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Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis

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World Journal of Gastroenterology 2021年第11期27卷 1064-1075页

作者： José Carlos Rodrigues Nascimento Lianna C Pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B silva silvio Alencar C sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho james s owen Pierluigi Toniutto Reinaldo B Oriá Department of Anesthesia and surgery Liver Transplantation Fortaleza General HospitalFortaleza 60150-160CEBrazil Laboratory of the Biology of Tissue Healing Ontogeny and NutritionDepartment of Morphology and Institute of BiomedicineSchool of MedicineFederal University of CearáFortaleza 60430-270CEBrazil Department of Dental Clinic Federal University of CearáFortaleza 60430-270CEBrazil Department of surgery Liver Transplant Unit of Federal University of CearáFortaleza 60430-270CEBrazil Transplantation Division Hospital Geral de FortalezaFortaleza 60175-742CEBrazil Institute of Virology CharitéUniversitätsmedizin BerlinBerlin 10117Germany UCL Medical school Royal Free CampusLondon NW32PFUnited Kingdom Department of specialized Medicine Hepatology Liver Transplantation UnitAzienda Sanitaria Universitaria Integrata of UdineUdine I-33100Italy

BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular *** E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver *** To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODs This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)*** injury severity was assessed using different criteria,including METAVIR and models for endstage liver *** polymorphisms were analyzed by quantitative real-time polymerase chain *** The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to *** addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 *** fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUsION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients.

关键词： Apolipoprotein E Polymorphism Liver cirrhosis Hepatitis C virus Hepatocellular carcinoma Liver transplantation

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Prime gradient noise

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Computational Visual Media 2021年第3期7卷 349-362页

作者： sheldon Taylor owen sharpe Jiju Peethambaran Graphics&spatial Computing Lab Dept.of Math&CSSaint Mary’s UniversityHailifaxNSCanadaB3H3C3

Procedural noise functions are fundamental tools in computer graphics used for synthesizing virtual geometry and texture ***,a procedural noise function should be compact,aperiodic,parameterized,and randomly *** lattice noise functions such as Perlin noise,however,exhibit periodicity due to the axial correlation induced while hashing the lattice vertices to the *** this paper,we introduce a parameterized lattice noise called prime gradient noise(PGN)that minimizes discernible periodicity in the noise while enhancing the algorithmic *** utilizes prime gradients,a set of random unit vectors constructed from subsets of prime numbers plotted in polar coordinate *** map axial indices of lattice vertices to prime gradients,PGN employs szudzik pairing,a bijection F:N2→*** of szudzik pairing functions are used in higher *** the core of PGN is the ability to parameterize noise generation though prime sequence offsetting which facilitates the creation of fractal noise with varying levels of heterogeneity ranging from homogeneous to hybrid multifractals.A comparative spectral analysis of the proposed noise with other noises including lattice noises show that PGN significantly reduces axial correlation and hence,periodicity in the noise *** demonstrate the utility of the proposed noise function with several examples in procedural modeling,parameterized pattern synthesis,and solid texturing.

关键词： procedural noise procedural texture Perlin noise prime numbers

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A review of progress on nano-aperture VCsEL Invited Paper

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Chinese Optics Letters 2008年第10期6卷 748-754页

作者： sonny Vo james s.Harris solid state and Photonics Laboratory Stanford UniversityStanfordCalifornia94305USA

This paper reviews the progress on nano-aperture vertical-cavity surface-emitting lasers （VCsELs）. The design, fabrication, and polarization control of nano-aperture VCsELs are reviewed. With the nanoaperture evolving from conventional circular and square aperture to unique C-shaped, H-shaped, I-shaped, and bowtie-shaped aperture, both the near-field intensity and near-field beam confinement from nanoaperture VCsELs are significantly improved. As a high-intensity compact light source with sub-100- nm spot size, nano-aperture VCsELs are promising to realize many new near-field optical systems and applications.

