检索结果-南通市图书馆

Treatmen.-Plan.Comparison.of Three Advan.ed Radiation.Treatmen. Modalities for Fraction.ted Stereotactic Radiotherapy to the Head an. n.ck

引用

In.ern.tion.l Journ.l of Medical Physics, Clin.cal En.in.erin. an. Radiation.On.ology 2019年第2期8卷 106-120页

作者： He Wan. james n. yang Xiaodon. Zhan. Jin. Li Steven.J. Fran. Zhon.xian. Zhao Dershan.Luo Xiaoron. Zhu Con.jun.Wan. Samuel Tun. Adam S. Garden.David I. Rosen.hal Clifton.David Fuller Gary Bran.on.Gun. Amol J. Ghia Jay P. Reddy Shaan.M. Raza Fran.o De Mon.e Mark S. Chambers Paul D. Brown.Shirley Su Jack Phan Departmen. of Radiation.Physics The University of Texas MD Anderson Cancer Center Houston TX USA Departmen. of Radiation.On.ology The University of Texas MD Anderson Cancer Center Houston TX USA Departmen. of n.urosurgery The University of Texas MD Anderson Cancer Center Houston TX USA Departmen. of On.ologic Den.istry Prosthodon.ics Thoracic/Head &Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX USA Departmen. of Radiation.On.ology The Mayo Clinic Rochester MN USA

Purpose: Fraction.ted stereotactic radiosurgery (FSRS) can.be given.with at least three modalities: Gamma Kn.fe, with the n.n.n.asive frameless exten. system (GKE);lin.ar accelerator-based volumetric modulated arc therapy (VMAT);an. in.en.ity-modulated proton.therapy (IMPT). We extracted treatmen. plan. for patien.s who had received FSRS with GKE for recurren. skull base or in.racran.al tumors, created correspon.in. plan. for VMAT an. IMPT, an. compared the quality of the three sets of plan.. Methods an. materials: Plan. were extracted for 9 patien.s with recurren. malign.n. skull-base tumors (n.= 6) or large in.racran.al tumors (n.= 3) who had received FSRS with GKE (median.dose 24 Gy in.3 fraction.) in.2013 through 2015. Plan. for VMAT were gen.rated with a TrueBeam STx LIn.C machin. usin. 6-MV photon., an. plan. for IMPT were gen.rated with multi-field optimization. The optimized VMAT an. IMPT plan. were n.rmalized to achieve the best possible target coverage while meetin. the same dose-volume con.train.s on.organ. at risk (OARs) as the GKE plan.. Plan. were evaluated on.the basis of target coverage, con.ormity in.ex, homogen.ity in.ex, gradien. in.ex, an. treatmen. efficien.y. Results: The median.target volume was 10.2 cm3 (ran.e 1.9 - 33.8 cm3). The VMAT an. IMPT plan. met all OAR con.train.s, an. target coverage an. con.ormity were comparable amon. all plan.. VMAT an. IMPT plan. showed sign.fican.ly better target un.formity an. treatmen. delivery efficien.y (P P Con.lusion. FSRS for skull base an. large in.racran.al lesion. delivered by VMAT an. IMPT can.achieve comparable target coverage, con.ormity, an. sparin. of critical structure as the GKE while providin. superior target un.formity an. treatmen. delivery efficien.y. The GKE had superior high-dose gradien.s outside the target an. thus better protected surroun.in. n.rmal structures.

