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Mark.t k.owledge and Stak.holder Considerations for the Biopharmaceutics Sector—Incorporating User Value and Societal Needs in Therapeutic Interventions

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Health 2021年第11期13卷 1365-1395页

作者： james k. timmis Raymond X. Van Der Waal Jennifer Herz Mark.B. Van Der Waal Eric Claassen Linda H. M. Van De Burgwal Athena Institute for Research on Innovation and Communication in Health and Life Sciences Vrije Universiteit Amsterdam Amsterdam The Netherlands Institute for Nursing Science Faculty of Medicine University of Freiburg Freiburg Germany Biointelect Sydney Australia

Purpose: Many health systems are considered ill-equipped to adequately meet future demand. Although academic entrepreneurs and small and medium-sized enterprises (SMEs) drive health technology innovation, they often suboptimally consider important mark.t and stak.holder requirements. This can result in missed opportunities to improve health system performance, address demand-supply gaps, and achieve financial rewards. Mark.t intelligence can provide crucial information in this regard, but scientifically sourced guidance on how to perform mark.t research for biopharmaceutics is scarce. Our objective was, therefore, to create and provide an easily accessible biopharmaceutics mark.t research toolbox that can be perused by academic entrepreneurs and SMEs to improve the alignment of their developments with stak.holder needs. Design: Guided by mark.t orientation theory, we interviewed senior managers and commercialisation experts from the biopharmaceutics sector. We ask.d them which information they consider most relevant, and how they collect, analyse and respond to new information to align product features, positioning and stak.holder-relationship management with mark.t needs. Findings: Our innovator toolbox consists of a high-level overview of mark.t intelligence considerations mapped against a novel innovation framework. a stak.holder reasoning and value model, and detailed considerations (check.ists) per stak.holder of biopharmaceutics interventions. Originality: We provide here the first mark.t orientation-based overview of mark.t intelligence considerations for the biopharmaceutics sector. Although primarily collated for academic entrepreneurs and SMEs, our innovator toolbox for the biopharmaceutics sector can help all stak.holders better understand their orientation towards mark.ts.

关键词： Healthcare Biopharmaceutic Mark.t Orientation Mark.t Research Unmet Need

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Analysis of the Oscillatory Flows of Multiple Shock.Waves in a Constant Area Duct

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Journal of Thermal Science 2024年第3期33卷 794-806页

作者： k.james Jintu k.M Heuy Dong Department of Mechanical Engineering Andong National UniversityAndong36729Republic of Korea CAD-IT k.rea Co. Ltd.Seoul08591Republic of Korea

The oscillatory response of multiple shock.waves to downstream perturbations in a supersonic flow is studied numerically in a rectangular *** shock.waves are formed inside the duct at a shock.Mach number of *** duct has an exit height of H,and the effect of duct resonance on multiple shock.oscillations is investigated by attaching exit ducts of lengths 0H,50H,and *** downstream disturbance frequency varied from 10 Hz to 200 Hz to explore the oscillation characteristics of the multiple shock.*** oscillatory response of shock.waves under self-excited and forced oscillation conditions are analyzed in terms of wall static pressure,shock.train leading-edge location,shock.train length,and the size of the separation *** extent of the initial shock.location increases with an increase in exit duct length for the self-excited oscillation *** analysis of the shock.train leading edge and the spectral analysis of wall static pressure variations are *** variation in the shock.train length is analyzed using the pressure ratio method for self-excited as well as forced *** RMS amplitude of the normalized shock.train length(ζ_(ST))increases with an increase in the exit duct length for the self-excited oscillation *** the downstream perturbation frequency is increased,ζ_(ST)is decreased for exit duct *** all exit duct designs and downstream forcing frequencies,the size of the separation bubble grows and shrink. during the shock.oscillations,demonstrating the dependence on duct resonance and forced oscillations.

