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journal of Ocean University of China 2021年第6期20卷 1515-1527页

作者： zhang Meng LI Wanbo ZHU Yangyang WANG Weijia WANG Zhiyong Key Laboratory of Healthy Mariculture for the East China Sea Ministry of Agriculture and Rural AffairsJimei UniversityXiamen 361021China Laboratory for Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and TechnologyQingdao 266235China Fujian Engineering Research Center of Aquatic Breeding and Healthy Aquaculture Jimei UniversityXiamen 361021China

Elovl4 is a fatty acyl elongase which participates in the biosynthesis of long-chain polyunsaturated fatty acids(LCPUFA).Herein we isolated and functionally characterized the elovl4a gene in the large yellow croaker Larimichthys crocea,and investigated the regulatory effects of transcription factors Hnf4α,Lxrα,Pparαon the activity of elovl4a *** expression pattern revealed that elovl4a was widely expressed in several tissues and predominantly in *** expression in yeast showed that *** Elovl4a could effectively elongate both C18 and C20 PUFA substrates to C22 fatty *** addition,the affinity of large yellow croaker Elovl4a to n-6 series fatty acids is weak and cannot prolong 18:2n-6 and 18:***,*** elovl4a reporter activities were elevated by 1.31-,1.39-and 1.48-fold via over-expression of Lxrα,Pparαand Hnf4α,*** above findings can enrich the knowledge of biosynthesis pathway of LC-PUFA in the large yellow croaker and contribute to elucidate the LC-PUFA anabolism mechanism in fish.

关键词： Larimichthys crocea elovl4a long-chain polyunsaturated fatty acids promoter

Effect of heat treatment on the microstructure and mechanical properties of structural steel–mild steel composite plates fabricated by explosion welding

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International journal of Minerals,Metallurgy and Materials 2020年第8期27卷 1115-1122页

作者： En-ming zhang Yi-ming Zhao Zhong-mou Wang Wen-ya Li State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of Friction Welding TechnologiesSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'an710072China

Two dissimilar steel plates,structural steel and mild steel,were joined by explosion welding to form a *** composite was then heat-treated by quenching at 840℃ for 30 min followed by tempering at 200℃ for 3 *** microstructure was investigated under an optical microscope and a scanning electron *** mechanical properties were measured using Vickers microhardness and Charpy impact *** results show a deformed interface with typical wave features at the welding zone,but no defects were ***,the ferrite in the parent plate in the weld zone was elongated due to the strong plastic deformation from the *** heat treatment,the hardness of the flyer plate(structural steel)was over HV0.2800,while that of the parent plate(mild steel)was *** increase in hardness was due to the presence of ***,the average impact energy was increased from 18.5 to 44.0 j following heat treatment;this is because of the formation of recrystallized grains at the weld interface,which is due to the dynamic recovery and local recrystallization,and the strong elemental diffusion that occurred between the two plates.

关键词： explosion welding steel composite plate microstructure mechanical properties

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新时代高职院校体育教师专业发展研究

冰雪体育创新研究 2024年第7期 149-151页

作者：叶超卢小龙张卫峰云南体育运动职业技术学院云南昆明650228

高职院校体育教师专业发展,是新时代高职院校体育教育教学质量提升的关键,也是高职院校高质量内涵式发展的重要举措。当前中国高等职业在体育教师专业化发展方面还存在着很多问题,作为体育教学实施者的体育教师群体,其专业化的发展是高... 详细信息

高职院校体育教师专业发展,是新时代高职院校体育教育教学质量提升的关键,也是高职院校高质量内涵式发展的重要举措。当前中国高等职业在体育教师专业化发展方面还存在着很多问题,作为体育教学实施者的体育教师群体,其专业化的发展是高职院校体育教师发展的核心部分。基于此,主要是针对目前新时期发展环境给体育教师专业发展造成的影响和存在的问题进行深入分析和研究,并且提出合理的建议和对策。

关键词：新时代高职院校体育教师专业发展现状对策

Multiplex imaging reveals the architecture of the tumor immune microenvironment

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Cancer Biology & Medicine 2021年第4期18卷 949-954页

作者： junlei zhang jinyuan Song jianpeng Sheng Xueli Bai Tingbo Liang Department of Hepatobiliary and Pancreatic Surgery Zhejiang Provincial Key Laboratory of Pancreatic Diseasethe First Affiliated HospitalZhejiang University School of MedicineZhejiang University Cancer CentreZhejiang UniversityHangzhou 310002China

The tumor immune microenvironment(TME)is composed of a variety of components,such as tumor cells,immune cells,and the extracellular *** TME has been studied through transcriptomic,proteomic,metabolomic,and phosphoprot... 详细信息

关键词： immune tumor microenvironment

Phosphatidylinositol 4-kinase β is required for the ciliogenesis of zebrafish otic vesicle

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journal of Genetics and Genomics 2020年第10期47卷 627-636页

