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A Pressure relaxation Closure Model for One-Dimensional, Two-Material Lagrangian Hydrodynamics Based on the riemann Problem

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Communications in Computational Physics 2010年第5期7卷 927-976页

作者： james r.kamm Mikhail J.Shashkov Applied Physics Division Los Alamos National LaboratoryLos AlamosNM 87545USA Theoretical Division Los Alamos National LaboratoryLos AlamosNM 87545USA

Despite decades of development, Lagrangian hydrodynamics of strengthfree materials presents numerous open issues, even in one dimension. We focus on theproblem of closing a system of equations for a two-material cell under the assumptionof a single velocity model. There are several existing models and approaches, eachpossessing different levels of fidelity to the underlying physics and each exhibitingunique features in the computed solutions. We consider the case in which the changein heat in the constituent materials in the mixed cell is assumed equal. An instantaneous pressure equilibration model for a mixed cell can be cast as four equations infour unknowns, comprised of the updated values of the specific internal energy andthe specific volume for each of the two materials in the mixed cell. The unique contribution of our approach is a physics-inspired, geometry-based model in which theupdated values of the sub-cell, relaxing-toward-equilibrium constituent pressures arerelated to a local riemann problem through an optimization principle. This approachcouples the modeling problem of assigning sub-cell pressures to the physics associated with the local, dynamic evolution. We package our approach in the frameworkof a standard predictor-corrector time integration scheme. We evaluate our model using idealized, two material problems using either ideal-gas or stiffened-gas equationsof state and compare these results to those computed with the method of Tipton andwith corresponding pure-material calculations.

关键词： Lagrangian hydrodynamics compressible flow multi-material flow pressure relaxation

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Absence of Myosin Phosphatase Target Subunit 1 Alters Smooth Muscle Subtype through Ca2+ Sensitization

Absence of Myosin Phosphatase Target Subunit 1 Alters Smooth...

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“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： Kristine E.kamm james T.Stull Department of Physiology University of Texas Southwestern Medical CenterDallasTexasUSA

Smooth muscles can be classified into phasic and tonic subtypes based on their different contractile properties,but the molecular determinants that defines phasic and tonic subtypes remains *** this report,we analyzed contractile properties of phasic intestinal smooth muscle in the mice with smooth muscle-specific ablation of myosin phosphatase target subunit 1(MYPT1).The mutant intestinal smooth muscle displayed a loss of peristaltic contractile activity,and during activation,it exhibited a robust initial contraction followed by a sustained steady state with slow rate of force activation and relaxation and

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Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility

Myosin light chain kinase is central to smooth muscle contra...

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中国遗传学会“发育、遗传和疾病”研讨会

作者： robert Feil Kristine E. kamm james T.Stull Interfakultres Institut für Biochemie(IFIB) Signaltransduktion-Transgene Modelle Universitt Tübingen Hoppe-Seyler-Str.4 72076 Tübingen Germany Department of Physiology UT Southwestern Medical Center 5323 Harry Hines Blvd Dallas TX 75390 USA Department of Physiology UT Southwestern Medical Center 5323 Harry Hines Blvd Dallas TX 75390 USA

Smooth muscle contractility is essential for maintaining various physiological activities and adaptive responses to stresses imposed by pathological *** signaling networks define many potential mechanisms for initiating smooth muscle contraction with or without myosin regulatory light chain（rLC）phosphorylation by myosin light chain kinase（MLCK）.Here we provide direct loss-of-function evidence in adult mice that shows the primary importance of *** deletion of MLCK in adult smooth muscle results in severe gut dysmotility,characterized by weak peristalsis,dilation of the digestive tract and reduction of feces excretion and food *** muscles show a loss of rLC phosphorylation and force development induced by *** kinase knockout also markedly reduced rLC phosphorylation and force development with acetylcholine which also activates Ca-sensitizing *** conclude that MLCK and its phosphorylation of rLC are required physiologically for smooth muscle contraction and essential for normal gastrointestinal motility.

关键词： Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility

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Alteration of Contractile Phenotypes of Intestinal Smooth Muscle in Myosin Phosphatase Target Subunit 1 Deficient Mice

Alteration of Contractile Phenotypes of Intestinal Smooth Mu...

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2012年中国科协海峡两岸青年科学家学术活动月——第九届海峡两岸细胞生物学学术研讨会

作者： Wei-Qi He Yan-Ning Qiao Ya-Jing Peng Juan-Min Zha Chen-Hai Zhang Chen Chen Cai-Ping Chen Pei Wang Xiao Yang Chao-Jun Li Kristine E.kamm james T.Stull 朱敏生 Model Animal research Center and MOE Key Laboratory of Model Animal for Disease Study Nanjing University The School of Medicine Nanjing University Department of Geratology the First Hospital Affiliated with the Nanjing Medical University State Key Laboratory of Proteomics Genetic Laboratory of Development and DiseaseInstitute of Biotechnology Department of Physiology University of Texas Southwestern Medical CenterDallasTXUSA

Smooth muscles can be classified into phasic and tonic subtypes based on their different contractile properties,but the molecular determinants that define phasic and tonic subtypes remain *** generated smooth muscle-s... 详细信息

关键词： MYPT1,smooth muscle phasic tonic Ca2+ sensitivity

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