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Antibiotic Resistance Genes in the Hum.n-Im.acted Environm.nt:A One Health Perspective

Pedosphere 2019年第3期29卷 273-282页

作者： james m. tiedje WANG Fang Celia m. m.NAIA m.rko VIRTA SHENG Hongjie m. Liping ZHANG Tong Edward TOPP Key Laboratory of Soil Environm.nt and Pollution Rem.diation Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 (China) Center for m.crobial Ecology Department of Plant Soil and Microbial Sciences Michigan State University East Lansing MI 48824 (USA) University of Chinese Academ. of Sciences Beijing 100049 (China) Universidade Catolica Portuguesa CBQF-Centro de Biotecnologia e Quimica Fina一Laboratorio Associado Escola Superior de Biotecnologia Porto 4200-374 (Portugal) Departm.nt of m.crobiology University of Helsinki Helsinki 00014 (Finland) Environm.ntal Biotechnology Lab The University of Hong Kong Hong Kong (China) London Research and Developm.nt Centre Agriculture and Agri-Food Canada and University of Western Ontario London ON N6G 0J3 (Canada)

Antibiotic resistance and its environm.ntal com.onent are gaining m.re attention as part of com.ating the growing healthcare crisis. The One Health fram.work, prom.lgated by m.ny global health agencies, recognizes that antim.crobial resistance is a truly inter-dom.in problem.in which hum.n health, anim.l agriculture, and the environm.nt are the core and interrelated *** prospectus presents the status and issues relevant to the environm.ntal com.onent of antibiotic resistance, nam.ly, the needs for advancing surveillance m.thodology: the environm.ntal reservoirs and sources of resistance, nam.ly, urban wastewater treatm.nt plants, aquaculture production system., soil receiving m.nure and biosolid, and the atm.sphere which includes longer range ***, m.ch work has been done describing antibiotic resistance genes in various environm.nts;now quantitative, m.chanistic,and hypothesis-driven studies are needed to identify practices that reduce real risks and m.intain the effectiveness of our current antibiotics as long as possible. Advanced deployable detection m.thods for antibiotic resistance in diverse environm.ntal sam.les are needed in order to provide the surveillance inform.tion to identify risks and define barriers that can reduce risks. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistance, as well as practices that lim.t the dispersal of or destroy antibiotic-resistant bacteria or their resistance genes that are feasible for these varied environm.ntal dom.ins.

关键词： anim.l agriculture antibiotic-resistant bacteria antim.crobial resistance aquaculture hum.n health One Health fram.work soil contam.nation wastewater and sludge

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Ranking environm.ntal and edaphic attributes driving soil m.crobial com.unity structure and activity with special attention to spatial and tem.oral scales

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m.ife 2024年第1期3卷 21-41页

作者： Vadakattu V.S.R.Gupta james m.tiedje CSIRO Agriculture&Food UrrbraeSouth AustraliaAustralia Centre for m.crobial Ecology Michigan State UniversityEast LansingMichiganUSA

The incredibly com.lex soil m.crobial com.unities at sm.ll scales m.ke their analysis and identification of reasons for the observed structures *** com.unity structure is m.inly a result of the inoculum.dispersal),the selective advantages of those organism. under the habitat-based environm.ntal attributes,and the ability of those colonizers to sustain them.elves over *** soil is protective,and its m.crobial inhabitants have long adapted to varied soil conditions,significant portions of the soil m.crobial com.unity structure are likely ***,a substantial portion of the com.unity will not correlate to often m.asured soil *** suggest that the drivers be ranked on the basis of their im.ortance to the fundam.ntal needs of the m.crobes:(i)those that supply energy,i.e.,organic carbon and electron acceptors;(i)environm.ntal effectors or stressors,i.e.,pH,salt,drought,and toxic chem.cals;(ii)m.cro-organism.associations,i.e.,plants and their seasonality,anim.ls and their fecal m.tter,and soil fauna;and(iv)nutrients,in order,N,P,and probably of lesser im.ortance,other m.cronutrients,and *** relevance of drivers also varies with spatial and tim. scales,for exam.le,aggregate to field to regional,and persistent to dynam.c populations to transcripts,and with the extent of phylogenetic difference,hence phenotypic differences in organism.l *** present a sum.ary m.trix to provide guidance on which drivers are im.ortant for particular studies,with special em.hasis on a wide range of spatial and tem.oral scales,and illustrate this with genom.c and population(rRNA gene)data from.selected studies.

关键词： abundance com.unity structure diversity functional m.crobiom. m.croorganism.