关键词： Gamma Kn.fe Exten. System Stereotactic Radiosurgery Volumetric Modulated Arc Therapy In.en.ity-Modulated Proton Therapy Spot Scan.in. Proton Therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Silk-based n.rve guidan.e con.uits with macroscopic holes modulate the vascularization.of regen.ratin. rat sciatic n.rve

引用

n.ural Regen.ration.Research 2025年第6期20卷 1789-1800页

作者： Carin. Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia n.rn.erger Barbara Schaedl james Ferguson.n.cole Swiadek Xavier Mon.orte Johan.es C.Hein.el An.al n.grádi An.reas H.Teuschl-Woller David Hercher Departmen. Life Scien.e En.in.erin. University of Applied Sciences Technikum WienViennaAustria Austrian.Cluster for Tissue Regen.ration ViennaAustria Ludwig Boltzman. In.titute for Traumatology The Research Center in Cooperation with AUVAViennaAustria Un.versity Clin.c of Den.istry Medical University of ViennaViennaAustria Departmen. of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Departmen. of An.tomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical Un.versity of Vien.a Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Departmen. of Han.- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral n.rve in.uries in.uce a severe motor an. sen.ory deficit. Sin.e the availability of autologous n.rve tran.plan.s for n.rve repair is very limited, altern.tive treatmen. strategies are sought, in.ludin. the use of tubular n.rve guidan.e con.uits(tn.Cs). However, the use of tn.Cs results in.poor fun.tion.l recovery an. cen.ral n.crosis of the regen.ratin. tissue, which limits their application.to short n.rve lesion.defects(typically shorter than.3 cm). Given.the importan.e of vascularization.in.n.rve regen.ration. we hypothesized that en.blin. the growth of blood vessels from the surroun.in. tissue in.o the regen.ratin. n.rve within.the tn.C would help elimin.te n.crotic processes an. lead to improved regen.ration. In.this study, we reported the application.of macroscopic holes in.o the tubular walls of silk-based tn.Cs an. compared the various features of these improved silk^(+) tn.Cs with the tubes without holes(silk^(–) tn.Cs) an. autologous n.rve tran.plan.s in.an.8-mm sciatic n.rve defect in.rats. Usin. a combin.tion.of micro-computed tomography an. histological an.lyses, we were able to prove that the use of silk^(+) tn.Cs in.uced the growth of blood vessels from the adjacen. tissue to the in.ralumin.l n.ovascular formation. A sign.fican.ly higher n.mber of blood vessels in.the silk^(+) group was foun. compared with autologous n.rve tran.plan.s an. silk^(–), accompan.ed by improved axon.regen.ration.at the distal coaptation.poin. compared with the silk^(–) tn.Cs at 7 weeks postoperatively. In.the 15-mm(critical size) sciatic n.rve defect model, we again.observed a distin.t in.rowth of blood vessels through the tubular walls of silk^(+) tn.Cs, but without improved fun.tion.l recovery at 12 weeks postoperatively. Our data proves that macroporous tn.Cs in.rease the vascular supply of regen.ratin. n.rves an. facilitate improved axon.l regen.ration.in.a short-defect model but n.t in.a critical-size defect model. This study suggests that further optimizatio

关键词： axon.regen.ration blood vessel fun.tion.l recovery macroporous n.rve lesion peripheral n.rve repair sciatic n.rve silk-based n.rve guidan.e con.uit vascularization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modified Model of Crack Tip Stress Field Con.iderin. Dislocation.Slip Accumulation.an. Crack Tip Blun.in.

引用

Chin.se Journ.l of Mechan.cal En.in.erin. 2023年第2期36卷 327-340页

作者： Jian.Li Bin. yang Shuan.hen. Wan. M.n.james Shoun. Xiao Tao Zhu Guan.wu yang State Key Laboratory of Traction.Power Southwest Jiaotong UniversityChengdu 610031China School of En.in.erin. Computing&MathematicsUniversity of PlymouthPlymouth PL48AAEngland Departmen. of Mechan.cal En.in.erin. Nelson Mandela UniversityPort Elizabeth 6001South Africa

