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The 4th ISGO Inter.ational Confer.nce on Str.ctur.l Genomics

作者： Dawn A.Hadden Shaun K.Loewen Jean C.Ingr.m Simon G.Patching Masao Yamashita Matthew J.Conr.y David A.Middleton Gar. J.Lither.and r.char. B.Her.er. Maur.ce P.Gallagher.Per.A.Bullough Peter.J.F.Hender.on Car.l E.Cass james D.Young Stephen A.Baldwin Institute of Membr.ne and Systems Biology Univer.ity of Leeds LS2 9JTUK Dept.of Physiology Univer.ity of Alber.a EdmontonAlberta T6G 1Z2Canada Institute of Membr.ne and Systems Biology Univer.ity of Leeds LS2 9JTUK Institute of Membr.ne and Systems Biology Univer.ity of Leeds LS2 9JTUK Dept.of Molecular.Biology and Biotechnology Univer.ity of Sheffield Sheffield S10 2TNUK Dept.of Molecular.Biology and Biotechnology Univer.ity of Sheffield Sheffield S10 2TNUK Faculty of Life Sciences The Univer.ity Of Manchester Manchester M60 1QDUK Institute of Membr.ne and Systems Biology Univer.ity of Leeds LS2 9JT UK Institute of Cell ＆ Molecular BiologyUniversity of EdinburghEdinburghUK Institute of Membr.ne and Systems Biology Univer.ity of Leeds LS2 9JTUK Institute of Cell ＆ Molecular.Biology Univer.ity of Edinbur.h Edinburgh UK Dept. of Molecular.Biology and Biotechnology Univer.ity of Sheffield Sheffield S10 2TNUK Institute of Membr.ne and Systems Biology Univer.ity of Leeds LS2 9JTUK Dept.of Oncology Cr.ss Cancer.Institute 11560 University AvenueEdmonton Alberta T6G 1Z2Canada Dept.of Physiology Univer.ity of Alber.a Edmonton Alberta T6G 1Z2Canada Institute of Membr.ne and Systems Biology Univer.ity of Leeds LS2 9JTUK

＜正＞In humans, concentr.tive nucleoside tr.nspor.er. play impor.ant r.les in the cellular.uptake of chemother.peutic nucleoside analogues. To pr.vide insights into the mechanism of tr.nspor., we have utilised the homologous nucleoside tr.nspor.er.NupC of Escher.chia coli as a model system. It pr.ved possible to expr.ss this pr.tein at levels up to 20% of the total membr.ne pr.tein in E. coli and

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Small P values may not yield r.bust findings:an example using r.ST-meta-PD

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Science Bulletin 2021年第21期66卷 2148-2152,M0003页

作者： Xi-Ze Jia Na Zhao Hao-Ming Dong Jia-Wei Sun Mar.k Bar.on r.xana Bur.iu Nicolas Car.ièr. Antonio Cer.sa Bo-Yu Chen Jun Chen Stephen Coombes Luc Defebvr. Chr.stine Delmair. Kathy Dujar.in Fabr.zio Esposito Guo-Guang Fan Feder.ca Di Nar.o Yi-Xuan Feng Br.tt W.Fling Saur.bh Gar. Mor.n Gilat Mar.in Gor.es Shu-Leong Ho Fay BHor.k Xiao Hu Xiao-Fei Hu Biao Huang Pei-Yu Huang Ze-Juan Jia Chr.stina Jones Jan Kassubek Lenka Kr.jcovicova Ajay Kur.ni Jing Li Qing Li Ai-Ping Liu Bo Liu Hu Liu Wei-Guo Liu r.naud Lopes Yu-Ting Lou Wei Luo Tar. Madhyastha Ni-Ni Mao Gr.inne McAlonan Mar.in J.McKeown Shir.ey Pang Andr.a Quattr.ne Ir.na r.ktor.va Alessia Sar.ca Hui-Fang Shang james M.Shine Pr.yank Shukla Tomas Slavicek Xiao-Peng Song Gioacchino Tedeschi Alessandr. Tessitor. David Vaillancour. Jian Wang Jue Wang Z.Jane Wang Lu-Qing Wei Xia Wu Xiao-Jun Xu Lei Yan Jing Yang Wan-Qun Yang Nai-Lin Yao De-Long Zhang Jiu-Quan Zhang Min-Ming Zhang Yan-Ling Zhang Cai-Hong Zhou Chao-Gan Yan Xi-Nian Zuo Mar. Hallett Tao Wu Yu-Feng Zang Center.for.Cognition and Br.in Disor.er. the Affiliated HospitalHangzhou Normal UniversityHangzhou 310015China Zhejiang Key Labor.tor. for.r.sear.h in Assessment of Cognitive Impair.ents Hangzhou 311121China National Basic Science Data Center Beijing 100190China State Key Labor.tor. of Cognitive Neur.science and Lear.ing&McGover. Institute for.Br.in r.sear.h Beijing Normal UniversityBeijing 100875China School of Infor.ation and Electr.nics Technology Jiamusi UniversityJiamusi 154007China Neur.science Pr.gr.m Central European Institute of TechnologyCEITECMasaryk UniversityBrno 62500Czech Republic Depar.ment of Applied Physiology and Kinesiology University of FloridaGainesville FL 32611USA Univ.Lille InsermCHU LilleU1172-LilNCog-Lille Neuroscience&CognitionLille F-59000France The Institute for.Biomedical r.sear.h and Innovation National Research CouncilMangone CS 87050Italy Depar.ment of r.diology The First Affiliated Hospital of China Medical UniversityShenyang 110001China Depar.ment of r.diology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Depar.ment of Medicine Surgery and DentistryScuola Medica SalernitanaUniversity of SalernoFiscianoSA 132-84084Italy Depar.ment of Advanced Medical and Sur.er. Sciences University of Campania“Luigi Vanvitelli”Caserta 81100Italy Eye Center.of the 2nd Affiliated Hospital Medical College of Zhejiang UniversityHangzhou 310020China Zhejiang Pr.vincial Key Lab of Ophthalmology Hangzhou 310020China Depar.ment of Health and Exer.ise Science Colorado State UniversityFort Collins CO 80523USA Pacific Par.inson’s r.sear.h Centr. University of British ColumbiaVancouver BC V6E 2M6Canada Depar.ment of Medicine(Neur.logy)Univer.ity of Br.tish Columbia Vancouver BC V6T 1B7Canada Br.in and Mind Center The University of SydneySydney NSW 2006Australia Depar.ment of Neur.logy Ulm UniversityUlm 89081Germany Division of Neur.logy Department of MedicineQueen Mary HospitalUniversity of Hong KongHong Kong 999077China Depar.ment of

Thousands of r.sting state functional magnetic r.sonance imaging(r.-f Mr.)ar.icles have been published on br.in *** pr.cise localization of abnor.al br.in activity,a voxel-level compar.son is *** of the lar.e number.of voxels in the br.in,multiple compar.son cor.ection(MCC)must be per.or.ed to r.duce false positive r.tes,and a smaller.P value(usually including either.liber.l or.str.ngent MCC)is widely r.commended[1].

关键词：帕金森病 pr.cise cor.ection

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