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A Perspective on ESL Testing in the United States

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英语考试研究 2009年第7期 56-57页

作者： james hill

快速转诊的大量增加改善了英国肠癌患者的预后吗?

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英国医学杂志中文版 2021年第4期24卷 193-196页

作者： Michael Thompson Daniel’Leary Iona Heath Lynn Faulds Wood Brian Ellis Karen Flashman Neil Smart John Nicholls Neil Mortensen Paul Finan Asha Senapati Robert Steele Peter Dawson james hill Brendan Moran 白静雯(译) 张国君(校) Queen Alexandra Hospital PortsmouthUK London UK University of Exeter Medical School ExeterUK Imperial College LondonUK John Radcliffe Hospital OxfordUK St james′s University Hospital LeedsUK University of Dundee DundeeUK Manchester University ManchesterUK North Hampshire Hospital BasingstokeUK 厦门大学附属翔安医院肿瘤诊治中心

Michael Thompson及其同事认为,需要更精确的风险分层以确保及时诊断肠癌,同时避免不必要的检查。英国卫生部为了提高肠癌患者的生存率,制定了全科医生转诊指南和公众宣传活动的政策,这些政策增加了紧急转诊到医院的人数,还导致了并无... 详细信息

Michael Thompson及其同事认为,需要更精确的风险分层以确保及时诊断肠癌,同时避免不必要的检查。英国卫生部为了提高肠癌患者的生存率,制定了全科医生转诊指南和公众宣传活动的政策,这些政策增加了紧急转诊到医院的人数,还导致了并无明显临床获益的不必要肠镜检查和CT结肠造影。

关键词：肠癌患者全科医生肠镜检查公众宣传转诊风险分层及时诊断临床获益

Semi-transparent,flexible,and electrically conductive silicon mesh by capillarity-driven welding of vapor-liquid-solid-grown nanowires over large areas

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Nano Research 2020年第5期13卷 1465-1471页

作者： Thomas A.Celano Seokhyoung Kim David J.hill james F.Cahoon Department of Chemistry University of North Carolina at Chapel HillChapel HillNC 27599-3290USA

Bottom-up synthesis of semiconductor nanowires(NWs)by the vapor-liquid-solid(VLS)mechanism has enabled diverse technological applications for these *** metallic NWs,however,it has been challenging to form large-area interconnected NW ***,we generate centimeter-scale meshes of mechanically and electrically interconnected Si NWs by sequentially growing,collapsing,and joining the NWs using a capillarity-driven welding *** fabricate meshes from VLS-grown NWs ranging in diameter from 20 to 100 nm and find that the meshes are three-dimensional with a thickness ranging from^1 to^10 microns depending on the NW *** extinction measurements reveal that the networks are semi-transparent with a color that depends on the absorption and scattering characteristics of individual ***,active voltage contrast imaging of both centimeter-and micron-scale meshes reveals widespread electrical *** a sacrificial layer,we demonstrate that the mesh can be liberated from the growth substrate,yielding a highly flexible and transparent *** transport measurements both on the growth substrate and on liberated,flexible films reveal electrical conduction across a centimeter scale with a sheet resistance of^160-180 kΩ/square that does not change significantly upon *** the ability to encode complex functionality in semiconductor NWs through the VLS process,we believe these meshes of networked NWs could find application as neuromorphic memory,electrode scaffolds,and bioelectronic interfaces.

关键词： semiconductor nanowire conductive network flexible electronics welding thermal annealing active-voltage contrast

A simple umbelliferone based fluorescent probe for the detection of nitroreductase

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Frontiers of Chemical Science and Engineering 2018年第2期12卷 311-314页

作者： Adam C. Sedgwick Alex Hayden Barry hill Steven D. Bull Robert B. P. Elmes Tony D. james Department of Chemistry University of Bath Bath BA2 7AY UK Department of Chemistry Maynooth University Maynooth Co. Kildare Ireland

A simple nitrobenzyl-umbelliferone （NCOU1） was synthesised containing a nitroreductase （NTR） trigger moiety. The presence of NTR, resulted in the fragmentation of the parent molecule and release of the highly emissive fluorophore umbelliferone via an NTR-catalyzed reduction of the nitro group. In the presence of the NTR enzyme, NCOU1 gave rise to a 5-fold increase in fluorescence intensity at 455 nm and was selective for NTR over other reductive enzymes. These results indicate that NCOU1 can be used as a simple assay for the detection of NTR.

关键词： NITRO RADICALS NTSR1 gene FLUORESCENT PROBES Skimmetin Nitroreductases noise-temperature ratio

Cystatin C Peptide Effects on B16F10 Melanoma Cells

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CellBio 2021年第1期10卷 1-9页

作者： Mathieu hill james L. Cox AT Still University Department of Biochemistry West Jefferson Kirksville Missouri USA

Background: Metastasis is a major problem for effective therapy of cancer. Small cysteine protease inhibitors, cystatins have been shown to be anti-metastatic for a number of different cancers. We have identified a small peptide of cystatin which exhibits anti-cancer properties for B16 melanoma cells in vitro. Methods: B16 melanoma cells were measured for growth, proliferation, migration, and apoptosis in the presence and absence of cystatin peptide. Results: The cystatin peptide reduced melanoma cell growth, proliferation, migration, and increased apoptosis in melanoma cells in culture. Conclusion: Cystatin peptide exhibits anti-cancer effects on highly metastatic B16 melanoma cells in culture.