关键词： shock.train downstream disturbance supersonic flow shock.wave boundary layer interaction duct resonance flow separation

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Commentary on“Incidence of urinary incontinence following endoscopic laser enucleation of the prostate by en-bloc and non-en-bloc techniques:a multicenter,real-world experience of 5068 patients”

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Asian Journal of Andrology 2024年第3期26卷 333-334页

作者： james F Jiang Narmina k.Onder Ak.il k.Das Department of Urology University of California Irvine Orange CA 92868 USA

Laser enucleation of the prostate is a proven and effectivesize-independent method for the surgical management of symptomaticbenign prostatic hyperplasia(BPH)and is considered as the“goldstandard”by many *** major hurdles that stand in theway of this becoming a universally used procedure for BPH are thesteep learning curve associated with mastering the procedure andpossibility of perioperative transient *** advances inteaching methodologies have helped tack.e the difficulty in learning itand increased the number of urologists utilizing the *** forthe second hurdle,transient incontinence rates postlaser enucleationof the prostate have improved with the advent of newer techniques *** et al.1 assesses the incidence of stress,urge,andmixed urinary incontinence following laser enucleation of the prostateby comparing en-bloc and non-en-bloc techniques in a multicenterseries of 5068 men with BPH.

关键词： urinary incontinence transient

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Insm1:orchestrating cellular mimicry in the thymus medulla

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Cellular & Molecular Immunology 2024年第4期21卷 414-416页

作者： k.D.james J.E.Cowan UCL Institute of Immunity and Transplantation The Pears BuildingRowland Hill StreetLondonNW32PPUK

The thymus is the primary production site for a functional and self-tolerant T-cell *** establishment of immune tolerance is mediated by the generation and presentation of tissue-restricted self-antigens(TRAs)by medullary thymic epithelial cells(mTECs),which screen T-cell receptors for self-reactivity to eliminate autoreactive T *** studies have extended our understanding of mTEC heterogeneity by examining the mechanisms by which mTECs mimic the peripheral self[1].

关键词： medullary eliminate restricted

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Time-Aware LSTM Neural Network. for Dynamic Personalized Recommendation on Business Intelligence

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Tsinghua Science and Technology 2024年第1期29卷 185-196页

作者： Xuan Yang james A.Esquivel Graduate School Angeles University FoundationAngeles City 2009Philippines Shandong Provincial University Laboratory for Protected Horticulture Weifang University of Science and TechnologyWeifang 262700China

Personalized recommendation plays a critical role in providing decision-mak.ng support for product and service analysis in the field of business ***,deep neural network.based sequential recommendation models gained considerable ***,existing approaches pay litle attention to users'dynamically evolving interests,which are influenced by product attributes,especially product *** overcome these challenges,we propose a dynamic personalized recommendation model:***,we first embed product information and attribute information into a unified data ***,we exploit long short-term memory(LsTM)network. to characterize sequential behavior over multiple time periods and seize evolving interests by hierarchical LSTM ***,similarity values between users are measured through pairwise interest features,and personalized recommendation lists are generated.A series of experiments reveal the superiority of the proposed method compared withotheradvanced methods.

关键词： personalized recommendations evolving interests embedding LsTM network.

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Probing turbulence in galaxies with fast radio burst scintillation

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 177-178页

作者： james M.Cordes Department of Astronomy the Cornell Center for Astrophysics and Planetary ScienceCornell UniversityIthaca NY 14853USA

Interstellar scintillation(ISS)is a well-k.own phenomenon observed from pulsars in the Milk. *** comprises intensity variations *** and frequency caused by constructive and destructive interference from multipath propagation,which is due to diffraction from fluctuations in electron density in the interstellar medium(ISM)on scales as small as~100 *** density fluctuations appear to be part of a turbulence process combined with discrete structures in electron density from other astrophysical processes;together these fluctuations extend to scales of pc or larger.

关键词： scales galaxies turbulence

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LSTM Network.Based Adaptation Approach for Dynamic Integration in Intelligent End-Edge-Cloud Systems

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Tsinghua Science and Technology 2024年第4期29卷 1219-1231页

作者： Xuan Yang james A.Esquivel Graduate School Angeles University FoundationAngeles City 2009Philippinesand also with Shandong Provincial University Laboratory for Protected HorticultureWeifang University of Science and TechnologyWeifang 262700China Graduate School Angeles University FoundationAngeles City 2009Philippines

Edge computing, which migrates compute-intensive task. to run on the storage resources of edge devices, efficiently reduces data transmission loss and protects data privacy. However, due to limited computing resources and storage capacity, edge devices fail to support real-time streaming data query and processing. To address this challenge, first, we propose a Long Short-Term Memory (LSTM) network.based adaptive approach in the intelligent end-edge-cloud system. Specifically, we maximize the Quality of Experience (QoE) of users by automatically adapting their resource requirements to the storage capacity of edge devices through an event mechanism. Second, to reduce the uncertainty and non-complete adaption of the edge device towards the user’s requirements, we use the LSTM network.to analyze the storage capacity of the edge device in real time. Finally, the storage features of the edge devices are aggregated to the cloud to re-evaluate the comprehensive capability of the edge devices and ensure the fast response of the user devices during the dynamic adaptation matching process. A series of experimental results show that the proposed approach has superior performance compared with traditional centralized and matrix decomposition based approaches.

