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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina hromada Patrick heimel Markus kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl james Ferguson Nicole Swiadek Xavier Monforte Johannes C.heinzel Antal Nógrádi Andreas h.Teuschl-Woller David hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). however, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Fish-on-Chips:unveiling neural processing of chemicals in small animals through precise fluidic control

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Neural Regeneration Research 2024年第11期19卷 2351-2353页

作者： Samuel k.h.Sy ho ko Division of Neurology Department of Medicine and TherapeuticsFaculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Li ka Shing Institute of health Sciences Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Department of Electrical and Electronic Engineering Faculty of EngineeringThe University of Hong KongPok Fu LamHong Kong IslandHong Kong Special Administrative RegionChina Advanced Biomedical Instrumentation Center Hong Kong Science ParkPak Shek KokNew TerritoriesHong Kong Special Administrative RegionChina Margaret k.L.Cheung Research Center for Management of Parkinsonism Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Lau Tat-chuen Research Center of Brain Degenerative Diseases in Chinese Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Gerald Choa Neuroscience Institute The Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina

Precise chemical cue presentation alongside advanced brainwide imaging techniques is important to the study of chemosensory processing in ***,the dynamic nature of chemical-carrying media,such as water or air,poses a significant challenge for delivering highly-controlled chemical flow to an animal ***,contact-based cue manipulation and delivery easily shift the position of the animal subject,which is often undesirable for high-quality brain ***,more advanced interfacing tools that align with the diverse range of body part sizes of an animal,ranging from micrometer-scale neurons to meter-long limbs,are much *** is particularly crucial when dealing with dimensions that are beyond the reach of conventional experimental tools.

关键词： dealing precise sizes

Candida albicans aspects of binary titanium alloys for biomedical applications

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Regenerative Biomaterials 2020年第2期7卷 213-220页

作者： Shuyang Chen james k.h.Tsoi Peter C.S.Tsang Yeong-Joon Park ho-Jun Song Jukka P.Matinlinna Dental Materials Science Division of Applied Oral Sciences&Community Dental CareFaculty of DentistryThe University of Hong KongPrince Philip Dental Hospital34 Hospital RoadHong Kong SARPeople’s Republic of China Department of Prosthodontics Tianjin Stomatological HospitalNo.75Dagu RoadHeping DistrictTianjin 300041People’s Republic of China Division of Restorative Dental Sciences Faculty of DentistryThe University of Hong KongPrince Philip Dental Hospital34 Hospital RoadHong Kong SARPeople’s Republic of China and 4 Department of Dental Materials and MRC for hard-tissue Biointerface School of DentistryChonnam National UniversityGwangju 61186Republic of Korea

Titanium and its alloys are widely used in biomedical devices,***,due to its biocompati-bility and osseointegration *** fact,fungal(Candida spp.)infection has been identified as one of the key reasons causing the failure of the device that is inevitable and impactful to the ***,this study evaluated the surface morphology,surface chemical composition and Candida albicans adhesion on specimens of 16 binary Tialloys(-5 wt%of any one of the alloy elements:Ag,AI,Au,Co,Cr,Cu,Fe,In,Mn,Mo,Nb,Pd,Pt,Sn,V and Zr)compared with cp-Ti,targeting to seek for the binary Ti-alloys which has the lowest *** *** albicans cultures were grown on the specimens for 48 h,and colony forming units(CFUs)and real-time polymerase chain reaction(RT-PCR)were used to evaluate the biofilm formation *** electron mi-croscopy and confocal laser scanning microscopy confirmed the formation of *** biofilm on all specimens'surfaces,such that CFU results showed Ti-Mo,Ti-Zr,Ti-AI and Ti-V have less *** formed on the surfaces than ***-PCR showed Ti-Zr and Ti-Cu have significantly higher *** DNA concentrations than Ti-AI and Ti-V(Phereas Ti-Cu has even showed a statistically higher concentration than Ti-Au,Ti-Co,Ti-In and Ti-Pt(Phis study confirmed that Ti-Mo,Ti-Zr,Ti-AI and Ti-V have lower the occurrence of *** which might be clinically advantageous for medical devices,but Ti-Cu should be used in caution.

