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Ultrahigh resolution optical coherence tomography with femtosecond Ti:sapphire laser and photonic crystal fiber

Chinese Science Bulletin 2008年第13期53卷 1963-1966页

作者： XUE Ping james g fujimoto Department of Physics Laboratory of Atomic and Molecular Nanosciences of Ministry of Education Tsinghua University Beijing 100084 China Department of Electrical Engineering and Computer Science Research Laboratory of Electronics Massachusetts Institute of Technology Cambridge Massachusetts 02139-4307 USA

Optical coherence tomography (OCT) with ultrahigh axial resolution was achieved by the super-contin-uum generated by coupling femtosecond pulses from a commercial Ti:sapphire laser into an air-silica microstructure fiber. The visible spectrum of the super-continuum from 450 to 700 nm centered at 540 nm can be generated. A free-space axial OCT resolution of 0.64 μm was achieved. The sensitivity of OCT system was 108 dB with incident light power 3 mW at sample,only 7dB below the theoretical limit. Subcellular OCT imaging was also demonstrated,showing great potential for biomedical application.

关键词： X线摄影连续介质晶体纤维蓝宝石激光

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Assessment of chronic radiation proctopathy and radiofrequency ablation treatment follow-up with optical coherence tomography angiography: A pilot study

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World Journal of gastroenterology 2019年第16期25卷 1997-2009页

作者： Osman Oguz Ahsen Kaicheng Liang Hsiang-Chieh Lee Zhao Wang james g fujimoto Hiroshi Mashimo Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology gastroenterology Section VA Boston Healthcare System Harvard School of Medicine Boston

BACKgROUND Chronic radiation proctopathy(CRP) occurs as a result of pelvic radiation therapy and is associated with formation of abnormal vasculature that may lead to persistent rectal bleeding. While incidence is declining due to refinement of radiation delivery techniques, CRP remains one of the major complications of pelvic radiation therapy and significantly affects patient quality of *** ablation(RFA) is an emerging treatment modality for eradicating abnormal vasculature associated with CRP. However, questions remain regarding CRP pathophysiology and optimal disease *** To study feasibility of optical coherence tomography angiography(OCTA) for investigating subsurface vascular alterations in CRP and response to RFA *** Two patients with normal rectum and 8 patients referred for, or undergoing endoscopic RFA treatment for CRP were imaged with a prototype ultrahighspeed optical coherence tomography(OCT) system over 15 OCT/colonoscopy visits(2 normal patients, 5 RFA-na?ve patients, 8 RFA-follow-up visits). OCT and OCTA was performed by placing the OCT catheter onto the dentate line and rectum without endoscopic guidance. OCTA enabled depth-resolved microvasculature imaging using motion contrast from flowing blood, withoutrequiring injected dyes. OCTA features of normal and abnormal microvasculature were assessed in the mucosa and submucosa. Blinded reading of OCTA images was performed to assess the association of abnormal rectal microvasculature with CRP and RFA treatment, and rectal telangiectasia density endoscopic *** OCTA/OCT images are intrinsically co-registered and enabled depth-resolved visualization of microvasculature in the mucosa and submucosa. OCTA visualized normal vascular patterns with regular honeycomb patterns vs abnormal vasculature with distorted honeycomb patterns and ectatic/tortuous microvasculature in the rectal mucosa. Normal arterioles and venules < 200 μm in diameter versus abnormal he

关键词： Optical coherence tomography Optical coherence tomography angiography Radiofrequency ablation Chronic radiation proctopathy Rectal telangiectasia density scoring system Subsurface microvascular imaging

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Cervical inlet patch-optical coherence tomography imaging and clinical significance

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World Journal of gastroenterology 2012年第20期18卷 2502-2510页

作者： Chao Zhou Tejas Kirtane Tsung-Han Tsai Hsiang-Chieh Lee Desmond C Adler Joseph M Schmitt Qin Huang james g fujimoto Hiroshi Mashimo Department of Electrical Engineering and Computer Science Research Laboratory of Electronics Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02139-4307 United States gastroenterology Section VA Boston Healthcare System/Harvard School of Medicine 150 S. Huntington Avenue Boston MA 02131 United States Light Lab Imaging-St Jude Medical Inc. Westford MN 55117-9983 United States

AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were *** light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT *** OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(gI)*** hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux *** CIP region appeared as a pink circular lesion in the upper esophagus under white light *** imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum ***,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E *** results demonstrated the feasibility of using OCT to evaluate gI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP.

关键词： Cervical inlet patch Heterotopic gastric mucosa Optical coherence tomography Optical biopsy Barrett’s esophagus

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青光眼视网膜神经纤维层厚度的光学相干断层扫描纵向评估

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美国医学会眼科杂志（中文版） 2005年第4期17卷 214-220页

作者： gadi Wollstein Joel S. Schuman Lori L. Price Ali Aydin Paul C. Stark Ellen Hertzmark Edward Lai Hiroshi Ishikawa Cynthia Mattox james g. fujimoto Lelia A. Paunescu 刘春（译）朱志忠（校） New England Eye Center Biostatistics Research Center Division of Clinical Care Research Department of Epidemiology Harvard School of Public Health Boston Department of Electrical Engineering and Research laboratory of Electranics Massachusetts Institute of Technology Cambridge Tufts-New England Medical Center Tufts University School of Medicine Boston Mass UPMC Eye Center Department of Ophthahnology University of Pittsburgh School of Medicine Pittsburgh Pa 不详

目的：纵向评估光学相干断层扫描（OCT）视盘周围神经纤维层厚度测量，并将这些检查与临床状态和自动视野计检查作横向比较。方法：对参与前瞻性纵向研究的青光眼或疑似青光眼患者64只眼（37例）作回顾性评估。所有参与者每6个月作一次... 详细信息

目的：纵向评估光学相干断层扫描（OCT）视盘周围神经纤维层厚度测量，并将这些检查与临床状态和自动视野计检查作横向比较。方法：对参与前瞻性纵向研究的青光眼或疑似青光眼患者64只眼（37例）作回顾性评估。所有参与者每6个月作一次全面的临床评估、视野检查和OCT。视野进展按可重复性测量的视野平均偏差至少比基线降低2dB，OCT进展按可重复性测量视网膜神经纤维层平均厚度至少变薄20pro。结果：每个患者在中位值为4．7年的随访中有5个可使用的OCT扫描。青光眼和疑似青光眼患者之间视网膜神经纤维层厚度线性回归斜度的差异对所有变量均不显著；然而，Kaplan-Meier生存曲线分析显示视野比OCT测量有较高的进展率。在随访期间66％的眼是稳定的。22％只有OCT进展，9％单有视野平均偏差进展。3％视野和OCT都有进展。结论：OCT比全自动视野计对辨别青光眼进展有更大的可能性。这可能反映OCT的敏感性或在常规方法发现之前其真实损害就能被OCT发现。

关键词：视网膜神经纤维层厚度光学相干断层扫描青光眼患者全自动视野计前瞻性纵向研究重复性测量视野检查平均偏差随访期间 OCT

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移动天线系统手册

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作者：藤本共荣(K. fujimoto) J.R.·詹姆斯(J.R. james)

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