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红紫珠二萜类成分及其抗炎活性研究

中草药 2024年第6期55卷 1890-1898页

作者：张雪儿黄逸敏方巧苗赵钟祥林朝展祝晨蔯吴爱芝广州中医药大学中药学院广东广州510006

目的研究红紫珠Callicarpa rubella枝叶的二萜类化学成分及其体外抗炎活性。方法采用多种色谱方法对红紫珠化学成分进行系统分离纯化,运用核磁共振谱、质谱及X-单晶衍射实验等技术鉴定化合物结构。以脂多糖(lipopolysaccharide,LPS)诱... 详细信息

目的研究红紫珠Callicarpa rubella枝叶的二萜类化学成分及其体外抗炎活性。方法采用多种色谱方法对红紫珠化学成分进行系统分离纯化,运用核磁共振谱、质谱及X-单晶衍射实验等技术鉴定化合物结构。以脂多糖(lipopolysaccharide,LPS)诱导的小鼠巨噬细胞RAW264.7为抗炎模型,选择6个结构差异明显的二萜类化合物进行抗炎活性评价。结果从红紫珠石油醚部位和醋酸乙酯部位共分离得到20个二萜类化合物,分别鉴定为kolavic acid-15-metyl ester(1)、rubellapene A(2)、rubellapene B(3)、rubellapene C(4)、13,14,15,16-四降碳-3-克罗-12,18-二羧酸(5)、对映异海松烷-8(14),15-烯-19-羧酸(6)、dichrocephnoids C(7)、15-去甲基半日-8(20)12E-二烯-14-甲醛-19-羧酸(8)、8S-kolavic acid 15-methyl ester(9)、粘叶莸酸(10)、melanocane B(11)、dodovislactones B(12)、tinotufolin B(13)、amphiacric acid A(14)、patagonic acid(15)、(+)-15-methoxyfloridolide A(16)、去甲基-左旋哈氏豆属酸(17)、15-羟基-16-羰基-15,16H-左旋哈氏豆属酸(18)、(−)-顺式-克罗-3,13-烯-16-羟基-15,18-二羧酸-15,16-内酯(19)、polylauioid j(20)。结论首次得到化合物1的单晶X射线衍射晶体结构数据。化合物5、7~14、16~20为首次从紫珠属植物中分离,其余化合物为首次从红紫珠中分离得到,主要以克罗烷型和半日花烷型二环二萜为主。体外抗炎活性实验表明,6个二萜类化合物均能够抑制LPS刺激的小鼠RAW264.7巨噬细胞中NO的分泌,其中化合物1抑制NO能力最强,推测C-13位双键的存在有利于提高抗炎活性。

关键词：红紫珠二萜克罗烷型半日花烷型抗炎活性 X-射线单晶衍射 13,14,15,16-四降碳-3-克罗-12,18-二羧酸对映异海松烷-8(14),15-烯-19-羧酸

Rapid responses:Receptor-like kinases directly regulate the functions of membrane transport proteins in plants

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journal of Integrative Plant Biology 2022年第7期64卷 1303-1309页

作者： Xiaopeng Li jingjie zhang Hongyong Shi Bo Li jia Li Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations School of Life SciencesLanzhou UniversityLanzhou730000China Guangdong Provincial Key Laboratory of Plant Adaptation and Molecular Design School of Life SciencesGuangzhou UniversityGuangzhou 510006China

Receptor-like kinases(RLKs)are a large group of plant-specific transmembrane proteins mainly acting as receptors or co-receptors of various extracellular *** usually turn extracellular signals into intracellular responses via altering gene expression ***,recent studies confirmed that many RLKs can physically interact with diverse membrane-localized transport proteins and regulate their activities for speedy responses in limited tissues or *** this minireview,we highlight recent discoveries regarding how RLKs can work with membrane transport proteins collaboratively and thereby trigger cellular responses in a precise and rapid *** is anticipated that such regulation broadly presents in plants and more examples will be gradually revealed when in-depth analyses are conducted for the functions of RLKs.

关键词： channel pump receptor-like kinase signal trans-duction transporter

High Resolution ID-TIMS Redefines the Distribution and Age of the Main Mesozoic Lacustrine Hydrocarbon Source Rocks in the Ordos Basin,China

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Acta Geologica Sinica(English Edition) 2023年第2期97卷 581-588页

作者： CUI jingwei ZHU Rukai zhang Zhongyi jahandar RAMEZANI LI Yang Research Institute of Petroleum Exploration and Development PetroChinaBeijing 100083China Research Institute of Petroleum Exploration and Development of the Changqing Oil Field China National Petroleum CorporationXi'an 710018China Department of Earth Atmospheric and Planetary SciencesMassachusetts Institute of Technology77 Massachusetts AvenueCambridgeMassachusetts 02139USA