作者： Yufei Feng Ping Yu jingyu Li Ying Cao jingjing zhang Affiliated Hospital of Guangdong Medical University&Key Laboratory of Zebrafish Model for Development and Disease of Guangdong Medical University Zhanjiang 524001China Clinical and Translational Research Center Shanghai First Maternity and Infant HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

The primary cilium,an important microtubule-based organelle,protrudes from nearly all the vertebrate *** motility of cilia is necessary for various developmental and physiological ***(PIs)and its metabolite,Ptd Ins(4,5)P2,have been revealed to contribute to cilia assembly and *** an important kinase of the PI pathway and signaling,phosphatidylinositol 4-kinaseβ(PI4 KB)is the one of the most extensively studied phosphatidylinositol 4-kinase ***,its potential roles in organ development remain to be *** investigate the developmental role of Pi4 kb,especially its function on zebrafish ciliogenesis,we generated pi4 kb deletion mutants using clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9 *** homozygous pi4 kb mutants exhibit an absence of primary cilia in the inner ear,neuromasts,and pronephric ducts accompanied by severe edema in the eyes and other ***,smaller otic vesicle,malformed semicircular canals,and the insensitivity on sound stimulation were characteristics of pi4 kb *** the protein level,both in vivo and in vitro analyses revealed that synthesis of Pi4 p was greatly reduced owing to the loss of Pi4 *** addition,the expression of the Pi4 kb-binding partner of neuronal calcium sensor-1,as well as the phosphorylation of phosphatidylinositol-4-phosphate downstream effecter of Akt,was significantly inhibited in pi4 kb *** together,our work uncovers a novel role of Pi4 kb in zebrafish inner ear development and the functional formation of hearing ability by determining hair cell ciliogenesis.

关键词： Ciliogenesis Pi4kb Hair cell Hearing loss Zebrafish

Rufoolivacin B,a novel polyketide pigment from the fruiting bodies of the fungus Cortinarius rufo-olivaceus(basidiomycetes)

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Chinese Chemical Letters 2009年第11期20卷 1324-1326页

作者： An Ling zhang jian Chun Qin Ming Sheng Bai jin Ming Gao Ya Mei zhang Sheng Xiang Yang Hartmut Laatsch College of Science Northwest A & F University Yangling Shaanxi 712100 China Department of Orgnic Chemistry University of Gottingen Tammannstrasse 2 D-3 7077 Gottingen Germany College of Life Sciences Northwest A & F University Yangling Shaanxi 712100 China Center for Experiments & Education Technology Linyi Normal University Linyi Shandong 276005 China

A novel polyketide pigment （1） with the 4＇,10-coupled linkage between 1-naphthalenol and 1,4-anthraquinone, named rufoolivacin B together with the known analog rufoolivacin （2）, has been isolated from the fruiting bodies of the Chinese toadstool Cortinarius rufo-olivaceus （basidiomycetes）. Their structures were characterized by means of analysis of spectroscopic methods, including 2D-NMR experiments and HR-ESI-MS.

关键词： Anthraquinone Polyketide Basidiomycetes Cortinarius rufo-olivaceus Fungal pigment Rufoolivacin B

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菜籽饼超微粉酶解制备抗氧化活性肽

农业工程学报 2024年第4期40卷 284-291页

作者：翟晓娜胡龙彪李媛媛梁亮胡雪芳张志民班世栋王萍裴海生农业农村部规划设计研究院农业农村部农产品产地初加工重点实验室北京100121

为探究菜籽饼超微粉直接酶解制备抗氧化肽技术,该研究以菜籽饼超微粉为原料,利用碱性蛋白酶、风味蛋白酶对其进行酶解,通过测定2,2’-联氮双(3-乙基苯并噻唑啉-6-磺酸)(ABTS)自由基清除能力、1,1-二苯基-2-苦基肼自由基清除能力和总抗... 详细信息

为探究菜籽饼超微粉直接酶解制备抗氧化肽技术,该研究以菜籽饼超微粉为原料,利用碱性蛋白酶、风味蛋白酶对其进行酶解,通过测定2,2’-联氮双(3-乙基苯并噻唑啉-6-磺酸)(ABTS)自由基清除能力、1,1-二苯基-2-苦基肼自由基清除能力和总抗氧化能力表征酶解产物体抗氧化活性,使用膜分离、Sephadex G-15凝胶层析对酶解产物进行分离纯化,利用高效液相色谱-串联质谱联用技术分析鉴定抗氧化活性组分的氨基酸序列。结果表明,风味蛋白酶酶解产物的肽含量较高,并以分子量小于1 kDa肽段为主,碱性蛋白酶解产物以5~10 kDa肽段为主,但同等浓度下(1 mg/mL)的碱性蛋白酶酶解产物抗氧化活性较高;膜分离后,同种酶解产物中低分子量(j3经氨基酸序列鉴定,结合PeptideRanker生物活性预测筛选得到5个肽段,肽段的N-端均为苯丙氨酸且肽段中疏水性氨基酸的含量占比达50%以上。该结果可为深入开发菜籽饼蛋白资源提供理论参考。

