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Liver-directed therapiesfor fibrolamellar carcinoma:Asingle-center experience

Oncology Research 2024年第12期32卷 1831-1836页

作者： SAM son AKSHAAR BRAHMBHATT KEN ZHAO BRETT MARINELLI james HARDING WILLIAM JARNAGIN GHASSAN K.ABOU-ALFA HOOMAN YARMOHAMMADI Department of Radiology Memorial Sloan Kettering Cancer Center and Weill Medical College at Cornell UniversityNew YorkNY 10065USA Department of Medicine Memorial Sloan Kettering Cancer Center and Weill Medical College at Cornell UniversityNew YorkNY 10065USA Division of Hepatobiliary Surgery Department of SurgeryMemorial Sloan Kettering Cancer Center and Weill Medical College at Cornell UniversityNew YorkNY 10065USA

Background:This article aims to present the single-institution outcomes of patients with Fibrolamellar Carcinoma(FLC)treated with liver-directed therapies(LDT).Methods:In this single-center retrospective study,all patients diagnosed with FLC who underwent LDT were identiﬁ*** July 2012 and July 2023,six patients were identiﬁ*** patient was excluded due to *** and clinical parameters were *** within 30 days of the LDT were *** treatment responses at 1,6,and 12 months were assessed per ***:A total ofﬁve patients,which included three females and two males,were *** patients were treated with transarterial hepatic embolization(TAE;n=3),transarterial radioembolization(TARE;n=1),and combined TAE+radiofrequency ablation(n=1).The objective response rate at one month was 80%[CR=2(40%),PR=2(40%),and SD=1(20%)].At 12 months(n=4),two patients demonstrated CR(50%)and two demonstrated PR(50%).Overall survival from LDT atﬁve years was 50%.There was no 30-day mortality among this group of patients or any adverse event attributable to the ***:TAE,TARE,and ablation are safe and effective therapeutic options for *** on this study and previously published case reports,ablation and TARE yielded the most favorable results.

关键词： Fibrolamellar carcinoma(FLC) Hepatocellular carcinoma(HCC) Liver-directed therapy(LDT) Transarterial radioembolization(TARE) Hepatic artery embolization

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Pesticide Exposure Levels and Risk Assessment in Operators Involved in the Cashew Production in Côte d’Ivoire

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Agricultural Sciences 2022年第1期13卷 86-104页

作者： Yao Stéphane Koffi james Halbin Kouadio Diakalia son Research Group of Crop Production Quality Management Laboratory of Agrovalorisation UFR Agroforesterie Jean Lorougnon Guédé University Daloa C&#244 te d’Ivoire Agrosystèmes et Ingénierie de l’Environnement (Sy.N.A.I.E) Unité Santé des Plantes du Laboratoire Systèmes Naturels Institut du Développement Rural (IDR) Université Nazi Boni (UNB) Bobo-Dioulasso Burkina Faso

To assess the level of producers’ exposure and the health risk in relation to phytosanitary practices in cashew crops in C?te d’Ivoire, a descriptive longitudinal toxicological study was conducted in 2018-2019 with 76 cashew producers in the areas of Mankono, Dabakala and Bondoukou. The data collected permitted the assessment of phytosanitary risks on the health of producers according to the Quebec-IRPeQ pesticide risk indicators. Field observations translated into scenarios were used to determine the exposure levels of producers via the UK-POEM predictive model. The main active substances used were glyphosate, 2,4-D, cypermethrin, acetamiprid, lambdacyhalothrin, profenofos, imidacloprid, deltamethrin, mancozeb and metalaxyl. The risk indicators showed that 2,4-D (TRI = 1332.25;SRI = 432.98), profenofos (TRI = 2550.25;SRI = 637.56) and mancozeb (TRI = 841;SRI = 147.18) among herbicides, insecticides and fungicides respectively could have more adverse health effects after exposure. These findings translated into scenarios specifically showed high exposure of producers to herbicides, with exposure levels ranging from 1.31 mg/kg bw/day to 1.67 mg/kg bw/day, well above the acceptable operator’s exposure levels (AOEL). These health risks could be significantly reduced if the required personal protective equipment is worn. But, recommended doses of pesticides should be reconsidered, because in some cases, applicators exposure remained high despite the protective equipment.

关键词： Cashew Pesticides Health Risks UK-POEM Côte d’Ivoire

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The Backstairs Battle for White House Influence

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中国翻译 1983年第12期 48-49页

作者： james Reston

President Reagan’s White House staff isdivided into three parts:the upstairs part headedby the pragmatic james Baker,the downstairspart headed by the conservative William Clark,and the backstairs part patrolled by theirassistants,who tell the press about the differencesbetween upstairs and *** have been differences among mostpresidents’advisers ever since Thomas Jeffer-son was accused of relying on an"invisible,inscrutable"group of associates that engagedin"backstairs influence."So the current ru-mors of a struggle for the president’s mind amongthe Big Four—***,***,Michael

关键词： The Backstairs Battle for White House Influence

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WHAT A TANGLED WEB WE WEAVE...

