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Analytical procedures to classify organic pollutants in natural waters, sediments, and benthic organisms

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Acta Oceanologica Sinica 1988年第2期7卷 226-236页

作者： Jinshu Zheng and james G. quinn Third Institute of Oceanography, State Oceanic Administration, Xiamen, ChinaGraduate School of Oceanography, University of Rhode Island, Narragansett, Rhode Island, U.S.A. Third Inst of Oceanog State Oceanic Admin Xiamen China China

Procedures are described to extract, fractionate and analyze organic pollutants in environmental samples. The methods are based on organic solvent extraction to isolate the pollutants, liquid-solid adsorption chromatography to separate the various pollutants into four fractions, and analyses of the fractions using glass capillary gas-chromatography. Based on a number of considerations, the procedures were found suitable for the analyses of trace level organic pollutants in a variety of sample types. The data from these studies has provided important information on the biogeochemistry of organic pollutants in the aquatic environment.

关键词： Bay and benthic organisms sediments Analytical procedures to classify organic pollutants in natural waters

Indicators of global sustainable sourcing as a set covering problem:an integrated approach to sustainability

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Ecosystem Health and Sustainability 2015年第2期1卷 12-20页

作者： Patrick R.Huber Nathaniel P.Springer Allan D.Hollander V.Ryan Haden Sonja Brodt Thomas P.Tomich james F.quinn Information Center for the Environment University of CaliforniaDavisCalifornia 95616 USA Agricultural Sustainability Institute University of CaliforniaDavisCalifornia 95616 USA

Sustainability describes a broad set of themes centered on current human uses of the planet’s *** multiple uses and users of the term have led to a proliferation of salient issues and associated *** present a new method to systematically link these issues and indicators under two conceptual frameworks of sustainability in order to enable quantitative *** demonstrate this approach with a specific use case focused on the global sourcing of agricultural *** use the optimization software Marxan in a novel way to develop minimum sets of indicators that provide maximum coverage of sustainability *** covering sets were identified and accumulation curves were developed to measure the contribution of each indicator in each set to overall issues *** greater detail in the assessment of each indicator would likely provide more effective sets of indicators,those that were generated provide optimism that this approach can bring better focus to sustainability assessments.

关键词： global sourcing indicators Marxan software minimum covering set optimization sustainability

厦门港和员当湖表层沉积物中的石油烃和多环芳香烃

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海洋环境科学 2003年第4期22卷 49-53页

作者：欧寿铭郑建华郑金树 james G.quinn 厦门市环境保护科学研究所福建厦门361006 国家海洋局第三海洋研究所福建厦门361005 美国罗得岛大学海洋研究生院

2002年4月厦门港沿岸设9个站,员当湖设两个站采集表层沉积物,用有机溶剂萃取,硅胶柱色层分离,气相色谱-质谱联机带SIM数据采集系统对样品的石油烃类(M/Z=55),多环芳香烃类进行分析,结果显示员当湖石油烃和多环芳香烃质量分数分别高达139... 详细信息

2002年4月厦门港沿岸设9个站,员当湖设两个站采集表层沉积物,用有机溶剂萃取,硅胶柱色层分离,气相色谱-质谱联机带SIM数据采集系统对样品的石油烃类(M/Z=55),多环芳香烃类进行分析,结果显示员当湖石油烃和多环芳香烃质量分数分别高达1397和1376.5ng/g。厦门港船只活动,厦门港四周工业废水、车辆燃油滴漏是石油烃和多环芳香烃污染的主要来源。

关键词：厦门港表层沉积物石油烃类多环芳香烃类

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Interface:第一个吃螃蟹的人

商学院 2008年第10期 44-46页

作者： Rogelio Oliva james quinn 邓小莉哈佛商学院

面对产品销售利润日薄西山的时候,从产品走向服务的模式是企业的自然选择。很多企业开始大胆放弃产品路线,将他们原有的模式转变为基于解决方案的模式。Interface是其中的一家先行者。早在十年多年前,它将自己的地毯销售模式转变为"租... 详细信息

面对产品销售利润日薄西山的时候,从产品走向服务的模式是企业的自然选择。很多企业开始大胆放弃产品路线,将他们原有的模式转变为基于解决方案的模式。Interface是其中的一家先行者。早在十年多年前,它将自己的地毯销售模式转变为"租赁长期的地板覆盖服务"的服务模式。但是经过七年的努力,他的成果却并不显著。让我们从这个失败的案例开始思考企业从产品向服务转型的过程中可能面临的挑战。我们的专家以及更多的先行者将为我们解读示范,为所有希望进入这一领域的企业提供可参考的解决方案。