关键词： VCsEL view A review of progress on nano-aperture VCsEL Invited Paper

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Detecting the ?ngerprints of observed climate change on surface ozone variability

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science Bulletin 2019年第6期64卷 359-360页

作者： owen R.Cooper Cooperative Institute for Research in Environmental sciences University of Colorado NOAA Earth system Research Laboratory

At the surface, tropospheric ozone is an air pollutant that adversely impacts human health, natural vegetation and crop yield and quality. This important trace gas also plays key roles as a greenhouse gas, and as the primary source of the hydroxyl (OH) radical, which determines the lifetime of many other trace gases in the atmosphere. Tropospheric ozone has a variety of sources including photochemical production from anthropogenic and naturally occurring precursor gases, and transport from the stratosphere. As a result of 让s high reactivity and its wide range of sources,*sozone lifetime can vary from minutes in the polluted boundary layer to several weeks in the mid- and upper troposphere.

关键词： tropospheric ozone greenhouse gas polluted boundary layer

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Abiotic and biotic constituents of oil sands process-affected waters

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Journal of Environmental sciences 2023年第5期127卷 169-186页

作者： Nora A.s.Hussain james L.stafford Department of Biological sciences University of AlbertaEdmontonAlberta T6G 2N8Canada

The oil sands in Northern Alberta are the largest oil sands in the world,providing an important economic resource for the Canadian energy *** extraction of petroleum in the oil sands begins with the addition of hot water to the bituminous sediment,generating oil sands process-affected water(OsPW),which is acutely toxic to *** of litres of OsPW are stored on oil sands mining leased sites in man-made reservoirs called tailings *** the volume of OsPW increases,concerns arise regarding the reclamation and eventual release of this water back into the *** is composed of a complex and heterogeneous mix of components that vary based on factors such as company extraction techniques,age of the water,location,and bitumen ore ***,the effective remediation of OsPW requires the consideration of abiotic and biotic constituents within it to understand short and long term effects of treatments *** review summarizes selected chemicals and organisms in these waters and their interactions to provide a holistic perspective on the physiochemical and microbial dynamics underpinning OsPW.

关键词： OsPW toxicants Reclamation Tailings ponds Remediation Microbial AOPs Bioremediation

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Elephants Can Mimic1 Traffic and Other Noises

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大学英语 2005年第5期 21-23页

作者： james owen 刘嘉

It isn't only children playing with toy cars who make engine noises. Elephants produce a similar roar2, though in their case it's the rumble3 of trucks on an African highway that the animals imitate4, scientists *** experts behind the discovery say elephants are capable of vocal6 imitation, joining a select group of animals that includes parrots7, songbirds8, dolphins9, and humans.

关键词：大学英语注释读物科普文阅读

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Current recommendations of managing HBV infection in preconception or pregnancy

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Frontiers of Medicine 2014年第2期8卷 158-165页

作者： james s. Park Calvin Pan Division of Gastroenterology Department of Medicine NYU Langone Medical Center NYU School of Medicine New York 10016 USA

Hepatitis B remains a leading cause of cirrhosis, hepatocellular carcinoma and liver transplantation worldwide. Management of chronic hepatitis B during pregnancy is challenging. Transmission of hepatitis B to infants still occurs perinataily although immunoprophylaxis is widely available for infants born to mothers with chronic hepatitis B infection. The emerging data suggest that initiation of antiviral therapy in the beginning of the third trimester in highly viremic mothers can prevent immunoprophylaxis failure in their infants. The available drug safety data show that lamivudine, telbivudine and tenofovir are generally safe to be used during the pregnancy. In order to minimize the fetal exposure to the antiviral medication, antiviral therapy during the pregnancy should be limited to a selected group of patients with cirrhosis, high hepatitis B viral load, or prior history immunoprophylaxis failure. An elective Caesarean section may reduce the risk of perinatal transmission. For those females planning for pregnancy or in early stage of pregnancy, communication and follow-up among obstetrician, gastroenterologist, and primary care physician are important. In this article, we will review the features of hepatitis B infection before, during and after the pregnancy; the risk factors that increase mother-tochild transmission; safety data on antiviral drug use during pregnancy; and the potential role of Caesarean section in selected cases.

