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A Simulation for Flavivirus Infection Decoy Responses

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Advances in Microbiology 2015年第2期5卷 123-142页

作者： james k. peterson Alison M. k.sson Nicholas J. C. k.ng Department of Mathematical and Biological Sciences Clemson University Clemson USA Discipline of Paediatrics and Child Health Sydney Institute for Emerging Infectious Diseases and Biosecurity Sydney Medical School The Children’s Hospital at Westmead Westmead Australia Discipline of Pathology University of Sydney Sydney Australia

In this work. we discuss the development of simulation code for a model of the cross-reactive adaptive immune response seen in flavivirus infections. The model specifically addresses flavivirus pathogen virulence in G0?vs G1?cell states. The MHC-I upregulation of resting cells (G0 state) allows the T-cells generated for flavivirus peptide antigens to attack.healthy cells also. The cells in G1?state are not upregulated as much and so virus hides in them and hence is propagated upon rupture. Hence, this type of model is referred to as a decoy model because the immune system is decoyed into preferentially recognizing the upregulated cells while the virus actively propagates in another small, but important, cell population. We show that the generic assumption of upregulation via a model which includes the?G0/G1?differential upregulation leads to immunopathological consequences. We outline the details behind the simulation code decisions and provide some theoretical justification for our model of collateral damage and upregulation.

关键词： West Nile Virus Decoy Model MHC-I Upregulation G0 vs G1 Cell State Upregulation Differences

An integrated analysis of air pollution from US coal-fired power plants

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Geoscience Frontiers 2023年第2期14卷 204-216页

作者： Mik.lai Filonchyk.Michael P.peterson Faculty of Geomatics Lanzhou Jiaotong UniversityLanzhou 730070China Gansu Provincial Engineering Laboratory for National Geographic State Monitoring Lanzhou 730070China Department of Geography/Geology University of Nebraska OmahaOmahaNE 68182USA

The United States is one of the world’s leaders in electricity production,generating about 4116 billion k.h in 2021,of which coal accounted for 21.8%of the *** study applies an integrated approach using both terrestrial and satellite data to specifically examine emissions from coal-fired power plants and its spatial *** study also highlights the effectiveness of government policies to reduce *** was found that emission of pollutants from the country’s energy sector has been steadily declining,with annual emissions of sulfur dioxide(SO_(2))and nitrogen oxides(NOx)decreasing from the US electric power sector between 1990 and 2020 by 93.4%and 84.8%,respectively,and carbon dioxide(CO_(2))by 37%between 2007 and *** overall emissions from coal-fired power plants are declining,some individual plants have yet to install environmental equipment to control *** to US government data,major emitters of SO_(2),NO_(x),and CO_(2) in the US are the Martin Lak. power plant in East Texas,the Labadie power plant near ***,Missouri,and the james H Miller Jr plant near Birmingham,*** study also integrates TROPOMI satellite data to detect point emissions from individual power *** the highest levels of measured pollutants were over the country’s major cities and areas of fossil fuel extraction,TROPOMI could clearly distinguish the pollution caused by power plants in more rural *** the US has made great strides in reducing emissions from coal-fired power plants,these plants still represent a major source of pollution and remain a major *** eliminating coal as a power source will be difficult with the higher power demands resulting from the transition to electric automobiles.

关键词： Coal-fired power plants Emissions TROPOMI Air pollution Sulfur dioxide Nitrogen oxides

Discussion of prior-based Bayesian information criterion(PBIC)by ***,james ***,Woncheol Jang,Surajit Ray,Luis ***,and Ingmar Visser

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Statistical Theory and Related Fields 2019年第1期3卷 32-34页

作者： Ryan A.peterson Joseph E.Cavanaugh Department of Biostatistics University of IowaIowa CityIAUSA

We congratulate the authors on their innovative and illuminating *** paper should not only lead to more refined and defensible applications of the Bayesian information criterion(BIC)through their proposed variants,but... 详细信息

关键词： criterion refined innovative

Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleuk.n-6 signaling through inter-organ crosstalk

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3836-3846页

作者： Melissa M.Clemens Stefanie k.nnon-McGill Joel H.Vazquez Owen W.Stephens Erich A.peterson Donald J.Johann Felicia D.Allard Eric U.Yee Sandra SMcCullough Laura P.james Brian N.Finck.Mitchell R.McGill Department of Pharmacology and Toxicology College of MedicineUniversity of Arkansas for Medical SciencesLittle RockAR 72205USA Interdisciplinary Graduate Program in Biomedical Sciences Graduate SchoolUniversity of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Environmental and Occupational Health Fay W.Boozman College of Public HealthUniversity of Arkansas for Medical SciencesLittle RockAR 72205USA Winthrop P.Rock.feller Cancer Institute University of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Pathology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA Department of Pediatrics College of MedicineUniversity of Arkansas for Medical SciencesLittle RockAR2205USA Division of Geriatrics and Nutritional Sciences Department of Internal MedicineWashington University School of MedicineSt.LouisMO 63110USA Center for Dietary Supplement Research University of Arkansas for Medical SciencesLittle RockAR 72205USA

