aphidius ervi Haliday）. Plants were grown under glass with live or sterile AM fungal spores and supplied with sufficient or reduced water supply. Plants were infested with 1 of 3 genotypes ofM. euphorbiae or maintained as aphidfree controls; aphid abundance was scored after 1 week, after which aphid susceptibility to A. ervi was assayed explanta. Solarium tuberosum accumulated c. 20% more dry mass than S. berthaultii, and root mass of S. berthaultii was smallest under reduced water supply in the presence of AM fungi. Aphid abundance was lowest on S. berthaultii and highest for genotype ＂2＂ aphids; genotype ＂1＂ aphid density was particularly reduced on S. berthaultii. Aphid genotype ＂1＂ exhibited low susceptibility to parasitism and was attacked less frequently than the other two more susceptible aphid genotypes. Neither AM fungi nor water availability affected insect performance. Our study suggests a fitness trade-offin M. euphorbiae between parasitism resistance and aphid performance on poor quality Solarium hosts that warrants further exploration, and indicates the importance of accounting for genotype identity in determining the outcome of multitrophic interactions.

关键词： Aphidius ervi arbuscular mycorrhizal fungi multitrophic interaction parasitism resistance Solanum spp.

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An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation

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Bioactive Materials 2022年第8期7卷 52-60页

作者： Jing Chen Julia S.Caserto Ida Ang Kaavian Shariati james Webb Bo Wang Xi Wang Nikolaos Bouklas Minglin Ma College of Pharmacy Nanjing University of Chinese MedicineNanjing210023China Department of Biological and Environmental Engineering Cornell UniversityIthacaNY14853USA Robert Frederick smith School of Chemical and Biomolecular Engineering Cornell UniversityIthacaNY14853USA Sibley School of Mechanical and Aerospace Engineering Cornell UniversityIthacaNY14853USA

Adhesive hydrogels have been recently proposed as a potential option to seal and treat gastric perforation(GP)which causes high mortality despite advancements in surgical ***,to be effective,the hydrogels must have sufficient tissue adhesiveness,tough mechanical property,tunable biodegradability and ideally are easy to apply and ***,we report an adhesive and resilient hydrogel for the sealing and treatment of gastric *** hydrogel consists of a bioactive,transglutaminase(TG)-crosslinked gelatin network and a dynamic,borate-crosslinked poly-N-[Tris(hydroxymethyl)methyl]acrylamide(PTH)*** hydrogel can be formed in situ,facilitating easy delivery to the GP and allowing for precise sealing of the *** vivo experiments,using a perforated stomach mouse model,shows that the adhesive hydrogel plug effectively seals GP defects and promotes gastric mucosa ***,this hydrogel represents a promising biomaterial for GP treatment.

关键词： Adhesive hydrogel plug Gastric perforation Thermo-responsive Regeneration

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