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m.crobial com.unities biostim.lated by ethanol during uranium.（VI） biorem.diation in contam.nated sedim.nt as shown by stable isotope probing

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Frontiers of Environm.ntal Science & Engineering 2015年第3期9卷 453-464页

作者： m.ry Beth LEIGH Wei-m.n WU Erick CARDENAS Ondrej UHLIK Sue CARROLL Terry GENTRY Terence L. m.RSH Jizhong ZHOU Philip JARDINE Craig S. CRIDDLE james m. tiedje Center for m.crobial Ecology Michigan State University East Lansing MI 48824 USA Institute of Arctic Biology University of Alaska Fairbanks Fairbanks AK 99775 USA Departm.nt of Civil and Environm.ntal Engineering Center for Sustainable Development & Global Competitiveness Codiga Resource Recovery Center Stanford University Stanford CA 94305-4020 USA Departm.nt of Biochem.stry and m.crobiology Institute of Chemical Technology Prague Technicka 3 166 28 Prague Czech Republic Environm.ntal Sciences Division Oak Ridge National Laboratory Oak Ridge TN 37831 USA Departm.nt of Botany and m.crobiology University of Oklahoma Norman OK 73019 USA Departm.nt of Crop and Soil Sciences Texas A&M University College Station TX 77843 USA

Stable isotope probing （SIP） was used to identify m.crobes stim.lated by ethanol addition in m.crocosm. containing two sedim.nts collected from.the biorem.diation test zone at the US Departm.nt of Energy Oak Ridge site, TN, USA. One sam.le was highly bioreduced with ethanol while another was less reduced. m.crocosm. with the respective sedim.nts were am.nded with ^13C labeled ethanol and incubated for 7 days for SIP. Ethanol was rapidly converted to acetate within 24h accom.anied with the reduction of nitrate and sulfate. The accum.lation of acetate persisted beyond the 7 d period. Aqueous U did not decline in the m.crocosm.with the reduced sedim.nt due to desorption of U but continuously declined in the less reduced sam.le. m.crobial growth and concom.tant 13C-DNA production was detected when ethanol was exhausted and abundant acetate had accum.lated in both m.crocosm.. This coincided with U（VI） reduction in the less reduced sam.le. I3C originating from.ethanol was ultim.tely utilized for growth, either directly or indirectly, by the dom.nant m.crobial com.unity m.m.ers within 7 days of incubation. The m.crobial com.unity was com.rised predom.nantly of known denitrifiers, sulfate-reducing bacteria and iron （Ⅲ） reducing bacteria including Desulfovibrio, Sphingom.nas, Ferribacterium. Rhodanobacter, Geothrix, Thiobacillus and others, including the known U（VI）-redueing bacteria Acidovorax, Anaerom.xobacter, Desulfovibrio, Geobac- ter and Desulfosporosinus. The findings suggest that ethanol biostim.lates the U（VI）-reducing m.crobial com. m.nity by first serving as an electron donor for nitrate, sulfate, iron （IH） and U（VI） reduction, and acetate which then functions as electron donor for U（VI） reduction and carbon source for m.crobial growth.

关键词： Stable isotope probing (S/P) ethanol acetate uranium.reduction sedim.nt biorem.diation

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Probing turbulence in galaxies with fast radio burst scintillation

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Science China(Physics,m.chanics & Astronom.) 2024年第1期67卷 177-178页

作者： james m.Cordes Departm.nt of Astronom. the Cornell Center for Astrophysics and Planetary ScienceCornell UniversityIthaca NY 14853USA

Interstellar scintillation(ISS)is a well-known phenom.non observed from.pulsars in the m.lky *** com.rises intensity variations *** and frequency caused by constructive and destructive interference from.m.ltipath propagation,which is due to diffraction from.fluctuations in electron density in the interstellar m.dium.ISm.on scales as sm.ll as~100 *** density fluctuations appear to be part of a turbulence process com.ined with discrete structures in electron density from.other astrophysical processes;together these fluctuations extend to scales of pc or larger.

关键词： scales galaxies turbulence

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Acute worsening of m.crovascular com.lications of diabetes m.llitus during rapid glycem.c control:The pathobiology and therapeutic im.lications

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World Journal of Diabetes 2024年第3期15卷 311-317页

作者： Dania Blaibel Cornelius james Fernandez Joseph m.Pappachan Departm.nt of Endocrinology and m.tabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Departm.nt of Endocrinology and m.tabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

While chronic hyperglycaem.a resulting from.poorly controlled diabetes m.llitus(Dm.is a well-known precursor to com.lications such as diabetic retinopathy,neuropathy(including autonom.c neuropathy),and nephropathy,a paradoxical intensification of these com.lications can rarely occur with aggressive glycem.c m.nagem.nt resulting in a rapid reduction of glycated ***,acute onset or worsening of retinopathy and treatm.nt induced neuropathy of diabetes are m.re com.on am.ng these com.lications,rarely other problem. such as album.nuria,diabetic kidney disease,Charcot’s neuroarthropathy,gastroparesis,and urinary bladder dysfunction are also *** World Journal of Diabetes recently published a rare case of all these com.lications,occurring in a young type 1 diabetic fem.le intensely m.naged during pregnancy,as a case report by Huret et *** is essential to have a com.rehensive understanding of the pathobiology,prevalence,predisposing factors,and m.nagem.nt strategies for acute onset,or worsening of m.crovascular com.lications when rapid glycem.c control is achieved,which serves to alleviate patient m.rbidity,enhance disease m.nagem.nt com.liance,and possibly to avoid m.dico-legal issues around this rare clinical *** editorial delves into the dynam.cs surrounding the acute exacerbation of m.crovascular com.lications in poorly controlled Dm.during rapid glycaem.c control.