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The World of Chinese 2016年第2期 32-33页

作者： james WILKINson

WHEN IT COMES TO ONLINE CELEBRITY,SHAME LEADS TO FAMEProbably the most notable—and certainly the most notorious—web celebrity at present is Wang Sicong,the big-spending,big-mouthed son of the richest man in China,Dalian Wanda Group CEO Wang *** the heir to what is now a 32.7 billion USD fortune,the younger Wang had long been a well-known name,but it wasn’t until 2011 that he made his first big splash in the world of online *** April of that year he got into

关键词： spending fortune younger Dalian until claimed notable Jiangsu really ahead

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Briancoppinsia,a new coelomycetous genus of Arthoniaceae(Arthoniales)for the lichenicolous Phoma cytospora,with a key to this and similar taxa

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Fungal Diversity 2012年第1期52卷 1-12页

作者： Paul Diederich james D.Lawrey Masoumeh Sikaroodi Pieter P.Gvan den Boom Damien Ertz Musée national d’histoire naturelle 25 rue Munster2160 LuxembourgLuxembourg Department of Environmental Science and Policy George Mason University4400 University DriveFairfaxVA 22030-4444USA Arafura 16 5691 JA Sonthe Netherlands Jardin Botanique National de Belgique Domaine de Bouchout1860 MeiseBelgium

Morphological,anatomical,chemical and molecular data suggest that a relatively common lichenicolous coelomycete on Lecanora conizaeoides is conspecific with Phoma cytospora,previously known only from parmelioid lichens,and that further populations on Cladonia and Pertusaria belong to the same *** species is distinguished from Phoma by several taxonomically important characters and obviously represents a previously unrecognized genus,for which the name Briancoppinsia is *** analyses using nuLSU and mtSSU sequences of isolates obtained in pure culture suggest that the new genus belongs to the Arthoniaceae(Arthoniales).This is the first obligate lichenicolous,non-lichenized anamorph confirmed to belong to the Arthoniales based on molecular data.

关键词： Anamorphic fungi Arthonia Conidial fungi Mitosporic fungi

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Shrinking in the dark: Parallel endosymbiont genome erosions are associated with repeated host transitions to an underground life

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Insect Science 2024年第6期31卷 1810-1821页

作者： Perry G.Beasley-Hall Yukihiro Kinjo Harley A.Rose james Walker Charles S.P.Foster Toby G.L.Kovacs Thomas Bourguignon Simon Y.W.Ho Nathan Lo School of Life and Environmental Sciences University of SydneySydneyNew South WalesAustralia School of Biological Sciences University of AdelaideAdelaideSouth AustraliaAustralia Evolutionary Genomics Unit Okinawa Institute of Science&Technology Graduate UniversityOnna-sonOkinawaJapan Australian Government Department of Agriculture Water and Environment CanberraAustralia School of Biomedical Sciences University of New South WalesSydneyNew South WalesAustralia

Microbial symbioses have had profound impacts on the evolution of ***,changes in host biology may impact the evolutionary trajectory of symbionts *** cuenoti is present in almost all cockroach species and enables hosts to subsist on a nutrient-poor *** investigate if host biology has impacted Blattabacterium at the genomic level,we sequenced and analyzed 25 genomes from Australian soil-burrowing cockroaches(Blaberidae:Panesthiinae),which have undergone at least seven separate subterranean,subsocial transitions from above-ground,wood-feeding *** find at least three independent instances of genome erosion have occurred in Blattabacterium strains exclusive to Australian soil-burrowing *** shrinkages have involved the repeated inactivation of genes involved in amino acid biosynthesis and nitrogen recycling,the core role of Blattabacterium in the host-symbiont *** most drastic of these erosions have occurred in hosts thought to have transitioned underground the earliest relative to other lineages,further suggestive of a link between gene loss in Blattabacterium and the burrowing behavior of *** Blattabacterium is unable to fulfill its core function in certain host lineages,these findings suggest soil-burrowing cockroaches must acquire these nutrients from novel *** study represents one of the first cases,to our knowledge,of parallel host adaptations leading to concomitant parallelism in their mutualistic symbionts,further underscoring the intimate relationship between these two partners.

关键词： Blattabacterium endosymbiosis gene loss molecular evolution parallel evolution subterranean habitats

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关于引力模型的拓展：对边境之谜的一个解释

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经济资料译丛 2006年第4期 64-86页

作者： james E.Anderson Eric van Wincoop 王思婷胡朝霞厦门大学经济学院国际经济与贸易系 361005

引力方程是经济学在实证研究上所取得的最伟大的成功之一。它将双边贸易流量与GDP、距离和其他影响贸易壁垒的因素联系起来。该方程波广泛运用于推断如关税同盟、汇率机制、民族纽带、语言文化等体系的贸易流动效应。与常理相悖，该实... 详细信息

引力方程是经济学在实证研究上所取得的最伟大的成功之一。它将双边贸易流量与GDP、距离和其他影响贸易壁垒的因素联系起来。该方程波广泛运用于推断如关税同盟、汇率机制、民族纽带、语言文化等体系的贸易流动效应。与常理相悖，该实证性的引力方程并不具备理论基础。由Ander son[1979]首次提出的理论告诉我们：在控制了经济规模之后，

关键词：引力模型边境实证研究贸易流量贸易壁垒关税同盟汇率机制贸易流动

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