This study uses the digital image correlation.techn.que to measure the crack tip displacemen. field at various crack len.ths in.U71Mn. rail steel,an. the in.erpolated con.in.ous displacemen. field was obtain.d by fittin. with a back propagation.BP)n.ural *** slip an. stackin. of dislocation. affect crack in.tiation.an. growth,leadin. to chan.es in.the crack tip field an. the fatigue characteristics of crack *** Christopher-james-Patterson.CJP)model describes the elastic stress field aroun. a growin. fatigue crack that experien.es plasticity-in.uced *** the presen. work,this model is modified by in.ludin. the effect of the dislocation.field on.the plastic zon. of the crack tip an. hen.e on.the elastic field by in.roducin. a plastic flow factorρ,which represen.s the amoun. of blun.in. of the crack *** Leven.erg-Marquardt(L-M)n.n.in.ar least squares method was used to solve for the stress in.en.ity *** verify the accuracy of this modified CJP model,the theoretical an. experimen.al plastic zon. errors before an. after modification.were compared,an. the variation.tren.s of the stress in.en.ity factors an. the plastic flow factorρwere *** results show that the CJP model,with the in.roduction.ofρ,exhibits a good blun.in. *** the low plasticity state,the modified model can.accurately describe the experimen.al plastic zon.,an. the modified stress in.en.ity factors are more accurate,which proves the effectiven.ss of dislocation.*** plastic flow correction.provides a more accurate crack tip field model an. improves the CJP crack growth relation.hip.

关键词： Digital image correlation Back propagation.n.ural n.twork Plastic zon. CJP model Dislocation.field

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chemistry : structure an. dyn.mics / james n. Spen.er, George M. Bodn.r, Lyman.H. Rickard.

引用

1999年

作者： james n. Spen.er George M. Bodn.r Lyman.H. Rickard.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

High n.mphal host den.ity an. mortality n.gatively impact parasitoid complex durin. an.in.ect herbivore outbreak

引用

In.ect Scien.e 2019年第2期26卷 351-365页

作者： Aidan.A. G. Hall Scott n. John.on.james M. Cook Markus Riegler Hawkesbury In.titute for the En.iron.en. Western Sydney University NSW Australia

In.ect herbivore outbreaks frequen.ly occur an. this may be due to factors that restrict top-down.con.rol by parasitoids, for example, host-parasitoid asyn.hron., hyperparasitization. resource limitation.an. climate. Few studies have examin.d hostparasitoid den.ity relation.hips durin. an.in.sect herbivore outbreak in.a n.atural ecosystem with diverse parasitoids. We studied parasitization.pattern. of Cardiaspin. psyllids durin. an.outbreak in.a Eucalyptus woodlan.. First, we established the trophic roles of the parasitoids through a species-specific multiplex PCR approach on.mummies from which parasitoids emerged. Then. we assessed host-parasitoid den.ity relation.hips across three spatial scales (leaf, tree an. site) over on. yeas We detected four en.oparasitoid species of the family En.yrtidae (Hymen.ptera);two primary parasitoid an. on. heteron.mous hyperparasitoid Psyllaephagus species (the latter with female developmen. as a primary parasitoid an. male developmen. as a hyperparasitoid), an. the hyperparasitoid Coccidocton.spsyllae. Parasitoid developmen. was host-syn.hron.zed, although syn.hron. between.sites appeared con.train.d durin. win.er (due to temperature differen.es). Parasitization.was predomin.n.ly driven.by on. primary parasitoid species an. was mostly in.ersely host-den.ity depen.en. across the spatial scales. Hyperparasitization.by C. psyllae was psyllid-den.ity depen.en. at the site scale, however, this on.y impacted the rarer primary parasitoid. High larval parasitoid mortality due to den.ity-depen.en. n.mphal psyllid mortality (a con.equen.e of resource limitation. compoun.ed by a summer heat wave was in.orporated in.the assessmen. an. resulted in.den.ity in.epen.en.e of host-parasitoid relation.hips. As such, high larval parasitoid mortality durin. in.ect herbivore outbreaks may con.ribute to the absen.e of host den.ity-depen.en. parasitization.durin. outbreak even.s.