Using high-precision zircon U-Pb ID-TIMS geochronology,tuffs from the Chang 9 shale and the Chang 7 shale were *** tuff in the Chang 9 shale is 241.47±0.17 Ma,which falls between the top tuff age of 241.06±0.12 Ma and the bottom tuff age of 241.558±0.093 Ma in the Chang 7 *** reveal that the Chang 9 and Chang 7 shales are contemporaneous,belonging to the Ladinian stage of the Middle *** insight expands the region of the main source rock of Chang 7 to the northeast and will inform the search for the deep Chang 9 shale petroleum system,increasing the scope for exploring the Chang 7 shale system in northern *** research results clarify the relationship between the two sets of shale in the Yanchang Formation and redefine the distribution range of the Chang 7 shale in the Ordos *** the same time,it shows that there is a cross-layer problem in the stratigraphic division of the Yanchang Formation in different regions,the high-precision U-Pb dating technology providing a reference for the fine stratigraphic correlation of other continental basins in the world.

关键词： ID-TIMS high precision age redefining distribution Chang 7 shale Chang 9 shale Ordos Basin

A Comparison Study of Synkinematic Illite Isolation,Quantitative X-ray Powder Diffraction,and K-Ar Dating for Direct Fault Gouge Analyses

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Acta Geologica Sinica(English Edition) 2023年第2期97卷 636-650页

作者： ZHENG Yong LI Haibing LI junjie zhang Guohe SI jialiang Key Laboratory of Deep-Earth Dynamics of Ministry of Natural Resources Institute of GeologyChinese Academy of Geological SciencesBeijing 100037China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China jiangsu Donghai Continental Deep Hole Crustal Activity National Observation and Research Station DonghaiJiangsu 222300China Beijing Research Institute of Uranium Geology Beijing 100029China Military and Civilian Integration Geological Survey Center Chengdu 610000China

K-Ar dating of synkinematic illite is increasingly recognized as a central method to constrain the timing of shallow crustal *** of efficient sample preparation and quantitative identification of illite polytypes are critical to acquiring K-Ar isotope data for authigenic *** this respect,we compared the commonly used clay size separation method through centrifugation with vacuum filtration technology,showing that the former is prone to extract fractions with finer particle sizes under similar conditions,thus improving the error in the authigenic end-member ***,we demonstrated that the side-packed mounting method for X-ray diffraction analysis can significantly enhance the randomness in powder samples,thus improving the quantification accuracy compared with the front-packed and back-packed *** validity of our quantification method was confirmed by comparing Profex■modeling patterns with a suite of synthetic mixtures of known compositions,yielding an average analytical error of 3%.Dating results of these artificial mixtures and the reference materials indicated that a large range in percentages of detrital illite and a sufficient amount of age data will produce reliable results for ages of both extrapolated ***,if the range is limited,the extrapolated age close to those of datasets is still reliable.

关键词： illite polytypes fault gouge clay size separation mounting method Profex■ extrapolated K-Ar age

EV713C protease cleaves host anti-viral factor OAS3 and enhances virus replication

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Virologica Sinica 2022年第3期37卷 418-426页

作者： Xiaolei Zhou Li Tian jian Wang Baisong Zheng Wenyan zhang Center for Infectious Diseases and Pathogen Biology Institute of Virology and AIDS ResearchKey Laboratory of Organ Regeneration and Transplantation of the Ministry of EducationThe First Hospital of Jilin UniversityJilin130021China

The global spread of enteroviruses(EVs)has become more frequent,severe and ***(IFN)I has been proved to control EVs by regulating IFN-stimulated genes(ISG)expression.20-50-oligoadenylate synthetases 3(OAS3)is an important ISG in the OAS/RNase L antiviral *** relationship between OAS3 and EVs is still ***,we reveal that OAS3,superior to OAS1 and OAS2,significantly inhibited EV71 replication in ***,EV71 utilized autologous 3C protease(3C^(pro))to cleave intracellular OAS3 and enhance viral ***,a human rhinovirus 3C protease inhibitor,completely abolished the cleavage of EV713C^(pro)on *** the proteolytically deficient mutants H40G,E71A,and C147G of EV713C^(pro)also lost the ability of OAS3 ***,the Q982-G983 motif in C-terminal of OAS3 was identified as a crucial 3C^(pro)cutting *** investigation indicated that OAS3 inhibited not only EV71 but also Coxsackievirus B3(CVB3),Coxsackievirus A16(CA16),Enterovirus D68(EVD68),and Coxsackievirus A6(CA6)***,unlike other four subtypes,CA163C^(pro)could not cleave *** key amino acids variation Ile36 and Val86 in CA163C^(pro)might result in weak and delayed virus replication of CA16 because of failure of OAS and 3AB *** works elucidate the broad anti-EVs function of OAS3,and illuminate a novel mechanism by which EV71 use 3C^(pro)to escape the antiviral effect of *** findings can be an important entry point for developing novel therapeutic strategies for multiple EVs infection.