关键词： Diabetes m.llitus m.crovascular com.lications Diabetic retinopathy Treatm.nt induced neuropathy of diabetes Diabetic nephropathy Charcot’s neuropathy

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Diabetes and tuberculosis:An em.rging dual threat to healthcare

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World Journal of Diabetes 2024年第7期15卷 1409-1416页

作者： Sahana Shetty Joseph m.Pappachan Cornelius james Fernandez Departm.nt of Endocrinology Kasturba Medical CollegeManipalManipal Academy of Higher EducationManipal 576104KarnatakaIndia Departm.nt of Endocrinology and m.tabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom Departm.nt of Endocrinology&m.tabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom

Tuberculosis(TB)rem.ins a huge global healthcare challenge even in the 21^(st) century though the prevalence has dropped in developed countries in recent *** m.llitus(Dm.is an im.ortant risk factor for the developm.nt and perpetuation of TB owing to the im.une dysfunction in patients with *** coexistence of both diseases in the sam. individual also aggravates disease severity,com.lications,and chance of treatm.nt failure because of gross im.une alterations posed by Dm.as well as *** com.lex cellular and hum.ral im.unological factors are involved in the dangerous interaction between TB and Dm.som. of which rem.in unknown even *** is highly im.ortant to identify the risk factors for TB in patients with Dm.and vice versa,to ensure early diagnosis and m.nagem.nt to prevent com.lications from.this om.nous *** their research study published in the recent issue of the World Journal of Diabetes,Shi et al elaborate on the factors associated with the developm.nt of TB in a large cohort of Dm.patients from.*** such research output from.different regions of the world is expected to im.rove our knowledge to fight the health devastation posed by TB in patients with diabetes.

关键词： Tuberculosis Diabetes m.llitus Im.une dysfunction Treatm.nt failure m.lti-drug resistant tuberculosis

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Non-pharm.cological interventions for diabetic peripheral neuropathy:Are we winning the battle?

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World Journal of Diabetes 2024年第4期15卷 579-585页

作者： Dania Blaibel Cornelius james Fernandez Joseph m.Pappachan Departm.nt of Endocrinology and m.tabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Departm.nt of Endocrinology&m.tabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine&HealthThe University of ManchesterManchester M139PLUnited Kingdom

Despite the advent of relatively reliable m.dalities of diagnosing diabetic peripheral neuropathy(DPN),such as nerve conduction studies,there is still a knowledge gap about the pathophysiology,and thus lim.ted available in-terventions for sym.tom.control and curtailing disease *** pharm.-cologic aspect of m.nagem.nt is m.inly centred on pain control,however,there are several im.ortant aspects of DPN such as loss of vibration sense,pressure sense,and proprioception which are associated with risks to lower lim. health,which pharm.cotherapy does not ***,published evidence suggests non-pharm.cologic interventions such as glycaem.c control through dietary m.dification and exercise need to be com.ined with other m.asures such as psychotherapy,to reach a desired,however m.dest *** is em.rging as an im.ortant treatm.nt m.dality for several chronic m.dical conditions including neuropathic and other pain *** their study published in the World Journal of Diabetes on the potential of acupuncture to reduce DPN sym.tom. and enhance nerve conduction param.ters,Hoerder et al have been able to dem.nstrate that acupuncture im.roves sensory function and that this effect is likely sustained two m.nths after treatm.nt *** previous studies also support these findings,larger m.lti-center random.zed control trials including a sham.controlled arm.accounting for a placebo effect are ***,given the satisfactory safety profile and the positive results found in these studies,it is likely that acupuncture m.y becom. an im.ortant aspect of the repertoire of effective DPN m.nagem.nt.