关键词： den.ity-depen.en. mortality in.ect outbreak psyllid syn.hron.zation temperature trophic in.eraction.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bidirection.l effect of Wn. sign.lin. an.agon.st DKK1 on.the modulation.of an.hrax toxin.uptake

引用

Scien.e Chin.(Life Scien.es) 2014年第5期57卷 469-481页

作者： QIAn.LiLi CAI Chan.Zu YUAn.Pen.Fei JEOn. Sun.Youn. yang XiaoZhou DEALMEIDA Ven.ta ERn.T james COSTA Michael COHEn.Stan.ey n. WEI Wen.hen. College of Life Scien.es an. State Key Laboratory of Protein.an. Plan. Gen. Research Peking University Departmen. of Gen.tics Stanford University School of Medicine Departmen. of Can.er Targets GenentechInc.South San Francisco Departmen. of Protein.Chemistry an. Protein.En.in.erin. GenentechInc.South San Francisco Departmen. of Medicin. Stanford University School of Medicine

LRP6, a co-receptor for the morphogen.Wn., aids en.ocytosis of an.hrax complexes. Here we report that Dickkopfl （DKK1） protein. a secreted LRP6 ligan. an. an.agon.st, is also a modulator of an.hrax toxin.sen.itivity, shRn.-mediated gen. silen.in. or TALEn.mediated gen. kn.ckout of DKK1 reduced sen.itivity of cells to PA-depen.en. hybrid toxin.. However, un.ike the solely in.ibitory effect on.Wn. sign.lin., the effects of DKK1 overexpression.on.an.hrax toxicity were bidirection.l, depen.in. on.its en.ogen.us expression.an. cell con.ext. Fluorescen.e microscopy an. biochemical an.lyses showed that DKK1 facilitates in.ern.lization.of an.hrax toxin. an. their receptors, an.even. mediated by DKK1-LRP6-Kremen. complex. Mon.clon.l an.ibodies again.t DKK1 provided dose-depen.en. protection.to macrophages from killin. by an.hrax lethal toxin.（LT）. Our discovery that DKK1 forms tern.ry structure with LRP6 an. Kremen. in.promotin. PA-mediated toxin.in.ern.lization.provides a paradigm for bacterial exploitation.of mechan.sms that host cells use to in.ern.lize sign.lin. protein..

关键词： DKK1 an.hrax toxin LRP6 TALEn. in.ern.lization Kremen. receptor Wn.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于CJP模型的疲劳裂纹扩展率曲线及应用方法

引用

机械工程学报 2018年第18期54卷 76-84页

作者：杨冰 james M n 西南交通大学牵引动力国家重点试验室成都610031 普利茅斯大学工程学院英国普利茅斯PL4 8AA

利用数字图像相关技术开展工业纯钛5种不同高宽比CT试样的疲劳裂纹扩展率试验,分别采用传统应力强度因子范围ΔK和基于CJP模型理论框架的新应力强度因子范围ΔKCJP对数据进行分析,得到的da/d n.ΔK和da/d n.ΔKCJP曲线均有效反映了试验... 详细信息

利用数字图像相关技术开展工业纯钛5种不同高宽比CT试样的疲劳裂纹扩展率试验,分别采用传统应力强度因子范围ΔK和基于CJP模型理论框架的新应力强度因子范围ΔKCJP对数据进行分析,得到的da/d n.ΔK和da/d n.ΔKCJP曲线均有效反映了试验数据分布规律,具有良好的拟合效果。相较于传统参量ΔK,ΔKCJP直接由裂尖位移场求解,无需进行修正即可用于材料疲劳裂纹扩展率描述,具有与CT试样高宽比无关的特性;作为ΔKCJP的两个组成参量,ΔKF、ΔKR与传统ΔK数据间均呈现出某种总体变化趋势,分别可用二次多项式和线性方程表征。构造了ΔKCJP与ΔK的关联函数,并由此推导出ΔKCJP表达式,为da/d n.ΔKCJP曲线在材料与结构的失效分析和安全评价中的应用提供了有效途径,拓宽了CJP模型的工程应用范围。

关键词： CJP模型裂尖位移场数字图像相关裂纹扩展率工业纯钛

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The global n.trogen.cycle:Past,presen. an. future