关键词：酶膜菜籽饼风味蛋白酶碱性蛋白酶膜分离氨基酸序列抗氧化活性

High Thermal Conductivity of Carboxyl-rich Carbon/Polyethylene Glycol Composites for Enhanced Photothermal Conversion and Latent Heat Storage

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Chinese journal of Chemistry 2021年第12期39卷 3245-3254页

作者： Huizhi Yang Yufeng Bai Chunhua Ge Shangyu Li Xiangdong zhang College of Chemistry Liaoning UniversityChongshan Road No.66ShenyangLiaoning 110036China

Polyethylene glycol(PEG)as phase change material(PCM)and carboxyl-rich carbon(RHTC)with different carboxyl content was introduced to prepare RHTC/PEG *** composites have high thermal conductivity,photothermal conversion ability,and improved the phase change enthalpy of the *** microstructure and thermal properties of the samples were analyzed by various characterization *** promoted the benign growth of PEG crystallinity(110.0%),influenced the phase change enthalpy of PEG,and improved the latent heat storage capacity of *** non-leakage loading of PEG in the composites can be as high as 97 wt%,and the actual phase change enthalpy is 10.7 j/g higher than that of pure PEG,10%higher than the theoretical *** to the heat storage bridge formed between PEG and RHTC,the thermal conductivity of the composites was up to 0.51 W/mK,which was 99.4%higher than that of ***,the introduction of environmentally friendly and low-cost RHTC gives the composites excellent photothermal conversion capability,and its photothermal conversion energy storage efficiency is as high as 90.1%.These results prove that the prepared composites are promising potential candidates in the field of thermal storage and thermal management systems.

关键词： Latent heat storage Carboxylation Renewable resources Photothermal conversion capacity Thermochemistry

Pseudo-Markovian viscosity solutions of fully nonlinear degenerate PPDEs

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Probability, Uncertainty and Quantitative Risk 2016年第1期1卷 218-251页

作者： Ibrahim Ekren jianfeng zhang ETH Department of Mathematics ZurichSwitzerland University of Southern California Department of MathematicsLos AngelesCaliforniaUSA

In this paper,we propose a new type of viscosity solutions for fully nonlinear path-dependent *** restricting the solution to a pseudo-Markovian structure defined below,we remove the uniform non-degeneracy condition needed in our earlier works(Ekren,I,Touzi,N,zhang,j,Ann Probab,44:1212–1253,2016a;Ekren,I,Touzi,N,zhang,j,Ann Probab,44:2507–2553,2016b)to establish the uniqueness *** establish the comparison principle under natural and mild ***,we apply our results to two important classes of PPDEs:the stochastic HjB equations and the path-dependent Isaacs equations,induced from the stochastic optimization with random coefficients and the path-dependent zero-sum game problem,respectively.

关键词： Path dependent PDEs Viscosity solutions Comparison principle Stochastic HjB equations Isaacs equations

Mitochondrial H_(2)S_(n)-Mediated Anti-Inflammatory Theranostics

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Nano-Micro Letters 2021年第12期13卷 1-13页

作者： Won Young Kim Miae Won Seyoung Koo Xingcai zhang jong Seung Kim Department of Chemistry Korea UniversitySeoul 02841Korea john A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA School of Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

The insistent demand for space-controllable delivery,which reduces the side effects of non-steroidal antiinflammatory drugs(NSAIDs),has led to the development of a new theranostics-based approach for anti-inflammatory *** current anti-inflammatory treatments can be improved by designing a drug delivery system responsive to the inflammatory site biomarker,hydrogen polysulfide(H_(2)S_(n)).Here,we report a noveltheranostic agent 1(TA1),consisting of three parts:H_(2)S_(n)-mediated triggering part,a two-photon fluorophore bearing mitochondria targeting unit(Rhodol-TPP),and anti-inflammatory COX inhibitor(indomethacin).In vitro experiments showed that TA1 selectively reacts with H_(2)S_(n)to concomitantly release both Rhodol-TPP and ***-microscopy imaging of inflammation-inducedlive cells suggested that TA1 is localized in the mitochondria where the H_(2)S_(n)is *** TA1 reacted with H_(2)S_(n)in the endogenous and exogenous H_(2)S_(n)environments and in lipopolysaccharide treated inflammatory ***,TA1 suppressed COX-2 level in the inflammatory-induced cells and prostaglandin E 2(PGE2)level in blood serum from inflammation-induced mouse *** vivo experiments with inflammation-induced mouse models suggested that TA1 exhibits inflammation-site-elective drug release followed by significant therapeutic e ects,showing its function as a theranostic agent,capable of both anti-inflammatory therapy and precise *** behavior of TA1 is highly applicable in vivo model therapeutics for the inflammatory disease.

关键词： Theranostics Anti-inflammation Mitochondria Hydrogen polysulfides