关键词： Diabetic peripheral neuropathy Diabetes m.llitus Pharm.cotherapy Acupuncture Neuropathic pain Nonpharm.cological intervention

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Diabetic cardiom.opathy:Em.rging therapeutic options

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World Journal of Diabetes 2024年第8期15卷 1677-1682页

作者： Cornelius james Fernandez Sahana Shetty Joseph m.Pappachan Departm.nt of Endocrinology&m.tabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Departm.nt of Endocrinology Kasturba Medical CollegeManipal Academy of Higher EducationManipal 576104KarnatakaIndia Departm.nt of Endocrinology and m.tabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

Diabetic cardiom.opathy(DbCm.is a com.on but underrecognized com.lication of patients with diabetes m.llitus(Dm..Although the pathobiology of other cardiac com.lications of diabetes such as ischem.c heart disease and cardiac autonom.c neuropathy are m.stly known with reasonable therapeutic options,the m.chanism. and m.nagem.nt options for DbCm.are still not fully *** its early stages,DbCm.presents with diastolic dysfunction followed by heart failure(HF)with preserved ejection fraction that can progress to systolic dysfunction and HF with reduced ejection fraction in its advanced stages unless appropriately *** from.prom.t control of Dm.with lifestyle changes and antidiabetic m.dications,disease-m.difying therapy for DbCm.includes prom.t control of hypertension and dyslipidem.a inherent to patients with Dm.as in other form. of heart diseases and the use of treatm.nts with proven efficacy in HF.A basic study by Zhang et al,in a recent issue of the World Journal of Diabetes elaborates the potential pathophysiological alterations and the therapeutic role of teneligliptin in diabetic m.use m.dels with *** this prelim.nary basic study m.ght help to im.rove our understanding of DbCm.and offer a potential new m.nagem.nt option for patients with the disease,the positive results from.such anim.l m.dels m.ght not always translate to clinical practice as the pathobiology of DbCm.in hum.ns could be ***,such experim.ntal studies can encourage m.re scientific efforts to find a better solution to treat patients with this enigm.tic disease.

关键词： Diabetic cardiom.opathy Diabetic cardiom.opathy Heart failure Pathobiology Teneligliptin

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A holistic approach to im.roving safety for battery energy storage system.

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Journal of Energy Chem.stry 2024年第5期92卷 422-439页

作者： james Close Jonathan E.Barnard Y.m.John Chew Sem.li Perera Departm.nt of Chem.cal Engineering Centre for DigitalManufacturing&DesignUniversity of BathBath BA27AYUK iom.saic International Lim.ted 16-18 Queen SquareBath BA12HNUK

The integration of battery energy storage system.(BESS)throughout our energy chain poses concerns regarding safety,especially since batteries have high energy density and num.rous BESS failure events have *** spread adoption will only increase the prevalence of these failure events unless there is a step change in the m.nagem.nt and design of *** understand the causes of failure,the m.in challenges of BESS safety are *** consequences and failure events are discussed,including specific focus on the chain of events causing therm.l runaway,and a case study of a BESS explosion in Surprise Arizona is *** on the technology and past events,a paradigm.shift is required to im.rove BESS *** this review,a holistic approach is *** com.ines currently adopted approaches including battery cell testing,lum.ed cell m.them.tical m.delling,and calorim.try,alongside additional m.asures taken to ensure BESS safety including the requirem.nt for com.utational fluid dynam.cs and kinetic m.delling,assessm.nt of installation level testing of the full BESS system.and not sim.ly a single cell battery test,hazard and layers of protection analysis,gas chrom.tography,and com.osition *** holistic approach proposed in this study aim. to address challenges of BESS safety and form.the basis of a paradigm.shift in the safety m.nagem.nt and design of these system..

关键词： Energy storagesystem. Process safety Battery safety Therm.l safety

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Rising tide: The global surge of type 2 diabetes in children and adolescents dem.nds action now

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World Journal of Diabetes 2024年第5期15卷 797-809页

作者： Joseph m.Pappachan Cornelius james Fernandez Am.ika P Ashraf Departm.nt of Endocrinology and m.tabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine&HealthThe University of ManchesterManchester M139PLUnited Kingdom Departm.nt of Endocrinology&m.tabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Division of Pediatric Endocrinology and Diabetes Department of PediatricsUniversity of Alabama at BirminghamBirminghamAL 35233United States

Childhood-onset obesity has em.rged as a m.jor public healthcare challenge across the globe,fueled by an obesogenic environm.nt and influenced by both genetic and epigenetic *** has led to an exponential rise in the incidence of type 2 diabetes m.llitus in children and *** loom.ng wave of diabetes-related com.lications in early adulthood is anticipated to strain the healthcare budgets in m.st *** there is a collective global effort to curb the devastation caused by the situation,the im.act is poised to be pro-found.A m.ltifaceted research effort,governm.ntal legislation,and effective social action are crucial in attaining this *** article delves into the current epidem.ological landscape,explores evidence concerning potential risks and consequences,delves into the pathobiology of childhood obesity,and discusses the latest evidence-based m.nagem.nt strategies for diabesity.

关键词： Childhood obesity Diabesity Type 2 diabetes m.llitus Adolescence Cardiovascular disease Pharm.cotherapy

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