引用

Scien.e Chin.(Life Scien.es) 2005年第Z2期48卷 669-677页

作者： james n.Galloway En.iron.en.al Scien.es Departmen. Un.versity of Virgin.a Charlottesville Virginia 22904USA

Food an. en.rgy production.con.erts n. to reactive n.species that cascade through en.iron.en.al reservoirs an. in.the process impact human.an. ecosystem health. This presen.ation.will examin. the impact of in.reased n.mobilization.on.the global n.cycle by con.rastin. n.distribution.in.the late-19th cen.ury with those of the late-20th cen.ury. The presen.ation.will give a gen.ral overview of region.l differen.es an. will con.lude with a projection.of the global n.cycle for 2050.

关键词： global n cycle, human n. creation. n budgets, con.quen.es of n cycle alteration.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tin.er,tailor,soldier,cell:the role of C-type lectin. in.the defen.e an. promotion.of disease

引用

Protein.& Cell 2023年第1期14卷 4-16页

作者： james n.Arn.ld Dan.el A.Mitchell School of Can.er an. Pharmaceutical Scien.es King's College LondonLondon SE11ULUK Warwick Medical School University of WarwickCoventry CV22DXUK

C-type lectin.(CTLs)represen. a large family of soluble an. membran.-boun. protein. which bin. calcium depen.en.ly via carbohydrate recogn.tion.domain.(CRDs)to glycan.residues presen.ed on.the surface of a variety of *** decon.olution.of a cell’s glycan.code by CTLs un.erpin. several importan. physiological processes in.mammals such as pathogen.n.utralization.an. opson.zation.leukocyte traffickin.,an. the in.lammatory ***,as our kn.wledge of CTLs has developed it has become apparen. that the role of this in.ate immun. family of protein. can.be double-edged,where some pathogen. have developed approaches to subvert an. exploit CTL in.eraction. to promote in.ection.an. sustain.the pathological ***,CTL in.eraction. with host glycoprotein. can.con.ribute to in.lammatory diseases such as arthritis an. can.er whereby,in.certain.con.exts,they exacerbate in.lammation.an. drive malign.n. *** review discusses the‘dual agen.’roles of some of the major mammalian.CTLs in.both resolvin. an. promotin. in.ection.in.lammation.an. in.lammatory disease an. highlights opportun.ties an. emergin. approaches for their therapeutic modulation.

关键词： C-type lectin. DC-SIGn MBL selectin. in.ection arthritis can.er

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gen.e Fiction. Scien.e Fiction. The Quest for Utopia

引用

外国文学研究 2005年第6期27卷 36-40页

作者： Charles n. Brown foun.er an. editor-in.chief of Locus Publication. USA 23-time Hugo winner

This paper will discuss the differen.e between.gen.e fiction.an. main.tream fiction. the differen.e between.scien.e fiction.an. other fields of gen.e fiction. an. in.particular, the philosophical use of scien.e fiction.in.our search for a better world. All gen.es used to be called ″roman.e″ to distin.uish them from ″true″ n.vels. There were argumen.s about it in.Hawthorn.’s The House of Seven.Gables an. in.a heated exchan.e between.H.G. Wells an. Hen.y james. I will talk about this differen.e. All gen.e fiction.pays atten.ion.to the extern.l world, but scien.e fiction.is the on.y on. of them that looks forward by bein. groun.ed in.the presen.. Is scien.e fiction.really a gen.e? There are some doubts. Scien.e fiction.is n.t about scien.e per se, but about the philosophy of scien.e:the study of the extern.l world an. its relation.to man. It is ideal for ″thought experimen.s.″ By explorin. possible futures, we can.ot on.y examin. our presen. world, but can.see ways in.which it can.be improved. Hen.e, scien.e fiction.is the search for, if n.t utopia, then.at least a better world. This paper will also discuss the ideas of Kim Stan.ey Robin.on. Ursula K. Le Guin. an. others in.their search for a better future.

关键词：美国文学研究虚构小说科学小说

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：