关键词： antiviral therapy Caesarean section cirrhosis hepatitis B irnmunoprophylaxis mother-to-child transmission pregnancy prevention

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New sharks,Rays Discovered in Indonesia Fish Markets

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科技英语学习 2007年第5期 31-33页

作者： james owen 潘晓雯

海洋是神秘的,它是生命孕育的摇篮。各种各样的生物游弋其间,逍遥自在。海洋为它们的生存和繁衍提供了广阔无垠的舞台。对于大海,自古以来,人们就有一种本能的渴望。好奇心驱使人类不断探索大海的深处,搜寻缤纷多彩的海洋生物。而对于... 详细信息

海洋是神秘的,它是生命孕育的摇篮。各种各样的生物游弋其间,逍遥自在。海洋为它们的生存和繁衍提供了广阔无垠的舞台。对于大海,自古以来,人们就有一种本能的渴望。好奇心驱使人类不断探索大海的深处,搜寻缤纷多彩的海洋生物。而对于作为海霸王的鲨鱼,人们更是怀着一种敬畏的心情。它的神秘与强大为人们提供了巨大的幻想空间。近年来,随着研究的不断深入和科技的日新月异,鲨鱼的面纱正被揭开。许多鲨鱼新品种的被发现就是很好的例证。

关键词： In New sharks,Rays Discovered in Indonesia Fish Markets

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Implicit Continuous User Authentication for Mobile Devices based on Deep Reinforcement Learning

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Computer systems science & Engineering 2023年第2期44卷 1357-1372页

作者： Christy james Jose M.s.Rajasree Government Engineering College Idukki685603India APJ Abdul Kalam Technological University Thiruvananthapuram695016India

The predominant method for smart phone accessing is conﬁned to methods directing the authentication by means of Point-of-Entry that heavily depend on physiological biometrics like,ﬁngerprint or *** continuous authentication initiating to be loftier to conventional authentication mechanisms by continuously conﬁrming users’identities on continuing basis and mark the instant at which an illegitimate hacker grasps dominance of the ***,divergent issues remain *** research aims to investigate the power of Deep Reinforcement Learning technique to implicit continuous authentication for mobile devices using a method called,Gaussian Weighted Cauchy Kriging-based Continuous Czekanowski’s(GWCK-CC).First,a Gaussian Weighted Non-local Mean Filter Preprocessing model is applied for reducing the noise pre-sent in the raw input face *** Kriging Regression function is employed to reduce the ***,Continuous Czekanowski’s Clas-siﬁcation is utilized for proﬁcient classiﬁcation between the genuine user and *** this way,the proposed GWCK-CC method achieves accurate authen-tication with minimum error rate and *** assessment of the pro-posed GWCK-CC method and existing methods are carried out with different factors by using UMDAA-02 Face *** results conﬁrm that the proposed GWCK-CC method enhances authentication accuracy,by 9%,reduces the authen-tication time,and error rate by 44%,and 43%as compared to the existing methods.

关键词： Deep reinforcement learning gaussian weighted non-local meanﬁlter cauchy kriging regression continuous czekanowski’s implicit continuous authentication mobile devices

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Estimating REY content of eastern Kentucky coal samples based on their associated ash elements

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Journal of Rare Earths 2018年第11期36卷 1234-1238页

作者： s.Chehreh Chelgani james C.Hower Department of Electrical Engineering and Computer science University of Michigan Center for Applied Energy Research University of Kentucky

Coal and coal combustion byproducts can be considered as an alternative source of rare earth elements and yttrium （REY）. The study of relationships between REY and other main coal properties could have several advantages such as estimating REY content of coal particles and designing beneficial extraction method. In this investigation, inter-correlations between REY content with coal parameters （proximate and ash elements） for a wide range of eastern Kentucky coal samples （708 records） were explored. Results demonstrate that zircon and monazite are the main source of heavy and light rare earth elements （HREE and LREE）, respectively. Zr has the highest correlation with Y and Th has the strength relationship with Ce and La. In general, LREE have higher interaction with coal ash content in comparison with HREE. Results indicated that REY can be estimated quite satisfactorily by using their associated elements in coal ash.

关键词： Coal Heavy rare earth Light rare earth Proximate Ash elements

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