关键词： Cystatin Peptide Melanoma Metastasis

Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model

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International Journal of Oral Science 2018年第4期10卷 212-222页

作者： R.Nicole Howie Samuel Herberg Emily Durham Zachary Grey Grace Bennfors Mohammed Elsalanty Amanda C.LaRue William D.hill james J.Cray Oral Health Sciences Medical University of South CarolinaCharlestonSCUSA Biomedical Engineering Case Western Reserve UniversityClevelandOHUSA Cellular Biology and Anatomy Augusta UniversityAugustaGAUSA Oral Biology Augusta UniversityAugustaGAUSA Orthopaedic Surgery Augusta UniversityAugustaGAUSA Pathology and Laboratory Medicine Medical University of South CarolinaCharlestonSCUSA Institute for Regenerative and Reparative Medicine Augusta UniversityAugustaGAUSA Research Service of the Ralph H Johnson VA Medical Center CharlestonSCUSA Charlie Norwood VA Medical Center AugustaGAUSA Department of Regenerative Medicine and Cellular Biology CharlestonSCUSA Wake Forest Institute for Regenerative Medicine Wake Forest School of MedicineWinston-SalemNCUSA Division of Anatomy College of MedicineOhio State UniversityColumbusOHUSA

Bone wound healing is a highly dynamic and precisely controlled process through which damaged bone undergoes repair and complete regeneration. External factors can alter this process, leading to delayed or failed bone wound healing. The findings of recent studies suggest that the use of selective serotonin reuptake inhibitors(SSRIs) can reduce bone mass, precipitate osteoporotic fractures and increase the rate of dental implant failure. With 10% of Americans prescribed antidepressants, the potential of SSRIs to impair bone healing may adversely affect millions of patients’ ability to heal after sustaining trauma. Here, we investigate the effect of the SSRI sertraline on bone healing through pre-treatment with(10 mg·kg-1sertraline in drinking water, n = 26) or without(control, n = 30) SSRI followed by the creation of a 5-mm calvarial defect. Animals were randomized into three surgical groups:(a) empty/sham,(b) implanted with a DermaMatrix scaffold soak-loaded with sterile PBS or(c) DermaMatrix soak-loaded with542.5 ng BMP2. SSRI exposure continued until sacrifice in the exposed groups at 4 weeks after surgery. Sertraline exposure resulted in decreased bone healing with significant decreases in trabecular thickness, trabecular number and osteoclast dysfunction while significantly increasing mature collagen fiber formation. These findings indicate that sertraline exposure can impair bone wound healing through disruption of bone repair and regeneration while promoting or defaulting to scar formation within the defect site.

关键词： Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model

Group dynamics motivation to increase exercise intensity with a virtual partner

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Journal of Sport and Health Science 2019年第3期8卷 289-297页

作者： Stephen Samendinger Christopher R.hill Norbert L.Kerr Brian Winn Alison Ede james M.Pivarnik Lori Ploutz-Snyder Deborah L.Feltz Department of Kinesiology Michigan State University NASA Johnson Space Center Universities Space Research Association Department of Psychology Michigan State University Department of Media and Information College of Communication Arts & Sciences Michigan State University

Background: The effect of the K?hler group dynamics paradigm(i.e., working together with a more capable partner where one's performance is indispensable to the team outcome) has been shown to increase motivation to exercise longer at a strength task in partnered exercise video games (exergames) using a software-generated partner(SGP). However, the effect on exercise intensity with an SGP has not been investigated. The purpose of this study was to examine the motivation to maintain or increase exercise intensity among healthy, physically active middle-aged adults using an SGP in an aerobic ***: Participants(n = 85, mean age = 44.9 years) exercised with an SGP in a 6-day cycle ergometer protocol, randomly assigned to either(a)no partner control,(b) superior SGP who was not a teammate, or(c) superior SGP as a teammate(team score was dependent on the inferior member). The protocol alternated between 30-min continuous and 4-min interval lhigh-intensity session days, during which participants could change cycle power output(watts) from target intensity to alter distance and ***: Mean change in watts from a targeted intensity(75% and 90% maximum heart rate) was the primary dependent variable reflecting motivational effort. Increases in performance over baseline were demonstrated without significant differences between conditions. Self-efficacy and enjoyment were significantly related to effort in the more intense interval ***: Under these conditions, no K?hler effect was observed. Exercise performance during the higher-intensity interval format is more closely related to enloyment and self-efficacy beliefs compared to the continuous sessions.

关键词： Exercise intensity Kohler effect Motivation Software-generated partner

Functional Enrichment of Utopian Distribution of Plant Life-Forms

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American Journal of Plant Sciences 2013年第12期4卷 37-48页

作者： james N. Furze Quanmin Zhu Feng Qiao Jennifer hill Faculty of Environment and Technology University of the West of England Bristol UK Faculty of Information and Control Engineering Shenyang Jianzhu University Shenyang China.

Adaptive fuzzy neural inference systems are used to illustrate the primary nodal number of plant life-forms. Categorization of two candidate areas is carried out using the water-energy dynamic (for Ecuador, South America) and Macedonia, Southern Europe), within which the life-form spectra are distributed. Genetic optimization methods are used to expand the primary nodal number to the complete number of life-form categories. The distribution of the elements exhibits a stochastic, binomial distribution and the utopia line and curve are summarized which enhance accuracy of the climatic data and of the consequent numbers of plant species occurrences. Expansion of the distribution of each life-form category is approximated within the Z utopia hyperplane with use of the functional approximation algorithm. This process gives additional structure and informative value to the Z plane, enhancing our ability to make informed policy decisions concerning species and ecosystem conservation.

关键词： Adaptive Neural Fuzzy Inference System Plant Life-Form Genetic Optimization Stochastic Utopia Functional Approximation Algorithm

Drought in wheat:combining genetics and metabolomics to identify novel drought tolerance-related traits

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Drought in wheat:combining genetics and metabolomics to iden...