We previously demonstrated that endogenous phosphatidic acid(PA)promotes liver regeneration after acetaminophen(APAP)***,we hypothesized that exogenous PA is also *** test that,we treated mice with a toxic APAP dose at 0 h,followed by PA or vehicle(Veh)*** then collected blood and liver at 6,24,and 52 ***-treatment with PA 2 h after APAP protected against liver injury at 6 h,and the combination of PA and N-acetyl-L-cysteine(NAC)reduced injury more than NAC ***,PA did not affect canonical mechanisms of APAP ***,transcriptomics revealed that PA activated interleuk.n-6(IL-6)signaling in the *** with that,serum IL-6 and hepatic signal transducer and activator of transcription 3(Stat3)phosphorylation increased in PA-treated ***,PA failed to protect against APAP in IL-6-deficient ***,IL-6 expression increased 18-fold in adipose tissue after PA,indicating that adipose is a source of PA-induced circulating ***,however,exogenous PA did not alter regeneration,despite the importance of endogenous PA in liver repair,possibly due to its short *** data demonstrate that exogenous PA is also beneficial in APAP toxicity and reinforce the protective effects of IL-6 in this model.

关键词： Acute liver injury Acute liver failure Adipok.ne Cytok.ne Dietary supplement Drug-induced liver injury Hepatotoxicity Lipid

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Petri网

计算机工程与应用 1980年第5期 45-65+76页

作者： james L.peterson,彭澄廉,陈廷槐德克萨斯大学计算机科学系上海复旦大学重庆大学

近十年来,Petri网的应用日益增长,并用作异步并行计算机系统的基本模型。本文综述了Petri网的基本概念及其应用。文中介绍了Petri网的结构,它的标记和执行、计算机硬件和软件的Petri网模型的几个例子,以及对Petri网分析方面的研究,如某... 详细信息

近十年来,Petri网的应用日益增长,并用作异步并行计算机系统的基本模型。本文综述了Petri网的基本概念及其应用。文中介绍了Petri网的结构,它的标记和执行、计算机硬件和软件的Petri网模型的几个例子,以及对Petri网分析方面的研究,如某些Petri网问题的可达性树、可判定性和复杂性的应用。还扼要的讨论了Petri网语言、有关Petri网计算的模型以及Petri网模型的扩充和子类等。

关键词：模拟能力可达性能达性 Petri 标记图网语言可达集定义概念思维形式有标记等价序列

Reactive optical matter: light-induced motility in electrodynamically asymmetric nanoscale scatterers

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Light(Science & Applications) 2018年第1期7卷 26-32页

作者： Yuval Yifat Delphine Coursault Curtis W.peterson John Park.r Ying Bao Stephen k.Gray Stuart A.Rice Norbert F.Scherer james Franck.Institute The University of Chicago929 E.57th StreetChicagoIL 60637USA Department of Chemistry The University of Chicago929 East 57th StreetChicagoIL 60637USA Department of Physics The University of Chicago929 East 57th StreetChicagoIL 60637USA Center for Nanoscale Materials Argonne National Laboratory9700 South Cass AvenueArgonneIL 60439USA UniversitéBordeaux CNRS LOMAUMR 5798F-33400 TalenceFrance Department of Chemistry Western Washington University516 High StreetBellinghamWA 98225USA

From Newton’s third law,which is k.own as the principle of actio et reactio1,we expect the forces between interacting particles to be equal and opposite for closed ***,“nonreciprocal”forces can arise.2 This has been shown theoretically in the interaction between dissimilar optically trapped particles that are mediated by an external field.3 As a result,despite the incident external field not having a transverse component of momentum,the particle pair experiences a force in a direction that is transverse to the light propagation direction.3,4 In this letter,we directly measure the net nonreciprocal forces in electrodynamically interacting asymmetric nanoparticle dimers and nanoparticle structures that are illuminated by plane waves and confined to pseudo one-dimensional *** show via electrodynamic theory and simulations that interparticle interactions cause asymmetric scattering from ***,the putative nonreciprocal forces are actually a consequence of momentum *** study demonstrates that asymmetric scatterers exhibit directed motion due to the break.own of mirror symmetry in their electrodynamic interactions with external fields.

