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Insect transmission of plant viruses： Multilayered interactions optimize viral propagation

Insect Science 2017年第6期24卷 929-946页

作者： Beatriz Dader Chrstiane Then Edwige Berthelot Marie Ducousso james C. k. Ng Martin Druck.r INRA UMR 385 BGPI (CIRAD-INRA-SupAgroM) Montpellier France Department of Plant Pathology and Microbiology and Center for Disease Vector Research University of California Riverside USA

By serving as vectors of transmission, insects play a k.y role in the infection cycle of many plant viruses. Viruses use sophisticated transmission strategies to overcome the spatial barrier separating plants and the impediment imposed by the plant cell wall. Interactions among insect vectors, viruses, and host plants mediate transmission by integrating all organizational levels, from molecules to populations. Best-examined on the molecular scale are two basic transmission modes wherein virus-vector interactions have been well characterized. Whereas association of virus particles with specific sites in the vector＇s mouthparts or in alimentary tract regions immediately posterior to them is required for noncirculative transmission, the cycle of particles through the vector body is necessary for circulative transmission. Virus transmission is also determined by interactions that are associated with changes in vector feeding behaviors and with alterations in plant host＇s morphology and/or metabolism that favor the attraction or deterrence of vectors. A recent concept in virus-host-vector interactions proposes that when vectors land on infected plants, vector elicitors and effectors ＂inform＂ the plants of the confluence of interacting entities and trigger signaling pathways and plant defenses. Simultaneously, the plant responses may also influence virus acquisition and inoculation by vectors. Over- all, a picture is emerging where transmission depends on multilayered virus-vector-host interactions that define the route of a virus through the vector, and on the manipulation of the host and the vector. These interactions guarantee virus propagation until one or more of the interactants undergo changes through evolution or are halted by environmental interventions.

关键词： arbovirus defense host plant insect vector interactions plant virus transmission

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选择家政学专业，踏上寻找美好生活之路

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求学 2024年第4期 50-51页

作者： james 河北师范大学

本文主角：家政学讲述人：james（河北师范大学）适合人群：喜欢吃喝玩乐，热爱生活，关注家庭，具有一定审美与生活能力，或是想要培养审美，提高自身生活能力的同学家政学是新学科？怎么没听说过？家政学专业与大家熟知的法学、汉语...

本文主角：家政学讲述人：james（河北师范大学）适合人群：喜欢吃喝玩乐，热爱生活，关注家庭，具有一定审美与生活能力，或是想要培养审美，提高自身生活能力的同学家政学是新学科？怎么没听说过？家政学专业与大家熟知的法学、汉语言文学、计算机科学与技术等专业相比，确实算是一门小众冷门学科，但我国家政学这一学科的历史可以追溯到1907年。

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Lipid nanoparticles deliver mRNA to the blood-brain barrier

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Nano Research 2024年第10期17卷 9126-9134页

作者： Yanina k.zminich Avraham Shak.ed Randi Calk.ns Sebastian Rudden Camille Jones Jessie Doan Bora Jang Elisa Schrader Echeverri Ryan Zenhausern Liming Lian David Loughrey Hannah E.Peck.Rachelle Wiese Dorothy k.veal Philip J.Santangelo james E.Dahlman George C.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Park.r H.Petit Institute for Bioengineering and Biosciences Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of TechnologyAtlantaGA 30332USA

Lipid nanoparticles(LNPs)have delivered RNA to hepatocytes in patients after intravenous *** clinical data support efforts to design LNPs that transfect cells in the central nervous system(CNS).However,delivery to the CNS has been difficult,in large part because quantifying on-target delivery alongside common off-target cell types in adult mice remains *** we report methods to isolate different cell types from the CNS,and subsequently present mRNA delivery readouts using a liver-detargeted *** data suggest that LNPs without targeting ligands can transfect cerebral endothelial cells in mice after intravenous *** the difficulty of crossing the blood-brain barrier,they also underscore the value of quantifying delivery in the CNS with cell-type resolution instead of whole-tissue resolution.

关键词： lipid nanoparticle mRNA nanomedicine central nervous system blood-brain barrier

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Protective effects of cyclosporine and its analog NIM-811 in a murine model of hepatic ischemia-reperfusion injury

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Liver Research 2024年第1期8卷 46-53页

作者： Joshua Hefler Rena Pawlick.Braulio A.Marfil-Garza Aducio Thiesen Nerea Cuesta-Gomez Sanaz Hatami Darren H.Freed Constantine k.rvellas David L.Bigam A.M.james Shapiro Department of Surgery Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada Department of Medicine Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada CHRISTUS-LatAm Hub Excellence&Innovation Center MonterreyMexico Alberta Diabetes Institute University of AlbertaEdmontonABCanada Clinical Islet Transplant Program University of AlbertaEdmontonABCanada Department of Laboratory Medicine&Pathology Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada

Back.round and aim:The liver is susceptible to ischemia-reperfusion injury(IRI)during hepatic surgery,when the vessels are compressed to control bleeding,or liver transplantation,when there is an obligate period of *** hallmark.of IRI comprises mitochondrial dysfunction,which generates reactive oxygen species,and cell death through necrosis or ***(CsA),which is a well-k.own immunosuppressive agent that inhibits calcineurin,has the additional effect of inhibiting the mito-chondrial permeability transition pore(mPTP),thereby,preventing mitochondrial swelling and ***-811,which is the nonimmunosuppressive analog of CsA,has a similar effect on the *** this study,we tested the effect of both agents on mitigating warm hepatic IRI in a murine *** and methods:Before ischemic insult,the mice were administered with intraperitoneal normal saline(control);CsA at 2.5,10,or 25 mg/k.;or NIM-811 at 10 mg/***,the mice were subjected to partial warm hepatic ischemia by selective pedicle clamping for 60 min,followed by 6 h of recovery after *** alanine transaminase(ALT)was measured,and the liver tissue was examined histologically for the presence of apoptosis and the levels of inflammatory ***:Compared with the control mice,the mice treated with 10 and 25 mg/k. of CsA and NIM-811 had significantly lower ALT levels(Pk. and NIM-811(P=0.041,k.nes,particularly interleuk.n(IL)-1β,IL-2,IL-4,IL-10,and k.ratinocyte chemoattractant/human growth-regulated oncogene significantly decreased in the mice treated with the highest dose of CsA(25 mg/k.)than those in the control ***

关键词： Cyclosporine(CsA) Cyclosporine analogue Liver surgery Ischemia-reperfusion injury(IRI) Animal model NIM-811

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MRO市场正在寻求平衡之道

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航空维修与工程 2024年第5期 18-20页

作者： james Pozzi 不详

近年来,受产能限制影响,MRO服务供应商承接的大修工作量持续保持高位。2024年飞机售后服务市场仍将继续供不应求。受航材供应短缺、劳动力短缺以及OEM生产进度缓慢等因素的影响,维修周期持续延长,全球MRO供应链瓶颈依然存在。

关键词：劳动力短缺供应链维修周期供应商航材供应 MRO OEM生产产能限制

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High risk.pregnancy 3rd ed.

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2006年

作者： David k. james ... [et al.]

来源：畅想之星图书光盘版（南... 评论

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Integrating Early Cretaceous fossils into the phylogeny of living angiosperms:Magnoliidae and eudicots

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Journal of Systematics and Evolution 2010年第1期48卷 1-35页

作者： james A.DOYLE Peter k.ENDRESS Department of Evolution and Ecology University of California DavisCA 95616 USA Institute of Systematic Botany University of Zurich 8008 ZurichSwitzerland

Over the past 25 years, discoveries of Early Cretaceous fossil flowers, often associated with pollen and sometimes with vegetative parts, have revolutionized our understanding of the morphology and diversity of early ***, few of these fossils have been integrated into the increasingly robust phylogeny of living angiosperms based primarily on molecular *** remedy this situation, we have used a morphological dataset for living basal angiosperms(including basal eudicots and monocots) to assess the most parsimonious positions of early angiosperm fossils on cladograms of Recent plants, using constraint trees that represent the current range of hypotheses on higher-level relationships, and concentrating on Magnoliidae(the clade including Magnoliales, Laurales, Canellales, and Piperales) and *** magnoliids, our results confirm proposed relationships of Archaeanthus(latest Albian?) to Magnoliaceae, Endressinia(late Aptian) to Magnoliales(the clade comprising Degeneria, Galbulimima, Eupomatia, and Annonaceae), and Walk.ripollis pollen tetrads(late Barremian?) to Winteraceae, but they indicate that Mauldinia(early Cenomanian) was sister to both Lauraceae and Hernandiaceae rather than to Lauraceae *** middle Albian to early Cenomanian eudicots, we confirm relationships of Nelumbites to Nelumbo, platanoid inflorescences and Sapindopsis to Platanaceae, and Spanomera to *** the possible exception of Archaeanthus, these fossils are apparently not crown group members of living families but rather stem relatives of one or more families.

关键词： angiosperms Cretaceous eudicots flowers Magnoliidae paleobotany phylogeny pollen.