关键词：产品销售利润螃蟹自然选择模式转变先行者企业

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手部撕裂伤缝合与保守治疗的随机对照试验

英国医学杂志中文版 2003年第1期6卷 25-27页

作者： james quinn Steven Cummings Michael Callaham Karen Sellers 刘占兵 Division of Emergency Medicine University of California at San Francisco505 Parnassus AvenueSan FranciscoCA 94143-0208USA Department of Medicine University of California at San FranciscoSan FranciscoCA 94118

目的:评价手部撕裂伤缝合或保守治疗两种方法的临床结局差异。试验设计:随机对照试验。试验地点:三级医院急诊室。入选对象:全部2000年2月16日至11月30日间就诊的不伴有并发症,在正常情况下需要缝合的手部撕裂伤病人(全层裂开<2cm,... 详细信息

目的:评价手部撕裂伤缝合或保守治疗两种方法的临床结局差异。试验设计:随机对照试验。试验地点:三级医院急诊室。入选对象:全部2000年2月16日至11月30日间就诊的不伴有并发症,在正常情况下需要缝合的手部撕裂伤病人(全层裂开<2cm,无肌腱、关节、骨折或神经并发症)。共154例病人合格,其中58例拒绝参与试验,5例失访,91例病人共计有撕裂伤95处纳入本试验。试验干预:试验对象被随机分为缝合组或保守治疗组。主要结局的评定:主要结局是3月后伤口的外观,按照以前已被验证的可视类比分级进行评定。对治疗周期、治疗过程中的疼痛程度、病人对结局的自我评价、病人恢复正常活动的时间也进行评定。结果:3月后,由互不知情的医生(单盲法)对伤口外观进行评定,发现缝合组和保守治疗组之间没有显著差别,可视类比分级是83mm:80mm(平均差3mm,95％可信区间-1～8mm)。两组病人恢复正常活动的平均时间相同(3.4天),保守治疗组病人疼痛相对较轻,两组相差18(12～24)mm,治疗时间缩短了14(10～18)分钟。结论:对于伤口小且没有并发症的手部撕裂伤,在伤口外观和功能上,保守治疗和缝合两种方法结果是相似的,保守治疗处理伤口省时、疼痛轻。

关键词：手部撕裂伤缝合保守治疗随机对照试验

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Tissue adhesives in clinical medicine / 2nd ed.

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Novel data-driven subtypes and stages of brain atrophy in the ALS-FTD spectrum

2005年

作者： quinn james V.

来源：畅想之星图书光盘版（南... 评论

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Translational Neurodegeneration 2023年第1期12卷 50-69页

作者： Ting Shen Jacob W.Vogel Jeffrey Duda Jeffrey S.Phillips Philip ACook james Gee Lauren Elman Colin quinn Defne A.Amado Michael Baer Lauren Massimo Murray Grossman David J.Irwin Corey T.McMillan Penn Frontotemporal Degeneration Center Department of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Clinical Sciences SciLifeLabLund University22242 LundSweden Penn Image Computing and Science Lab(PICSL) Department of RadiologyPerelman School of MedicineUniversity of Penn-sylvaniaPhiladelphiaPA 19104USA Department of Neurology Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Digital Neuropathology Laboratory Department of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA.

Background TDP-43 proteinopathies represent a spectrum of neurological disorders,anchored clinically on either end by amyotrophic lateral sclerosis(ALS)and frontotemporal degeneration(FTD).The ALS-FTD spectrum exhibits a diverse range of clinical presentations with overlapping phenotypes,highlighting its *** study was aimed to use disease progression modeling to identify novel data-driven spatial and temporal subtypes of brain atrophy and its progression in the ALS-FTD *** We used a data-driven procedure to identify 13 anatomic clusters of brain volume for 57 behavioral variant FTD(bvFTD;with either autopsy-confirmed TDP-43 or TDP-43 proteinopathy-associated genetic variants),103 ALS,and 47 ALS-FTD patients with likely TDP-43.A Subtype and Stage Inference(SuStaIn)model was trained to identify subtypes of individuals along the ALS-FTD spectrum with distinct brain atrophy patterns,and we related subtypes and stages to clinical,genetic,and neuropathological features of *** SuStaIn identified three novel subtypes:two disease subtypes with predominant brain atrophy in either prefrontal/somatomotor regions or limbic-related regions,and a normal-appearing group without obvious brain *** limbic-predominant subtype tended to present with more impaired cognition,higher frequencies of pathogenic variants in TBK1 and TARDBP genes,and a higher proportion of TDP-43 types B,E and *** contrast,the prefrontal/somatomotor-predominant subtype had higher frequencies of pathogenic variants in C9orf72 and GRN genes and higher proportion of TDP-43 type *** normal-appearing brain group showed higher frequency of ALS relative to ALS-FTD and bvFTD patients,higher cognitive capacity,higher proportion of lower motor neuron onset,milder motor symptoms,and lower frequencies of genetic pathogenic *** overall SuStaIn stages also correlated with evidence for clinical progression including longer disease duration,higher King’s stage,and cog