关键词： titanium binary titanium alloy C.albicans,fungal infection medical devices

Decoding hereditary spastic paraplegia pathogenicity through transcriptomic profiling

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Zoological Research 2023年第3期44卷 650-662页

作者： Nicolas james ho Xiao Chen Yong Lei Shen Gu School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Dr.Li Dak Sum-Yip Yio Chin Center for Stem Cells and Regenerative Medicine and Department of Orthopedic Surgery of the Second Affiliated hospital Zhejiang University School of MedicineHangzhouZhejiang 310058China key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province Zhejiang University School of MedicineHangzhouZhejiang 310058China Zhejiang University-University of Edinburgh Institute&School of Basic Medicine Zhejiang University School of MedicineHangzhouZhejiang 310058China Department of Sports Medicine Zhejiang University School of MedicineHangzhouZhejiang 310058China China Orthopedic Regenerative Medicine Group(CORMed) HangzhouZhejiang310058 China School of Medicine The Chinese University of Hong Kong(Shenzhen)ShenzhenGuangdong 518172China The Chinese University of hong kong(Shenzhen) Shenzhen Futian Biomedical Innovation R&D CenterShenzhenGuangdong 518172China key Laboratory for Regenerative Medicine Ministry of EducationSchool of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina kunming Institute of Zoology-The Chinese University of hong kong(kIZ-CUhk)Joint Laboratory of Bioresources and Molecular Research of Common Diseases Hong Kong SARChina hong kong Branch of CAS Center for Excellence in Animal Evolution and Genetics The Chinese University of Hong KongHong Kong SARChina

hereditary spastic paraplegia(hSP)is a group of genetic motor neuron diseases resulting from length-dependent axonal degeneration of the corticospinal upper motor *** to the advancement of next-generation sequencing,more than 70 novel hSP disease-causing genes have been identified in the past *** this,our understanding of hSP physiopathology and the development of efficient management and treatment strategies remain *** major challenge in studying hSP pathogenicity is selective neuronal vulnerability,characterized by the manifestation of clinical symptoms that are restricted to specific neuronal populations,despite the presence of germline disease-causing variants in every cell of the ***,disease genes may exhibit ubiquitous expression patterns and involve a myriad of different pathways to cause motor neuron *** the current review,we explore the correlation between transcriptomic data and clinical manifestations,as well as the importance of interspecies models by comparing tissue-specific transcriptomic profiles of humans and mice,expression patterns of different genes in the brain during development,and single-cell transcriptomic data from related ***,we discuss the potential of emerging single-cell RNA sequencing technologies to resolve unanswered questions related to hSP pathogenicity.

关键词： degeneration transcript hereditary

Binary titanium alloys as dental implant materials—a review

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Regenerative Biomaterials 2017年第5期4卷 315-323页

作者： Xiaotian Liu Shuyang Chen james k.h.Tsoi Jukka Pekka Matinlinna Department of Orthodontics Tianjin Stomatological Hospital of Nankai UniversityTianjinP.R.China Dental Materials Science Faculty of DentistryThe University of Hong KongPrince Philip Dental Hospital34 Hospital RoadHong Kong SARP.R.China Department of Prosthodontics Tianjin Stomatological Hospital of Nankai UniversityTianjinP.R.China