关键词： asymmetric forces reciprocal

Nature：大规模研究揭示生命所必需的基因

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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dick.nson, Mary E. Flennik.n, Ann M. Ji, Xiao Teboul, Lydia Wong, Michael D. White, Jacqueline k. Meehan, Terrence F. Weninger, Wolfgang J. Westerberg, Henrik.Adissu, Hibret Bak.r, Candice N. Bower, Lynette Brown, james M. Caddle, L. Brianna Chiani, Francesco Clary, Dave Cleak. james Daly, Mark.J. Denegre, james M. Doe, Brendan Dolan, Mary E. Edie, Sarah M. Fuchs, Helmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, Juan Guo, Shiying Horner, Neil R. Hsu, Chih-Wei Johnson, Sara J. k.laga, Sowmya k.ith, Lance C. Lanoue, Louise Lawson, Thomas N. Lek. Monk.l Mark. Manuel Arschall, Susan M. Mason, Jeremy McElwee, Melissa L. Newbigging, Susan Nutter, Lauryl M. J. peterson, k.vin A. Ramirez-Solis, Ramiro Rowland, Douglas J. Ryder, Edward Samocha, k.itlin E. Seavitt, John R. Selloum, Mohammed Szok.-k.vacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose, Ilinca Wak.na, Shigeharu Warren, Jonathan Wendling, Olivia West, David B. Wong, Leeyean Yoshik., Atsushi MacArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek. Paul Bradley, Allan Sk.rnes, William C. Justice, Monica J. Park.nson, Helen E. Moore, Mark.Wells, Sara Braun, Robert E. Svenson, k.ren L. de Angelis, Martin Hrabe Herault, Yann Mohun, Tim Mallon, Ann-Marie Henk.lman, R. Mark.Brown, Steve D. M. Adams, David J. Lloyd, k. C. k.nt Mck.rlie, Colin Beaudet, Arthur L. Bucan, Maja Murray, Stephen A. Dept Mol Physiol & Biophys Houston TX 77030 USA Toronto Ctr Phenogen Toronto ON M5T 3H7 Canada Mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA Med Res Council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England Mary Lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick.Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England Med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick.Children 555 Univ Ave Toronto ON M5G 1X8 Canada Jack.on Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA German Res Ctr Environm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany German Mouse Clin D-85764 Neuherberg Germany Baylor Coll Med Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIk.N BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens Hosp Oak.and Res Inst Oakland CA 94609 USA IMPC San Anselmo CA 94960 USA Tech Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany German Ctr Diabet Res DZD D-85764 Neuherberg Germany Francis Crick.Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput discovery of novel developmental phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

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加快大型数据中心服务的可重构结构

中国集成电路 2015年第1期24卷 55-68,89页

作者： Andrew Putnam Adrian M.Caulfield Eric S.Chung Derek.Chiou k.pros Constantinide John Demme Hadi Esmaeilzadeh Jeremy Fowers Gopi Prashanth Gopal Jan Gray Michael Haselman Scott Hauck.Stephen Heil Amir Hormati Joo-Young k.m Sitaram Lank. james Larus Eric peterson Simon Pope Aaron Smith Jason Thong Phillip Yi Xiao Doug Burger 微软公司

数据中心的工作负载要求高计算能力、灵活性、能效和低成本。同时改善所有这些因素非常具有挑战性。为了推进数据中心超出商用服务器设计可以提供的能力,我们设计并构建了一个可组合、可重构的结构,来加速部分大型软件服务。结构的每个... 详细信息

数据中心的工作负载要求高计算能力、灵活性、能效和低成本。同时改善所有这些因素非常具有挑战性。为了推进数据中心超出商用服务器设计可以提供的能力,我们设计并构建了一个可组合、可重构的结构,来加速部分大型软件服务。结构的每个实例都由嵌入48台机器的半机架6×8二维环面高端Stratix V FPGA组成。每台服务器中都放置了一个FPGA,可以通过PCIe来访问,并用成对的10 Gb SAS电缆直接连接到其他FPGA。在本文中,我们描述了这种结构在1,632台服务器组(bed)的中等规模的部署,并测量了其在加快Bing搜索引擎方面的功效。我们描述了系统的要求和架构,详细介绍了关键技术挑战,以及使系统在出现故障情况下保持鲁棒性所需的解决方案,还有根据排名候选文档测量的系统性能、功率和弹性。在高负载时,一定范围内的可重构结构提高了每台服务器固定延迟分布的吞吐量排名95%——或在保持等效吞吐量时,减少29%的尾延迟。

关键词：可重构结构服务器组数据中心 Stratix FPGA 计算能力工作负载软件服务