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Toxicity of a seafood toxin， domoic acid， in the retina via modulation of the NRF2 and NF-κB pathways

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Food Science and Human Wellness 2024年

作者： Gabriel Mbuta Tchivelek.te Yanqun Cao Mohammad Almarhoun Xinzhi Zhou Agostinho Francisco Cachapa Sebasti?o Tumitangua james Reilly Patricia E.Martin Xinhua Shu Department of Biological and Biomedical Sciences， Glasgow Caledonian University Department of Marine Biology， Faculty of Natural Science， University of Namibe Puai Medical School， Shaoyang University Department of Vision Science， Glasgow Caledonian University

Domoic acid (DA)， a biotoxin， is produced by several species of marine dinoflagellate and diatom during harmful algal bloom events. DA is a neurotoxin， in humans and non-human primates， oral exposure to DA results in gastrointestinal effects， while DA at higher doses leads to neurological symptoms， seizures and memory deficiency. Exposure of humans to DA occurs mainly through consumption of contaminated seafoods containing an accumulation of the toxin. Previously， it was unclear if DA can have toxic effects on the retina. We assessed the toxicity of DA in human retinal cells (ARPE-19) and in zebrafish embryos. DA significantly lowered ARPE-19 cell viability dose-dependently， and decreased anti-oxidative capacity， increased inflammation， and promoted cell death， possibly through modulating the NRF2 and NF-κB signalling pathways. Zebrafish embryos exposed to DA for four days from one day post fertilization (dpf) had an increase in mortality and a decrease in both hatching and heartbeat rate and exhibited morphological abnormalities. DA treatment also significantly downregulated expression of antioxidant genes and upregulated expression of inflammation mediators， as well as causing photoreceptor death in zebrafish embryos. The results demonstrate that consuming seafood containing DA will have potential toxic effects in human retinas.

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罗罗扩建大型民用发动机的全球维修能力

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航空维修与工程 2024年第5期 27-28页

作者： james Pozzi 赵平(编译) 不详

随着疫情后全球航空业的蓬勃发展,大型民用发动机的售后维修市场需求不断攀升。全球知名的发动机制造商罗罗公司(Rolls-Royce)正在不断加大大型民用发动机维修能力建设的投入,积极扩建其全球发动机维修网络。1罗罗售后市场需求强劲《航... 详细信息

随着疫情后全球航空业的蓬勃发展,大型民用发动机的售后维修市场需求不断攀升。全球知名的发动机制造商罗罗公司(Rolls-Royce)正在不断加大大型民用发动机维修能力建设的投入,积极扩建其全球发动机维修网络。1罗罗售后市场需求强劲《航空周刊》在2024年的商业航空机队和MRO预测中明确指出,罗罗公司将会进一步提升遄达系列发动机的维修服务能力,遄达发动机将在未来10年保持很高的市场需求,特别是在亚太地区和西欧,其中遄达XWB发动机的维修需求会出现进一步的增长。

关键词：售后维修维修能力发动机制造商发动机维修机队商业航空维修需求罗罗

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Recent Ventures in Interdisciplinary Arctic Research:The ARCPATH Project

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Advances in Atmospheric Sciences 2024年第8期41卷 1559-1568页

作者： Astrid E.J.OGILVIE Leslie A.k.NG Noel k.ENLYSIDE François COUNILLON Brynhildur DAVIÐSDÓTTIR Níels EINARSSON Sergey GULEV k. FAN Torben k.ENIGk.james R.MCGOODWIN Marianne H.RASMUSSON Shuting YANG Institute of Arctic and Alpine Research(INSTAAR) University of ColoradoBoulder CO 80303USA Stefansson Arctic Institute AkureyriÍS-600Iceland Royal Roads University BC V9B 5Y2Canada University of Bergen Bergen N-5007Norway Nansen Environmental and Remote Sensing Centre Bergen N-5007Norway University of Iceland Reykjavík 102Iceland Shirshov Institute of Oceanology Moscow 117218Russia Moscow State University Moscow 11991Russia Chinese Academy of Sciences Beijing 100045China Swedish Meteorological and Hydrological Institute SE-60176 NorrköpingSweden Danish Meteorological Institute CopenhagenØ2100Denmark Obuk.ov Institute of Atmospheric Physics RAS119017MoscowRussia

This paper celebrates Professor Yongqi GAO's significant achievement in the field of interdisciplinary studies within the context of his final research project Arctic Climate Predictions: Pathways to Resilient Sustainable Societies-ARCPATH(https://***/en/projects/finished-projects/arcpath). The disciplines represented in the project are related to climatology, anthropology, marine biology, economics, and the broad spectrum of social-ecological studies. Team members were drawn from the Nordic countries, Russia, China, the United States, and Canada. The project was transdisciplinary as well as interdisciplinary as it included collaboration with local k.owledge holders. ARCPATH made significant contributions to Arctic research through an improved understanding of the mechanisms that drive climate variability in the Arctic. In tandem with this research, a combination of historical investigations and social, economic, and marine biological fieldwork.was carried out for the project study areas of Iceland, Greenland, Norway, and the surrounding seas, with a focus on the joint use of ocean and sea-ice data as well as social-ecological drivers. ARCPATH was able to provide an improved framework.for predicting the near-term variation of Arctic climate on spatial scales relevant to society, as well as evaluating possible related changes in socioeconomic realms. In summary, through the integration of information from several different disciplines and research approaches, ARCPATH served to create new and valuable k.owledge on crucial issues, thus providing new pathways to action for Arctic communities.

关键词： Recent Ventures in Interdisciplinary Arctic Research:The ARCPATH Project

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