Titanium(Ti)has been used for long in dentistry and medicine for implant *** the years,not only the commercially pure Ti but also some alloys such as binary and tertiary Ti alloys were *** aim of this review is to describe and compare the current literature on binary Ti alloys,including Ti-Zr,Ti-In,Ti-Ag,Ti-Cu,Ti-Au,Ti-Pd,Ti-Nb,Ti-Mn,Ti-Mo,Ti-Cr,Ti-Co,Ti-Sn,Ti-Ge and Ti-Ga,in particular to mechanical,chemical and biological parameters related to implant *** was searched using the PubMed and Web of Science databases,as well as google without limiting the year,but with principle key terms such as‘Ti alloy’,‘binary Ti’,‘Ti-X’(with X is the alloy element),‘dental implant’and‘medical implant’.Only laboratory studies that intentionally for implant or biomedical applications were *** to available literatures,we might conclude that most of the binary Ti alloys with alloyinghave high potential as implant materials,due to good mechanical performance without compromising the biocompatibility and biological behaviour compare to cp-Ti.

关键词： binary Ti Ti alloy dental implant biocompatibility

Analysis of the Oscillatory Flows of Multiple Shock Waves in a Constant Area Duct

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Journal of Thermal Science 2024年第3期33卷 794-806页

作者： k james Jintu kIM heuy Dong Department of Mechanical Engineering Andong National UniversityAndong36729Republic of Korea CAD-IT korea Co. Ltd.Seoul08591Republic of Korea

The oscillatory response of multiple shock waves to downstream perturbations in a supersonic flow is studied numerically in a rectangular *** shock waves are formed inside the duct at a shock Mach number of *** duct has an exit height of h,and the effect of duct resonance on multiple shock oscillations is investigated by attaching exit ducts of lengths 0h,50h,and *** downstream disturbance frequency varied from 10 hz to 200 hz to explore the oscillation characteristics of the multiple shock *** oscillatory response of shock waves under self-excited and forced oscillation conditions are analyzed in terms of wall static pressure,shock train leading-edge location,shock train length,and the size of the separation *** extent of the initial shock location increases with an increase in exit duct length for the self-excited oscillation *** analysis of the shock train leading edge and the spectral analysis of wall static pressure variations are *** variation in the shock train length is analyzed using the pressure ratio method for self-excited as well as forced *** RMS amplitude of the normalized shock train length(ζ_(ST))increases with an increase in the exit duct length for the self-excited oscillation *** the downstream perturbation frequency is increased,ζ_(ST)is decreased for exit duct *** all exit duct designs and downstream forcing frequencies,the size of the separation bubble grows and shrinks during the shock oscillations,demonstrating the dependence on duct resonance and forced oscillations.

关键词： shock train downstream disturbance supersonic flow shock wave boundary layer interaction duct resonance flow separation

Redox Charge Transfer kinetics and Reversibility of VO_(2) in Aqueous and Non-Aqueous Electrolytes of Na-Ion Storage

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Energy & Environmental Materials 2022年第4期5卷 1222-1228页

作者： Sul ki Park kang ho Shin Puritut Nakhanivej harpalsinh h.Rana ho Seok Park School of Chemical Engineering College of EngineeringSungkyunkwan University2066Seobu-roJangan-guSuwon-si Gyeonggi-do 440-746Republic of Korea Department of Engineering University of CambridgeCambridge CB30FSUK Department of health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan University2066SeoburoJangan-guSuwon 440-746South Korea SkkU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan University2066SeoburoJangan-guSuwon 440-746South Korea

The deep understanding about the electrochemical behavior of the nanostructured electrode in electrolytes provides crucial insights for the rational design of electrode for sodium(Na)-ion storage system(NIS).here,we report redox charge transfer kinetics and reversibility of VO_(2)(B) nanorod electrodes in both aqueous and organic electrolytes for *** assynthesized VO_(2)(B) nanorods show the reversible redox reaction with the higher specific and rate capacitances at high current density in aqueous electrolytes than in organic ***-dependent impedance measurements demonstrate the more facile interfacial charge transfer of Na ions into VO_(2)(B) nanorods in aqueous *** reversible evolution in oxidation state and chemical composition of VO_(2)(B) nanorods is observed in aqueous electrolytes,as confirmed by ex situ XRD and ex situ X-ray photoelectron spectroscopy *** by the facile and reversible pseudocapacitive feature,the electrochemical performances of VO_(2)(B) nanorods are further improved by constructing the hierarchical structure of the reduced graphene oxide-VO_(2) composite for aqueous Na+ion storage.

