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Formulation and Assessment of the Efficacy and Stability of an Ointment Containing Ocimum americanum ***

Clinical Complementary Medicine and Pharmacology 2023年第1期3卷 62-72页

作者： Nakamwi Akombaetwa Lungwani Tyson Muungo james nyirenda Sergio Muwowo Aubrey Kalungia Chichonyi Moses Mukosha Chiluba Mwila Department of Pharmacy School of Health SciencesUniversity of ZambiaLusaka 10101Zambia Department of Chemistry School of Natural SciencesUniversity of ZambiaLusaka 10101Zambia Histopathology Department University Teaching HospitalLusaka 10101Zambia

Background:Ocimum americanum *** an annual herbaceous plant used to manage pain and *** of standard dosage forms,and safety and efficacy data potentially exposes users of this medicinal plant to the risk of toxic or sub-therapeutic effects,as well as drug-herb ***:The study developed a standard dosage form containing *** extract and assessed its anti-inflammatory efficacy and ***:The fusion method was used to formulate an ointment comprising acetone extract,beeswax,and *** optimization involved the application of Box-Behnken Design(BBD)to design an exper-iment whose input variables were%beeswax and%soft-paraffin and its melting *** variables were drug release and viscosity which were quantified using a vertical diffusion cell(VDC)and stanhope-seta viscometer,*** albino rats were used in carrageenan-induced rat hind paw edema(n=6/test,positive and negative control)to assess the anti-inflammatory *** studies comprised assessment of spreadability,thin layer chromatograms(TLC),and microbial growth in ointment batches stored at 25±2℃/60±5%RH and 40±2℃/75±5%***:Temperature and%beeswax significantly influenced drug release(P=0.0024).Optimal drug release and viscosity were obtained at 5.4%beeswax,89.6%soft-paraffin melted at 58℃.The predominant drug release mechanism was Higuchi(R^(2)=0.967±0.023),which implied longer contact between formulation and skin favours drug *** of edema by the ointment was comparable to 1%(w/w)diclofenac gel(t=2.1;CI=(-8.29)-1.15),and both differed significantly with negative control(t=11.3 and 13.4;CI=14.5-23.9 and 18.1-27.5 respectively).Insignificant changes in spreadability(P=0.112),absence of new spots on chromatograms,and deficiency of microbial colonies on agar plates implied physical,chemical,and microbial stability,***:A formulated ointment containing *** extract ex

关键词： O.americanum Formulation optimization Anti-inflammatory Stability

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