关键词： quality of experience data query end-edge-cloud Long Short-Term Memory(LSTM)network.

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Characterization and Modeling of Mechanical Properties of Additively Manufactured Coconut Fiber-Reinforced Polypropylene Composites

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Advances in Materials Physics and Chemistry 2024年第6期14卷 95-112页

作者： George Mosi Bernard W. Ik.a Samuel k. k.bini james W. Mwangi Department of Mechatronic Engineering Jomo Kenyatta University of Agriculture and Technology Juja Kenya

In the face of the increased global campaign to minimize the emission of greenhouse gases and the need for sustainability in manufacturing, there is a great deal of research focusing on environmentally benign and renewable materials as a substitute for synthetic and petroleum-based products. Natural fiber-reinforced polymeric composites have recently been proposed as a viable alternative to synthetic materials. The current work.investigates the suitability of coconut fiber-reinforced polypropylene as a structural material. The coconut fiber-reinforced polypropylene composites were developed. Samples of coconut fiber/polypropylene (PP) composites were prepared using Fused Filament Fabrication (FFF). Tests were then conducted on the mechanical properties of the composites for different proportions of coconut fibers. The results obtained indicate that the composites loaded with 2 wt% exhibited the highest tensile and flexural strength, while the ones loaded with 3 wt% had the highest compression strength. The ultimate tensile and flexural strength at 2 wt% were determined to be 34.13 MPa and 70.47 MPa respectively. The compression strength at 3 wt% was found to be 37.88 MPa. Compared to pure polypropylene, the addition of coconut fibers increased the tensile, flexural, and compression strength of the composite. In the study, an artificial neural network.model was proposed to predict the mechanical properties of polymeric composites based on the proportion of fibers. The model was found to predict data with high accuracy.

关键词： Additive Manufacturing Artificial Neural Network Mechanical Properties Natural Fibers Polypropylene

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Learning physically based material and lighting decompositions for face editing

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Computational Visual Media 2024年第2期10卷 295-308页

作者： Qian Zhang Vik.s Thamizharasan james Tompk.n Brown University ProvidenceRhode Island 02906USA

Lighting is crucial for portrait photography,yet the complex interactions between the sk.n and incident light are expensive to model computationally in graphics and difficult to reconstruct analytically via computer ***,to allow fast and controllable reflectance and lighting editing,we developed a physically based decomposition through deep learned priors from path-traced portrait *** approaches that used simplified material models or low-frequency or low-dynamic-range lighting struggled to model specular reflections or relight directly without intermediate ***,we estimate the surface normal,sk.n albedo and roughness,and high-frequency HDRI maps,and propose an architecture to estimate both diffuse and specular reflectance *** our experiments,we show that this approach can represent the true appearance function more effectively than simpler baseline methods,leading to better generalization and higher-quality editing.

关键词： intrinsic decomposition portrait relighting inverse rendering deep learning

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Event-triggered sliding mode control of linear repetitive processes and its application in metal rolling process

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Science China(Information Sciences) 2024年第3期67卷 167-181页

作者： Xinyu LV Yugang NIU james LAM k.y Laboratory of Smart Manufacturing in Energy Chemical Process (East China University of Science and Technology) Ministry of Education Department of Mechanical Engineering The University of Hong Kong

This paper investigates the design problem of a sliding mode controller for linear repetitive processes(LRPs) with a finite pass length on each pass. Under limited communication resources, an eventtriggered mechanism is implemented from the sensors to the controller, whose triggered sequence is consistent with the evolution direction of LRPs. To periodically orchestrate communication between the controller and actuator, a round-robin scheduling mechanism is established based on the pass length. A sliding function involving the state and pass profile is constructed, and the sliding mode controller is designed using triggered states and pass profile signals. Feasible controller gains are attained to ensure the stability of the resultant closed-loop system. Finally, the proposed strategy is implemented for a multi-roll metal rolling process.

关键词： event-triggered mechanism linear repetitive processes metal rolling process round-robin scheduling sliding mode control

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