关键词： aqueous electrolyte energy storage mechanism hierarchical structure nanorod sodium ion storage

Techniques for colorectal anastomosis

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World Journal of Gastroenterology 2010年第13期16卷 1610-1621页

作者： Yik-hong ho Mohamed Ahmed Tawfi k Ashour Discipline of Surgery School of Medicine James Cook University

Colorectal anastomotic leak remains one of the most feared post-operative complications, particularly after anterior resection of the rectum with, the shift from abdomino-peritoneal resections to total mesorectal excision and primary anastomosis. The literature fails to demonstrate superiority of stapled over hand-sewn techniques in colorectal anastomosis, regardless of the level of anastomosis, although a high stricture rate was noted in the former technique. Thus, improvements in safety aspects of anastomosis and alternatives to handsewn and stapled techniques are being sought. here, we review alternative anastomotic techniques used to fashion bowel anastomosis. Compression anastomosis using compression anastomotic clips, endoluminal compression anastomotic rings, AkA-2, biofragmental anastomotic rings, or Magnamosis all involve the concept of creating a sutureless end-to-end anastomosis by compressing two bowel ends together, leading to a simultaneous necrosis and healing process that joins the two lumens. Staple line reinforcement is a new approach that reduce the drawbacks of staplers used in colorectal practice, i.e. leakage, bleeding, misfi ring, and inadequate tissue approximation. Various nonabsorbable, semi or fully absorbable materials are now available. Two other techniques can provide alternative anastomotic support to the suture line: a colorectal drain and a polyester stent, which can be utilized in ultra-low rectal excision and can negate the formation of a defunctioning stoma. Doxycycline coated sutures have been used to overcome the post-operative weakness in anastomosis secondary to rapid matrix degradation mediated by matrix metalloproteinase. Another novel technique, the electric welding system, showed promising results in construction of a safe, neat, smooth sutureless bowel anastomosis. Various anastomotic techniques have been shown to be comparable to the standard techniques of suturing and stapling. however, most of these alternatives need t

关键词： Alternative anastomosis Compression anastomotic clip Compression anastomotic ring Biofragmental anastomotic ring AkA-2 Magnamosis (magnetic anastomosis) Matrix metallo-proteinase Sutureless

Regulating lithium nucleation and growth by zinc modified current collectors

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Nano Research 2020年第1期13卷 45-51页

作者： Na Zhang Seung-ho Yu héctor D.Abruna Baker Laboratory Department of Chemistry and Chemical BiologyCornell UniversityIthacaNew York14853USA Department of Chemical and Biological Engineering Korea University145 Anam-roSeongbuk-guSeoul02841Republic of Korea

Lithium metal is commonly regarded as the“holy Grail”anode material for high energy density rechargeable ***,the uncontrollable growth of Li dendrites has posed safety concerns and thus greatly hindered its large-scale *** we have modified the surface of a commercial anode current collector,Cu foil,with a thin layer of Zn by a facile electroplating method,in order to regulate the Li nucleation and the following growth *** of the formation of a solid solution buffer layer and Li-Zn alloy phases,the Li nucleation overpotential was dramatically reduced,realizing a uniform Li nucleation and a smooth Li plating *** a result,significantly improved long-term cycling performance with a high Coulombic efficiency was achieved by the lithiophilic Zn coated Cu foil as a current *** cells of Li-LiFePO4 and Li-S using the Li deposited on the Zn modified Cu as the anode,showed increased capacity with low voltage hysteresis and greatly enhanced cycling stability,ascribed to the uniform Li deposition and formation of a stable SEI *** work demonstrates the feasibility of employing lithiophilic modified Cu foils as Li metal current collectors for practical applications.

关键词： lithium metal anode lithium dendrite current collector zinc layer