关键词： Enteroviruses EV71 3C protease Cleavage Anti-viral factor OAS3

Isolation of microsatellite loci in the pollinating fig wasp of Ficus hispida, Ceratosolen solmsi

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Insect Science 2008年第4期15卷 303-306页

作者： Hao Yu Tong-Xin zhang Hao-Yuan Hu Li-Ming Niu Hui Xiao Yan-Zhou zhang Da-Wei Huang Institute of Zoology Chinese Academy of Sciences Beijing Graduate School of the Chinese Academy of Sciences Beijing Plant Protection College Shandong Agricultural University Tai' an Shandong China

Microsatellite loci were isolated for Ceratosolen solmsi, pollinator of the dioecious Ficus hispida. We developed nine polymorphic microsatellite loci based on the method of polymerase chain reaction isolation of microsatellite arrays （PIMA）. Enrichment of genomic libraries was performed by random amplified polymorphic DNA （RAPD）. A subset of 38 positive clones was sequenced; 15 clones showed microsatellite loci. We tested 15 designed primer pairs and nine of them produced polymorphic amplification in 48 individual wasps collected from different fruits of the dioecious host fig Ficus hispida in China. Among the 48 individuals, 49 alleles were obtained at the nine loci. The observed heterozygosity ranged between 0.357 and 0.634.

关键词： Ficus fig wasp markers microsatellite loci polymorphism primers

Amyloidβ-based therapy for Alzheimer’s disease:challenges,successes and future

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3374-3399页

作者： Yun zhang Huaqiu Chen Ran Li Keenan Sterling Weihong Song National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina The Second Affiliated Hospital and Yuying Children’s Hospital Institute of AgingKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceWenzhou Medical UniversityWenzhouZhejiangChina Townsend Family Laboratories Department of PsychiatryThe University of British ColumbiaVancouverBC V6T 1Z3Canada Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiangChina

Amyloidβprotein(Aβ)is the main component of neuritic plaques in Alzheimer’s disease(AD),and its accumulation has been considered as the molecular driver of Alzheimer’s pathogenesis and progression.Aβhas been the prime target for the development of AD ***,the repeated failures of Aβ-targeted clinical trials have cast considerable doubt on the amyloid cascade hypothesis and whether the development of Alzheimer’s drug has followed the correct course.

关键词： Alzheimer Aβ clinical

Corneal damage effects induced by infrared optical parametric oscillator radiation at 3743 nm

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journal of Innovative Optical Health Sciences 2021年第2期4卷 84-92页

作者： Luguang jiao Chao Wang Kaizeng zhang jiarui Wang Zaifu Yang Beijing Institute of Radiation Medicine Beijing 100850P.R.China

The main aim of this paper is to investigate the corneal damage effects induced by mid-infrared optical parametric oscillator(OPO)*** were performed to determine the corneal damage thresholds of New Zealand white rabbit at the wavelength of 3743 nm for ex-posurédurations of 0.1 s,1.0 s and 10.0 *** slit-lamp biomicroscope and histopathology,corneal injury characteristics were *** damage thresholds were 3.73 j/cm^(2),7.91 j/cm^(2)and 31.1 j/cm^(2),respectively,for exposure durations of 0.1 s,1.0 s and 10.0 *** damage data was correlated by an empirical equation:Radiant exposure at the threshold=9.72×exposure duration,^(0.46)where the units of radiant exposure and exposure duration were j/cm^(2)and *** near-threshold level,corneal injuries at 1 h post-exposure mainly involved the epithelium,and the epithelium damages repaired at 24-h *** are sufficient safety margins be-tween the damage thresholds and the maximum permitted exposures from current international laser safety standard IEC 60825-1.

关键词： Corneal damage threshold optical parametric oscillator radiation laser safety standard

Namib desert beetle inspired special patterned fabric with programmable and gradient wettability for efficient fog harvesting

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journal of Materials Science & Technology 2021年第2期61卷 85-92页

作者： Zhihua Yu Huimei zhang jianying Huang Shuhui Li Songnan zhang Yan Cheng jiajun Mao Xiuli Dong Shouwei Gao Shanchi Wang Zhong Chen Yaoxing jiang Yuekun Lai College of Chemical Engineering Fuzhou UniversityFuzhou 350116China National Engineering Laboratory for Modem Silk College of Textile and Clothing EngineeringSoochow UniversitySuzhou 215123China School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore

Efficient collection of water from fog provides a potential solution to solve the global freshwater shortage problem, particularly in the desert or arid regions. In this work, a flexible and highly efficient fog collector was prepared by mimicking the back exoskeleton structure of the Namib desert beetle. The improved fog collector was constructed by a superhydrophobic-superhydrophilic patterned fabric via a simple weaving method, followed by in-situ deposition of copper particles. Compared with the conventional fog collector with a plane structure, the fabric has shown a higher water-harvesting rate at 1432.7 mg/h/cm2,owing to the biomimetic three-dimensional structure, its enhanced condensation performance enabled by the copper coating and the rational distribution of wetting units. The device construction makes use of the widely available textile materials through mature manufacturing technology, which makes it highly suitable for large-scale industrial production.

关键词： Superwettability Fabric Copper Namib desert beetle Fog harvesting