关键词： Amyotrophic lateral sclerosis Frontotemporal degeneration Disease heterogeneity SuStaIn model

A Toxicological Assessment of Endocrine Disrupting Chemicals Found in the BMW (Border, Midland and Western) Region of Ireland

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Journal of Environmental Protection 2012年第4期3卷 304-315页

作者： Kathryn M. quinn-Hosey james J. Roche Andrew M. Fogarty Concepta A. Brougham Endocrine Disruption Group Department of Life and Physical Sciences School of Science Athlone Institute of Technology Athlone Co. Westmeath Ireland

A battery of tests was established to determine the oestrogenic, mutagenic and genotoxic potential of two categories of endocrine disrupting chemicals (EDCs), phthalates and alkylphenols. Diisononylphthalate (DINP), diethylhexylphthalate (DEHP), dibutylphthalate (DBP), diisododecylphthalate (DIDP) and 4-nonylphenol (4-NP) were oestrogenic in the yeast estrogen screen (YES) assay and potently oestrogenic in the MVLN and E-SCREEN assays at environmentally relevant concentrations. DINP and 4-NP were mutagenic in the Ames assay and also induced significant levels of unscheduled DNA synthesis and DNA strand breakage. Significant induction in the percentage of cells containing micronuclei was observed after treatment with DINP, DEHP and 4-NP. In addition, sewage effluents from sewage treatment plants (STPs) in the Border, Midlands and Western (BMW) region of Ireland were significantly oestrogenic in the YES assay. Moreover, analysis of levels of phthalates and alkylphenol identified in Irish rivers receiving treated effluent showed potent oestrogenicity in the YES assay. The proliferative and genotoxic ability of the phthalates and alkylphenol, and the oestrogenicity of the treated effluents reported here, is significant as these EDCs and EDCs within the effluent may play a role in the etiology of human abnormalities.

关键词： Endocrine Disrupting Chemicals (EDCs) Proliferation Transactivation Mutagenicity Genotoxicity Sewage Treatment Plant (STP) Border Midlands and Western (BMW) Region of Ireland

Screening for Genotoxicity and Oestrogenicity of Endocrine Disrupting Chemicals <i>in Vitro</i>

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Journal of Environmental Protection 2012年第8期3卷 902-914页

作者： Karthryn M. quinn-Hosey james J. Roche Andrew M. Fogarty Concepta A. Brougham Endocrine Disruption Group Department of Life and Physical Sciences School of Science Athlone Institute of Technology Athlone Co. Westmeath Ireland

A diverse range of endocrine disrupting chemicals (EDCs) was examined, using an in vitro test system, for critical events required for the onset of carcinogenesis in vivo. The initiation stage of carcinogenesis is a genotoxic process. 4-Octylphenol (alkylphenol), bisphenol A (plasticiser), coumestrol and genistein (phytoestrogens), 2,4-dichlorophe- noxyacetic acid and toxaphene (pesticides) and ethinylestradiol (synthetic hormone) were investigated for potential mutagencicity, DNA strand breakage, clastogenicity and DNA repair. Significant induction in the percentage of cells containing micronuclei was observed for all the EDCs. Toxaphene and coumestrol were mutagenic in the Ames assay. They also induced significant levels of unscheduled DNA synthesis and DNA strand breakage. Bisphenol A induced low level DNA strand breakage in HepG2 cells in the comet assay. The EDCs, with the exception of toxaphene, induced transcriptional activation in the yeast estrogen screen (YES) assay. They were potently oestrogenic in the mammalian based MVLN (transactivation) and E-SCREEN (proliferation) assays. This report on the transactivational, proliferative and genotoxic ability of the EDCs suggests that these chemicals may play a role in the etiology of male and female reproductive cancers.

关键词： Four Endocrine Disrupting Chemicals (EDCs) Proliferation Mutagenicity DNA Strand Breakage Comet Assay DNA Repair Unscheduled DNA Synthesis Assay (UDS) E-SCREEN Assay YES Assay MVLN Assay